{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:17:48Z","timestamp":1791285468320,"version":"4.1.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Tuberous sclerosis (TSC)\u2013associated kidney disease is a leading cause of mortality in adults with TSC. This study aimed to understand TSC features in children, particularly kidney involvement, to inform clinical care for this specific group.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This retrospective cohort study included all paediatric (&lt;\u200919\u00a0years) TSC cases at a large tertiary paediatric nephrology centre. Relevant data were collected from patients\u2019 records, statistical analyses were performed to identify associations between variables, survival probabilities were estimated with Kaplan\u2012Meier curves, and log-rank tests were conducted to assess survival differences among genetic mutations.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 182 children with TSC were included. Among the 145 children with available kidney imaging data, 78.6% (114\/145) exhibited kidney lesions. Angiomyolipomas (AMLs) were significantly more prevalent in the <jats:italic>TSC2<\/jats:italic> mutation group (<jats:italic>p<\/jats:italic>\u2009=\u20090.018). Children with <jats:italic>TSC2<\/jats:italic> mutations generally had poorer lesion-free survival than those with <jats:italic>TSC1<\/jats:italic> mutations, but this difference was only significant for AMLs (<jats:italic>p<\/jats:italic>\u2009=\u20090.030). The change in size of largest AMLs increased with age and doubled in children above 9\u00a0years; a similar pattern was observed when stratified by genetic mutation. In contrast, kidney cysts exhibited two peaks: one in children under 5\u00a0years (2.31\u00a0mm\/year) and the second in children between 15\u201319\u00a0years (2.82\u00a0mm\/year). Chronic kidney disease was observed in 12.3% (10\/81) of children, and high-risk AMLs above 3\u00a0cm were observed in 9% (13\/145).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>While TSC kidney disease emerges later in the disease course than neurological features, our findings emphasise the importance of kidney surveillance during childhood, including routine kidney imaging, kidney function, and blood pressure monitoring.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1007\/s00467-024-06417-2","type":"journal-article","created":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T05:01:28Z","timestamp":1717477288000},"page":"2927-2937","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The extent of kidney involvement in paediatric tuberous sclerosis complex"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2537-4477","authenticated-orcid":false,"given":"Andrew","family":"Limavady","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7503-7893","authenticated-orcid":false,"given":"Matko","family":"Marlais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,4]]},"reference":[{"key":"6417_CR1","doi-asserted-by":"publisher","first-page":"2489","DOI":"10.1007\/s00381-020-04726-z","volume":"36","author":"D Marom","year":"2020","unstructured":"Marom D (2020) Genetics of tuberous sclerosis complex: an update. Childs Nerv Syst 36:2489\u20132496. https:\/\/doi.org\/10.1007\/s00381-020-04726-z","journal-title":"Childs Nerv Syst"},{"key":"6417_CR2","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1146\/annurev-genom-083118-015354","volume":"20","author":"CL Salussolia","year":"2019","unstructured":"Salussolia CL, Klonowska K, Kwiatkowski DJ, Sahin M (2019) Genetic etiologies, diagnosis, and treatment of tuberous sclerosis complex. Annu