{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:35:40Z","timestamp":1792017340028,"version":"4.4.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T00:00:00Z","timestamp":1693612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T00:00:00Z","timestamp":1693612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Renovascular hypertension (RenoVH) is a cause of hypertension in children. A common cause of RenoVH is renal artery stenosis which acts by reducing blood supply to renal parenchyma and activating the renin\u2013angiotensin\u2013aldosterone axis, often leading to cardiac remodelling. This longitudinal observational study aims to describe occurrence of cardiovascular changes secondary to RenoVH and also any improvement in cardiac remodelling after successful endovascular and\/or surgical intervention.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>All patients with RenoVH referred to our centre, who received\u2009\u2265\u20091 endovascular intervention (some had also undergone surgical interventions) were included. Data were collected by retrospective database review over a 22-year period. We assessed oscillometric blood pressure and eight echocardiographic parameters pre- and post-intervention.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>One hundred fifty-two patients met inclusion criteria and had on average two endovascular interventions; of these children, six presented in heart failure. Blood pressure (BP) control was achieved by 54.4% of patients post-intervention. Average <jats:italic>z<\/jats:italic>-scores improved in interventricular septal thickness in diastole (IVSD), posterior Wall thickness in diastole (PWD) and fractional shortening (FS); left ventricular mass index (LVMI) and relative wall thickness (RWT) also improved. PWD saw the greatest reduction in mean difference in children with abnormal (<jats:italic>z<\/jats:italic>-score reduction 0.25, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and severely abnormal (<jats:italic>z<\/jats:italic>-score reduction 0.23, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) <jats:italic>z<\/jats:italic>-scores between pre- and post-intervention echocardiograms. Almost half (45.9%) had reduction in prescribed antihypertensive medications, and 21.3% could discontinue all antihypertensive therapy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our study reports improvement in cardiac outcomes after endovascular\u2009+\u2009\/\u2009\u2212\u2009surgical interventions. This is evidenced by BP control, and echocardiogram changes in which almost half achieved normalisation in systolic BP readings and reduction in the number of children with abnormal echocardiographic parameters.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1007\/s00467-023-06123-5","type":"journal-article","created":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T14:01:29Z","timestamp":1693663289000},"page":"521-530","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cardiovascular outcomes improve in children with renovascular hypertension following endovascular and surgical interventions"],"prefix":"10.1007","volume":"39","author":[{"given":"Emily C. G.","family":"Redhead","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3891-904X","authenticated-orcid":false,"given":"Alicia","family":"Paessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zainab","family":"Arslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Premal","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishore","family":"Minhas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Forman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Hollis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiano","family":"Lava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florin","family":"Ionescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devi","family":"Manuel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samiran","family":"Ray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicos","family":"Kessaris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Giardini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vineetha","family":"Ratnamma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Dobby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjell","family":"Tullus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Simmonds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Stojanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,2]]},"reference":[{"key":"6123_CR1","doi-asserted-by":"publisher","first-page":"3853","DOI":"10.1007\/s00467-021-05063-2","volume":"36","author":"JL de Oliveira Campos","year":"2021","unstructured":"de Oliveira Campos JL, Bitencourt L, Pedrosa AL, Silva DF, Lin FJJ, de Oliveira Dias LT et al (2021) Renovascular hypertension in pediatric patients: