{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T01:22:53Z","timestamp":1752283373166,"version":"3.37.3"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T00:00:00Z","timestamp":1651622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T00:00:00Z","timestamp":1651622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"NIDDK Diabetic Complications Consortium","award":["DK076169"],"award-info":[{"award-number":["DK076169"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1007\/s00467-022-05531-3","type":"journal-article","created":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T09:03:01Z","timestamp":1651654981000},"page":"193-202","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Plasma levels of carboxylic acids are markers of early kidney dysfunction in young people with type 1 diabetes"],"prefix":"10.1007","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7087-8570","authenticated-orcid":false,"given":"Timothy","family":"Vigers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carissa","family":"Vinovskis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu-Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pottumarthi","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiddo","family":"Heerspink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"D\u2019Alessandro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie A.","family":"Reisz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Piani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David Z.","family":"Cherney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel H.","family":"van Raalte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen J.","family":"Nadeau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meda E.","family":"Pavkov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert G.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Pyle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petter","family":"Bjornstad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,5,4]]},"reference":[{"key":"5531_CR1","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.2337\/db08-1543","volume":"58","author":"PH Groop","year":"2009","unstructured":"Groop PH, Thomas MC, Moran JL, Wad\u00e8n J, Thorn LM, M\u00e4kinen VP, Roseng\u00e5rd-B\u00e4rlund M, Saraheimo M, Hietala K, Heikkil\u00e4 O, Forsblom C, FinnDiane Study Group (2009) The presence and severity of chronic kidney disease predicts all-cause mortality in type 1 diabetes. Diabetes 58:1651\u20131658","journal-title":"Diabetes"},{"key":"5531_CR2","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1007\/s00125-010-1860-3","volume":"53","author":"TJ Orchard","year":"2010","unstructured":"Orchard TJ, Secrest AM, Miller RG, Costacou T (2010) In the absence of renal disease, 20 year mortality risk in type 1 diabetes is comparable to that of the general population: a report from the Pittsburgh Epidemiology of Diabetes Complications Study. Diabetologia 53:2312\u20132319","journal-title":"Diabetologia"},{"key":"5531_CR3","doi-asserted-by":"publisher","first-page":"3678","DOI":"10.2337\/dc13-0631","volume":"36","author":"P Bjornstad","year":"2013","unstructured":"Bjornstad P, Snell-Bergeon JK, Rewers M, Jalal D, Chonchol MB, Johnson RJ, Maahs DM (2013) Early diabetic nephropathy: a complication of reduced insulin sensitivity in type 1 diabetes. Diabetes Care 36:3678\u20133683","journal-title":"Diabetes Care"},{"key":"5531_CR4","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1146\/annurev.ph.48.030186.000301","volume":"48","author":"SP Soltoff","year":"1986","unstructured":"Soltoff SP (1986) ATP and the regulation of renal cell function. Annu Rev Physiol 