{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:06:08Z","timestamp":1789610768239,"version":"build-2803163510"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oliguria is a sign of impaired kidney function and has been shown to be an early predictor of adverse prognoses in patients with acute kidney injury. The relationship between urine output (UOP) and early lactate levels in neonates with perinatal asphyxia (PA) has not been extensively explored. This study aimed to investigate the link between oliguria during the first 24\u00a0h of life and early lactate levels in neonates with PA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The medical records of 293 term neonates with asphyxia from 9216 hospitalized newborns were retrospectively analyzed, including 127 cases designated as the oliguria group and 166 cases as controls. Peripheral arterial blood gas after PA and UOP within 24\u00a0h after birth were analyzed. Logistic regression analyses and receiver operating characteristic curve analysis were conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Oliguria occurred in 43.34% of neonates with PA. The median UOP of the oliguria and control groups were 0.65 and 1.46\u00a0mL\/kg\/h, respectively. Elevated lactate levels after PA are an independent risk factor for oliguria in the following 24\u00a0h (p\u2009=\u20090.01; OR: 1.19; 95%CI: 1.04\u20131.35) and show a moderate discriminatory power for oliguria (AUC\u2009=\u20090.62). Using a cut off value of 8.15\u00a0mmol\/L, the positive and negative predictive values and the specificity were 59.34%, 63.86%, and 78.30%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Neonates with elevated lactate levels after PA face a risk of oliguria in the following 24\u00a0h. Based on early elevated lactate levels after resuscitation, especially\u2009\u2265\u20098.15\u00a0mmol\/L, meticulously monitoring UOP will allow this vulnerable population to receive early, tailored fluid management and medical intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s00467-024-06322-8","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T14:02:19Z","timestamp":1709042539000},"page":"2227-2234","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Initial lactate levels linked to oliguria in term neonates with perinatal asphyxia"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9878-2228","authenticated-orcid":false,"given":"Yu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4598-4141","authenticated-orcid":false,"given":"Huihui","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"key":"6322_CR1","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1093\/ndt\/gfs604","volume":"28","author":"CT Bezerra","year":"2013","unstructured":"Bezerra CT, Vaz Cunha LC, Lib\u00f3rio AB (2013) Defining reduced urine output in neonatal ICU: importance for mortality and acute kidney injury classification. 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The clinical and research activities being reported are consistent with the principles of the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent from the participants\u2019 legal guardian\/next of kin was not required to participate in this study in accordance with the national legislation and the institutional requirements.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"This manuscript has not been published or presented elsewhere in part or in entirety and is not under consideration by another journal. Both authors have reviewed and agreed upon the final version of the manuscript and consented to its submission to <i>Pediatric Nephrology<\/i>.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no conflict of interest.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}