update on diagnosis and management. Pediatr Nephrol 36:3853\u20133868","journal-title":"Pediatr Nephrol"},{"key":"6123_CR2","doi-asserted-by":"publisher","first-page":"e20171904","DOI":"10.1542\/peds.2017-1904","volume":"140","author":"JT Flynn","year":"2017","unstructured":"Flynn JT, Kaelber DC, Baker-Smith CM, Blowey D, Carroll AE, Daniels SR et al (2017) Clinical practice guideline for screening and management of high blood pressure in children and adolescents. Pediatrics 140:e20171904","journal-title":"Pediatrics"},{"key":"6123_CR3","first-page":"533","volume-title":"Pediatric Hypertension","author":"K Tullus","year":"2003","unstructured":"Tullus K, Stojanovic J (2003) Renovascular hypertension, vasculitis, and aortic coarctation. In: Flynn JT, Ingelfinger JR, Brady TM (eds) Pediatric Hypertension. Springer, Cham, pp 533\u2013548"},{"key":"6123_CR4","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1093\/icvts\/ivz157","volume":"29","author":"O Peker","year":"2019","unstructured":"Peker O, Aki FT, Kumbasar U, Guvener M, Y\u0131lmaz M, Dogan R et al (2019) Surgical management of renovascular hypertension in children and young adults: a 13-year experience. Interact Cardiovasc Thorac Surg 29:746\u2013752","journal-title":"Interact Cardiovasc Thorac Surg"},{"issue":"2 Pt 2","key":"6123_CR5","first-page":"II19","volume":"9","author":"RB Devereux","year":"1987","unstructured":"Devereux RB (1987) Detection of left ventricular hypertrophy by M-mode echocardiography. Anatomic validation, standardization, and comparison to other methods. Hypertension 9(2 Pt 2):II19-26","journal-title":"Hypertension"},{"issue":"2 Suppl 4th Rep","key":"6123_CR6","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1542\/peds.114.S2.555","volume":"114","author":"National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents","year":"2004","unstructured":"National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents (2004) The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 114(2 Suppl 4th Report):555\u2013576","journal-title":"Pediatrics"},{"key":"6123_CR7","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1681\/ASN.2008030287","volume":"20","author":"GJ Schwartz","year":"2009","unstructured":"Schwartz GJ, Munoz A, Schneider MF, Mak RH, Kaskel F, Warady BA, Furth SL (2009) New equations to estimate GFR in children with CKD. J Am Soc Nephrol 20:629\u2013637","journal-title":"J Am Soc Nephrol"},{"key":"6123_CR8","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s00431-014-2355-x","volume":"174","author":"J Humbert","year":"2015","unstructured":"Humbert J, Roussey-Kesler G, Guerin P, Lefran\u00e7ois T, Connault J, Chenouard A et al (2015) Diagnostic and medical strategy for renovascular hypertension: report from a monocentric pediatric cohort. Eur J Pediatr 174:23\u201332","journal-title":"Eur J Pediatr"},{"key":"6123_CR9","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1136\/archdischild-2013-305886","volume":"100","author":"JA Kari","year":"2015","unstructured":"Kari JA, Roebuck DJ, McLaren CA, Davis M, Dillon MJ, Hamilton G et al (2015) Angioplasty for renovascular hypertension in 78 children. Arch Dis Child 100:474\u2013478","journal-title":"Arch Dis Child"},{"key":"6123_CR10","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1016\/j.jpedsurg.2017.12.008","volume":"53","author":"IN Lobeck","year":"2018","unstructured":"Lobeck IN, Alhajjat AM, Dupree P, Racadio JM, Mitsnefes MM, Karns R et al (2018) The management of pediatric renovascular hypertension: a single center experience and review of the literature. J Pediatr Surg 53:1825\u20131831","journal-title":"J Pediatr Surg"},{"key":"6123_CR11","doi-asserted-by":"publisher","first-page":"285","DOI":"10.5152\/dir.2014.13208","volume":"20","author":"G Zhu","year":"2014","unstructured":"Zhu G, He F, Gu Y, Yu H, Chen B, Hu Z et al (2014) Angioplasty for pediatric renovascular hypertension: a 13-year experience. Diagn Interv Radiol 20:285\u2013292","journal-title":"Diagn Interv Radiol"},{"issue":"79\u201389","key":"6123_CR12","first-page":"e2","volume":"74","author":"SS Kim","year":"2021","unstructured":"Kim SS, Stein DR, Ferguson MA, Porras D, Chaudry G, Singh MN et al (2021) Surgical management of pediatric renovascular hypertension and midaortic syndrome at a single-center multidisciplinary program. J Vasc Surg 74(79\u201389):e2","journal-title":"J Vasc Surg"},{"key":"6123_CR13","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.jvir.2021.10.035","volume":"33","author":"L Zhao","year":"2022","unstructured":"Zhao L, Zhao X, Hu X, Yang H, Wu L (2022) Midterm outcomes of angioplasty for pediatric renovascular hypertension. J Vasc Interv Radiol 33:399\u2013407","journal-title":"J Vasc Interv Radiol"},{"key":"6123_CR14","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1093\/ajh\/hpz103","volume":"32","author":"L