48:9\u201331","journal-title":"Annu Rev Physiol"},{"key":"5531_CR5","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.kint.2020.02.041","volume":"98","author":"AC Hesp","year":"2020","unstructured":"Hesp AC, Schaub JA, Prasad PV, Vallon V, Laverman GD, Bjornstad P, van Raalte DH (2020) The role of renal hypoxia in the pathogenesis of diabetic kidney disease: a promising target for newer renoprotective agents including SGLT2 inhibitors? Kidney Int 98:579\u2013589","journal-title":"Kidney Int"},{"key":"5531_CR6","first-page":"F423","volume":"236","author":"JJ Cohen","year":"1979","unstructured":"Cohen JJ (1979) Is the function of the renal papilla coupled exclusively to an anaerobic pattern of metabolism? Am J Phys 236:F423\u2013F433","journal-title":"Am J Phys"},{"key":"5531_CR7","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1038\/nrneph.2017.107","volume":"13","author":"P Bhargava","year":"2017","unstructured":"Bhargava P, Schnellmann RG (2017) Mitochondrial energetics in the kidney. Nat Rev Nephrol 13:629\u2013646","journal-title":"Nat Rev Nephrol"},{"key":"5531_CR8","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1681\/ASN.2013020126","volume":"24","author":"K Sharma","year":"2013","unstructured":"Sharma K, Karl B, Mathew AV, Gangoiti JA, Wassel CL, Saito R, Pu M, Sharma S, You YH, Wang L, Diamond-Stanic M, Lindenmeyer MT, Forsblom C, Wu W, Ix JH, Ideker T, Kopp JB, Nigam SK, Cohen CD et al (2013) Metabolomics reveals signature of mitochondrial dysfunction in diabetic kidney disease. J Am Soc Nephrol 24:1901\u20131912","journal-title":"J Am Soc Nephrol"},{"key":"5531_CR9","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1681\/ASN.2005070757","volume":"17","author":"M Nangaku","year":"2006","unstructured":"Nangaku M (2006) Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure. J Am Soc Nephrol 17:17\u201325","journal-title":"J Am Soc Nephrol"},{"key":"5531_CR10","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/ncpneph0757","volume":"4","author":"DK Singh","year":"2008","unstructured":"Singh DK, Winocour P, Farrington K (2008) Mechanisms of disease: the hypoxic tubular hypothesis of diabetic nephropathy. Nat Clin Pract Nephrol 4:216\u2013226","journal-title":"Nat Clin Pract Nephrol"},{"key":"5531_CR11","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.1007\/s00726-015-2019-9","volume":"47","author":"T Nemkov","year":"2015","unstructured":"Nemkov T, D'Alessandro A, Hansen KC (2015) Three-minute method for amino acid analysis by UHPLC and high-resolution quadrupole orbitrap mass spectrometry. Amino Acids 47:2345\u20132357","journal-title":"Amino Acids"},{"key":"5531_CR12","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/978-1-4939-9236-2_2","volume":"1978","author":"T Nemkov","year":"2019","unstructured":"Nemkov T, Reisz JA, Gehrke S, Hansen KC, D'Alessandro A (2019) High-throughput metabolomics: isocratic and gradient mass spectrometry-based methods. Methods Mol Biol 1978:13\u201326","journal-title":"Methods Mol Biol"},{"key":"5531_CR13","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1002\/rcm.7834","volume":"31","author":"T Nemkov","year":"2017","unstructured":"Nemkov T, Hansen KC, D'Alessandro A (2017) A three-minute method for high-throughput quantitative metabolomics and quantitative tracing experiments of central carbon and nitrogen pathways. Rapid Commun Mass Spectrom 31:663\u2013673","journal-title":"Rapid Commun Mass Spectrom"},{"key":"5531_CR14","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/j.xkme.2020.05.013","volume":"2","author":"JC Seegmiller","year":"2020","unstructured":"Seegmiller JC, Wolf BJ, Albtoush N, Melena I, Gross SP, Vinovskis C, Ix JH, Bjornstad P (2020) Tubular