{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T13:34:27Z","timestamp":1780925667724,"version":"3.54.1"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T00:00:00Z","timestamp":1711324800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T00:00:00Z","timestamp":1711324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Paediatric acute liver failure (PALF) is often characterised by its rapidity of onset and potential for significant morbidity and even mortality. Patients often develop multiorgan dysfunction\/failure, including severe acute kidney injury (AKI). Whilst the management of PALF focuses on complications of hepatic dysfunction, the associated kidney impairment can significantly affect patient outcomes. Severe AKI requiring continuous kidney replacement therapy (CKRT) is a common complication of both PALF and liver transplantation. In both scenarios, the need for CKRT is a poor prognostic indicator. In adults, AKI has been shown to complicate ALF in 25\u201350% of cases. In PALF, the incidence of AKI is often higher compared to other critically ill paediatric ICU populations, with reports of up to 40% in some observational studies. Furthermore, those presenting with AKI regularly have a more severe grade of PALF at presentation. Observational studies in the paediatric population corroborate this, though data are not as robust\u2014mainly reflecting single-centre cohorts. Perioperative benefits of CKRT include helping to clear water-soluble toxins such as ammonia, balancing electrolytes, preventing fluid overload, and managing raised intracranial pressure. As liver transplantation often takes 6\u201310\u00a0h, it is proposed that these benefits could be extended to the intraoperative period, avoiding any hiatus. Intraoperative CKRT (IoCKRT) has been shown to be practicable, safe and may help sicker recipients tolerate the operation with outcomes analogous with less ill patients not requiring IoCKRT. Here, we provide a comprehensive guide describing the rationale, practicalities, and current evidence base surrounding IoCKRT during transplantation in the paediatric population.<\/jats:p>","DOI":"10.1007\/s00467-023-06272-7","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T14:01:24Z","timestamp":1711375284000},"page":"2899-2910","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intraoperative kidney replacement therapy in acute liver failure"],"prefix":"10.1007","volume":"39","author":[{"given":"Daniel","family":"Henderson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anish","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shina","family":"Menon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8430-5570","authenticated-orcid":false,"given":"Akash","family":"Deep","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,25]]},"reference":[{"key":"6272_CR1","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1002\/hep.32223","volume":"75","author":"J de Ville de Goyet","year":"2022","unstructured":"de Ville de Goyet J, Baumann U, Karam V, Adam R, Nadalin S, Heaton N, Reding R, Branchereau S, Mirza D, Klempnauer JL, Fischer L, Kalicinski P, Colledan M, Lopez Santamaria M, de Kleine RH, Chardot C, Yilmaz S, Kilic M, Boillot O, di Francesco F, Polak WG, Verkade HJ (2022) European Liver, Intestine Transplant Association. European Liver Transplant Registry: donor and transplant surgery aspects of 16,641 liver transplantations in children. Hepatology 75:634\u2013645. https:\/\/doi.org\/10.1002\/hep.32223","journal-title":"Hepatology"},{"key":"6272_CR2","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/S2352-4642(22)00190-0","volume":"6","author":"A Deep","year":"2022","unstructured":"Deep A, Alexander EC, Bulut Y, Fitzpatrick E, Grazioli S, Heaton N, Dhawan A (2022) Advances in medical management of acute liver failure in children: promoting native liver survival. Lancet Child Adolesc Health 6:725\u2013737. https:\/\/doi.org\/10.1016\/S2352-4642(22)00190-0","journal-title":"Lancet