{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T16:40:07Z","timestamp":1756744807075,"version":"3.44.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T00:00:00Z","timestamp":1750464000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T00:00:00Z","timestamp":1750464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s00467-025-06860-9","type":"journal-article","created":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T04:51:59Z","timestamp":1750481519000},"page":"3263-3271","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Advanced hemodynamic monitoring: feasibility of leveraging non-invasive electrocardiometry in critically ill pediatric patients requiring continuous kidney replacement therapy"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3864-7654","authenticated-orcid":false,"given":"Anna M.","family":"Lang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayse","family":"Akcan-Arikan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christin","family":"Silos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack F.","family":"Price","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srivaths","family":"Poyyapakkam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joey","family":"Alge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameer","family":"Thadani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,21]]},"reference":[{"key":"6860_CR1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1056\/NEJMoa1611391","volume":"376","author":"A Kaddourah","year":"2017","unstructured":"Kaddourah A, Basu RK, Bagshaw SM et al (2017) Epidemiology of acute kidney injury in critically ill children and young adults. N Engl J Med 376:11\u201320. https:\/\/doi.org\/10.1056\/NEJMoa1611391","journal-title":"N Engl J Med"},{"key":"6860_CR2","doi-asserted-by":"publisher","first-page":"785392","DOI":"10.4061\/2011\/785392","volume":"2011","author":"RK Basu","year":"2011","unstructured":"Basu RK, Wheeler DS, Goldstein S, Doughty L (2011) Acute renal replacement therapy in pediatrics. Int J Nephrol 2011:785392. https:\/\/doi.org\/10.4061\/2011\/785392","journal-title":"Int J Nephrol"},{"key":"6860_CR3","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1007\/s00134-019-05707-w","volume":"45","author":"A Douvris","year":"2019","unstructured":"Douvris A, Zeid K, Hiremath S et al (2019) Mechanisms for hemodynamic instability related to renal replacement therapy: a narrative review. Intensive Care Med 45:1333\u20131346. https:\/\/doi.org\/10.1007\/s00134-019-05707-w","journal-title":"Intensive Care Med"},{"key":"6860_CR4","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1681\/ASN.2020111665","volume":"32","author":"CH Robinson","year":"2021","unstructured":"Robinson CH, Jeyakumar N, Luo B et al (2021) Long-term kidney outcomes following dialysis-treated childhood acute kidney injury: a population-based cohort study. J Am Soc Nephrol 32:2005\u20132019. https:\/\/doi.org\/10.1681\/ASN.2020111665","journal-title":"J Am Soc Nephrol"},{"key":"6860_CR5","doi-asserted-by":"publisher","first-page":"R184","DOI":"10.1186\/cc8172","volume":"13","author":"MJ Santiago","year":"2009","unstructured":"Santiago MJ, L\u00f3pez-Herce J, Urbano J et al (2009) Complications of continuous renal replacement therapy in critically ill children: a prospective observational evaluation study. Crit Care 13:R184. https:\/\/doi.org\/10.1186\/cc8172","journal-title":"Crit Care"},{"key":"6860_CR6","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1007\/s00467-022-05424-5","volume":"37","author":"S Thadani","year":"2022","unstructured":"Thadani S, Fogarty T, Mottes T et al (2022) Hemodynamic instability during connection to continuous kidney replacement therapy in critically ill pediatric patients. Pediatr Nephrol 