Rev Genomics Hum Genet 20:217\u2013240. https:\/\/doi.org\/10.1146\/annurev-genom-083118-015354","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"6417_CR3","doi-asserted-by":"publisher","first-page":"104309","DOI":"10.1016\/j.ejmg.2021","volume":"64","author":"K Babol-Pokora","year":"2021","unstructured":"Babol-Pokora K, Bielska M, Bobeff K, Jatczak-Pawlik I, Borkowska J, Kotulska K, J\u00f3\u017awiak S, M\u0142ynarski W, Treli\u0144ska J (2021) A multistep approach to the genotype-phenotype analysis of Polish patients with tuberous sclerosis complex. Eur J Med Genet 64:104309. https:\/\/doi.org\/10.1016\/j.ejmg.2021","journal-title":"Eur J Med Genet"},{"key":"6417_CR4","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/S0140-6736(08)61279-9","volume":"372","author":"P Curatolo","year":"2008","unstructured":"Curatolo P, Bombardieri R, Jozwiak S (2008) Tuberous sclerosis. Lancet 372:657\u2013668. https:\/\/doi.org\/10.1016\/S0140-6736(08)61279-9","journal-title":"Lancet"},{"key":"6417_CR5","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1615\/CritRevOncog.2022042857","volume":"27","author":"JJ Bissler","year":"2022","unstructured":"Bissler JJ, Batchelor D, Kingswood JC (2022) Progress in tuberous sclerosis complex renal disease. Crit Rev Oncog 27:35\u201349. https:\/\/doi.org\/10.1615\/CritRevOncog.2022042857","journal-title":"Crit Rev Oncog"},{"key":"6417_CR6","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1111\/dmcn.13352","volume":"59","author":"S Amin","year":"2017","unstructured":"Amin S, Lux A, Calder N, Laugharne M, Osborne J, O\u2019Callaghan F (2017) Causes of mortality in individuals with tuberous sclerosis complex. Dev Med Child Neurol 59:612\u2013627. https:\/\/doi.org\/10.1111\/dmcn.13352","journal-title":"Dev Med Child Neurol"},{"key":"6417_CR7","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1007\/s00467-018-4003-6","volume":"33","author":"P Janssens","year":"2018","unstructured":"Janssens P, Van Hoeve K, De Waele L, De Rechter S, Claes KJ, Van de Perre E, Wissing KM, Bammens B, Jansen A, Mekahli D (2018) Renal progression factors in young patients with tuberous sclerosis complex: a retrospective cohort study. Pediatr Nephrol 33:2085\u20132093. https:\/\/doi.org\/10.1007\/s00467-018-4003-6","journal-title":"Pediatr Nephrol"},{"key":"6417_CR8","doi-asserted-by":"publisher","first-page":"3253","DOI":"10.1007\/s00467-022-05820-x","volume":"38","author":"S Gallo-Bernal","year":"2023","unstructured":"Gallo-Bernal S, Kilcoyne A, Gee MS, Paul E (2023) Cystic kidney disease in tuberous sclerosis complex: current knowledge and unresolved questions. Pediatr Nephrol 38:3253\u20133264. https:\/\/doi.org\/10.1007\/s00467-022-05820-x","journal-title":"Pediatr Nephrol"},{"key":"6417_CR9","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.juro.2016.09.082","volume":"197","author":"JC Warncke","year":"2017","unstructured":"Warncke JC, Brodie KE, Grantham EC, Catarinicchia SP, Tong S, Kondo KL, Cost NG (2017) Pediatric renal angiomyolipomas in tuberous sclerosis complex. J Urol 197:500\u2013506. https:\/\/doi.org\/10.1016\/j.juro.2016.09.082","journal-title":"J Urol"},{"key":"6417_CR10","doi-asserted-by":"publisher","first-page":"757","DOI":"10.21037\/tp-20-150","volume":"9","author":"Z Xu","year":"2020","unstructured":"Xu Z, Wu J, Xu G, Luo H (2020) Abdominal ultrasonographic manifestations in pediatric patients with tuberous sclerosis complex. Transl Pediatr 9:757\u2013767. https:\/\/doi.org\/10.21037\/tp-20-150","journal-title":"Transl Pediatr"},{"key":"6417_CR11","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1186\/s12887-023-04137-4","volume":"23","author":"K