Child Adolesc Health"},{"key":"6272_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1542\/peds.2022-057424","volume":"150","author":"U Baumann","year":"2022","unstructured":"Baumann U, Karam V, Adam R, Fondevila C, Dhawan A, Sokal E, Jacquemin E, Kelly DA, Grabhorn E, Pawlowska J, Dantiga L, Jara Vega P, Debray D, Polak WG, de Ville de Goyet J, Verkade HJ (2022) Prognosis of children undergoing liver transplantation: a 30-year European study. Paediatrics 150:e2022057424. https:\/\/doi.org\/10.1542\/peds.2022-057424","journal-title":"Paediatrics"},{"key":"6272_CR4","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1097\/MPG.0000000000001178","volume":"63","author":"VL Ng","year":"2009","unstructured":"Ng VL, Li R, Loomes KM, Leonis MA, Rudnick DA, Belle SH, Squires RH (2009) Outcomes of children with and without hepatic encephalopathy from the paediatric acute liver failure study group. J Pediatr Gastroenterol Nutr 63:357\u2013364. https:\/\/doi.org\/10.1097\/MPG.0000000000001178","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"6272_CR5","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1002\/hep.27191","volume":"60","author":"RH Squires","year":"2014","unstructured":"Squires RH, Ng V, Romero R, Ekong U, Hardikar W, Emre S, Mazariegos GV (2014) Evaluation of the pediatric patient for liver transplantation: 2014 practice guideline by the American Association for the Study of Liver Diseases, American Society of Transplantation and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. Hepatology 60:362\u2013398. https:\/\/doi.org\/10.1002\/hep.27191","journal-title":"Hepatology"},{"issue":"Suppl 1","key":"6272_CR6","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1111\/ajt.15674","volume":"20","author":"A Kwong","year":"2020","unstructured":"Kwong A, Kim WR, Lake JR, Smith JM, Schladt DP, Skeans MA, Noreen SM, Foutz J, Miller E, Snyder JJ, Israni AK, Kasiske BL (2020) OPTN\/SRTR 2018 annual data report: liver. Am J Transplant 20(Suppl 1):193\u2013299. https:\/\/doi.org\/10.1111\/ajt.15674","journal-title":"Am J Transplant"},{"key":"6272_CR7","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1097\/mpg.0000000000003268","volume":"74","author":"JE Squires","year":"2022","unstructured":"Squires JE, Alonso EM, Ibrahim SH, Kasper V, Kehar M, Martinez M, Squires RH (2022) North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition position paper on the diagnosis and management of pediatric acute liver failure. J Pediatr Gastroenterol Nutr 74:138\u2013158. https:\/\/doi.org\/10.1097\/mpg.0000000000003268","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"6272_CR8","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1053\/j.gastro.2014.05.005","volume":"147","author":"R Jalan","year":"2014","unstructured":"Jalan R, Yurdaydin C, Bajaj JS, Acharya SK, Arroyo V, Lin HC, Gines P, Kim WR, Kamath PS (2014) World Gastroenterology Organization Working Party: toward an improved definition of acute-on-chronic liver failure. J Gastro 147:4\u201310. https:\/\/doi.org\/10.1053\/j.gastro.2014.05.005","journal-title":"J Gastro"},{"key":"6272_CR9","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.4254\/wjh.v13.i10.1289","volume":"13","author":"A Islek","year":"2021","unstructured":"Islek A, Tumgor G (2021) Acute-on-chronic liver failure in children. World J Hepatol 13:1289\u20131298. https:\/\/doi.org\/10.4254\/wjh.v13.i10.1289","journal-title":"World J Hepatol"},{"key":"6272_CR10","first-page":"107","volume-title":"Diseases of the liver and biliary system in children","author":"PF Whitington","year":"2007","unstructured":"Whitington PF, Alonso EM (2007) Fulminant hepatitis and acute liver failure. In: Kelly DA (ed) Diseases of the liver and biliary system in children, 2nd edn. Blackwell Publishing Ltd, Oxford, pp 107\u2013126","edition":"2"},{"issue":"Suppl 1","key":"6272_CR11","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s40265-018-1018-z","volume":"79","author":"K