{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:14:44Z","timestamp":1740107684538,"version":"3.37.3"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T00:00:00Z","timestamp":1678924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T00:00:00Z","timestamp":1678924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100006447","name":"University of Zurich","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006447","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Kidney transplantation in children in 1970 was considered by many to be unethical, as long-term survival was minimal. It was therefore risky at the time to offer transplantation to a child.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case diagnosis\/treatment<\/jats:title>\n                <jats:p>A 6-year-old boy with kidney failure due to haemolytic uraemic syndrome received 4\u00a0months of intermittent peritoneal dialysis followed by 6\u00a0months of haemodialysis until at\u00a06\u00a0years and 10\u00a0months, he underwent bilateral nephrectomy and received a kidney transplant from a deceased 18-year-old donor. Despite moderate long-term immunosuppression of prednisone (20\u00a0mg\/48\u00a0h) and azathioprine (62.5\u00a0mg\/day), at the last visit in September 2022, he was well, normotrophic, with a serum creatinine of\u00a0157\u00a0\u00b5mol\/l (<jats:italic>eGFR<\/jats:italic> 41\u00a0ml\/min\/1.73 m<jats:sup>2<\/jats:sup>) and no haematuria, proteinuria or hypertension. Except for benign skin lesions due to azathioprine, and undergoing an aortic valve replacement and an aortic aneurysm repair in adulthood, the now 58-year-old man has had no major complications.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>We speculate that stable and unmodified immunosuppressive therapy, started before the era of calcineurin inhibitors, the lack of significant rejection episodes, the absence of donor-specific antibodies, and the young donor age have contributed to maintaining exceptional long-term kidney transplant survival. Luck, a robust health system and an adherent patient are also important. To the best of our knowledge,  this\u00a0is the longest functioning kidney transplant from a deceased donor performed in a child worldwide. Despite its risky nature at the time, this transplant paved the way for others.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00467-023-05901-5","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T16:03:36Z","timestamp":1678982616000},"page":"3489-3492","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Deceased donor kidney transplanted in childhood functioning well after 52\u00a0years"],"prefix":"10.1007","volume":"38","author":[{"given":"Giuseppina","family":"Spart\u00e0","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karine","family":"Hadaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc","family":"Paunier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Girardin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernst","family":"Leumann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,3,16]]},"reference":[{"key":"5901_CR1","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1001\/jama.1969.03160290029005","volume":"210","author":"RN Fine","year":"1969","unstructured":"Fine RN, Brennan LP, Edelbrock HH, Riddell H, Stiles Q, Lieberman E (1969) Use of pediatric cadaver kidneys for homotransplantation in children. JAMA 210:477\u2013484","journal-title":"JAMA"},{"key":"5901_CR2","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/s0022-3476(70)80473-5","volume":"76","author":"RN Fine","year":"1970","unstructured":"Fine RN, Korsch BM, Stiles Q, Riddell H, Edelbrock HH, Brennan LP, Grushkin CM, Lieberman E (1970) Renal homotransplantation in children. J Pediatr 76:347\u2013357. https:\/\/doi.org\/10.1016\/s0022-3476(70)80473-5","journal-title":"J Pediatr"},{"key":"5901_CR3","first-page":"432","volume":"45","author":"D Potter","year":"1970","unstructured":"Potter D, Belzer FO, Rames L, Holliday MA, Kountz SL, Najarian JS (1970) The treatment of chronic uremia in childhood. I Transplantation. 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N Engl J Med 385:729\u2013743. https:\/\/doi.org\/10.1056\/NEJMra2014530","journal-title":"N Engl J Med"},{"key":"5901_CR8","doi-asserted-by":"publisher","first-page":"2824","DOI":"10.1111\/ajt.16463","volume":"21","author":"ED Poggio","year":"2021","unstructured":"Poggio ED, Augustine JJ, Arrigain S, Brennan DC, Schold JD (2021) Long-term kidney transplant graft survival-making progress when most needed. Am J Transplant 21:2824\u20132832. https:\/\/doi.org\/10.1111\/ajt.16463","journal-title":"Am J Transplant"},{"key":"5901_CR9","doi-asserted-by":"publisher","first-page":"e46","DOI":"10.1097\/tp.0000000000003012","volume":"104","author":"E Van Loon","year":"2020","unstructured":"Van Loon E, Bernards J, Van Craenenbroeck AH, Naesens M (2020) The causes of kidney allograft failure: more than alloimmunity. 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N Engl J Med 386:497\u2013498. https:\/\/doi.org\/10.1056\/NEJMc2115207","journal-title":"N Engl J Med"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-023-05901-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00467-023-05901-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-023-05901-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T14:07:15Z","timestamp":1693318035000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00467-023-05901-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,16]]},"references-count":11,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["5901"],"URL":"https:\/\/doi.org\/10.1007\/s00467-023-05901-5","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"type":"print","value":"0931-041X"},{"type":"electronic","value":"1432-198X"}],"subject":[],"published":{"date-parts":[[2023,3,16]]},"assertion":[{"value":"24 December 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 January 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 January 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The patient\u00a0has consented to the submission of the case report, including the photograph, to the journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}