Pearsson","year":"2023","unstructured":"Pearsson K, Bjork Werner J, Lundgren J, Granse L, Karlsson E, Kallen K, Eklund EA, Bekassy Z (2023) Childhood tuberous sclerosis complex in southern Sweden: a paradigm shift in diagnosis and treatment. BMC Pediatr 23:329. https:\/\/doi.org\/10.1186\/s12887-023-04137-4","journal-title":"BMC Pediatr"},{"key":"6417_CR12","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1093\/ndt\/gfy063","volume":"34","author":"JC Kingswood","year":"2019","unstructured":"Kingswood JC, Belousova E, Benedik MP, Carter T, Cottin V, Curatolo P, Dahlin M, D\u2019Amato L, d\u2019Augeres GB, de Vries PJ, Ferreira JC, Feucht M, Fladrowski C, Hertzberg C, Jozwjak S, Lawson JA, Macaya A, Marques R, Nabbout R, O\u2019Callaghan F, Qin J, Sander V, Sauter M, Shah S, Takahashi Y, Touraine R, Youroukos S, Zonnenberg B, Jansen AC (2019) Renal angiomyolipoma in patients with tuberous sclerosis complex: findings from the TuberOus SClerosis registry to increase disease Awareness. Nephrol Dial Transplant 34:502\u2013508. https:\/\/doi.org\/10.1093\/ndt\/gfy063","journal-title":"Nephrol Dial Transplant"},{"key":"6417_CR13","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1097\/HJH.0000000000001039","volume":"34","author":"E Lurbe","year":"2016","unstructured":"Lurbe E, Agabiti-Rosei E, Cruickshank JK, Dominiczak A, Erdine S, Hirth A, Invitti C, Litwin M, Mancia G, Pall D, Rascher W, Redon J, Schaefer F, Seeman T, Sinha M, Stabouli S, Webb NJ, W\u00fchl E, Zanchetti A (2016) 2016 European Society of Hypertension guidelines for the management of high blood pressure in children and adolescents. J Hypertens 34:1887\u20131920. https:\/\/doi.org\/10.1097\/HJH.0000000000001039","journal-title":"J Hypertens"},{"key":"6417_CR14","unstructured":"Kulon M (2015) Pediatric Kidney Size Percentile Calculator: Radiology-universe.org https:\/\/radiology-universe.org\/calculator\/pediatric-kidney-sizes\/calculator.php. Accessed 12 June 2023"},{"key":"6417_CR15","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1681\/ASN.2008030287","volume":"20","author":"GJ Schwartz","year":"2009","unstructured":"Schwartz GJ, Munoz A, Schneider MF, Mak RH, Kaskel F, Warady BA, Furth SL (2009) New equations to estimate GFR in children with CKD. J Am Soc Nephrol 20:629\u2013637. https:\/\/doi.org\/10.1681\/ASN.2008030287","journal-title":"J Am Soc Nephrol"},{"key":"6417_CR16","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1093\/ndt\/gfs037","volume":"27","author":"P Palatini","year":"2012","unstructured":"Palatini P (2012) Glomerular hyperfiltration: a marker of early renal damage in pre-diabetes and pre-hypertension. Nephrol Dial Transplant 27:1708\u20131714. https:\/\/doi.org\/10.1093\/ndt\/gfs037","journal-title":"Nephrol Dial Transplant"},{"key":"6417_CR17","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/nrneph.2012.19","volume":"8","author":"I Helal","year":"2012","unstructured":"Helal I, Fick-Brosnahan GM, Reed-Gitomer B, Schrier RW (2012) Glomerular hyperfiltration: definitions, mechanisms and clinical implications. Nat Rev Nephrol 8:293\u2013300. https:\/\/doi.org\/10.1038\/nrneph.2012.19","journal-title":"Nat Rev Nephrol"},{"key":"6417_CR18","doi-asserted-by":"publisher","first-page":"972","DOI":"10.3389\/fneur.2020.00972","volume":"11","author":"JC Kingswood","year":"2020","unstructured":"Kingswood JC, Belousova E, Benedik MP, Carter T, Cottin V, Curatolo P, Dahlin M, D\u2019Amato L, Beaure d\u2019Aug\u00e8res G, de Vries PJ, Ferreira JC, Feucht M, Fladrowski C, Hertzberg C, Jozwiak S, Lawson JA, Macaya A, Marques R, Nabbout R, O\u2019Callaghan