37:2167\u20132177. https:\/\/doi.org\/10.1007\/s00467-022-05424-5","journal-title":"Pediatr Nephrol"},{"key":"6860_CR7","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1111\/hdi.12760","volume":"23","author":"M Slessarev","year":"2019","unstructured":"Slessarev M, Salerno F, Ball IM, McIntyre CW (2019) Continuous renal replacement therapy is associated with acute cardiac stunning in critically ill patients. Hemodial Int 23:325\u2013332. https:\/\/doi.org\/10.1111\/hdi.12760","journal-title":"Hemodial Int"},{"key":"6860_CR8","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.jcrc.2019.07.004","volume":"54","author":"K Shawwa","year":"2019","unstructured":"Shawwa K, Kompotiatis P, Jentzer JC et al (2019) Hypotension within one-hour from starting CRRT is associated with in-hospital mortality. J Crit Care 54:7\u201313. https:\/\/doi.org\/10.1016\/j.jcrc.2019.07.004","journal-title":"J Crit Care"},{"key":"6860_CR9","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1186\/s13054-014-0624-8","volume":"18","author":"JA Silversides","year":"2014","unstructured":"Silversides JA, Pinto R, Kuint R et al (2014) Fluid balance, intradialytic hypotension, and outcomes in critically ill patients undergoing renal replacement therapy: a cohort study. Crit Care 18:624. https:\/\/doi.org\/10.1186\/s13054-014-0624-8","journal-title":"Crit Care"},{"key":"6860_CR10","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s00467-018-4047-7","volume":"34","author":"S Fern\u00e1ndez","year":"2019","unstructured":"Fern\u00e1ndez S, Santiago MJ, Gonz\u00e1lez R et al (2019) Hemodynamic impact of the connection to continuous renal replacement therapy in critically ill children. Pediatr Nephrol 34:163\u2013168. https:\/\/doi.org\/10.1007\/s00467-018-4047-7","journal-title":"Pediatr Nephrol"},{"key":"6860_CR11","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1007\/s00467-020-04804-z","volume":"36","author":"SN Fern\u00e1ndez Lafever","year":"2021","unstructured":"Fern\u00e1ndez Lafever SN, L\u00f3pez J, Gonz\u00e1lez R et al (2021) Hemodynamic disturbances and oliguria during continuous kidney replacement therapy in critically ill children. Pediatr Nephrol 36:1889\u20131899. https:\/\/doi.org\/10.1007\/s00467-020-04804-z","journal-title":"Pediatr Nephrol"},{"key":"6860_CR12","doi-asserted-by":"publisher","first-page":"286","DOI":"10.3345\/kjp.2012.55.8.286","volume":"55","author":"YB Sohn","year":"2012","unstructured":"Sohn YB, Paik KH, Cho HY et al (2012) Continuous renal replacement therapy in neonates weighing less than 3 kg. Korean J Pediatr 55:286\u2013292. https:\/\/doi.org\/10.3345\/kjp.2012.55.8.286","journal-title":"Korean J Pediatr"},{"key":"6860_CR13","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1111\/aor.13086","volume":"42","author":"SN Fern\u00e1ndez Lafever","year":"2018","unstructured":"Fern\u00e1ndez Lafever SN, Santiago MJ, L\u00f3pez J et al (2018) Hemodynamic effects of connection to continuous renal replacement therapy in a pediatric animal model. Artif Organs 42:640\u2013646. https:\/\/doi.org\/10.1111\/aor.13086","journal-title":"Artif Organs"},{"key":"6860_CR14","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1007\/BF00265116","volume":"13","author":"J Damen","year":"1987","unstructured":"Damen J, Wever JE (1987) The use of balloon-tipped pulmonary artery catheters in children undergoing cardiac surgery. Intensive Care Med 13:266\u2013272. https:\/\/doi.org\/10.1007\/BF00265116","journal-title":"Intensive Care Med"},{"key":"6860_CR15","first-page":"315","volume":"78","author":"D Heise","year":"2012","unstructured":"Heise D, Faulstich M, M\u00f6rer O et al (2012) Influence of continuous renal replacement therapy on cardiac output measurement using thermodilution techniques. Minerva Anestesiol 