{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T18:06:11Z","timestamp":1764785171639,"version":"3.37.3"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1007\/s00467-023-06019-4","type":"journal-article","created":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T04:02:06Z","timestamp":1688443326000},"page":"4043-4049","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Plasma leucine-rich \u03b1-2-glycoprotein 1 \u2013 a novel marker of diabetic kidney disease in children and adolescents with type 1 diabetes mellitus?"],"prefix":"10.1007","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6234-0874","authenticated-orcid":false,"given":"Selda Ay\u00e7a","family":"Alt\u0131nc\u0131k","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4788-3256","authenticated-orcid":false,"given":"Didem","family":"Y\u0131ld\u0131r\u0131m\u00e7akar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9173-0142","authenticated-orcid":false,"given":"Esin","family":"Avc\u0131","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6506-9461","authenticated-orcid":false,"given":"Bayram","family":"\u00d6zhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2617-4466","authenticated-orcid":false,"given":"\u0130lknur","family":"Giri\u015fgen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9415-1640","authenticated-orcid":false,"given":"Sel\u00e7uk","family":"Y\u00fcksel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,7,4]]},"reference":[{"key":"6019_CR1","doi-asserted-by":"publisher","first-page":"2864","DOI":"10.2337\/dc14-1296","volume":"37","author":"KR Tuttle","year":"2014","unstructured":"Tuttle KR, Bakris GL, Bilous RW et al (2014) Diabetic kidney disease: a report from an ADA Consensus Conference. Diabetes Care 37:2864\u20132883. https:\/\/doi.org\/10.2337\/dc14-1296","journal-title":"Diabetes Care"},{"issue":"Suppl 27","key":"6019_CR2","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1111\/pedi.12742","volume":"19","author":"KC Donaghue","year":"2018","unstructured":"Donaghue KC, Marcovecchio LM, Wadwa RP et al (2018) ISPAD clinical practice consensus guidelines 2018: Microvascular and macrovascular complications in children and adolescents. Pediatr Diabetes 19(Suppl 27):262\u2013274. https:\/\/doi.org\/10.1111\/pedi.12742","journal-title":"Pediatr Diabetes"},{"key":"6019_CR3","doi-asserted-by":"publisher","first-page":"15018","DOI":"10.1038\/nrdp.2015.18","volume":"1","author":"MC Thomas","year":"2015","unstructured":"Thomas MC, Brownlee M, Susztak K et al (2015) Diabetic kidney disease. Nat Rev Dis Primers 1:15018. https:\/\/doi.org\/10.1038\/nrdp.2015.18","journal-title":"Nat Rev Dis Primers"},{"key":"6019_CR4","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1681\/ASN.2007091048","volume":"19","author":"JF Navarro-Gonz\u00e1lez","year":"2008","unstructured":"Navarro-Gonz\u00e1lez JF, Mora-Fern\u00e1ndez C (2008) The role of inflammatory cytokines in diabetic nephropathy. J Am Soc Nephrol 19:433\u2013442. https:\/\/doi.org\/10.1681\/ASN.2007091048","journal-title":"J Am Soc Nephrol"},{"key":"6019_CR5","doi-asserted-by":"publisher","first-page":"e2841","DOI":"10.1002\/dmrr.2841","volume":"33","author":"N Papadopoulou-Marketou","year":"2017","unstructured":"Papadopoulou-Marketou N, Chrousos GP, Kanaka-Gantenbein C (2017) Diabetic nephropathy in type 1 diabetes: a review of early natural history, pathogenesis, and diagnosis. Diabetes Metab Res Rev 33:e2841. https:\/\/doi.org\/10.1002\/dmrr.2841","journal-title":"Diabetes Metab Res Rev"},{"key":"6019_CR6","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.semnephrol.2007.01.007","volume":"27","author":"R Zent","year":"2007","unstructured":"Zent R, Pozzi A (2007) Angiogenesis in diabetic nephropathy. Semin Nephrol 27:161\u2013171. https:\/\/doi.org\/10.1016\/j.semnephrol.2007.01.007","journal-title":"Semin Nephrol"},{"key":"6019_CR7","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1681\/ASN.2018060599","volume":"30","author":"Q Hong","year":"2019","unstructured":"Hong Q, Zhang L, Fu J et al (2019) LRG1 promotes diabetic kidney disease progression by enhancing TGF-\u03b2-induced angiogenesis. J Am Soc Nephrol 30:546\u2013562. https:\/\/doi.org\/10.1681\/ASN.2018060599","journal-title":"J Am Soc