F, Qin J, Sander V, Shah S, Takahashi Y, Touraine R, Youroukos S, Zonnenberg B, Jansen AC, Sauter M (2020) Renal manifestations of tuberous sclerosis complex: key findings from the final analysis of the TOSCA study focussing mainly on renal angiomyolipomas. Front Neurol 11:972. https:\/\/doi.org\/10.3389\/fneur.2020.00972","journal-title":"Front Neurol"},{"key":"6417_CR19","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/sj.ejhg.5201402","volume":"13","author":"O Sancak","year":"2005","unstructured":"Sancak O, Nellist M, Goedbloed M, Elfferich P, Wouters C, Maat-Kievit A, Zonnenberg B, Verhoef S, Halley D, van den Ouweland A (2005) Mutational analysis of the TSC1 and TSC2 genes in a diagnostic setting: genotype\u2013phenotype correlations and comparison of diagnostic DNA techniques in Tuberous Sclerosis Complex. Eur J Hum Genet 13:731\u2013741. https:\/\/doi.org\/10.1038\/sj.ejhg.5201402","journal-title":"Eur J Hum Genet"},{"key":"6417_CR20","doi-asserted-by":"publisher","unstructured":"Nair N, Chakraborty R, Mahajan Z, Sharma A, Sethi SK, Raina R (2020) Renal manifestations of tuberous sclerosis complex. J Kidney Cancer VHL 7:5\u201319. https:\/\/doi.org\/10.15586\/jkcvhl.2020.131","DOI":"10.15586\/jkcvhl.2020.131"},{"key":"6417_CR21","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1038\/s41436-020-0823-4","volume":"22","author":"B Ogorek","year":"2020","unstructured":"Ogorek B, Hamieh L, Hulshof HM, Lasseter K, Klonowska K, Kuijf H, Moavero R, Hertzberg C, Weschke B, Riney K, Feucht M, Scholl T, Krsek P, Nabbout R, Jansen AC, Benova B, Aronica E, Lagae L, Curatolo P, Borkowska J, Sadowski K, Doma\u0144ska-Pakie\u0142a D, Janson S, Kozlowski P, Urbanska M, Jaworski J, Jozwiak S, Jansen FE, Kotulska K, EPISTOP Consortium members, Kwiatkowski DJ (2020) TSC2 pathogenic variants are predictive of severe clinical manifestations in TSC infants: results of the EPISTOP study. Genet Med 22:1489\u20131497. https:\/\/doi.org\/10.1038\/s41436-020-0823-4","journal-title":"Genet Med"},{"key":"6417_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-024-00818-0","author":"D Mekahli","year":"2024","unstructured":"Mekahli D, M\u00fcller RU, Marlais M, Wlodkowski T, Haeberle S, de Argumedo ML, Bergmann C, Breysem L, Fladrowski C, Henske EP, Janssens P, Jouret F, Kingswood JC, Lattouf JB, Lilien M, Maleux G, Rozenberg M, Siemer S, Devuyst O, Schaefer F, Kwiatkowski DJ, Rouvi\u00e8re O, Bissler J (2024) Clinical practice recommendations for kidney involvement in tuberous sclerosis complex: a consensus statement by the ERKNet Working Group for Autosomal Dominant Structural Kidney Disorders and the ERA Genes & Kidney Working Group. Nat Rev Nephrol. https:\/\/doi.org\/10.1038\/s41581-024-00818-0","journal-title":"Nat Rev Nephrol"},{"key":"6417_CR23","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.pediatrneurol.2021.07.011","volume":"123","author":"H Northrup","year":"2021","unstructured":"Northrup H, Aronow ME, Bebin EM, Bissler J, Darling TN, de Vries PJ, Frost MD, Fuchs Z, Gosnell ES, Gupta N, Jansen AC, J\u00f3\u017awiak S, Kingswood JC, Knilans TK, McCormack FX, Pounders A, Roberds SL, Rodriguez-Buritica DF, Roth J, Sampson JR, Sparagana S, Thiele EA, Weiner HL, Wheless JW, Towbin AJ, Krueger DA, International Tuberous Sclerosis Complex Consensus Group (2021) Updated international tuberous sclerosis complex diagnostic criteria and surveillance and management recommendations. Pediatr Neurol 123:50\u201366. https:\/\/doi.org\/10.1016\/j.pediatrneurol.2021.07.011","journal-title":"Pediatr Neurol"},{"key":"6417_CR24","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.crad.2009.09.014","volume":"65","author":"D