78:315\u2013321","journal-title":"Minerva Anestesiol"},{"key":"6860_CR16","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1097\/00044067-199908000-00008","volume":"10","author":"MJ Osypka","year":"1999","unstructured":"Osypka MJ, Bernstein DP (1999) Electrophysiologic principles and theory of stroke volume determination by thoracic electrical bioimpedance. AACN Clin Issues 10:385\u2013399. https:\/\/doi.org\/10.1097\/00044067-199908000-00008","journal-title":"AACN Clin Issues"},{"key":"6860_CR17","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1093\/bja\/aem320","volume":"100","author":"K Norozi","year":"2008","unstructured":"Norozi K, Beck C, Osthaus WA et al (2008) Electrical velocimetry for measuring cardiac output in children with congenital heart disease. Br J Anaesth 100:88\u201394. https:\/\/doi.org\/10.1093\/bja\/aem320","journal-title":"Br J Anaesth"},{"key":"6860_CR18","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1186\/s13054-014-0603-0","volume":"18","author":"ME Blohm","year":"2014","unstructured":"Blohm ME, Obrecht D, Hartwich J et al (2014) Impedance cardiography (electrical velocimetry) and transthoracic echocardiography for non-invasive cardiac output monitoring in pediatric intensive care patients: a prospective single-center observational study. Crit Care 18:603. https:\/\/doi.org\/10.1186\/s13054-014-0603-0","journal-title":"Crit Care"},{"key":"6860_CR19","doi-asserted-by":"publisher","first-page":"101","DOI":"10.4236\/wjcs.2014.47016","volume":"04","author":"V Malik","year":"2014","unstructured":"Malik V, Subramanian A, Chauhan S, Hote M (2014) Correlation of electric cardiometry and continuous thermodilution cardiac output monitoring systems. World J Cardiovasc Surg 04:101\u2013108. https:\/\/doi.org\/10.4236\/wjcs.2014.47016","journal-title":"World J Cardiovasc Surg"},{"key":"6860_CR20","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1007\/s10877-019-00330-y","volume":"34","author":"M Sanders","year":"2020","unstructured":"Sanders M, Servaas S, Slagt C (2020) Accuracy and precision of non-invasive cardiac output monitoring by electrical cardiometry: a systematic review and meta-analysis. J Clin Monit Comput 34:433\u2013460. https:\/\/doi.org\/10.1007\/s10877-019-00330-y","journal-title":"J Clin Monit Comput"},{"key":"6860_CR21","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/s10877-012-9412-7","volume":"27","author":"R Rauch","year":"2013","unstructured":"Rauch R, Welisch E, Lansdell N et al (2013) Non-invasive measurement of cardiac output in obese children and adolescents: comparison of electrical cardiometry and transthoracic Doppler echocardiography. J Clin Monit Comput 27:187\u2013193. https:\/\/doi.org\/10.1007\/s10877-012-9412-7","journal-title":"J Clin Monit Comput"},{"key":"6860_CR22","doi-asserted-by":"publisher","first-page":"185","DOI":"10.5005\/jp-journals-10071-23730","volume":"25","author":"A Lalitha","year":"2021","unstructured":"Lalitha A, Rao SS, Reddy M, Ghosh S (2021) Electrocardiometry for hemodynamic categorization and assessment of fluid responsiveness in pediatric septic shock: a pilot observational study. Indian J Crit Care Med 25:185\u2013192. https:\/\/doi.org\/10.5005\/jp-journals-10071-23730","journal-title":"Indian J Crit Care Med"},{"key":"6860_CR23","doi-asserted-by":"publisher","unstructured":"Cattermole GN, Leung PYM, Ho GYL et al (2017) The normal ranges of cardiovascular parameters measured using the ultrasonic cardiac output monitor. Physiol Rep 5:e13195. https:\/\/doi.org\/10.14814\/phy2.13195","DOI":"10.14814\/phy2.13195"},{"key":"6860_CR24","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1186\/s13054-015-1054-y","volume":"19","author":"S Leteurtre","year":"2015","unstructured":"Leteurtre S, Duhamel A, Deken V et al (2015) Daily estimation