{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T12:55:45Z","timestamp":1784120145925,"version":"3.55.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T00:00:00Z","timestamp":1680480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T00:00:00Z","timestamp":1680480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["NIH K08GM12498"],"award-info":[{"award-number":["NIH K08GM12498"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017618","name":"Division of Diabetes, Endocrinology, and Metabolic Diseases","doi-asserted-by":"publisher","award":["NIH P50DK096418"],"award-info":[{"award-number":["NIH P50DK096418"]}],"id":[{"id":"10.13039\/100017618","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017618","name":"Division of Diabetes, Endocrinology, and Metabolic Diseases","doi-asserted-by":"publisher","award":["P50DK096418"],"award-info":[{"award-number":["P50DK096418"]}],"id":[{"id":"10.13039\/100017618","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1007\/s00467-023-05920-2","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T10:23:20Z","timestamp":1680517400000},"page":"3153-3161","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Acute kidney injury biomarker olfactomedin 4 predicts furosemide responsiveness"],"prefix":"10.1007","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6172-4756","authenticated-orcid":false,"given":"Denise C.","family":"Hasson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelli","family":"Krallman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristalynn M.","family":"Kempton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Steele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasad","family":"Devarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart L.","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew N.","family":"Alder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,3]]},"reference":[{"key":"5920_CR1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1056\/NEJMoa1611391","volume":"376","author":"A Kaddourah","year":"2017","unstructured":"Kaddourah A, Basu RK, Bagshaw SM, Goldstein SL, Investigators AWARE (2017) Epidemiology of acute kidney injury in critically ill children and young adults. N Engl J Med 376:11\u201320","journal-title":"N Engl J Med"},{"key":"5920_CR2","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1001\/jama.294.7.813","volume":"294","author":"S Uchino","year":"2005","unstructured":"Uchino S, Kellum JA, Bellomo R, Doig GS, Morimatsu H, Morgera S et al (2005) Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA 294:813\u2013818","journal-title":"JAMA"},{"key":"5920_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000313737","volume":"165","author":"EAJ Hoste","year":"2010","unstructured":"Hoste EAJ, Kellum JA, Katz NM, Rosner MH, Haase M, Ronco C (2010) Epidemiology of acute kidney injury. Contrib Nephrol 165:1\u20138","journal-title":"Contrib Nephrol"},{"key":"5920_CR4","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1053\/ajkd.2002.34505","volume":"40","author":"S Morgera","year":"2002","unstructured":"Morgera S, Kraft AK, Siebert G, Luft FC, Neumayer H-H (2002) Long-term outcomes in acute renal failure patients treated with continuous renal replacement therapies. Am J Kidney Dis 40:275\u2013279","journal-title":"Am J Kidney Dis"},{"key":"5920_CR5","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1053\/j.ajkd.2006.06.002","volume":"48","author":"SM Bagshaw","year":"2006","unstructured":"Bagshaw SM, Mortis G, Doig CJ, Godinez-Luna T, Fick GH, Laupland KB (2006) One-year mortality in critically ill patients by severity of kidney dysfunction: a population-based assessment. Am J Kidney Dis 48:402\u2013409","journal-title":"Am J Kidney Dis"},{"key":"5920_CR6","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1017\/S1047951121002560","volume":"32","author":"KM Gist","year":"2021","unstructured":"Gist KM, Borasino S, SooHoo M, Soranno DE, Mack E, Hock KM et al (2021) Transient and persistent acute kidney injury phenotypes following the Norwood operation: a retrospective study. Cardiol Young 32:564\u2013571","journal-title":"Cardiol Young"},{"key":"5920_CR7","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1038\/s41390-021-01363-3","volume":"90","author":"RK Basu","year":"2021","unstructured":"Basu RK, Hackbarth R, Gillespie