Nephrol"},{"key":"6019_CR8","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.1073\/pnas.82.7.1906","volume":"82","author":"N Takahashi","year":"1985","unstructured":"Takahashi N, Takahashi Y, Putnam FW (1985) Periodicity of leucine and tandem repetition of a 24-amino acid segment in the primary structure of leucine-rich 2-glycoprotein of human serum. Proc Natl Acad Sci U S A 82:1906\u20131910. https:\/\/doi.org\/10.1073\/pnas.82.7.1906","journal-title":"Proc Natl Acad Sci U S A"},{"key":"6019_CR9","doi-asserted-by":"publisher","first-page":"809225","DOI":"10.3389\/fphar.2021.809225","volume":"12","author":"Y Zou","year":"2022","unstructured":"Zou Y, Xu Y, Chen X et al (2022) Research progress on leucine-rich alpha-2 glycoprotein 1: a review. Front Pharmacol 12:809225. https:\/\/doi.org\/10.3389\/fphar.2021.809225","journal-title":"Front Pharmacol"},{"key":"6019_CR10","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1038\/nature12345","volume":"499","author":"X Wang","year":"2013","unstructured":"Wang X, Abraham S, McKenzie JAG et al (2013) LRG1 promotes angiogenesis by modulating endothelial TGF-\u03b2 signaling. Nature 499:306\u2013311. https:\/\/doi.org\/10.1038\/nature12345","journal-title":"Nature"},{"key":"6019_CR11","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1136\/ard.2009.118919","volume":"69","author":"S Serada","year":"2009","unstructured":"Serada S, Fujimoto M, Ogata A et al (2009) iTRAQ-based proteomic identification of leucine-rich alpha-2 glycoprotein as a novel inflammatory biomarker in autoimmune diseases. Ann Rheum Dis 69:770\u2013774. https:\/\/doi.org\/10.1136\/ard.2009.118919","journal-title":"Ann Rheum Dis"},{"key":"6019_CR12","doi-asserted-by":"publisher","first-page":"3270","DOI":"10.3892\/or.2019.7123","volume":"41","author":"Z Ban","year":"2019","unstructured":"Ban Z, He J, Tang Z et al (2019) LRG-1 enhances the migration of thyroid carcinoma cells through promotion of the epithelial-mesenchymal transition by activating MAPK\/p38 signaling. Oncol Rep 41:3270\u20133280. https:\/\/doi.org\/10.3892\/or.2019.7123","journal-title":"Oncol Rep"},{"key":"6019_CR13","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1161\/CIRCHEARTFAILURE.110.952200","volume":"4","author":"CJ Watson","year":"2011","unstructured":"Watson CJ, Ledwidge MT, Phelan D et al (2011) Proteomic analysis of coronary sinus serum reveals leucine-rich a2-glycoprotein as a novel biomarker of ventricular dysfunction and heart failure. Circ Heart Fail 4:188\u2013197. https:\/\/doi.org\/10.1161\/CIRCHEARTFAILURE.110.952200","journal-title":"Circ Heart Fail"},{"key":"6019_CR14","doi-asserted-by":"publisher","unstructured":"Zhang X, Pek SLT, Tavintharan S et al (2019) Leucine-rich \u03b1-2-glycoprotein predicts proliferative diabetic\nretinopathy in type 2 diabetes. J Diabetes Complicat 33:651\u2013656. https:\/\/doi.org\/10.1016\/j.jdiacomp.2019.05.021","DOI":"10.1016\/j.jdiacomp.2019.05.021"},{"key":"6019_CR15","doi-asserted-by":"publisher","first-page":"3683","DOI":"10.1210\/jc.2017-00930","volume":"102","author":"J Liu","year":"2017","unstructured":"Liu J, Pek SLT, Ang K (2017) Plasma leucine-rich a-2-glycoprotein 1 predicts rapid eGFR decline and albuminuria progression in type 2 diabetes mellitus. J Clin Endocrinol Metab 102:3683\u20133691. https:\/\/doi.org\/10.1210\/jc.2017-00930","journal-title":"J Clin Endocrinol Metab"},{"key":"6019_CR16","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1210\/jc.2014-3855","volume":"100","author":"SLT Pek","year":"2015","unstructured":"Pek SLT, Tavintharan S, Wang X (2015) Elevation of a novel angiogenic factor, leucine-rich- 2-glycoprotein (LRG1), is associated with arterial stiffness, endothelial dysfunction, and peripheral arterial disease in patients with type 2 diabetes. J Clin Endocrinol Metab 100:1586\u20131593. https:\/\/doi.org\/10.1210\/jc.2014-3855","journal-title":"J Clin Endocrinol Metab"},{"key":"6019_CR17","unstructured":"https:\/\/www.kidney.org\/professionals\/kdoqi\/gfr_calculatorped"},{"issue":"Suppl 1","key":"6019_CR18","doi-asserted-by":"publisher","first-page":"S46","DOI":"10.1016\/j.diabres.2008.09.018","volume":"82","author":"ET Rosolowsky","year":"2008","unstructured":"Rosolowsky ET, Niewczas MA, Ficociello LH et al (2008) Between hyperfiltration and impairment: demystifying early renal functional