{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T20:07:42Z","timestamp":1766520462656,"version":"3.48.0"},"reference-count":7,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003483","name":"Hebrew University of Jerusalem","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003483","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Emphysematous pyelonephritis (EPN) is a critical and life-threatening necrotizing urinary tract infection, marked by gas formation within the renal parenchyma, collecting system or peri-nephric tissue and is extremely rare in children. Proteinaceous calculi are a rare type of kidney stones, reported in only 0.5% of nephrolithiasis cases, and rarely reported in the pediatric population. We present a case of a 16-year-old female with concurrent EPN and proteinaceous calculi with recurrent\u00a0\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    \u00a0urinary tract infection.\n                  <\/jats:p>","DOI":"10.1007\/s00467-025-06918-8","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T13:07:36Z","timestamp":1759237656000},"page":"361-363","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Emphysematous pyelonephritis and infection-related calculi"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6461-1412","authenticated-orcid":false,"given":"Shimrit","family":"Tzvi-Behr","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaacov","family":"Frishberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Cytter-Kuint","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Chertin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilan Z.","family":"Kafka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efrat","family":"Ben-Shalom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"6918_CR1","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1001\/archinte.160.6.797","volume":"160","author":"JJ Huang","year":"2000","unstructured":"Huang JJ, Tseng CC (2000) Emphysematous pyelonephritis: clinicoradiological classification, management, prognosis, and pathogenesis. Arch Intern Med 160:797\u2013805","journal-title":"Arch Intern Med"},{"key":"6918_CR2","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1097\/INF.0000000000001254","volume":"35","author":"PR Ambaram","year":"2016","unstructured":"Ambaram PR, Kala UK, Petersen KL (2016) Emphysematous pyelonephritis in children. Pediatr Infect Dis J 35:1159\u20131161","journal-title":"Pediatr Infect Dis J"},{"key":"6918_CR3","doi-asserted-by":"crossref","unstructured":"Girgenti V, Pelizzo G, Amoroso S et al (2019) Emphysematous pyelonephritis following ureterovesical reimplantation for congenital obstructive megaureter. Pediatric case report and review of the literature. Front Pediatr 7:2","DOI":"10.3389\/fped.2019.00002"},{"key":"6918_CR4","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1007\/s11255-022-03131-6","volume":"54","author":"R Desai","year":"2022","unstructured":"Desai R, Batura D (2022) A systematic review and meta-analysis of risk factors and treatment choices in emphysematous pyelonephritis. Int Urol Nephrol 54:717\u2013736","journal-title":"Int Urol Nephrol"},{"key":"6918_CR5","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1007\/s00345-022-04060-w","volume":"40","author":"R Siener","year":"2022","unstructured":"Siener R, Herwig H, R\u00fcdy J, Schaefer RM, Lossin P, Hesse A (2022) Urinary stone composition in Germany: results from 45,783 stone analyses. World J Urol 40:1813\u20131820","journal-title":"World J Urol"},{"key":"6918_CR6","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1080\/17843286.2021.1999569","volume":"77","author":"M Steenbeke","year":"2022","unstructured":"Steenbeke M, De Buyzere ML, Speeckaert MM, Delanghe JR (2022) On the protein content of kidney stones: an explorative study. Acta Clin Belg 77:845\u2013852","journal-title":"Acta Clin Belg"},{"key":"6918_CR7","doi-asserted-by":"crossref","unstructured":"Martelli C, Marzano V, Iavarone F, Huang L, Vincenzoni F, Desiderio C, ... Gambaro G (2016) Characterization of the protein components of matrix stones sheds light on S100-A8 and S100-A9 relevance in the inflammatory pathogenesis of these rare renal calculi.\u00a0J Urol\u00a0196:911\u2013918","DOI":"10.1016\/j.juro.2016.04.064"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-025-06918-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00467-025-06918-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-025-06918-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T20:02:44Z","timestamp":1766520164000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00467-025-06918-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,30]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["6918"],"URL":"https:\/\/doi.org\/10.1007\/s00467-025-06918-8","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"type":"print","value":"0931-041X"},{"type":"electronic","value":"1432-198X"}],"subject":[],"published":{"date-parts":[[2025,9,30]]},"assertion":[{"value":"23 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Shimrit Tzvi-Behr,, Efrat Ben-Shalom, Ruth Cytter-Kuint, Yaacov Frishberg, Boris Chertin, and Ilan Z Kafka. The first draft of the manuscript was written by Shimrit Tzvi-Behr and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript. As Corresponding Author, I confirm that the manuscript has been read and approved for submission by all the named authors.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"We know of no conflicts of interest associated with this publication, and there has been no significant financial support for this work that could have influenced its outcome.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}