secretion markers, glomerular filtration rate, effective renal plasma flow, and filtration fraction in healthy adolescents. Kidney Med 2:670\u2013672","journal-title":"Kidney Med"},{"key":"5531_CR15","doi-asserted-by":"publisher","first-page":"2700","DOI":"10.2337\/db20-0457","volume":"69","author":"C Vinovskis","year":"2020","unstructured":"Vinovskis C, Li LP, Prasad P, Tommerdahl K, Pyle L, Nelson RG, Pavkov ME, van Raalte D, Rewers M, Pragnell M, Mahmud FH, Cherney DZ, Johnson RJ, Nadeau KJ, Bjornstad P (2020) Relative hypoxia and early diabetic kidney disease in type 1 diabetes. Diabetes 69:2700\u20132708","journal-title":"Diabetes"},{"key":"5531_CR16","doi-asserted-by":"publisher","first-page":"2024","DOI":"10.1093\/ndt\/gfh983","volume":"20","author":"P Delanaye","year":"2005","unstructured":"Delanaye P, Radermecker RP, Rorive M, Depas G, Krzesinski JM (2005) Indexing glomerular filtration rate for body surface area in obese patients is misleading: concept and example. Nephrol Dial Transplant 20:2024\u20132028","journal-title":"Nephrol Dial Transplant"},{"key":"5531_CR17","doi-asserted-by":"publisher","first-page":"i3","DOI":"10.1093\/ndt\/gfz230","volume":"35","author":"DZ Cherney","year":"2020","unstructured":"Cherney DZ, Kanbay M, Lovshin JA (2020) Renal physiology of glucose handling and therapeutic implications. Nephrol Dial Transplant 35:i3\u2013i12","journal-title":"Nephrol Dial Transplant"},{"key":"5531_CR18","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1161\/CIRCULATIONAHA.113.005081","volume":"129","author":"DZ Cherney","year":"2014","unstructured":"Cherney DZ, Perkins BA, Soleymanlou N, Maione M, Lai V, Lee A, Fagan NM, Woerle HJ, Johansen OE, Broedl UC, von Eynatten M (2014) Renal hemodynamic effect of sodium-glucose cotransporter 2 inhibition in patients with type 1 diabetes mellitus. Circulation 129:587\u2013597","journal-title":"Circulation"},{"key":"5531_CR19","first-page":"e13","volume":"71","author":"PK Whelton","year":"2018","unstructured":"Whelton PK, Carey RM, Aronow WS, Casey DE Jr, Collins KJ, Dennison Himmelfarb C, DePalma SM, Gidding S, Jamerson KA, Jones DW, MacLaughlin EJ, Muntner P, Ovbiagele B, Smith SC Jr, Spencer CC, Stafford RS, Taler SJ, Thomas RJ, Williams KA Sr et al (2018) 2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension 71:e13\u2013e115","journal-title":"Hypertension"},{"key":"5531_CR20","doi-asserted-by":"crossref","first-page":"Article 35","DOI":"10.2202\/1544-6115.1390","volume":"7","author":"KA Le Cao","year":"2008","unstructured":"Le Cao KA, Rossouw D, Robert-Granie C, Besse P (2008) A sparse PLS for variable selection when integrating omics data. Stat Appl Genet Mol Biol 7:Article 35","journal-title":"Stat Appl Genet Mol Biol"},{"key":"5531_CR21","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s11306-007-0099-6","volume":"4","author":"JA Westerhuis","year":"2008","unstructured":"Westerhuis JA, Hoefsloot HCJ, Smit S, Vis DJ, Smilde AK, van Velzen EJJ, van Duijnhoven JPM, van Dorsten FA (2008) Assessment of PLSDA cross validation. Metabolomics 4:81\u201389","journal-title":"Metabolomics"},{"key":"5531_CR22","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W, Smyth GK (2015) limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res 43:e47\u2013e47","journal-title":"Nucleic Acids Res"},{"key":"5531_CR23","doi-asserted-by":"publisher","first-page":"e1005752","DOI":"10.1371\/journal.pcbi.1005752","volume":"13","author":"D Schneidman","year":"2017","unstructured":"Schneidman D, Rohart F, Gautier B, Singh A, L\u00ea Cao K-A (2017) mixOmics: An R package for \u2018omics feature selection and multiple data integration. PLoS Comput Biol 13:e1005752","journal-title":"PLoS