of the severity of organ dysfunctions in critically ill children by using the PELOD-2 score. Crit Care 19:324. https:\/\/doi.org\/10.1186\/s13054-015-1054-y","journal-title":"Crit Care"},{"key":"6860_CR25","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1097\/CCM.0b013e31828a2bbd","volume":"41","author":"S Leteurtre","year":"2013","unstructured":"Leteurtre S, Duhamel A, Salleron J et al (2013) PELOD-2: an update of the pediatric logistic organ dysfunction score. Crit Care Med 41:1761\u20131773. https:\/\/doi.org\/10.1097\/CCM.0b013e31828a2bbd","journal-title":"Crit Care Med"},{"key":"6860_CR26","doi-asserted-by":"publisher","unstructured":"Gaies MG, Gurney JG, Yen AH et al (2010) Vasoactive\u2013inotropic score as a predictor of morbidity and mortality in infants after cardiopulmonary bypass. Pediatr Crit Care Med 11:234\u2013238. https:\/\/doi.org\/10.1097\/PCC.0b013e3181b806fc","DOI":"10.1097\/PCC.0b013e3181b806fc"},{"key":"6860_CR27","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1053\/j.ajkd.2009.10.048","volume":"55","author":"SM Sutherland","year":"2010","unstructured":"Sutherland SM, Zappitelli M, Alexander SR et al (2010) Fluid overload and mortality in children receiving continuous renal replacement therapy: the prospective pediatric continuous renal replacement therapy registry. Am J Kidney Dis 55:316\u2013325. https:\/\/doi.org\/10.1053\/j.ajkd.2009.10.048","journal-title":"Am J Kidney Dis"},{"key":"6860_CR28","doi-asserted-by":"publisher","unstructured":"Cozzolino M, Mangano M, Stucchi A et al (2018) Cardiovascular disease in dialysis patients. Nephrol Dial Transplant 33:iii28\u2013iii34. https:\/\/doi.org\/10.1093\/ndt\/gfy174","DOI":"10.1093\/ndt\/gfy174"},{"key":"6860_CR29","doi-asserted-by":"publisher","first-page":"3487","DOI":"10.1093\/ndt\/gfp267","volume":"24","author":"RHH Bemelmans","year":"2009","unstructured":"Bemelmans RHH, Boerma EC, Barendregt J et al (2009) Changes in the volume status of haemodialysis patients are reflected in sublingual microvascular perfusion. Nephrol Dial Transplant 24:3487\u20133492. https:\/\/doi.org\/10.1093\/ndt\/gfp267","journal-title":"Nephrol Dial Transplant"},{"key":"6860_CR30","first-page":"632","volume":"4","author":"M Zuber","year":"1989","unstructured":"Zuber M, Steinmann E, Huser B et al (1989) Incidence of arrhythmias and myocardial ischaemia during haemodialysis and haemofiltration. Nephrol Dial Transplant 4:632\u2013634","journal-title":"Nephrol Dial Transplant"},{"key":"6860_CR31","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1159\/000168710","volume":"14","author":"N Singh","year":"1994","unstructured":"Singh N, Langer A, Freeman MR, Goldstein MB (1994) Myocardial alterations during hemodialysis: insights from new noninvasive technology. Am J Nephrol 14:173\u2013181. https:\/\/doi.org\/10.1159\/000168710","journal-title":"Am J Nephrol"},{"key":"6860_CR32","doi-asserted-by":"publisher","first-page":"2912","DOI":"10.1681\/ASN.2021020193","volume":"32","author":"A Idrovo","year":"2021","unstructured":"Idrovo A, Pignatelli R, Loar R et al (2021) Preserved cerebral oxygenation with worsening global myocardial strain during pediatric chronic hemodialysis. J Am Soc Nephrol 32:2912\u20132919. https:\/\/doi.org\/10.1681\/ASN.2021020193","journal-title":"J Am Soc Nephrol"},{"key":"6860_CR33","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.5558","author":"N Fathima","year":"2019","unstructured":"Fathima N, Kashif T, Janapala RN et al (2019) Single-best choice between intermittent versus continuous renal replacement therapy: a review. Cureus. https:\/\/doi.org\/10.7759\/cureus.5558","journal-title":"Cureus"},{"key":"6860_CR34","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1111\/aor.13086","volume":"42","author":"SN Fernandez