{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:37:30Z","timestamp":1789385850084,"version":"build-2803163510"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T00:00:00Z","timestamp":1636070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T00:00:00Z","timestamp":1636070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1007\/s00467-021-05279-2","type":"journal-article","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T01:02:30Z","timestamp":1636074150000},"page":"1407-1413","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The relationship between hyperchloremia and acute kidney injury in pediatric diabetic ketoacidosis and its impact on clinical outcomes"],"prefix":"10.1007","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8086-3759","authenticated-orcid":false,"given":"Heba Mostafa","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagar Ramadan Hasb","family":"Elnaby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehab Muhammad Abd","family":"El kareem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Hodeib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,5]]},"reference":[{"key":"5279_CR1","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1111\/pedi.12701","volume":"19","author":"JI Wolfsdorf","year":"2018","unstructured":"Wolfsdorf JI, Glaser N, Agus M, Fritsch M, Hanas R, Rewers A et al (2018) ISPAD Clinical Practice Consensus Guidelines 2018: diabetic ketoacidosis and the hyperglycemic hyperosmolar state. Pediatr Diabetes 19:155\u2013177","journal-title":"Pediatr Diabetes"},{"key":"5279_CR2","doi-asserted-by":"publisher","first-page":"114","DOI":"10.5001\/omj.2010.31","volume":"25","author":"Z Razavi","year":"2010","unstructured":"Razavi Z (2010) Frequency of ketoacidosis in newly diagnosed type 1 diabetic children. Oman Med J 25:114\u2013117","journal-title":"Oman Med J"},{"key":"5279_CR3","doi-asserted-by":"publisher","first-page":"10358","DOI":"10.1038\/srep10358","volume":"19","author":"C Jefferies","year":"2015","unstructured":"Jefferies C, Cutfield SW, Derraik JG, Bhagvandas J, Albert BB, Hofman PL et al (2015) 15-year incidence of diabetic ketoacidosis at onset of type 1 diabetes in children from a regional setting (Auckland, New Zealand). Sci Rep 19:10358","journal-title":"Sci Rep"},{"key":"5279_CR4","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1542\/pir.23-2-47","volume":"23","author":"JC Chan","year":"2002","unstructured":"Chan JC, Williams DM, Roth KS (2002) Kidney failure in infants and children. Pediatr Rev 23:47\u201360","journal-title":"Pediatr Rev"},{"key":"5279_CR5","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s00467-018-4128-7","volume":"35","author":"AM Uber","year":"2020","unstructured":"Uber AM, Sutherland SM (2020) Acute kidney injury in hospitalized children: consequences and outcomes. Pediatr Nephrol 35:213\u2013220","journal-title":"Pediatr Nephrol"},{"key":"5279_CR6","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.2337\/dc09-9032","volume":"32","author":"AE Kitabchi","year":"2009","unstructured":"Kitabchi AE, Umpierrez GE, Miles JM, Fisher JN (2009) Hyperglycemic crises in adult patients with diabetes. Diabetes Care 32:1335\u20131343","journal-title":"Diabetes Care"},{"key":"5279_CR7","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.jcrc.2012.01.007","volume":"27","author":"HR Chua","year":"2012","unstructured":"Chua HR, Venkatesh B, Stachowski E, Schneider AG, Perkins K, Ladanyi S et al (2012) Plasma-Lyte 148 vs 0.9% saline for fluid resuscitation in diabetic ketoacidosis. J Crit Care 27:138\u2013145","journal-title":"J Crit Care"},{"key":"5279_CR8","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1177\/0885066612467149","volume":"29","author":"S Basnet","year":"2014","unstructured":"Basnet S, Venepalli PK, Andoh J, Verhulst S, Koirala J (2014) Effect of normal saline and half normal saline on serum electrolytes during recovery phase of diabetic ketoacidosis. J Intensive Care Med 29:38\u201342. https:\/\/doi.org\/10.1177\/0885066612467149","journal-title":"J Intensive Care Med"},{"key":"5279_CR9","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1056\/NEJMoa1711584","volume":"378","author":"MW Semler","year":"2018","unstructured":"Semler MW, Self WH, Wanderer JP, Ehrenfeld JM, Wang L, Byrne DW et al (2018) Balanced crystalloids versus saline in critically Ill adults. N Engl J Med 378:829\u2013839","journal-title":"N Engl J Med"},{"key":"5279_CR10","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1001\/jama.2015.12334","volume":"314","author":"P Young","year":"2015","unstructured":"Young P, Bailey M, Beasley R, Henderson S, Mackle D, McArthur C et al (2015) Effect of a buffered crystalloid solution vs saline on acute kidney injury among patients in the intensive care unit: the SPLIT randomized clinical trial. JAMA 314:1701\u20131710","journal-title":"JAMA"},{"key":"5279_CR11","first-page":"113","volume":"49","author":"AS Asl","year":"2011","unstructured":"Asl AS, Maleknejad S, Kelachaye ME (2011) Diabetic ketoacidosis and its complications among children. Acta Med Iran 49:113\u2013114","journal-title":"Acta Med Iran"},{"key":"5279_CR12","first-page":"e365","volume":"116","author":"I Toledo","year":"2018","unstructured":"Toledo I, Wainsztein R, Mannucci C, Ferraro M, Ferreira J, Balestracci A (2018) Impact of the hyperchloremic component of metabolic acidosis on the patient\u2019s hydration status and the treatment