Comput Biol"},{"key":"5531_CR24","doi-asserted-by":"publisher","first-page":"3647","DOI":"10.1210\/jc.2018-00433","volume":"103","author":"M Cree-Green","year":"2018","unstructured":"Cree-Green M, Stuppy JJ, Thurston J, Bergman BC, Coe GV, Baumgartner AD, Bacon S, Scherzinger A, Pyle L, Nadeau KJ (2018) Youth with type 1 diabetes have adipose, hepatic, and peripheral insulin resistance. J Clin Endocrinol Metab 103:3647\u20133657","journal-title":"J Clin Endocrinol Metab"},{"key":"5531_CR25","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.jdiacomp.2018.01.002","volume":"32","author":"RJ Millstein","year":"2018","unstructured":"Millstein RJ, Pyle LL, Bergman BC, Eckel RH, Maahs DM, Rewers MJ, Schauer IE, Snell-Bergeon JK (2018) Sex-specific differences in insulin resistance in type 1 diabetes: the CACTI cohort. J Diabetes Complicat 32:418\u2013423","journal-title":"J Diabetes Complicat"},{"key":"5531_CR26","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1210\/jc.2009-1756","volume":"95","author":"KJ Nadeau","year":"2010","unstructured":"Nadeau KJ, Regensteiner JG, Bauer TA, Brown MS, Dorosz JL, Hull A, Zeitler P, Draznin B, Reusch JE (2010) Insulin resistance in adolescents with type 1 diabetes and its relationship to cardiovascular function. J Clin Endocrinol Metab 95:513\u2013521","journal-title":"J Clin Endocrinol Metab"},{"key":"5531_CR27","doi-asserted-by":"publisher","first-page":"306","DOI":"10.2337\/db10-0328","volume":"60","author":"IE Schauer","year":"2011","unstructured":"Schauer IE, Snell-Bergeon JK, Bergman BC, Maahs DM, Kretowski A, Eckel RH, Rewers M (2011) Insulin resistance, defective insulin-mediated fatty acid suppression, and coronary artery calcification in subjects with and without type 1 diabetes: the CACTI study. Diabetes 60:306\u2013314","journal-title":"Diabetes"},{"key":"5531_CR28","doi-asserted-by":"publisher","first-page":"383","DOI":"10.2337\/db14-0765","volume":"64","author":"M Cree-Green","year":"2015","unstructured":"Cree-Green M, Newcomer BR, Brown MS, Baumgartner AD, Bergman B, Drew B, Regensteiner JG, Pyle L, Reusch JE, Nadeau KJ (2015) Delayed skeletal muscle mitochondrial ADP recovery in youth with type 1 diabetes relates to muscle insulin resistance. Diabetes 64:383\u2013392","journal-title":"Diabetes"},{"key":"5531_CR29","doi-asserted-by":"publisher","first-page":"e86976","DOI":"10.1172\/jci.insight.86976","volume":"1","author":"KM Sas","year":"2016","unstructured":"Sas KM, Kayampilly P, Byun J, Nair V, Hinder LM, Hur J, Zhang H, Lin C, Qi NR, Michailidis G, Groop PH, Nelson RG, Darshi M, Sharma K, Schelling JR, Sedor JR, Pop-Busui R, Weinberg JM, Soleimanpour SA et al (2016) Tissue-specific metabolic reprogramming drives nutrient flux in diabetic complications. JCI Insight 1:e86976","journal-title":"JCI Insight"},{"key":"5531_CR30","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1007\/s11306-018-1380-6","volume":"14","author":"PJ Saulnier","year":"2018","unstructured":"Saulnier PJ, Darshi M, Wheelock KM, Looker HC, Fufaa GD, Knowler WC, Weil EJ, Tanamas SK, Lemley KV, Saito R, Natarajan L, Nelson RG, Sharma K (2018) Urine metabolites are associated with glomerular lesions in type 2 diabetes. Metabolomics 14:84","journal-title":"Metabolomics"},{"key":"5531_CR31","doi-asserted-by":"publisher","first-page":"dgaa173","DOI":"10.1210\/clinem\/dgaa173","volume":"105","author":"N Tofte","year":"2020","unstructured":"Tofte N, Vogelzangs N, Mook-Kanamori D, Brahimaj A, Nano J, Ahmadizar F, Willems van Dijk K, Frimodt-Moller M, Arts I, Beulens JWJ, Rutters F, van der Heijden AA, Kavousi M, Stehouwer CDA, Nijpels G, van Greevenbroek MMJ, van der Kallen CJH, Rossing P, Ahluwalia