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A \u201cperitoneal dialysis (PD) first\u201d policy for paediatric AKI is more feasible than haemodialysis in low-resource settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective review of modalities and outcomes of children dialysed acutely at Red Cross War Memorial Children\u2019s Hospital between 1998 and 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 593 children with AKI who received dialysis, 463 (78.1%) received PD first. Median age was 9.0 (range 0.03\u2013219.3; IQR 13.0\u201369.6) months; 57.6% were\u2009&lt;\u20091\u00a0year old. Weights ranged from 0.9 to 2.0\u00a0kg (median 7.0\u00a0kg, IQR 3.0\u201316.0\u00a0kg); 38.6% were\u2009&lt;\u20095\u00a0kg. PD was used more in younger children compared to extracorporeal dialysis (ECD), with median ages 6.4 (IQR 0.9\u201330.4) vs. 73.9 (IQR 17.5\u2013113.9) months, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). PD was performed with Seldinger soft catheters (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009480\/578, 83%), predominantly inserted by paediatricians at the bedside (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009412\/490, 84.1%). Complications occurred in 99\/560 (17.7%) children receiving PD. Overall, 314\/542 (57.8%) children survived. Survival was significantly lower in neonates (&lt;\u20091\u00a0month old, 47.5%) and infants (1\u201312\u00a0months old, 49.2%) compared with older children (&gt;\u20091\u00a0year old, 70.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Survival was superior in the ECD (75.4%) than in the PD group (55.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\u201cPD First for Paediatric AKI\u201d is a valuable therapeutic approach for children with AKI. It is feasible in low-resourced settings where bedside PD catheter insertion can be safely taught and is an acceptable dialysis modality, especially in settings where children with AKI would otherwise not survive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s00467-024-06399-1","type":"journal-article","created":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T03:01:49Z","timestamp":1715396509000},"page":"2807-2818","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Dialysis for paediatric acute kidney injury in Cape Town, South Africa"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2876-4785","authenticated-orcid":false,"given":"Mignon I.","family":"McCulloch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7066-8135","authenticated-orcid":false,"given":"Valerie A.","family":"Luyckx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5193-918X","authenticated-orcid":false,"given":"Brenda","family":"Morrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5456-4456","authenticated-orcid":false,"given":"Peter","family":"Nourse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0364-9978","authenticated-orcid":false,"given":"Ashton","family":"Coetzee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5575-7586","authenticated-orcid":false,"given":"Deveshni","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6312-0569","authenticated-orcid":false,"given":"Christel","family":"Du Buisson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4945-2249","authenticated-orcid":false,"given":"Jonathan","family":"Buckley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilana","family":"Webber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2026-6423","authenticated-orcid":false,"given":"Alp","family":"Numanoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Sinclair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candice","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8368-6321","authenticated-orcid":false,"given":"Shamiel","family":"Salie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2513-3523","authenticated-orcid":false,"given":"Kirsten","family":"Reichmuth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9333-2036","authenticated-orcid":false,"given":"Andrew C.","family":"Argent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,11]]},"reference":[{"key":"6399_CR1","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/s41390-021-01452-3","volume":"91","author":"R Raina","year":"2022","unstructured":"Raina R, Chakraborty R, Tibrewal A, Sethi SK, Bunchman T (2022) Advances in pediatric acute kidney injury. 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The calculation for blocked PD catheters on page 2812 was originally quoted as:","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"\u201cThe overall complication rate was 127\/560 (22.7%) and included mainly technical problems including blockage or poor drainage (n = 72, 56.7%)\u2026\u201d. However, this should have read: (n = 72\/560 \u2013 12.9%).\"","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 September 2025","order":9,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":10,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":11,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00467-025-06880-5","URL":"https:\/\/doi.org\/10.1007\/s00467-025-06880-5","order":12,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}