{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T06:33:26Z","timestamp":1778049206538,"version":"3.51.4"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T00:00:00Z","timestamp":1596153600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T00:00:00Z","timestamp":1596153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100005627","name":"Thrasher Research Fund","doi-asserted-by":"publisher","award":["12754"],"award-info":[{"award-number":["12754"]}],"id":[{"id":"10.13039\/100005627","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1007\/s00467-020-04705-1","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T13:05:04Z","timestamp":1596200704000},"page":"323-331","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Chronic kidney disease impacts health-related quality of life of children in Uganda, East Africa"],"prefix":"10.1007","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8669-9267","authenticated-orcid":false,"given":"Peace D.","family":"Imani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Aujo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Kiguli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poyyapakkam","family":"Srivaths","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen D.","family":"Brewer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,7,31]]},"reference":[{"key":"4705_CR1","doi-asserted-by":"crossref","unstructured":"Wong CJ, Moxey-Mims M, Jerry-Fluker J, Warady BA, Furth SL (2012) CKiD (CKD in children) prospective cohort study: a review of current findings. Am J Kidney Dis 60(6):1002\u20131011","DOI":"10.1053\/j.ajkd.2012.07.018"},{"issue":"3","key":"4705_CR2","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1053\/j.ajkd.2007.12.006","volume":"51","author":"FA Arogundade","year":"2008","unstructured":"Arogundade FA, Barsoum RS (2008) CKD prevention in Sub-Saharan Africa: a call for governmental, nongovernmental, and community support. Am J Kidney Dis 51(3):515\u2013523","journal-title":"Am J Kidney Dis"},{"issue":"10","key":"4705_CR3","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1056\/NEJMp058318","volume":"354","author":"RS Barsoum","year":"2006","unstructured":"Barsoum RS (2006) Chronic kidney disease in the developing world. N Engl J Med 354(10):997\u2013999","journal-title":"N Engl J Med"},{"key":"4705_CR4","doi-asserted-by":"crossref","unstructured":"Davids MR, Eastwood JB, Selwood NH et al (2016) A renal registry for Africa: first steps. Clin Kidney J 9(1):162\u2013167","DOI":"10.1093\/ckj\/sfv122"},{"key":"4705_CR5","doi-asserted-by":"crossref","unstructured":"Gerson AC, Wentz A, Abraham AG et al (2010) Health-related quality of life of children with mild to moderate chronic kidney disease. Pediatrics 125(2):e349\u2013357","DOI":"10.1542\/peds.2009-0085"},{"key":"4705_CR6","doi-asserted-by":"crossref","unstructured":"Imani PD, Odiit A, Hingorani SR, Weiss NS, Eddy AA (2013) Acute kidney injury and its association with in-hospital mortality among children with acute infections. Pediatr Nephrol 28(11):2199\u20132206","DOI":"10.1007\/s00467-013-2544-2"},{"issue":"1","key":"4705_CR7","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1053\/j.ackd.2014.07.002","volume":"22","author":"SB Nicholas","year":"2015","unstructured":"Nicholas SB, Kalantar-Zadeh K, Norris KC (2015) Socioeconomic disparities in chronic kidney disease. Adv Chronic Kidney Dis 22(1):6\u201315","journal-title":"Adv Chronic Kidney Dis"},{"issue":"5","key":"4705_CR8","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1053\/j.ackd.2011.02.005","volume":"18","author":"HS Janjua","year":"2011","unstructured":"Janjua HS, Mahan JD (2011) Growth in chronic kidney disease. Adv Chronic Kidney Dis 18(5):324\u2013331","journal-title":"Adv Chronic Kidney Dis"},{"key":"4705_CR9","doi-asserted-by":"crossref","unstructured":"Gipson DS, Duquette PJ, Icard PF, Hooper SR et al (2007) The central nervous system in childhood chronic kidney disease. Pediatr Nephrol 22(10):1703\u20131710","DOI":"10.1007\/s00467-006-0269-1"},{"key":"4705_CR10","doi-asserted-by":"crossref","unstructured":"Ruebner RL, Laney N, Kim JY et al (2016) Neurocognitive dysfunction in children, adolescents, and young adults with CKD. Am J Kidney Dis 67(4):567\u2013575","DOI":"10.1053\/j.ajkd.2015.08.025"},{"key":"4705_CR11","doi-asserted-by":"crossref","unstructured":"Bakr A, Amr