S, Akcan-Arikan A, Brophy P, Bagshaw S et al (2021) Clinical phenotypes of acute kidney injury are associated with unique outcomes in critically ill septic children. Pediatr Res 90:1031\u20131038","journal-title":"Pediatr Res"},{"key":"5920_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/toxsci\/kfaa181","volume":"180","author":"BN Chorley","year":"2021","unstructured":"Chorley BN, Ellinger-Ziegelbauer H, Tackett M, Simutis FJ, Harrill AH, McDuffie J et al (2021) Urinary miRNA biomarkers of drug-induced kidney injury and their site specificity within the nephron. Toxicol Sci 180:1\u201316","journal-title":"Toxicol Sci"},{"key":"5920_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jcrc.2019.05.017","volume":"53","author":"N Stanski","year":"2019","unstructured":"Stanski N, Menon S, Goldstein SL, Basu RK (2019) Integration of urinary neutrophil gelatinase-associated lipocalin with serum creatinine delineates acute kidney injury phenotypes in critically ill children. J Crit Care 53:1\u20137","journal-title":"J Crit Care"},{"key":"5920_CR10","doi-asserted-by":"publisher","first-page":"1858","DOI":"10.1016\/j.ekir.2021.04.022","volume":"6","author":"NL Stanski","year":"2021","unstructured":"Stanski NL, Wong HR, Basu RK, Cvijanovich NZ, Fitzgerald JC, Weiss SL et al (2021) Recalibration of the renal angina index for pediatric septic shock. Kidney Int Rep 6:1858\u20131867","journal-title":"Kidney Int Rep"},{"key":"5920_CR11","doi-asserted-by":"publisher","first-page":"e2019209","DOI":"10.1001\/jamanetworkopen.2020.19209","volume":"3","author":"M Ostermann","year":"2020","unstructured":"Ostermann M, Zarbock A, Goldstein S, Kashani K, Macedo E, Murugan R et al (2020) Recommendations on acute kidney injury biomarkers from the acute disease quality initiative consensus conference: a consensus statement. JAMA Netw Open 3:e2019209","journal-title":"JAMA Netw Open"},{"key":"5920_CR12","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1093\/ndt\/gfv457","volume":"31","author":"S Menon","year":"2016","unstructured":"Menon S, Goldstein SL, Mottes T, Fei L, Kaddourah A, Terrell T et al (2016) Urinary biomarker incorporation into the renal angina index early in intensive care unit admission optimizes acute kidney injury prediction in critically ill children: a prospective cohort study. Nephrol Dial Transplant 31:586\u2013594","journal-title":"Nephrol Dial Transplant"},{"key":"5920_CR13","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1007\/s00467-020-04898-5","volume":"36","author":"SL Goldstein","year":"2021","unstructured":"Goldstein SL, Krallman KA, Schmerge A, Dill L, Gerhardt B, Chodaparavu P et al (2021) Urinary neutrophil gelatinase-associated lipocalin rules out nephrotoxic acute kidney injury in children. Pediatr Nephrol 36:1915\u20131921","journal-title":"Pediatr Nephrol"},{"key":"5920_CR14","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1007\/s00134-016-4670-3","volume":"43","author":"M Meersch","year":"2017","unstructured":"Meersch M, Schmidt C, Hoffmeier A, Van Aken H, Wempe C, Gerss J et al (2017) Prevention of cardiac surgery-associated AKI by implementing the KDIGO guidelines in high risk patients identified by biomarkers: the PrevAKI randomized controlled trial. Intensive Care Med 43:1551\u20131561","journal-title":"Intensive Care Med"},{"key":"5920_CR15","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1213\/ANE.0000000000005458","volume":"133","author":"A Zarbock","year":"2021","unstructured":"Zarbock A, K\u00fcllmar M, Ostermann M, Lucchese G, Baig K, Cennamo A et al (2021) Prevention of cardiac surgery-associated acute kidney injury by implementing the kdigo guidelines in high-risk patients identified by biomarkers: the PrevAKI-multicenter randomized controlled trial. Anesth Analg 133:292\u2013302","journal-title":"Anesth Analg"},{"key":"5920_CR16","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1097\/SLA.0000000000002485","volume":"267","author":"I G\u00f6cze","year":"2018","unstructured":"G\u00f6cze I, Jauch D, G\u00f6tz M, Kennedy P, Jung B, Zeman F et al (2018) Biomarker-guided intervention to prevent acute kidney injury after major surgery: the prospective randomized BigpAK study. Ann Surg 267:1013\u20131020","journal-title":"Ann Surg"},{"key":"5920_CR17","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.ekir.2016.04.005","volume":"1","author":"LS