{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:50:30Z","timestamp":1777661430373,"version":"3.51.4"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004718","name":"Universit\u00e9 de Toulouse","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004718","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>\n              <jats:sup>51<\/jats:sup>Cr-EDTA and <jats:sup>99 m<\/jats:sup>Tc-DTPA clearances are two reference methods of determining the glomerular filtration rate. The study aimed to compare these two radioisotopic clearance measurements using an original approach based on population pharmacokinetics in oncopediatrics.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Plasma concentrations of <jats:sup>51<\/jats:sup>Cr-EDTA and <jats:sup>99 m<\/jats:sup>Tc-DTPA obtained from, respectively, 40 and 19 children treated with nephrotoxic chemotherapy were simultaneously analyzed while accounting for three covariates (i.e., serum creatinine, plasma cystatin C, body weight) previously described as being related to the pediatric glomerular filtration rate. A binary covariate \u201cGFR measurement\u201d (MES\u2009=\u20090 or 1, respectively, for <jats:sup>51<\/jats:sup>Cr-EDTA or <jats:sup>99 m<\/jats:sup>Tc-DTPA) was added to the model.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Analysis revealed a non-significant bias (\u00b1\u200995% CI) of\u2009\u2212\u20090.9%\u2009\u00b1\u200911.4% between the two measurements (with <jats:sup>99 m<\/jats:sup>Tc-DTPA clearance overestimated).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>This result confirmed that both radioisotopic clearances are equivalent in pediatrics, as has been reported in the literature on adults based on intrapatient comparisons. The value of the population approach in comparing the pharmacokinetics of two different compounds is thus demonstrated.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Graphical Abstract<\/jats:title>\n          <\/jats:sec>","DOI":"10.1007\/s00467-025-06828-9","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T03:20:04Z","timestamp":1748488804000},"page":"3163-3168","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A population pharmacokinetic approach to compare 51Cr-EDTA and 99 mTc-DTPA clearances in measuring renal glomerular filtration rate in oncopediatrics"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9960-8156","authenticated-orcid":false,"given":"Matthieu","family":"Gracia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoire","family":"Ankaoua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marl\u00e8ne","family":"Pasquet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7740-9096","authenticated-orcid":false,"given":"Etienne","family":"Chatelut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,29]]},"reference":[{"key":"6828_CR1","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.pharma.2020.01.006","volume":"78","author":"J Dinet","year":"2020","unstructured":"Dinet J, Le Cloirec J, Becker S et al (2020) Arr\u00eat de production du chrome-51 (51Cr) a usage clinique\u202f: quelles alternatives possibles pour les services de radiopharmacie et de m\u00e9decine nucl\u00e9aire\u202f? 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According to French law on ethics, for the use of data and samples in the \u201cCysPedVal\u201d study, an information letter was given to parents or children\u2019s legal representatives but also to the children who were old enough to understand.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}