changes in diabetic nephropathy. Diabetes Res Clin Pract 82(Suppl 1):S46\u201353. https:\/\/doi.org\/10.1016\/j.diabres.2008.09.018","journal-title":"Diabetes Res Clin Pract"},{"key":"6019_CR19","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.1093\/ndt\/gfv121","volume":"30","author":"P Bjornstad","year":"2015","unstructured":"Bjornstad P, Cherney DZ, Snell-Bergeon JK et al (2015) Rapid GFR decline is associated with renal hyperfiltration and impaired GFR in adults with Type 1 diabetes. Nephrol Dial Transplant 30:1706\u20131711. https:\/\/doi.org\/10.1093\/ndt\/gfv121","journal-title":"Nephrol Dial Transplant"},{"key":"6019_CR20","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.2337\/dc09-1098","volume":"33","author":"ME Molitch","year":"2010","unstructured":"Molitch ME, Steffes M, Sun W et al (2010) Development and progression of renal insufficiency with and without albuminuria in adults with type 1 diabetes in the diabetes control and complications trial and the epidemiology of diabetes interventions and complications study. Diabetes Care 33:1536\u20131543. https:\/\/doi.org\/10.2337\/dc09-1098","journal-title":"Diabetes Care"},{"issue":"Suppl 2","key":"6019_CR21","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1111\/j.1464-5491.2008.02496.x","volume":"25","author":"R Bilous","year":"2008","unstructured":"Bilous R (2008) Microvascular disease: what does the UKPDS tell us about diabetic nephropathy? Diabet Med 25(Suppl 2):25\u201329. https:\/\/doi.org\/10.1111\/j.1464-5491.2008.02496.x","journal-title":"Diabet Med"},{"key":"6019_CR22","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.2337\/db09-0119","volume":"58","author":"T Nakagawa","year":"2009","unstructured":"Nakagawa T, Kosugi T, Haneda M et al (2009) Abnormal angiogenesis in diabetic nephropathy. Diabetes 58:1471\u20131478. https:\/\/doi.org\/10.2337\/db09-0119","journal-title":"Diabetes"},{"key":"6019_CR23","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.kint.2018.02.028","volume":"94","author":"J Fu","year":"2018","unstructured":"Fu J, Wei C, Zhang W et al (2018) Gene expression profiles of glomerular endothelial cells support their role in the glomerulopathy of diabetic mice. Kidney Int 94:326\u2013345. https:\/\/doi.org\/10.1016\/j.kint.2018.02.028","journal-title":"Kidney Int"},{"key":"6019_CR24","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1016\/j.bbrc.2009.03.104","volume":"382","author":"R Shirai","year":"2009","unstructured":"Shirai R, Hirano F, Ohkura N et al (2009) Up-regulation of the expression of leucine-rich (2)-glycoprotein in hepatocytes by the mediators of acute-phase response. Biochem Biophys Res Commun 382:776\u2013779. https:\/\/doi.org\/10.1016\/j.bbrc.2009.03.104","journal-title":"Biochem Biophys Res Commun"},{"key":"6019_CR25","doi-asserted-by":"publisher","first-page":"e2715","DOI":"10.1038\/cddis.2017.129","volume":"8","author":"Y Wang","year":"2017","unstructured":"Wang Y, Xu J, Zhang X et al (2017) TNF-\u03b1-induced LRG1 promotes angiogenesis and mesenchymal stem cell migration in the subchondral bone during osteoarthritis. Cell Death Dis 8:e2715. https:\/\/doi.org\/10.1038\/cddis.2017.129","journal-title":"Cell Death Dis"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-023-06019-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00467-023-06019-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-023-06019-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T12:05:18Z","timestamp":1697630718000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00467-023-06019-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,4]]},"references-count":25,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["6019"],"URL":"https:\/\/doi.org\/10.1007\/s00467-023-06019-4","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"type":"print","value":"0931-041X"},{"type":"electronic","value":"1432-198X"}],"subject":[],"published":{"date-parts":[[2023,7,4]]},"assertion":[{"value":"5 January 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the local Ethics Committee (date: 15.08.2018, number:60116787\u2013020\/34122).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The patients along with their caregivers gave their written consent to participate in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}