{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T19:04:44Z","timestamp":1793819084325,"version":"4.6.1"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100006389","name":"University of Geneva","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006389","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Primary renal lymphoma is a rare form of kidney tumor, accounting for less than 1% of all kidney masses, and with only a few pediatric cases reported in the literature. Bilateral forms can present with kidney failure, constituting a therapeutic challenge for both hematologists and nephrologists, with the need to combine complex chemotherapy regimens and kidney replacement therapy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We present a rare case of primary bilateral renal diffuse large B-cell lymphoma in a teenage girl presenting with kidney failure (eGFR of 7\u00a0ml\/min\/1.73 m<jats:sup>2<\/jats:sup>), proposing a practical approach to optimize chemotherapy on kidney replacement therapy. We discuss diagnostic methods, the management and adjustment of chemotherapy and hyperhydration protocols, and the tailoring of highly efficient hemodiafiltration sessions to grant sufficient drug exposure while avoiding drug accumulation and toxicity in the context of kidney failure.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>This approach permitted a substantial reduction of chemotherapy adverse effects while inducing remission and partial recovery of kidney function in our patient, with hemodialysis discontinuation after 6\u00a0months, and an eGFR that had improved to 28\u00a0ml\/min\/1.73 m<jats:sup>2<\/jats:sup> at 12\u00a0months.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Managing complex chemotherapy protocols in kidney failure can be challenging, and the collaboration of a multidisciplinary team is essential. The adjustment of drug dosing and the tailoring of hemodialysis can increase patients\u2019 tolerance while maintaining chemotherapy efficiency.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Graphical abstract<\/jats:title>\n          <\/jats:sec>","DOI":"10.1007\/s00467-025-06833-y","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T08:54:01Z","timestamp":1749545641000},"page":"3181-3186","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Primary renal diffuse large B-cell lymphoma presenting as new-onset kidney failure"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5861-4505","authenticated-orcid":false,"given":"Massimiliano","family":"Bertacchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Vasey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Wilhelm-Bals","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Laure","family":"Rougemont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Baleydier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Parvex","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"key":"6833_CR1","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1111\/ejh.13360","volume":"104","author":"A Taneja","year":"2020","unstructured":"Taneja A, Kumar V, Chandra AB (2020) Primary renal lymphoma: a population-based analysis using the SEER program (1973\u20132015). Eur J Haematol 104:390\u2013399. https:\/\/doi.org\/10.1111\/ejh.13360","journal-title":"Eur J Haematol"},{"key":"6833_CR2","doi-asserted-by":"publisher","first-page":"e234810","DOI":"10.1136\/bcr-2020-234810","volume":"13","author":"G Bruce","year":"2020","unstructured":"Bruce G, Chaudhury S, Reynolds B (2020) Bilateral primary renal diffuse large B-cell lymphoma: a rare presentation of paediatric renal disease mimicking juvenile nephronophthisis. BMJ Case Rep 13:e234810. https:\/\/doi.org\/10.1136\/bcr-2020-234810","journal-title":"BMJ Case Rep"},{"key":"6833_CR3","doi-asserted-by":"publisher","first-page":"bcr2018226328","DOI":"10.1136\/bcr-2018-226328","volume":"2018","author":"AM South","year":"2018","unstructured":"South AM (2018) Primary renal diffuse large B-cell lymphoma causing haemodialysis-dependent nephromegaly in a child. BMJ Case Rep 2018:bcr2018226328. https:\/\/doi.org\/10.1136\/bcr-2018-226328","journal-title":"BMJ Case Rep"},{"key":"6833_CR4","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1053\/j.ajkd.2007.08.008","volume":"50","author":"CJ Diskin","year":"2007","unstructured":"Diskin CJ, Stokes TJ, Dansby LM, Radcliff L, Carter TB, Graves E, Byron D, Cook WJ (2007) Acute renal failure due to a primary renal B-cell lymphoma. Am J Kidney Dis 50:885\u2013889. https:\/\/doi.org\/10.1053\/j.ajkd.2007.08.008","journal-title":"Am J Kidney Dis"},{"key":"6833_CR5","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/s11255-010-9728-5","volume":"43","author":"S Al-Salam","year":"2011","unstructured":"Al-Salam S, Shaaban A, Alketbi M, Haq NU, Abouchacra S (2011) Acute kidney injury secondary to renal large B-cell lymphoma: role of early renal biopsy. Int Urol Nephrol 43:237\u2013240. https:\/\/doi.org\/10.1007\/s11255-010-9728-5","journal-title":"Int Urol Nephrol"},{"key":"6833_CR6","doi-asserted-by":"publisher","unstructured":"Minard-Colin V, Aup\u00e9rin A, Pillon M et al; European Intergroup for Childhood Non-Hodgkin Lymphoma; Children\u2019s Oncology Group (2020) Rituximab for high-risk, mature B-cell non-Hodgkin\u2019s lymphoma in children. N Engl J Med 382:2207\u20132219. https:\/\/doi.org\/10.1056\/NEJMoa1915315","DOI":"10.1056\/NEJMoa1915315"},{"key":"6833_CR7","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1182\/blood-2018-02-778480","volume":"132","author":"K Dunleavy","year":"2018","unstructured":"Dunleavy K, Gross TG (2018) Management of aggressive B-cell NHLs in the AYA population: an adult vs pediatric perspective. Blood 132:369\u2013375. https:\/\/doi.org\/10.1182\/blood-2018-02-778480","journal-title":"Blood"},{"key":"6833_CR8","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.juro.2007.03.131","volume":"178","author":"A Volpe","year":"2007","unstructured":"Volpe A, Kachura JR, Geddie WR et al (2007) Techniques, safety and accuracy of sampling of renal tumors by fine needle aspiration and core biopsy. J Urol 178:379\u2013386. https:\/\/doi.org\/10.1016\/j.juro.2007.03.131","journal-title":"J Urol"},{"key":"6833_CR9","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.eururo.2018.12.011","volume":"75","author":"PS Macklin","year":"2019","unstructured":"Macklin PS, Sullivan ME, Tapping CR et al (2019) Tumour seeding in the tract of percutaneous renal tumour biopsy: a report on seven cases from a UK Tertiary Referral Centre. Eur Urol 75:861\u2013867. https:\/\/doi.org\/10.1016\/j.eururo.2018.12.011","journal-title":"Eur Urol"},{"key":"6833_CR10","doi-asserted-by":"publisher","unstructured":"Vujanic GM, Gessler M, Ooms AHAG et al; International Society of Paediatric Oncology\u2013Renal Tumour Study Group (SIOP\u2013RTSG) (2018) The UMBRELLA SIOP-RTSG 2016 Wilms tumour pathology and molecular biology protocol. 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A copy of the consent form is available for review by the corresponding author upon request. The publication of this work was reviewed and accepted by the Geneva Cantonal Commission on Ethics in Human Research (CCER), BASEC Req-2025\u201300620.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish and approval of the ethical commission"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}