Fan","year":"2019","unstructured":"Fan L, Zhang H, Cai J, Yang L, Wei D, Yu J et al (2019) Clinical course, management, and outcomes of pediatric Takayasu arteritis initially presenting with hypertension: a 16-year overview. Am J Hypertens 32:1021\u20131029","journal-title":"Am J Hypertens"},{"key":"6123_CR15","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1111\/chd.12608","volume":"13","author":"H Agrawal","year":"2018","unstructured":"Agrawal H, Moodie D, Qureshi AM, Acosta AA, Hernandez JA, Braun MC et al (2018) Interventions in children with renovascular hypertension: a 27-year retrospective single-center experience. Congenit Heart Dis 13:349\u2013356","journal-title":"Congenit Heart Dis"},{"key":"6123_CR16","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.jpedsurg.2016.08.011","volume":"52","author":"A Alexander","year":"2017","unstructured":"Alexander A, Richmond L, Geary D, Salle JL, Amaral J, Connolly B (2017) Outcomes of percutaneous transluminal angioplasty for pediatric renovascular hypertension. J Pediatr Surg 52:395\u2013399","journal-title":"J Pediatr Surg"},{"key":"6123_CR17","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1542\/peds.2005-2642","volume":"118","author":"R Shroff","year":"2006","unstructured":"Shroff R, Roebuck DJ, Gordon I, Davies R, Stephens S, Marks S et al (2006) Angioplasty for renovascular hypertension in children: 20-year experience. Pediatrics 118:268\u2013275","journal-title":"Pediatrics"},{"key":"6123_CR18","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1093\/ndt\/gfp537","volume":"25","author":"MB Stadermann","year":"2010","unstructured":"Stadermann MB, Montini G, Hamilton G, Roebuck DJ, McLaren CA, Dillon MJ et al (2010) Results of surgical treatment for renovascular hypertension in children: 30 year single centre experience. Nephrol Dial Transplant 25:807\u2013813","journal-title":"Nephrol Dial Transplant"},{"key":"6123_CR19","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1016\/S0140-6736(08)60626-1","volume":"371","author":"K Tullus","year":"2008","unstructured":"Tullus K, Brennan E, Hamilton G, Lord R, McLaren CA, Marks SD et al (2008) Renovascular hypertension in children. Lancet 371:1453\u20131463","journal-title":"Lancet"},{"key":"6123_CR20","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1111\/j.1651-2227.2005.tb02061.x","volume":"94","author":"I Daehnert","year":"2005","unstructured":"Daehnert I, Hennig B, Scheinert D (2005) Percutaneous transluminal angioplasty for renovascular hypertension in a neonate. Acta Paediatr 94:1149\u20131152","journal-title":"Acta Paediatr"},{"key":"6123_CR21","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1007\/s004310050866","volume":"157","author":"M Hofbeck","year":"1998","unstructured":"Hofbeck M, Singer H, Rupprecht T, Ruder H, Schmiedl N (1998) Successful percutaneous transluminal angioplasty for treatment of renovascular hypertension in a 15-month-old child. Eur J Pediatr 157:512\u2013514","journal-title":"Eur J Pediatr"},{"key":"6123_CR22","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1111\/j.1651-2227.1999.tb01009.x","volume":"88","author":"ML Lee","year":"2007","unstructured":"Lee ML, Chaou WT, Wang JK, Wu MH, Lue HC (2007) Percutaneous transluminal angioplasty of renal artery stenosis in a 9-month-old hypertensive girl with congestive heart failure. Acta Paediatr 88:1165\u20131167","journal-title":"Acta Paediatr"},{"key":"6123_CR23","doi-asserted-by":"publisher","first-page":"3367","DOI":"10.1007\/s00431-022-04550-4","volume":"181","author":"ED Kurt-Sukur","year":"2022","unstructured":"Kurt-Sukur ED, Brennan E, Davis M, Forman C, Hamilton G, Kessaris N et al (2022) Presentation, treatment, and outcome of renovascular hypertension below 2 years of age. Eur J Pediatr 181:3367\u20133375","journal-title":"Eur J Pediatr"},{"key":"6123_CR24","unstructured":"IBM (2022) Statistical Package for Social Sciences. 28.0.1.0 ed. Chicago, USA"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-023-06123-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00467-023-06123-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-023-06123-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T15:07:12Z","timestamp":1702912032000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00467-023-06123-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,2]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["6123"],"URL":"https:\/\/doi.org\/10.1007\/s00467-023-06123-5","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,2]]},"assertion":[{"value":"6 March 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.\u00a0The authors did not receive any funding for this study. There were no animal\u00a0participants and ethics approval was waived by our local centre.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}