Weissenborn","year":"2019","unstructured":"Weissenborn K (2019) Hepatic encephalopathy: definition, clinical grading and diagnostic principles. Drugs 79(Suppl 1):5\u20139. https:\/\/doi.org\/10.1007\/s40265-018-1018-z","journal-title":"Drugs"},{"key":"6272_CR12","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-023-04679-6","author":"JA Bartlett","year":"2023","unstructured":"Bartlett JA, Kohli R (2023) Hepatic encephalopathy in children. Indian J Pediatr. https:\/\/doi.org\/10.1007\/s12098-023-04679-6","journal-title":"Indian J Pediatr"},{"key":"6272_CR13","doi-asserted-by":"publisher","first-page":"1910","DOI":"10.1097\/ccm.0000000000001826","volume":"44","author":"A Deep","year":"2016","unstructured":"Deep A, Stewart CE, Dhawan A, Douiri A (2016) Effect of continuous renal replacement therapy on outcome in pediatric acute liver failure. Crit Care Med 44:1910\u20131919. https:\/\/doi.org\/10.1097\/ccm.0000000000001826","journal-title":"Crit Care Med"},{"key":"6272_CR14","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s00467-018-3893-7","volume":"34","author":"A Deep","year":"2019","unstructured":"Deep A, Saxena R, Jose B (2019) Acute kidney injury in children with chronic liver disease. Pediatr Nephrol 34:45\u201359. https:\/\/doi.org\/10.1007\/s00467-018-3893-7","journal-title":"Pediatr Nephrol"},{"key":"6272_CR15","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1016\/S0140-6736(20)30531-6","volume":"395","author":"S Gaudry","year":"2020","unstructured":"Gaudry S, Hajage D, Benichou N, Cha\u00efbi K, Barbar S, Zarbock A, Lumlertgul N, Wald R, Bagshaw SM, Srisawat N, Combes A, Geri G, Jamale T, Dechartres A, Quenot JP, Dreyfuss D (2020) Delayed versus early initiation of renal replacement therapy for severe acute kidney injury: a systematic review and individual patient data meta-analysis of randomised clinical trials. Lancet 395:1506\u20131515. https:\/\/doi.org\/10.1016\/S0140-6736(20)30531-6","journal-title":"Lancet"},{"key":"6272_CR16","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1097\/pcc.0000000000002045","volume":"20","author":"DL Hames","year":"2019","unstructured":"Hames DL, Ferguson MA, Salvin JW (2019) Risk factors for mortality in critically ill children requiring renal replacement therapy. Pediatr Crit Care Med 20:1069\u20131077. https:\/\/doi.org\/10.1097\/pcc.0000000000002045","journal-title":"Pediatr Crit Care Med"},{"key":"6272_CR17","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1097\/pcc.0000000000002717","volume":"22","author":"A Deep","year":"2021","unstructured":"Deep A (2021) The ever-changing paradigm of acute kidney injury definition: does duration and trajectory of acute kidney injury add another dimension? Pediatr Crit Care Med 22:676\u2013679. https:\/\/doi.org\/10.1097\/pcc.0000000000002717","journal-title":"Pediatr Crit Care Med"},{"key":"6272_CR18","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1053\/j.ackd.2015.06.006","volume":"22","author":"TM Leventhal","year":"2015","unstructured":"Leventhal TM, Liu KD (2015) What a nephrologist needs to know about acute liver failure. Advances in Chronic Kidney Disease. Adv Chronic Kidney Dis 22:376\u2013381. https:\/\/doi.org\/10.1053\/j.ackd.2015.06.006","journal-title":"Adv Chronic Kidney Dis"},{"key":"6272_CR19","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1111\/liv.13693","volume":"38","author":"BB Lal","year":"2018","unstructured":"Lal BB, Alam S, Sood V, Rawat D, Khanna R (2018) Profile, risk factors and outcome of acute kidney injury in paediatric acute-on-chronic liver failure. Liver Int 38:1777\u20131784. https:\/\/doi.org\/10.1111\/liv.13693","journal-title":"Liver Int"},{"key":"6272_CR20","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1007\/s12630-019-01454-0","volume":"66","author":"CJ Karvellas","year":"2019","unstructured":"Karvellas CJ, Taylor S, Bigam D, Kneteman NM, Shapiro AMJ, Romanovsky A, Gibney RTN, Townsend DR, Meeberg G, \u00d6zelsel