TS, \u2019t Hart LM (2020) Plasma metabolomics identifies markers of impaired renal function: a meta-analysis of 3,089 persons with type 2 diabetes. J Clin Endocrinol Metab 105:dgaa173","journal-title":"J Clin Endocrinol Metab"},{"key":"5531_CR32","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.jdiacomp.2016.10.014","volume":"31","author":"M Cree-Green","year":"2017","unstructured":"Cree-Green M, Gupta A, Coe GV, Baumgartner AD, Pyle L, Reusch JE, Brown MS, Newcomer BR, Nadeau KJ (2017) Insulin resistance in type 2 diabetes youth relates to serum free fatty acids and muscle mitochondrial dysfunction. J Diabetes Complicat 31:141\u2013148","journal-title":"J Diabetes Complicat"},{"key":"5531_CR33","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1038\/sj.ki.5000221","volume":"69","author":"VH Haase","year":"2006","unstructured":"Haase VH (2006) The VHL\/HIF oxygen-sensing pathway and its relevance to kidney disease. Kidney Int 69:1302\u20131307","journal-title":"Kidney Int"},{"key":"5531_CR34","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.2337\/dc16-0542","volume":"39","author":"S Mudaliar","year":"2016","unstructured":"Mudaliar S, Alloju S, Henry RR (2016) Can a shift in fuel energetics explain the beneficial cardiorenal outcomes in the EMPA-REG OUTCOME study? A unifying hypothesis. Diabetes Care 39:1115\u20131122","journal-title":"Diabetes Care"},{"key":"5531_CR35","first-page":"347","volume":"17","author":"N Clendenen","year":"2019","unstructured":"Clendenen N, Nunns GR, Moore EE, Gonzalez E, Chapman M, Reisz JA, Peltz E, Fragoso M, Nemkov T, Wither MJ, Sauaia A, Silliman CC, Hansen K, Banerjee A, D'Alessandro A, Moore HB (2019) Selective organ ischaemia\/reperfusion identifies liver as the key driver of the post-injury plasma metabolome derangements. Blood Transfus 17:347\u2013356","journal-title":"Blood Transfus"},{"key":"5531_CR36","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.kint.2018.10.020","volume":"95","author":"BM Fox","year":"2019","unstructured":"Fox BM, Gil HW, Kirkbride-Romeo L, Bagchi RA, Wennersten SA, Haefner KR, Skrypnyk NI, Brown CN, Soranno DE, Gist KM, Griffin BR, Jovanovich A, Reisz JA, Wither MJ, D'Alessandro A, Edelstein CL, Clendenen N, McKinsey TA, Altmann C, Faubel S (2019) Metabolomics assessment reveals oxidative stress and altered energy production in the heart after ischemic acute kidney injury in mice. Kidney Int 95:590\u2013610","journal-title":"Kidney Int"},{"key":"5531_CR37","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1161\/CIRCRESAHA.119.316298","volume":"127","author":"T Xie","year":"2020","unstructured":"Xie T, Chen C, Peng Z, Brown BC, Reisz JA, Xu P, Zhou Z, Song A, Zhang Y, Bogdanov MV, Kellems RE, D'Alessandro A, Zhang W, Xia Y (2020) Erythrocyte metabolic reprogramming by sphingosine 1-phosphate in chronic kidney disease and therapies. Circ Res 127:360\u2013375","journal-title":"Circ Res"},{"key":"5531_CR38","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/nature13909","volume":"515","author":"ET Chouchani","year":"2014","unstructured":"Chouchani ET, Pell VR, Gaude E, Aksentijevic D, Sundier SY, Robb EL, Logan A, Nadtochiy SM, Ord ENJ, Smith AC, Eyassu F, Shirley R, Hu CH, Dare AJ, James AM, Rogatti S, Hartley RC, Eaton S, Costa ASH et al (2014) Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature 515:431\u2013435","journal-title":"Nature"},{"key":"5531_CR39","doi-asserted-by":"publisher","first-page":"818","DOI":"10.3389\/fendo.2019.00818","volume":"10","author":"N Tofte","year":"2019","unstructured":"Tofte N, Suvitaival T, Trost K, Mattila IM, Theilade S, Winther SA, Ahluwalia TS, Frimodt-Moller M, Legido-Quigley C, Rossing P (2019) Metabolomic