Halpenny","year":"2010","unstructured":"Halpenny D, Snow A, McNeill G, Torreggiani WC (2010) The radiological diagnosis and treatment of renal angiomyolipoma-current status. Clin Radiol 65:99\u2013108. https:\/\/doi.org\/10.1016\/j.crad.2009.09.014","journal-title":"Clin Radiol"},{"key":"6417_CR25","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.nefro.2019.07.002","volume":"40","author":"G Ariceta","year":"2020","unstructured":"Ariceta G, Buj MJ, Furlano M, Martinez V, Matamala A, Morales M, Robles NR, Sans L, Villacampa F, Torra R (2020) Recommendations for the management of renal involvement in the tuberous sclerosis complex. Nefrologia (Engl Ed) 40:142\u2013151. https:\/\/doi.org\/10.1016\/j.nefro.2019.07.002","journal-title":"Nefrologia (Engl Ed)"},{"key":"6417_CR26","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1111\/j.1464-410X.2004.05046.x","volume":"94","author":"FJ O'Callaghan","year":"2004","unstructured":"O\u2019Callaghan FJ, Noakes MJ, Martyn CN, Osborne JP (2004) An epidemiological study of renal pathology in tuberous sclerosis complex. BJU Int 94:853\u2013857. https:\/\/doi.org\/10.1111\/j.1464-410X.2004.05046.x","journal-title":"BJU Int"},{"key":"6417_CR27","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1053\/j.ajkd.2015.05.016","volume":"66","author":"MJ Eijkemans","year":"2015","unstructured":"Eijkemans MJ, van der Wal W, Reijnders LJ, Roes KC, van Waalwijk van Doorn-Khosrovani SB, Pelletier C, Magestro M, Zonnenberg B (2015) Long-term follow-up assessing renal angiomyolipoma treatment patterns, morbidity, and mortality: an observational study in tuberous sclerosis complex patients in the Netherlands. Am J Kidney Dis 66:638\u2013645. https:\/\/doi.org\/10.1053\/j.ajkd.2015.05.016","journal-title":"Am J Kidney Dis"},{"key":"6417_CR28","doi-asserted-by":"publisher","first-page":"5629","DOI":"10.1002\/cam4.2484","volume":"8","author":"S Guo","year":"2019","unstructured":"Guo S, Yao K, He X, Wu S, Ye Y, Chen J, Wu CL (2019) Prognostic significance of laterality in renal cell carcinoma: a population-based study from the surveillance, epidemiology, and end results (SEER) database. Cancer Med 8:5629\u20135637. https:\/\/doi.org\/10.1002\/cam4.2484","journal-title":"Cancer Med"},{"key":"6417_CR29","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1111\/j.1600-0560.1981.tb01028.x","volume":"8","author":"NP Sanchez","year":"1981","unstructured":"Sanchez NP, Wick MR, Perry HO (1981) Adenoma sebaceum of Pringle: a clinicopathologic review, with a discussion of related pathologic entities. J Cutan Pathol 8:395\u2013403. https:\/\/doi.org\/10.1111\/j.1600-0560.1981.tb01028.x","journal-title":"J Cutan Pathol"},{"key":"6417_CR30","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1136\/jmg.33.6.480","volume":"33","author":"JA Cook","year":"1996","unstructured":"Cook JA, Oliver K, Mueller RF, Sampson J (1996) A cross sectional study of renal involvement in tuberous sclerosis. J Med Genet 33:480\u2013484. https:\/\/doi.org\/10.1136\/jmg.33.6.480","journal-title":"J Med Genet"},{"key":"6417_CR31","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1007\/s11547-015-0572-7","volume":"121","author":"A Robert","year":"2016","unstructured":"Robert A, Leroy V, Riquet A, Gogneaux L, Boutry N, Avni FE (2016) Renal involvement in tuberous sclerosis complex with emphasis on cystic lesions. Radiol Med 121:402\u2013408. https:\/\/doi.org\/10.1007\/s11547-015-0572-7","journal-title":"Radiol Med"},{"key":"6417_CR32","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/S0022-5347(01)63072-6","volume":"160","author":"DH