Chawla","year":"2016","unstructured":"Chawla LS, Ronco C (2016) Renal stress testing in the assessment of kidney disease. Kidney Int Rep 1:57\u201363","journal-title":"Kidney Int Rep"},{"key":"5920_CR18","doi-asserted-by":"publisher","first-page":"R207","DOI":"10.1186\/cc13015","volume":"17","author":"LS Chawla","year":"2013","unstructured":"Chawla LS, Davison DL, Brasha-Mitchell E, Koyner JL, Arthur JM, Shaw AD et al (2013) Development and standardization of a furosemide stress test to predict the severity of acute kidney injury. Crit Care 17:R207","journal-title":"Crit Care"},{"key":"5920_CR19","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1681\/ASN.2014060535","volume":"26","author":"JL Koyner","year":"2015","unstructured":"Koyner JL, Davison DL, Brasha-Mitchell E, Chalikonda DM, Arthur JM, Shaw AD et al (2015) Furosemide stress test and biomarkers for the prediction of AKI severity. J Am Soc Nephrol 26:2023\u20132031","journal-title":"J Am Soc Nephrol"},{"key":"5920_CR20","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/s13054-018-2021-1","volume":"22","author":"N Lumlertgul","year":"2018","unstructured":"Lumlertgul N, Peerapornratana S, Trakarnvanich T, Pongsittisak W, Surasit K, Chuasuwan A et al (2018) Early versus standard initiation of renal replacement therapy in furosemide stress test non-responsive acute kidney injury patients (the FST trial). Crit Care 22:101","journal-title":"Crit Care"},{"key":"5920_CR21","doi-asserted-by":"publisher","first-page":"2444","DOI":"10.1016\/j.jtcvs.2018.12.076","volume":"157","author":"J Penk","year":"2019","unstructured":"Penk J, Gist KM, Wald EL, Kitzmiller L, Webb TN, Li Y et al (2019) Furosemide response predicts acute kidney injury in children after cardiac surgery. J Thorac Cardiovasc Surg 157:2444\u20132451","journal-title":"J Thorac Cardiovasc Surg"},{"key":"5920_CR22","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1097\/CCM.0b013e31819fcc08","volume":"37","author":"HR Wong","year":"2009","unstructured":"Wong HR, Cvijanovich N, Allen GL, Lin R, Anas N, Meyer K et al (2009) Genomic expression profiling across the pediatric systemic inflammatory response syndrome, sepsis, and septic shock spectrum. Crit Care Med 37:1558\u20131566","journal-title":"Crit Care Med"},{"key":"5920_CR23","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1177\/1753425918817611","volume":"25","author":"MN Alder","year":"2019","unstructured":"Alder MN, Mallela J, Opoka AM, Lahni P, Hildeman DA, Wong HR (2019) Olfactomedin 4 marks a subset of neutrophils in mice. Innate Immun 25:22\u201333","journal-title":"Innate Immun"},{"key":"5920_CR24","doi-asserted-by":"publisher","first-page":"F809","DOI":"10.1152\/ajprenal.00443.2019","volume":"318","author":"JE Stark","year":"2020","unstructured":"Stark JE, Opoka AM, Mallela J, Devarajan P, Ma Q, Levinsky NC et al (2020) Juvenile OLFM4-null mice are protected from sepsis. Am J Physiol Renal Physiol 318:F809-816","journal-title":"Am J Physiol Renal Physiol"},{"key":"5920_CR25","doi-asserted-by":"publisher","first-page":"e15453","DOI":"10.14814\/phy2.15453","volume":"10","author":"DC Hasson","year":"2022","unstructured":"Hasson DC, Krallman K, VanDenHeuvel K, Menon S, Piraino G, Devarajan P et al (2022) Olfactomedin 4 as a novel loop of Henle-specific acute kidney injury biomarker. Physiol Rep 10:e15453","journal-title":"Physiol Rep"},{"key":"5920_CR26","first-page":"435","volume":"10","author":"J-P Roy","year":"2020","unstructured":"Roy J-P, Krallman KA, Basu RK, Chima RS, Fei L, Wilder S et al (2020) Early sequential risk stratification assessment to optimize fluid dosing, CRRT initiation and discontinuation in critically ill children with acute kidney injury: taking focus 2 process article. J Clin Trials 10:435","journal-title":"J Clin Trials"},{"key":"5920_CR27","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1093\/bja\/aeu140","volume":"113","author":"JA Kellum","year":"2014","unstructured":"Kellum JA, Mythen MG, Shaw AD (2014) The 12th consensus conference of the acute dialysis quality initiative (ADQI XII). Br J Anaesth 113:729\u2013731","journal-title":"Br J Anaesth"},{"key":"5920_CR28","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1146\/annurev.pharmtox.48.113006.094615","volume":"48","author":"VS Vaidya","year":"2008","unstructured":"Vaidya