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Part of the risk establishes at the beginning of T1DM. In fact, up to 65% of children during T1DM onset may experience an acute kidney injury (AKI) which predisposes to the development of a later chronic kidney disease (CKD). The other part of the risk establishes during the following course of T1DM and could be related to a poor glycemic control and the subsequent development of diabetic kidney disease. In this review, we discuss the acute and chronic effects of T1DM on the kidneys, and the implications of these events on the long-term prognosis of kidney function.<\/jats:p>","DOI":"10.1007\/s00467-022-05689-w","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T19:11:51Z","timestamp":1658949111000},"page":"1449-1458","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Acute and chronic kidney complications in children with type 1 diabetes mellitus"],"prefix":"10.1007","volume":"38","author":[{"given":"Giulio","family":"Rivetti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenden E.","family":"Hursh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Miraglia del Giudice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4682-0170","authenticated-orcid":false,"given":"Pierluigi","family":"Marzuillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,27]]},"reference":[{"key":"5689_CR1","doi-asserted-by":"publisher","first-page":"e2720","DOI":"10.1210\/clinem\/dgab090","volume":"106","author":"P Marzuillo","year":"2021","unstructured":"Marzuillo P, Iafusco D, Zanfardino A, Guarino S, Piscopo A, Casaburo F, Capalbo D, Ventre M, Arienzo MR, Cirillo G, De Luca Picione C, Esposito T, Montaldo P, Di Sessa A, Miraglia del Giudice E (2021) Acute kidney injury and renal tubular damage in children with type 1 diabetes mellitus onset. 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