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These physiological processes can be disrupted by inherited or acquired aetiologies. The net result is a tubulopathy. It is important to make a prompt and accurate diagnosis of tubulopathies in children and young adults. This allows timely and appropriate management, including disease-specific therapies, and avoids complications such as growth failure. Tubulopathies can present with a variety of non-specific clinical features which can be diagnostically challenging. In this review, we build from this common anatomical and physiological understanding to present a tangible appreciation of tubulopathies as they are likely to be clinically encountered among affected children and young adults.<\/jats:p>","DOI":"10.1007\/s00467-022-05606-1","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T18:02:50Z","timestamp":1652896970000},"page":"651-662","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["A clinical approach to tubulopathies in children and young adults"],"prefix":"10.1007","volume":"38","author":[{"given":"Rachael","family":"Kermond","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8752-2551","authenticated-orcid":false,"given":"Andrew","family":"Mallett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7357-4310","authenticated-orcid":false,"given":"Hugh","family":"McCarthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,18]]},"reference":[{"key":"5606_CR1","doi-asserted-by":"publisher","first-page":"620","DOI":"10.2215\/CJN.14481119","volume":"16","author":"M Downie","year":"2021","unstructured":"Downie M, Lopez Garcia S, Kleta R, Bockenhauer D (2021) Inherited tubulopathies of the kidney: insights from genetics. 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