VS, Ferguson MA, Bonventre JV (2008) Biomarkers of acute kidney injury. Annu Rev Pharmacol Toxicol 48:463\u2013493","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"5920_CR29","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1001\/jama.2016.5828","volume":"315","author":"A Zarbock","year":"2016","unstructured":"Zarbock A, Kellum JA, Schmidt C, Van Aken H, Wempe C, Pavenst\u00e4dt H et al (2016) Effect of early vs delayed initiation of renal replacement therapy on mortality in critically ill patients with acute kidney injury: the ELAIN randomized clinical trial. JAMA 315:2190\u20132199","journal-title":"JAMA"},{"key":"5920_CR30","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1016\/S0140-6736(21)00350-0","volume":"397","author":"S Gaudry","year":"2021","unstructured":"Gaudry S, Hajage D, Martin-Lefevre L, Lebbah S, Louis G, Moschietto S et al (2021) Comparison of two delayed strategies for renal replacement therapy initiation for severe acute kidney injury (AKIKI 2): a multicentre, open-label, randomised, controlled trial. Lancet 397:1293\u20131300","journal-title":"Lancet"},{"key":"5920_CR31","doi-asserted-by":"crossref","unstructured":"STARRT-AKI Investigators, Canadian Critical Care Trials Group, Australian and New Zealand Intensive Care Society Clinical Trials Group, United Kingdom Critical Care Research Group, Canadian Nephrology Trials Network, Irish Critical Care Trials Group et al (2020) Timing of initiation of renal-replacement therapy in acute kidney injury. N Engl J Med 383:240\u2013251","DOI":"10.1056\/NEJMoa2000741"},{"key":"5920_CR32","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1016\/j.kint.2019.11.013","volume":"97","author":"NI Skrypnyk","year":"2020","unstructured":"Skrypnyk NI, Gist KM, Okamura K, Montford JR, You Z, Yang H et al (2020) IL-6-mediated hepatocyte production is the primary source of plasma and urine neutrophil gelatinase-associated lipocalin during acute kidney injury. Kidney Int 97:966\u2013979","journal-title":"Kidney Int"},{"key":"5920_CR33","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1146\/annurev-physiol-031620-092817","volume":"83","author":"C Schaeffer","year":"2021","unstructured":"Schaeffer C, Devuyst O, Rampoldi L (2021) Uromodulin: roles in health and disease. Annu Rev Physiol 83:477\u2013501","journal-title":"Annu Rev Physiol"},{"key":"5920_CR34","doi-asserted-by":"publisher","first-page":"150","DOI":"10.2215\/CJN.06390420","volume":"16","author":"A Kipp","year":"2020","unstructured":"Kipp A, Olinger E (2020) What does uromodulin do? Clin J Am Soc Nephrol 16:150\u2013153","journal-title":"Clin J Am Soc Nephrol"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-023-05920-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00467-023-05920-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-023-05920-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T07:04:18Z","timestamp":1692169458000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00467-023-05920-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,3]]},"references-count":34,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["5920"],"URL":"https:\/\/doi.org\/10.1007\/s00467-023-05920-2","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,3]]},"assertion":[{"value":"13 December 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 April 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Study protocols were approved by and in accordance with the ethical standard of the CCHMC Institutional Review Board and in accordance with the 1964 Declaration of Helsinki. Given that urine samples were collected from an indwelling bladder catheter and considered to be discarded samples, the CCHMC IRB approved the TAKING FOCUS 2 study with a waiver of the need for patient or caregiver consent (IRB Number 2018\u20130724, PI Goldstein).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Financial interests: Stuart L Goldstein reports receiving personal fees from Baxter Healthcare, BioPorto Inc., CHF Solutions, Fresenius, MediBeacon, and Medtronic. Prasad Devarajan is a co-inventor on submitted patents for the use of NGAL as a biomarker for kidney injury.Non-financial interests: MNA, DCH, SLG, and PD have patents for the use of OLFM4 as\u00a0a renal injury biomarker.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}