M, Sarhan A et al (2007) Psychiatric disorders in children with chronic renal failure. Pediatr Nephrol 22(1):128\u2013131","DOI":"10.1007\/s00467-006-0298-9"},{"issue":"9","key":"4705_CR12","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.disamonth.2015.07.005","volume":"61","author":"R Gargiulo","year":"2015","unstructured":"Gargiulo R, Suhail F, Lerma EV (2015) Cardiovascular disease and chronic kidney disease. Dis Mon 61(9):403\u2013413","journal-title":"Dis Mon"},{"key":"4705_CR13","doi-asserted-by":"crossref","unstructured":"Fadrowski J, Cole SR, Hwang W et al (2006) Changes in physical and psychosocial functioning among adolescents with chronic kidney disease. Pediatr Nephrol 21(3):394\u2013399","DOI":"10.1007\/s00467-005-2122-3"},{"key":"4705_CR14","doi-asserted-by":"crossref","unstructured":"McKenna AM, Keating LE, Vigneux A, Stevens S, Williams A, Geary DF (2006) Quality of life in children with chronic kidney disease-patient and caregiver assessments. Nephrol Dial Transplant 21(7):1899\u20131905","DOI":"10.1093\/ndt\/gfl091"},{"key":"4705_CR15","doi-asserted-by":"crossref","unstructured":"Goldstein SL, Gerson AC, Goldman CW, Furth S (2006) Quality of life for children with chronic kidney disease. Semin Nephrol 26(2):114\u2013117","DOI":"10.1016\/j.semnephrol.2005.09.004"},{"issue":"1","key":"4705_CR16","first-page":"153","volume":"29","author":"N Eftimovska","year":"2008","unstructured":"Eftimovska N, Stojceva-Taneva O, Polenakovic M (2008) Slow progression of chronic kidney disease and what it is associated with. Prilozi 29(1):153\u2013165","journal-title":"Prilozi"},{"key":"4705_CR17","doi-asserted-by":"crossref","unstructured":"Furth SL, Cole SR, Fadrowski JJ et al (2007) The association of anemia and hypoalbuminemia with accelerated decline in GFR among adolescents with chronic kidney disease. Pediatr Nephrol 22(2):265\u2013271","DOI":"10.1007\/s00467-006-0313-1"},{"key":"4705_CR18","doi-asserted-by":"crossref","unstructured":"Levey AS, Atkins R, Coresh J et al (2007) Chronic kidney disease as a global public health problem: approaches and initiatives - a position statement from Kidney Disease Improving Global Outcomes. Kidney Int 72(3):247\u2013259","DOI":"10.1038\/sj.ki.5002343"},{"key":"4705_CR19","doi-asserted-by":"crossref","unstructured":"Schwartz GJ, Mu\u00f1oz A, Schneider MF et al (2009) New equations to estimate GFR in children with CKD. J Am Soc Nephrol 20(3):629\u2013637","DOI":"10.1681\/ASN.2008030287"},{"issue":"9","key":"4705_CR20","doi-asserted-by":"publisher","first-page":"2832","DOI":"10.1093\/ndt\/gfq370","volume":"25","author":"SI Hallan","year":"2010","unstructured":"Hallan SI, Orth SR (2010) The KDOQI 2002 classification of chronic kidney disease: for whom the bell tolls. Nephrol Dial Transplant 25(9):2832\u20132836","journal-title":"Nephrol Dial Transplant"},{"key":"4705_CR21","doi-asserted-by":"crossref","unstructured":"Ang YG, Heng BH, Saxena N, Liew STA, Chong PN (2016) Annual all-cause mortality rate for patients with diabetic kidney disease in Singapore. J Clin Transl Endocrinol 4:1\u20136","DOI":"10.1016\/j.jcte.2016.01.002"},{"key":"4705_CR22","doi-asserted-by":"crossref","unstructured":"Sharma P, McCullough K, Scotland G (2010) Does stage-3 chronic kidney disease matter?: a systematic literature review. Br J Gen Pract 60(575):e266\u2013e276","DOI":"10.3399\/bjgp10X502173"},{"key":"4705_CR23","unstructured":"National Guidelines for Research involving Humans as Research Participants (2014) Uganda National Council for Science and Technology: Kampala"},{"issue":"4","key":"4705_CR24","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1007\/s004670050312","volume":"11","author":"E Esbj\u00f6rner","year":"1997","unstructured":"Esbj\u00f6rner E, Berg U, Hansson S (1997) Epidemiology of chronic renal failure in children: a report from Sweden 1986-1994 Swedish Pediatric Nephrology Association. Pediatr Nephrol 11(4):438\u2013442","journal-title":"Pediatr Nephrol"},{"key":"4705_CR25","doi-asserted-by":"crossref","unstructured":"Stevens PE, Levin A, Members KDIGOCKDGDWG (2013) Evaluation and management of chronic kidney disease: synopsis of the kidney disease: improving global outcomes 2012 clinical practice guideline. Ann Intern Med 158(11):825\u2013830","DOI":"10.7326\/0003-4819-158-11-201306040-00007"},{"key":"4705_CR26","doi-asserted-by":"crossref","unstructured":"Halle