of diabetic ketoacidosis. Arch Argent Pediatr 116:e365\u2013e370","journal-title":"Arch Argent Pediatr"},{"key":"5279_CR13","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S0168-8227(96)01332-0","volume":"34","author":"MS Elisaf","year":"1996","unstructured":"Elisaf MS, Tsatsoulis AA, Katopodis KP, Siamopoulos KC (1996) Acid-base and electrolyte disturbances in patients with diabetic ketoacidosis. Diabetes Res Clin Pract 34:23\u201327","journal-title":"Diabetes Res Clin Pract"},{"key":"5279_CR14","doi-asserted-by":"publisher","first-page":"e170020","DOI":"10.1001\/jamapediatrics.2017.0020","volume":"171","author":"BE Hursh","year":"2017","unstructured":"Hursh BE, Ronsley R, Islam N, Mammen C, Panagiotopoulos C (2017) Acute kidney injury in children with type 1 diabetes hospitalized for diabetic ketoacidosis. JAMA Pediatr 171:e170020","journal-title":"JAMA Pediatr"},{"key":"5279_CR15","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s13312-018-1274-8","volume":"55","author":"M Baalaaji","year":"2018","unstructured":"Baalaaji M, Jayashree M, Nallasamy K, Singhi S, Bansal A (2018) Predictors and outcome of acute kidney injury in children with diabetic ketoacidosis. Indian Pediatr 55:311\u2013314","journal-title":"Indian Pediatr"},{"key":"5279_CR16","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.2215\/CJN.12751211","volume":"7","author":"M Zappitelli","year":"2012","unstructured":"Zappitelli M, Coca SG, Garg AX, Krawczeski CD, Heather PT, Sint K et al (2012) The association of albumin\/creatinine ratio with postoperative AKI in children undergoing cardiac surgery. Clin J Am Soc Nephrol 7:1761\u20131769","journal-title":"Clin J Am Soc Nephrol"},{"key":"5279_CR17","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1681\/ASN.2008060655","volume":"20","author":"M van der Velde","year":"2009","unstructured":"van der Velde M, Halbesma N, de Charro FT, Bakker SJ, de Zeeuw D, de Jong PE et al (2009) Screening for albuminuria identifies individuals at increased renal risk. J Am Soc Nephrol 20:852\u2013862","journal-title":"J Am Soc Nephrol"},{"key":"5279_CR18","doi-asserted-by":"publisher","first-page":"106","DOI":"10.3389\/fped.2016.00106","volume":"4","author":"IF Shatat","year":"2016","unstructured":"Shatat IF, Qanungo S, Hudson S, Laken MA, Hailpern SM (2016) Changes in urine microalbumin-to-creatinine ratio in children with sickle cell disease over time. Front Pediatr 4:106. https:\/\/doi.org\/10.3389\/fped.2016.00106","journal-title":"Front Pediatr"},{"key":"5279_CR19","doi-asserted-by":"publisher","first-page":"e0239160","DOI":"10.1371\/journal.pone.0239160","volume":"15","author":"SK Huang","year":"2020","unstructured":"Huang SK, Huang CY, Lin CH, Cheng BW, Chiang YT, Lee YC et al (2020) Acute kidney injury is a common complication in children and adolescents hospitalized for diabetic ketoacidosis. PLoS One 15:e0239160","journal-title":"PLoS One"},{"key":"5279_CR20","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1111\/j.1651-2227.1990.tb11491.x","volume":"79","author":"M Miltenyi","year":"1990","unstructured":"Miltenyi M, Szabo A, Tulassay T, K\u00f6rner A, Kenesei E et al (1990) Reduced glomerular filtration and elevated urinary protein excretion in diabetic ketoacidose. Acta Paediatr Scand 79:444\u2013447","journal-title":"Acta Paediatr Scand"},{"key":"5279_CR21","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1097\/PCC.0000000000001928","volume":"20","author":"B Parajuli","year":"2019","unstructured":"Parajuli B, Kumar Angurana S, Baalaaji M, Williams V (2019) Acute kidney injury inchildren with diabetic ketoacidosis: a real concern. Pediatr Crit Care Med 20:590\u2013591","journal-title":"Pediatr Crit Care Med"},{"key":"5279_CR22","doi-asserted-by":"publisher","first-page":"S55","DOI":"10.1016\/j.jcrc.2020.01.026","volume":"24","author":"V Williams","year":"2020","unstructured":"Williams V, Jayashree M, Nallasamy K, Dayal D, Rawat A (2020) 0.9% saline versus Plasma-Lyte as initial fluid in children with diabetic ketoacidosis (SPinK trial): a double-blind randomized controlled trial. Crit Care 24:S55\u2013S57","journal-title":"Crit Care"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-021-05279-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00467-021-05279-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-021-05279-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T12:01:21Z","timestamp":1654257681000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00467-021-05279-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,5]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["5279"],"URL":"https:\/\/doi.org\/10.1007\/s00467-021-05279-2","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,5]]},"assertion":[{"value":"28 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 September 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 September 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2022","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The name Rehab\u00a0Muhammad\u00a0Abd\u00a0El\u00a0kareem has been tagged correctly.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the local ethical committee of the faculty of Medicine, Beni-Suef University (FMBSUREC \/03122019. FWA00015574).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"An informed written consent was obtained from the care givers of the included participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}