T, Bishop E, Bagshaw SM (2019) Intraoperative continuous renal replacement therapy during liver transplantation: a pilot randomized-controlled trial (INCEPTION). Can J Anaesth 66:1151\u20131161. https:\/\/doi.org\/10.1007\/s12630-019-01454-0","journal-title":"Can J Anaesth"},{"key":"6272_CR21","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1002\/lt.25836","volume":"26","author":"CH Paine","year":"2020","unstructured":"Paine CH, Pichler RH (2020) Intraoperative renal replacement therapy for liver transplantation: is there really a benefit? Liver Transpl 26:971\u2013972. https:\/\/doi.org\/10.1002\/lt.25836","journal-title":"Liver Transpl"},{"key":"6272_CR22","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1002\/lt.25773","volume":"26","author":"HB Huang","year":"2020","unstructured":"Huang HB, Xu Y, Zhou H, Zhu Y, Qin JP (2020) Intraoperative continuous renal replacement therapy during liver transplantation: a meta-analysis. Liver Transpl 26:1010\u20131018. https:\/\/doi.org\/10.1002\/lt.25773","journal-title":"Liver Transpl"},{"key":"6272_CR23","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/lt.21650","volume":"15","author":"DR Townsend","year":"2009","unstructured":"Townsend DR, Bagshaw SM, Jacka MJ, Bigam D, Cave D, Gibney RTN (2009) Intraoperative renal support during liver transplantation. Liver Transpl 15:73\u201378. https:\/\/doi.org\/10.1002\/lt.21650","journal-title":"Liver Transpl"},{"key":"6272_CR24","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.jclinane.2009.07.013","volume":"22","author":"A Vitin","year":"2010","unstructured":"Vitin A, Muczynski K, Bakthavatsalam R, Martay K, Dembo G, Metzner J (2010) Treatment of severe lactic acidosis during the pre-anhepatic stage of liver transplant surgery with intraoperative hemodialysis. J Clin Anesth 22:466\u2013472. https:\/\/doi.org\/10.1016\/j.jclinane.2009.07.013","journal-title":"J Clin Anesth"},{"key":"6272_CR25","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1159\/000329485","volume":"32","author":"A Parmar","year":"2011","unstructured":"Parmar A, Bigam D, Meeberg G, Cave D, Townsend DR, Gibney RTN, Bagshaw SM (2011) An evaluation of intraoperative renal support during liver transplantation: a matched cohort study. Blood Purif 32:238\u2013248. https:\/\/doi.org\/10.1159\/000329485","journal-title":"Blood Purif"},{"key":"6272_CR26","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1002\/lt.23867","volume":"20","author":"MK Nadim","year":"2014","unstructured":"Nadim MK, Annanthapanyasut W, Matsuoka L, Appachu K, Boyajian M, Ji L, Sedra A, Genyk YS (2014) Intraoperative hemodialysis during liver transplantation: a decade of experience. Liver Transpl 20:756\u2013764. https:\/\/doi.org\/10.1002\/lt.23867","journal-title":"Liver Transpl"},{"key":"6272_CR27","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.advms.2022.04.004","volume":"67","author":"M Ko\u015bcielska","year":"2022","unstructured":"Ko\u015bcielska M, Matuszkiewicz-Rowi\u0144ska J, Giercuszkiewicz D, Krawczyk M, Niewi\u0144ski G, Sierdzi\u0144ski J, Zieniewicz K, \u017bebrowski P, Ma\u0142yszko J (2022) Intraoperative dialysis with the use of a mobile dialysis system during liver transplantation. Adv Med Sci 67:208\u2013215. https:\/\/doi.org\/10.1016\/j.advms.2022.04.004","journal-title":"Adv Med Sci"},{"key":"6272_CR28","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1159\/000452754","volume":"43","author":"A Deep","year":"2017","unstructured":"Deep A, Zoha M, Dutta Kukreja P (2017) Prostacyclin as an anticoagulant for continuous renal replacement therapy in children. Blood Purif 43:279\u2013289. https:\/\/doi.org\/10.1159\/000452754","journal-title":"Blood Purif"},{"key":"6272_CR29","doi-asserted-by":"publisher","first-page":"2486","DOI":"10.1016\/j.transproceed.2019.01.179","volume":"51","author":"O Ferah","year":"2019","unstructured":"Ferah O, Akbulut A, A\u00e7ik ME, G\u00f6kkaya Z, Acar U, Yenid\u00fcnya \u00d6, Yent\u00fcr