Lafever","year":"2018","unstructured":"Fernandez Lafever SN, Santiago MJ, Lopez J et al (2018) Hemodynamic effects of connection to continuous renal replacement therapy in a pediatric animal model. Artif Organs 42:640\u2013646. https:\/\/doi.org\/10.1111\/aor.13086","journal-title":"Artif Organs"},{"key":"6860_CR35","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1213\/01.ane.0000297421.92857.4e","volume":"106","author":"GB Hammer","year":"2008","unstructured":"Hammer GB, Drover DR, Cao H et al (2008) The effects of dexmedetomidine on cardiac electrophysiology in children. Anesth Analg 106:79\u201383. https:\/\/doi.org\/10.1213\/01.ane.0000297421.92857.4e","journal-title":"Anesth Analg"},{"key":"6860_CR36","first-page":"17","volume":"15","author":"ML Buck","year":"2010","unstructured":"Buck ML (2010) Dexmedetomidine use in pediatric intensive care and procedural sedation. J Pediatr Pharmacol Ther 15:17\u201329","journal-title":"J Pediatr Pharmacol Ther"},{"key":"6860_CR37","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1007\/s00467-018-4190-1","volume":"34","author":"R Raina","year":"2019","unstructured":"Raina R, Lam S, Raheja H et al (2019) Pediatric intradialytic hypotension: recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) Workgroup. Pediatr Nephrol 34:925\u2013941. https:\/\/doi.org\/10.1007\/s00467-018-4190-1","journal-title":"Pediatr Nephrol"},{"key":"6860_CR38","doi-asserted-by":"publisher","first-page":"564902","DOI":"10.3389\/fped.2020.564902","volume":"8","author":"L Sumbel","year":"2021","unstructured":"Sumbel L, Wats A, Salameh M et al (2021) Thoracic fluid content (TFC) measurement using impedance cardiography predicts outcomes in critically ill children. Front Pediatr 8:564902. https:\/\/doi.org\/10.3389\/fped.2020.564902","journal-title":"Front Pediatr"},{"key":"6860_CR39","unstructured":"(2015) Bioimpedance devices for the assessment of body fluid volume for patients undergoing dialysis: a review of the clinical effectiveness, cost-effectiveness and guidelines-an update. Canadian Agency for Drugs and Technologies in Health,\u00a0Ottawa"},{"key":"6860_CR40","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1111\/hdi.12919","volume":"25","author":"C Sommerer","year":"2021","unstructured":"Sommerer C, Felten P, Toernig J et al (2021) Bioimpedance analysis is not superior to clinical assessment in determining hydration status: a prospective randomized-controlled trial in a Western dialysis population. Hemodial Int 25:380\u2013390. https:\/\/doi.org\/10.1111\/hdi.12919","journal-title":"Hemodial Int"},{"key":"6860_CR41","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1097\/SHK.0000000000002483","volume":"63","author":"S Thadani","year":"2024","unstructured":"Thadani S, Lang A, Silos C et al (2024) Fluid overload modifies hemodynamic impact of CRRT: evidence of a covert cardiorenal syndrome? Shock 63:233\u2013239. https:\/\/doi.org\/10.1097\/SHK.0000000000002483","journal-title":"Shock"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-025-06860-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00467-025-06860-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-025-06860-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T16:04:55Z","timestamp":1756742695000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00467-025-06860-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,21]]},"references-count":41,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["6860"],"URL":"https:\/\/doi.org\/10.1007\/s00467-025-06860-9","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"type":"print","value":"0931-041X"},{"type":"electronic","value":"1432-198X"}],"subject":[],"published":{"date-parts":[[2025,6,21]]},"assertion":[{"value":"17 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}