{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:46:18Z","timestamp":1787769978973,"version":"build-2784847793"},"reference-count":5,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["00064203"],"award-info":[{"award-number":["00064203"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007397","name":"Charles University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>There is no specific treatment for proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID), a disease that is very rare in the pediatric population. We report the case of a 15-year-old boy who presented with mildly reduced kidney function and nephrotic syndrome. Kidney biopsy revealed PGNMID with monoclonal deposits of IgG3 with kappa light chain restriction. Flow cytometry showed a significant CD38 plasma cell population in the peripheral blood in the absence of other signs of hematological malignancy. The patient was treated with a 6-month course of daratumumab, a monoclonal antibody targeting CD38. There was a significant reduction in proteinuria and normalization of kidney function. Based on positive experience with adults, daratumumab should also be studied in children with PGNMID.<\/jats:p>","DOI":"10.1007\/s00467-024-06425-2","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T23:45:49Z","timestamp":1718063149000},"page":"3455-3457","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Proliferative glomerulonephritis with monoclonal IgG deposits in an adolescent successfully treated with daratumumab"],"prefix":"10.1007","volume":"39","author":[{"given":"Eva","family":"Svabova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Zieg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Sukova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Flachsova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Kment","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Tesar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,11]]},"reference":[{"key":"6425_CR1","doi-asserted-by":"publisher","first-page":"e13","DOI":"10.1053\/j.ajkd.2016.01.003","volume":"67","author":"MA Lusco","year":"2016","unstructured":"Lusco MA, Fogo AB, Najafian B, Alpers CE (2016) AJKD Atlas of Renal Pathology: proliferative glomerulonephritis with monoclonal immunoglobulin deposits. Am J Kidney Dis 67:e13\u2013e15","journal-title":"Am J Kidney Dis"},{"key":"6425_CR2","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1093\/ndt\/gfz176","volume":"36","author":"F Bridoux","year":"2021","unstructured":"Bridoux F, Javaugue V, Nasr SH, Leung N (2021) Proliferative glomerulonephritis with monoclonal immunoglobulin deposits: a nephrologist perspective. Nephrol Dial Transplant 36:208\u2013215","journal-title":"Nephrol Dial Transplant"},{"key":"6425_CR3","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1007\/s00467-018-3949-8","volume":"33","author":"G Xing","year":"2018","unstructured":"Xing G, Gillespie R, Bedri B, Quan A, Zhang P, Zhou XJ (2018) Proliferative glomerulonephritis with monoclonal IgG deposits in children and young adults. Pediatr Nephrol 33:1531\u20131538","journal-title":"Pediatr Nephrol"},{"key":"6425_CR4","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1681\/ASN.2020101541","volume":"32","author":"L Zand","year":"2021","unstructured":"Zand L, Rajkumar SV, Leung N, Sethi S, El Ters M, Fervenza FC (2021) Safety and efficacy of daratumumab in patients with proliferative GN with monoclonal immunoglobulin deposits. J Am Soc Nephrol 32:1163\u20131173","journal-title":"J Am Soc Nephrol"},{"key":"6425_CR5","doi-asserted-by":"publisher","first-page":"2203","DOI":"10.1016\/j.ekir.2021.05.008","volume":"6","author":"S Almaani","year":"2021","unstructured":"Almaani S, Parikh SV, Satoskar AA, Bumma N, Rovin BH, Sharma N, Efebera Y, Ayoub I (2021) Daratumumab in patients with bortezomib-refractory proliferative glomerulonephritis with monoclonal immunoglobulin deposits. Kidney Int Rep 6:2203\u20132206","journal-title":"Kidney Int Rep"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-024-06425-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00467-024-06425-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-024-06425-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T07:06:10Z","timestamp":1729839970000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00467-024-06425-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,11]]},"references-count":5,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["6425"],"URL":"https:\/\/doi.org\/10.1007\/s00467-024-06425-2","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,11]]},"assertion":[{"value":"25 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written consent to publish this case report was received from the patient and his parents.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient consent"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}}]}}