E, Tokat Y (2019) Acute kidney injury after pediatric liver transplantation. Transplant Proc 51:2486\u20132491. https:\/\/doi.org\/10.1016\/j.transproceed.2019.01.179","journal-title":"Transplant Proc"},{"key":"6272_CR30","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.anpede.2023.08.002","volume":"99","author":"M Azpilicueta-Idarreta","year":"2023","unstructured":"Azpilicueta-Idarreta M, Prieto-Torre M, Montijano-Herrero L, Fern\u00e1ndez-Ruiz L, Ant\u00f3n-Gamero M (2023) Kidney injury associated with liver transplantation. An Pediatr 99:232\u2013239. https:\/\/doi.org\/10.1016\/j.anpede.2023.08.002","journal-title":"An Pediatr"},{"key":"6272_CR31","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1186\/s12882-021-02360-8","volume":"22","author":"J Zhou","year":"2021","unstructured":"Zhou J, Zhang X, Lyu L, Ma X, Miao G, Chu H (2021) Modifiable risk factors of acute kidney injury after liver transplantation: a systematic review and meta-analysis. BMC Nephrol 22:149. https:\/\/doi.org\/10.1186\/s12882-021-02360-8","journal-title":"BMC Nephrol"},{"key":"6272_CR32","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1007\/s00467-020-04613-4","volume":"36","author":"BS Zoica","year":"2021","unstructured":"Zoica BS, Deep A (2021) Extracorporeal renal and liver support in pediatric acute liver failure. Pediatr Nephrol 36:1119\u20131128. https:\/\/doi.org\/10.1007\/s00467-020-04613-4","journal-title":"Pediatr Nephrol"},{"key":"6272_CR33","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1016\/j.transproceed.2017.03.094","volume":"49","author":"SD Baek","year":"2017","unstructured":"Baek SD, Jang M, Kim W, Yu H, Hwang S, Lee SG, Hwang GS, Lee EK, Kim SM, Chang JW (2017) Benefits of intraoperative continuous renal replacement therapy during liver transplantation in patients with renal dysfunction. Transplant Proc 49:1344\u20131350. https:\/\/doi.org\/10.1016\/j.transproceed.2017.03.094","journal-title":"Transplant Proc"},{"key":"6272_CR34","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1111\/aas.13664","volume":"64","author":"SR Rasmussen","year":"2020","unstructured":"Rasmussen SR, Kandler K, Nielsen RV, Jakobsen PC, Ranucci M, Ravn HB (2020) Association between transfusion of blood products and acute kidney injury following cardiac surgery. Acta Anaesthesiol Scand 64:1397\u20131404. https:\/\/doi.org\/10.1111\/aas.13664","journal-title":"Acta Anaesthesiol Scand"},{"key":"6272_CR35","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1097\/00007890-199903150-00024","volume":"67","author":"O Detry","year":"1999","unstructured":"Detry O, Arkadopoulos N, Ting P, Kahaku E, Margulies J, Arnaout W, Colquhoun SD, Rozga J, Demtriou AA (1999) Intracranial pressure during liver transplantation for fulminant hepatic failure. Transplantation 67:767\u2013770","journal-title":"Transplantation"},{"key":"6272_CR36","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1681\/asn.v981507","volume":"9","author":"D Hern\u00e1ndez","year":"1998","unstructured":"Hern\u00e1ndez D, D\u00edaz F, Rufino M, Lorenzo V, P\u00e9rez T, Rodr\u00edguez A, De Bonis E, Losada M, Gonz\u00e1lez-Posada JM, Torres A (1998) Subclavian vascular access stenosis in dialysis patients: natural history and risk factors. J Am Soc Nephrol 9:1507\u20131510. https:\/\/doi.org\/10.1681\/asn.v981507","journal-title":"J Am Soc Nephrol"},{"key":"6272_CR37","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1590\/0004-282x20170076","volume":"75","author":"PFM Junior","year":"2017","unstructured":"Junior PFM, Nogueira RC, Oliveira ML, Paschoal EHA, Teixeira MJ, D\u2019Albuquerque LAC, Bor-Seng-Shu E (2017) Cerebral hemodynamic and metabolic changes in fulminant hepatic failure. Arq Neuropsiquiatr 75:470\u2013476. https:\/\/doi.org\/10.1590\/0004-282x20170076","journal-title":"Arq Neuropsiquiatr"},{"key":"6272_CR38","doi-asserted-by":"publisher","first-page":"122","DOI":"10.5500\/wjt.v13.i4.122","volume":"13","author":"LE Mendoza