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Experimental studies have shown that V is a nephrotoxic agent, but little is known about its effects on human kidney health. This work evaluated the association between urinary V concentrations with early kidney damage biomarkers and function in a pediatric population without any disease diagnosed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional study was carried out and included 914 healthy subjects and determined urinary V concentrations, glomerular filtration rate (eGFR), albumin\u2013creatinine ratio (ACR), and the presence of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) in urine. We evaluated the V effect using linear and logistic regression models adjusted by confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Subjects found in the second and third tertiles of V showed an increase in urinary log-NGAL levels (\u03b2T2 vs. T1\u2009=\u20090.39; 95% CI 0.14, 0.64, and \u03b2T3 vs. T1\u2009=\u20091.04; 95% CI 0.75, 1.34) and log-KIM-1(\u03b2T2 vs. T1\u2009=\u20090.25; 95% CI 0.04, 0.45 and \u03b2T3 vs. T1\u2009=\u20090.39; 95% CI 0.15, 0.63); in addition, subjects in the third tertile had a positive and significant association with ACR (ORT3 vs. T1\u2009=\u20091.96; 95% CI 1.29, 2.97) and increased in eGFR (\u03b2T3 vs. T1\u2009=\u20093.98, 95% CI 0.39, 7.58), compared with subjects in the first tertile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study reports the effect of V on kidney markers in a healthy pediatric population. It could be related to tubulointerstitial lesions and function abnormalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s00467-024-06561-9","type":"journal-article","created":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T08:02:06Z","timestamp":1733558526000},"page":"1689-1700","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Vanadium exposure and kidney markers in a pediatric population: a cross-sectional study"],"prefix":"10.1007","volume":"40","author":[{"given":"Elodia","family":"Rojas-Lima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manolo","family":"Ortega-Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavio Gamaliel","family":"Aztatzi-Aguilar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Rubio-Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juana","family":"Narv\u00e1ez-Morales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariela","family":"Esparza-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"M\u00e9ndez-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0378-3675","authenticated-orcid":false,"given":"Olivier Christophe","family":"Barbier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,7]]},"reference":[{"key":"6561_CR1","volume-title":"Toxicological profile for vanadium","author":"Agency for Toxic Substances and Disease Registry (ATSDR)","year":"2012","unstructured":"Agency for Toxic Substances and Disease Registry (ATSDR) (2012) Toxicological profile for vanadium. 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