Assessment reveals alteration in polyols and branched chain amino acids associated with present and future renal impairment in a discovery cohort of 637 persons with type 1 diabetes. Front Endocrinol (Lausanne) 10:818","journal-title":"Front Endocrinol (Lausanne)"},{"key":"5531_CR40","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1007\/s00125-018-4619-x","volume":"61","author":"P Welsh","year":"2018","unstructured":"Welsh P, Rankin N, Li Q, Mark PB, Wurtz P, Ala-Korpela M, Marre M, Poulter N, Hamet P, Chalmers J, Woodward M, Sattar N (2018) Circulating amino acids and the risk of macrovascular, microvascular and mortality outcomes in individuals with type 2 diabetes: results from the ADVANCE trial. Diabetologia 61:1581\u20131591","journal-title":"Diabetologia"},{"key":"5531_CR41","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1038\/ki.2013.497","volume":"85","author":"MA Niewczas","year":"2014","unstructured":"Niewczas MA, Sirich TL, Mathew AV, Skupien J, Mohney RP, Warram JH, Smiles A, Huang X, Walker W, Byun J, Karoly ED, Kensicki EM, Berry GT, Bonventre JV, Pennathur S, Meyer TW, Krolewski AS (2014) Uremic solutes and risk of end-stage renal disease in type 2 diabetes: metabolomic study. Kidney Int 85:1214\u20131224","journal-title":"Kidney Int"},{"key":"5531_CR42","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/978-3-030-45328-2_5","volume":"1265","author":"X Li","year":"2020","unstructured":"Li X, Zheng S, Wu G (2020) Amino acid metabolism in the kidneys: nutritional and physiological significance. Adv Exp Med Biol 1265:71\u201395","journal-title":"Adv Exp Med Biol"},{"key":"5531_CR43","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/978-3-030-45328-2_2","volume":"1265","author":"Y Hou","year":"2020","unstructured":"Hou Y, Hu S, Li X, He W, Wu G (2020) Amino acid metabolism in the liver: nutritional and physiological significance. Adv Exp Med Biol 1265:21\u201337","journal-title":"Adv Exp Med Biol"},{"key":"5531_CR44","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1002\/iub.1291","volume":"66","author":"SM Pasiakos","year":"2014","unstructured":"Pasiakos SM, Carbone JW (2014) Assessment of skeletal muscle proteolysis and the regulatory response to nutrition and exercise. IUBMB Life 66:478\u2013484","journal-title":"IUBMB Life"},{"key":"5531_CR45","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1038\/nrendo.2014.171","volume":"10","author":"CJ Lynch","year":"2014","unstructured":"Lynch CJ, Adams SH (2014) Branched-chain amino acids in metabolic signalling and insulin resistance. Nat Rev Endocrinol 10:723\u2013736","journal-title":"Nat Rev Endocrinol"},{"issue":"Pt 1","key":"5531_CR46","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1042\/bj3180085","volume":"318","author":"PA Costeas","year":"1996","unstructured":"Costeas PA, Chinsky JM (1996) Effects of insulin on the regulation of branched-chain alpha-keto acid dehydrogenase E1 alpha subunit gene expression. Biochem J 318(Pt 1):85\u201392","journal-title":"Biochem J"},{"key":"5531_CR47","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1097\/MCO.0000000000000235","volume":"19","author":"P Giesbertz","year":"2016","unstructured":"Giesbertz P, Daniel H (2016) Branched-chain amino acids as biomarkers in diabetes. Curr Opin Clin Nutr Metab Care 19:48\u201354","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"5531_CR48","doi-asserted-by":"publisher","first-page":"e1002179","DOI":"10.1371\/journal.pmed.1002179","volume":"13","author":"LA Lotta","year":"2016","unstructured":"Lotta LA, Scott RA, Sharp SJ, Burgess S, Luan J, Tillin T, Schmidt AF, Imamura F, Stewart ID, Perry JR, Marney L, Koulman A, Karoly ED, Forouhi