{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:23:22Z","timestamp":1793316202409,"version":"4.5.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>With advanced technology, survival of neonates with congenital kidney failure (CKF) requiring continuous kidney replacement therapy (CKRT) has improved. Nutrition is essential but difficult to attain as CKRT removes proteins and micronutrients, and many patients have multiple co-morbidities. Scant data exist to guide clinicians on appropriate energy requirements for growth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed a retrospective study of neonates with CKF admitted to Children\u2019s of Alabama between 2016 and 2022 who required KRT within 10\u00a0days. We evaluated risk factors and growth in the 18\/24 (75%) infants who survived to 90\u00a0days. Our primary and secondary outcomes were length z-score\u2009\u2265\u2009\u2009\u2212\u20092 vs.\u2009&lt;\u2009\u2009\u2212\u20092 at 90\u00a0days and weight z-score\u2009\u2265\u2009\u2009\u2212\u20092 vs.\u2009&lt;\u2009\u2009\u2212\u20092 at 90\u00a0days, respectively. Demographics, comorbidities, CKRT Dose Eras (1-body surface area (2000\/1.73\/m\n                      <jats:sup>2<\/jats:sup>\n                      \/hr) vs. 2-weight-based era (24\u00a0ml\/kg\/hr)), and Nutrition Era 1 vs. 2 were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 90\u00a0days, 7\/18 (38.9%) had length z-score\u2009\u2265\u2009\u2009\u2212\u20092 while 10\/18 (55.6%) had a weight z-score\u2009\u2265\u2009\u2009\u2212\u20092. Factors for weight z-score\u2009\u2265\u2009\u2009\u2212\u20092 include time to PD transition and CKRT Dose Era 2. Factors for length z-score\u2009\u2265\u2009\u2009\u2212\u20092 included Era with higher calorie and protein goal targets (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Malnutrition in neonates with CKF on CKRT is high. More studies are needed to better understand optimal strategies to ensure adequate growth. Until then, we recommend 24\u00a0ml\/kg\/hr clearance dose and prescribing at least 130\u00a0kcal\/kg\/day and 4\u00a0g\/kg\/day amino acids to target higher actual intake to start for these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s00467-025-06887-y","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T16:52:00Z","timestamp":1754585520000},"page":"3733-3741","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Growth in neonates with congenital kidney failure requiring continuous kidney replacement therapy"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7663-1119","authenticated-orcid":false,"given":"Kara","family":"Short","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janelle","family":"Hanick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perrin","family":"Bickert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Potts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Askenazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,7]]},"reference":[{"key":"6887_CR1","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.21037\/tp-2020-fs-05","volume":"10","author":"A Irfan","year":"2021","unstructured":"Irfan A, O\u2019Hare E, Jelin E (2021) Fetal interventions for congenital renal anomalies. Transl Pediatr 10:1506\u20131517. https:\/\/doi.org\/10.21037\/tp-2020-fs-05","journal-title":"Transl Pediatr"},{"key":"6887_CR2","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1093\/ndt\/gfw106","volume":"31","author":"JR Ingelfinger","year":"2016","unstructured":"Ingelfinger JR, Kalantar-Zadeh K, Schaefer F, World Kidney Day Steering Committee (2016) Averting the legacy of kidney disease: focus on childhood. Nephrol Dial Transplant 31:1023. https:\/\/doi.org\/10.1093\/ndt\/gfw106","journal-title":"Nephrol Dial Transplant"},{"issue":"Suppl 2","key":"6887_CR3","doi-asserted-by":"publisher","first-page":"S139","DOI":"10.1002\/ncp.11048","volume":"38","author":"M Wong Vega","year":"2023","unstructured":"Wong Vega M, Vuong KT, Chmielewski J, Gollins L, Slagle C, Srivaths PR, Arikan AA (2023) Nutrition for critically ill children and neonates requiring dialysis: application of clinical practice recommendations. 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NeoReviews 25:e25\u2013e35. https:\/\/doi.org\/10.1542\/neo.25-1-e25","journal-title":"NeoReviews"},{"key":"6887_CR6","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1007\/s00467-019-04426-0","volume":"35","author":"V Shaw","year":"2020","unstructured":"Shaw V, Polderman N, Renken-Terhaerdt J, Paglialonga F, Oosterveld M, Tuokkola J, Anderson C, Desloovere A, Greenbaum L, Haffner D, Nelms C, Qizalbash L, Vande Walle J, Warady B, Shroff R, Rees L (2020) Energy and protein requirements for children with CKD stages 2\u20135 and on dialysis-clinical practice recommendations from the Pediatric Renal Nutrition Taskforce. Pediatr Nephrol 35:519\u2013531. https:\/\/doi.org\/10.1007\/s00467-019-04426-0","journal-title":"Pediatr Nephrol"},{"key":"6887_CR7","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1053\/j.ajkd.2020.05.006","volume":"76","author":"TA Ikizler","year":"2020","unstructured":"Ikizler TA, Burrowes JD, Byham-Gray LD, Campbell KL, Carrero JJ, Chan W, Fouque D, Friedman AN, Ghaddar S, Goldstein-Fuchs DJ, Kaysen GA, Kopple JD, Teta D, Yee-Moon Wang A, Cuppari L (2020) KDOQI clinical practice guideline for nutrition in CKD: 2020 update. 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All other authors do not have any conflicts of interest or disclosures.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}