Ewalt","year":"1998","unstructured":"Ewalt DH, Sheffield E, Sparagana SP, Delgado MR, Roach ES (1998) Renal lesion growth in children with tuberous sclerosis complex. Urol J 160:141\u2013145","journal-title":"Urol J"},{"key":"6417_CR33","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1378\/chest.117.1.25","volume":"117","author":"H Logginidou","year":"2000","unstructured":"Logginidou H, Ao X, Russo I, Henske EP (2000) Frequent estrogen and progesterone receptor immunoreactivity in renal angiomyolipomas from women with pulmonary lymphangioleiomyomatosis. Chest 117:25\u201330. https:\/\/doi.org\/10.1378\/chest.117.1.25","journal-title":"Chest"},{"key":"6417_CR34","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1016\/S0022-5347(01)62677-6","volume":"160","author":"HO Mesrobian","year":"1998","unstructured":"Mesrobian HO, Laud PW, Todd E, Gregg DC (1998) The normal kidney growth rate during year 1 of life is variable and age dependent. Urol J 160:989\u2013993. https:\/\/doi.org\/10.1016\/S0022-5347(01)62677-6","journal-title":"Urol J"},{"key":"6417_CR35","doi-asserted-by":"publisher","first-page":"6019","DOI":"10.3390\/ijms22116019","volume":"22","author":"K Talbi","year":"2021","unstructured":"Talbi K, Cabrita I, Schreiber R, Kunzelmann K (2021) Gender-dependent phenotype in polycystic kidney disease is determined by differential intracellular Ca(2+) signals. Int J Mol Sci 22:6019. https:\/\/doi.org\/10.3390\/ijms22116019","journal-title":"Int J Mol Sci"},{"key":"6417_CR36","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.urology.2016.04.027","volume":"95","author":"J Bissler","year":"2016","unstructured":"Bissler J, Cappell K, Charles H, Song X, Liu Z, Prestifilippo J, Gregory C, Hulbert J (2016) Long-term clinical morbidity in patients with renal angiomyolipoma associated with tuberous sclerosis complex. Urology 95:80\u201387. https:\/\/doi.org\/10.1016\/j.urology.2016.04.027","journal-title":"Urology"},{"key":"6417_CR37","unstructured":"NHS England (2016) Clinical Commissioning Policy Statement: Everolimus (Votubia\u00ae) for treatment of angiomyolipomas associated with tuberous sclerosis. https:\/\/www.england.nhs.uk\/wp-content\/uploads\/2018\/07\/Everolimus-Votubia-for-treatment-of-angiomyolipomas-associated-with-tuberous-sclerosis.pdf. Accessed 5 August 2023"},{"key":"6417_CR38","unstructured":"Fadem SZ (2012) GFR calculator for children and adolescents 1 to 17 years old: bedside Schwartz and Counahan-Barratt methods: Nephron.com. http:\/\/nephron.com\/bedside_peds_nic.cgi. Accessed 13 June 2023"},{"key":"6417_CR39","unstructured":"Rosner B, Flynn JT (n.d.) AAP Pediatric Hypertension Guidelines: MDCalc.com. https:\/\/www.mdcalc.com\/calc\/4052\/aap-pediatric-hypertension-guidelines. Accessed 14 June 2023"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-024-06417-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00467-024-06417-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-024-06417-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T15:06:25Z","timestamp":1724771185000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00467-024-06417-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,4]]},"references-count":39,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["6417"],"URL":"https:\/\/doi.org\/10.1007\/s00467-024-06417-2","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,4]]},"assertion":[{"value":"14 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Formal ethical review was not needed; this study was conducted as part of a registered clinical audit.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}