Vasquez","year":"2023","unstructured":"Mendoza Vasquez LE, Payne S, Zamper R (2023) Intracranial pressure monitoring in the perioperative period of patients with acute liver failure undergoing orthotopic liver transplantation. World J Transplant 13:122\u2013128. https:\/\/doi.org\/10.5500\/wjt.v13.i4.122","journal-title":"World J Transplant"},{"key":"6272_CR39","doi-asserted-by":"publisher","DOI":"10.1111\/petr.14377","volume":"26","author":"E Blanchette","year":"2022","unstructured":"Blanchette E, Pahlavan S, Yoeli D, Brigham D, Sater A, Wachs M, Bock M, Adams M (2022) Successful use of intra-operative continuous renal replacement therapy in pediatric liver transplant recipients: single center case series. Pediatr Transplant 26:e14377. https:\/\/doi.org\/10.1111\/petr.14377","journal-title":"Pediatr Transplant"},{"key":"6272_CR40","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1213\/ANE.0000000000002416","volume":"125","author":"DB Wax","year":"2017","unstructured":"Wax DB, DeMaria S Jr, Zerillo J (2017) Hypothermia risk with intraoperative continuous renal replacement therapy. Anesth Analg 125:1820\u20131821. https:\/\/doi.org\/10.1213\/ANE.0000000000002416","journal-title":"Anesth Analg"},{"key":"6272_CR41","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.0000000000000350","author":"C Paine","year":"2023","unstructured":"Paine C, Pichler R (2023) How we treat hyperammonaemia in acute liver failure. Clin J Am Soc Nephrol. https:\/\/doi.org\/10.2215\/CJN.0000000000000350","journal-title":"Clin J Am Soc Nephrol"},{"key":"6272_CR42","doi-asserted-by":"publisher","first-page":"R67","DOI":"10.1186\/cc4903","volume":"10","author":"Z Ricci","year":"2006","unstructured":"Ricci Z, Ronco C, Bachetoni A, D\u2019amico G, Rossi S, Alessandri E, Rocco M, Pietropaoli P (2006) Solute removal during continuous renal replacement therapy in critically ill patients: convection versus diffusion. Crit Care 10:R67. https:\/\/doi.org\/10.1186\/cc4903","journal-title":"Crit Care"},{"key":"6272_CR43","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1111\/aas.13616","volume":"64","author":"M Bell","year":"2020","unstructured":"Bell M, Ronco C, Hansson F, Broman M (2020) Hypothermia during CRRT, a comparative analysis. Acta Anaesthesiol Scand 64:1162\u20131166. https:\/\/doi.org\/10.1111\/aas.13616","journal-title":"Acta Anaesthesiol Scand"},{"key":"6272_CR44","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1111\/1744-9987.12224","volume":"19","author":"CD Goonasekera","year":"2015","unstructured":"Goonasekera CD, Wang J, Bunchman TE, Deep A (2015) Factors affecting circuit life during continuous renal replacement therapy in children with liver failure. Ther Apher Dial 19:16\u201322. https:\/\/doi.org\/10.1111\/1744-9987.12224","journal-title":"Ther Apher Dial"},{"key":"6272_CR45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182134","volume":"12","author":"K Rodriguez","year":"2017","unstructured":"Rodriguez K, Srivaths PR, Tal L, Watson MN, Riley AA, Himes RW, Desai MS, Braun MC, AkcanArikan A (2017) Regional citrate anticoagulation for continuous renal replacement therapy in pediatric patients with liver failure. PLoS One 12:e0182134. https:\/\/doi.org\/10.1371\/journal.pone.0182134","journal-title":"PLoS ONE"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-023-06272-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00467-023-06272-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-023-06272-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T15:05:15Z","timestamp":1724771115000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00467-023-06272-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,25]]},"references-count":45,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["6272"],"URL":"https:\/\/doi.org\/10.1007\/s00467-023-06272-7","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,25]]},"assertion":[{"value":"10 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}}]}}