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Children with steroid-sensitive nephrotic syndrome (SSNS) generally have a good prognosis regarding the maintenance of normal kidney function even in the case of frequent relapses. The course of SSNS is often complicated by a high rate of relapses and the associated side effects of repeated glucocorticoid (steroid) therapy. The following recommendations for the treatment of SSNS are based on the comprehensive consideration of published evidence by a working group of the German Society for Pediatric Nephrology (GPN) based on the systematic Cochrane reviews on SSNS and the guidelines of the KDIGO working group (Kidney Disease - Improving Global Outcomes).<\/jats:p>","DOI":"10.1007\/s00467-021-05135-3","type":"journal-article","created":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T20:02:57Z","timestamp":1622923377000},"page":"2971-2985","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Pediatric idiopathic steroid-sensitive nephrotic syndrome: diagnosis and therapy \u2014short version of the updated German best practice guideline (S2e) \u2014 AWMF register no. 166-001, 6\/2020"],"prefix":"10.1007","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3245-7481","authenticated-orcid":false,"given":"Rasmus","family":"Ehren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus R.","family":"Benz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul T.","family":"Brinkk\u00f6tter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"D\u00f6tsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang R.","family":"Eberl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jutta","family":"Gellermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9132-0282","authenticated-orcid":false,"given":"Peter F.","family":"Hoyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Jordans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Kamrath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus J.","family":"Kemper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kay","family":"Latta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6598-6910","authenticated-orcid":false,"given":"Burkhard","family":"T\u00f6nshoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutz T.","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the German Society for Pediatric Nephrology","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,6]]},"reference":[{"key":"5135_CR1","unstructured":"Fischer R, Franke I, Gahr M, Giani G, Griese M, Hahn A, Herrmann B, Jansson A, Lainka E, Liese J, Nowak-G\u00f6ttl U, Schmitt HJ, Wirth S (2007) ESPED \u2013 Jahresbericht 2006. 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RE, PTB, and LTW receive financial support from the DFG (German Research Foundation) for their work within the Clinical Research Unit 329 (\u201cDisease pathways in podocyte injury \u2014 from molecular mechanisms to individualized treatment options\u201d) at the University Hospital of Cologne.JD is a consultant and expert for Nestl\u00e9 Germany AG, Danone SA and Novartis Pharma GmbH (Advisory Board). WRE is a consultant and expert at Bayer AG, Biotest AG and Sobi AG and has received honoraria for lectures from CSL Behring GmbH, Bayer AG and Novo Nordisk Pharma GmbH. CK is on the scientific advisory board of BioMarin Pharmaceutical Inc., Aegerion Pharmaceuticals GmbH, and Sobi AG and has received honoraria for lectures and training from Aegerion Pharmaceuticals GmbH and Diurnal Ltd. Jun Oh is a consultant and reviewer for Alnylam Germany GmbH and Chiesi GmbH (Advisory Board) and has received lecture fees from Recordati Pharma GmbH. BT is a consultant and expert at Bristol-Myers Squibb GmbH. He is on the scientific advisory board of \u201ctransplant campus\u201d and conducts clinical studies with the companies Novartis Pharma GmbH and Astellas Pharma GmbH. LTW is a consultant and expert for Alexion-Pharma GmbH, Alnylam Germany GmbH, Greenovation Biotech GmbH and Chiesi GmbH. JG, PFH, IJ, MJK, KL, DM, and SW declare no conflict of interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}