NG, Sjogren RJ, Naslund E, Zierath JR, Krook A, Savage DB et al (2016) Genetic predisposition to an impaired metabolism of the branched-chain amino acids and risk of type 2 diabetes: a Mendelian randomisation analysis. PLoS Med 13:e1002179","journal-title":"PLoS Med"},{"key":"5531_CR49","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1016\/j.celrep.2017.04.071","volume":"19","author":"E Hou","year":"2017","unstructured":"Hou E, Sun N, Zhang F, Zhao C, Usa K, Liang M, Tian Z (2017) Malate and aspartate increase L-arginine and nitric oxide and attenuate hypertension. Cell Rep 19:1631\u20131639","journal-title":"Cell Rep"},{"key":"5531_CR50","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1093\/clinchem\/43.7.1209","volume":"43","author":"F Nielsen","year":"1997","unstructured":"Nielsen F, Mikkelsen BB, Nielsen JB, Andersen HR, Grandjean P (1997) Plasma malondialdehyde as biomarker for oxidative stress: reference interval and effects of life-style factors. Clin Chem 43:1209\u20131214","journal-title":"Clin Chem"},{"key":"5531_CR51","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/978-3-642-65404-6_12","volume-title":"Na-linked Transport of Organic Solutes","author":"A Kleinzeller","year":"1972","unstructured":"Kleinzeller A (1972) The Na-independent transport of sugars in renal tubular cells. In: Heinz E (ed) Na-linked Transport of Organic Solutes. Springer-Verlag, New York, pp 109\u2013115"},{"key":"5531_CR52","doi-asserted-by":"publisher","first-page":"F123","DOI":"10.1152\/ajprenal.00039.2014","volume":"307","author":"AC Boon","year":"2014","unstructured":"Boon AC, Bulmer AC, Coombes JS, Fassett RG (2014) Circulating bilirubin and defense against kidney disease and cardiovascular mortality: mechanisms contributing to protection in clinical investigations. Am J Physiol Ren Physiol 307:F123\u2013F136","journal-title":"Am J Physiol Ren Physiol"},{"key":"5531_CR53","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.2337\/db19-0145","volume":"68","author":"AV Mathew","year":"2019","unstructured":"Mathew AV, Jaiswal M, Ang L, Michailidis G, Pennathur S, Pop-Busui R (2019) Impaired amino acid and TCA metabolism and cardiovascular autonomic neuropathy progression in type 1 diabetes. Diabetes 68:2035\u20132044","journal-title":"Diabetes"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-022-05531-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00467-022-05531-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-022-05531-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T13:07:28Z","timestamp":1670936848000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00467-022-05531-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,4]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["5531"],"URL":"https:\/\/doi.org\/10.1007\/s00467-022-05531-3","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"type":"print","value":"0931-041X"},{"type":"electronic","value":"1432-198X"}],"subject":[],"published":{"date-parts":[[2022,5,4]]},"assertion":[{"value":"23 November 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The research protocols of CASPER and Renal-HEIR were approved by COMIRB, and all participants gave written informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"TV: none. CV: none. LL: none. PP: none. HH: none. AD: none. JAR: none. FP: none. DZC: none. DHvR: none. KJN: none. MEP: none. RGN: none. LP: none. PB: has acted as a consultant for AstraZeneca, Bayer, Bristol-Myers Squibb, Boehringer Ingelheim, Eli-Lilly, Sanofi, Novo Nordisk, and Horizon Pharma. PB serves on the advisory boards of AstraZeneca, Boehringer Ingelheim, and XORTX.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclaimer"}}]}}