MP, Lapsap CT, Barla E et al (2017) Epidemiology and outcomes of children with renal failure in the pediatric ward of a tertiary hospital in Cameroon. BMC Pediatr 17(1):202","DOI":"10.1186\/s12887-017-0955-0"},{"issue":"8","key":"4705_CR27","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.2215\/CJN.10751210","volume":"6","author":"L Copelovitch","year":"2011","unstructured":"Copelovitch L, Warady BA, Furth SL (2011) Insights from the Chronic Kidney Disease in Children (CKiD) study. Clin J Am Soc Nephrol 6(8):2047\u20132053","journal-title":"Clin J Am Soc Nephrol"},{"key":"4705_CR28","doi-asserted-by":"crossref","unstructured":"Lande MB, Gerson AC, Hooper SR et al (2011) Casual blood pressure and neurocognitive function in children with chronic kidney disease: a report of the children with chronic kidney disease cohort study. Clin J Am Soc Nephrol 6(8):1831\u20131837","DOI":"10.2215\/CJN.00810111"},{"key":"4705_CR29","doi-asserted-by":"crossref","unstructured":"Hooper SR, Gerson AC, Butler RW et al (2011) Neurocognitive functioning of children and adolescents with mild-to-moderate chronic kidney disease. Clin J Am Soc Nephrol 6(8):1824\u20131830","DOI":"10.2215\/CJN.09751110"},{"key":"4705_CR30","doi-asserted-by":"crossref","unstructured":"Mendley SR, Matheson MB, Shinnar S et al (2015) Duration of chronic kidney disease reduces attention and executive function in pediatric patients. Kidney Int 87(4):800\u2013806","DOI":"10.1038\/ki.2014.323"},{"issue":"2","key":"4705_CR31","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1097\/MNH.0b013e328335f939","volume":"19","author":"RK Soni","year":"2010","unstructured":"Soni RK, Weisbord SD, Unruh ML (2010) Health-related quality of life outcomes in chronic kidney disease. Curr Opin Nephrol Hypertens 19(2):153\u2013159","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"4705_CR32","doi-asserted-by":"crossref","unstructured":"Aguilar M, Andronis L, Pallan M, H\u00f6gler W, Frew E (2020) Micronutrient deficiencies and health-related quality of life: the case of children with vitamin D deficiency. Public Health Nutr 23(7):1165\u20131172","DOI":"10.1017\/S1368980018003841"},{"key":"4705_CR33","doi-asserted-by":"crossref","unstructured":"Abbasnezhad A, Amani R, Hasanvand A, Rad EY, Alipour M, Saboori S, Choghakhori R (2019) Association of serum vitamin D concentration with clinical symptoms and quality of life in patients with irritable bowel syndrome. J Am Coll Nutr 38(4):327\u2013333","DOI":"10.1080\/07315724.2018.1510349"},{"issue":"1","key":"4705_CR34","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s12955-018-0873-3","volume":"16","author":"N Alcubierre","year":"2018","unstructured":"Alcubierre N et al (2018) Vitamin D deficiency is associated with poorer satisfaction with diabetes-related treatment and quality of life in patients with type 2 diabetes: a cross-sectional study. Health Qual Life Outcomes 16(1):44","journal-title":"Health Qual Life Outcomes"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-020-04705-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00467-020-04705-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-020-04705-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T00:03:39Z","timestamp":1627689819000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00467-020-04705-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,31]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["4705"],"URL":"https:\/\/doi.org\/10.1007\/s00467-020-04705-1","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,31]]},"assertion":[{"value":"21 February 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Consent was obtained from all parents or caregivers, and assent obtained from children who were 8\u00a0years or older.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"This study was approved by the Baylor College of Medicine Institutional Review Board, the Makerere University Faculty of Medicine and Mulago Hospital Research and Ethics Committees, and the Uganda National Council of Science and Technology.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The findings and conclusions contained within the manuscript are those of the authors and do not necessarily reflect positions or policies of the Thrasher Research Fund.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclaimer"}}]}}