{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T18:18:05Z","timestamp":1785176285540,"version":"3.55.0"},"reference-count":5,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The reversed cortico\u2011medullary differentiation in fetal kidneys on ultrasound has been described in the literature, but there have been no descriptions of such a finding on fetal magnetic resonance imaging (MRI) so far. The authors present three unrelated fetuses with hyperechoic kidneys on ultrasound (US) and reversed signal intensity of their cortex and pyramids on SSFSE\/T2WI and FIESTA images on magnetic resonance imaging (MRI). All of them shared the same deletion of the long arm of chromosome 17 in the 17q12 region, responsible for the expression of clinical features of renal cysts and diabetes (RCAD) syndrome. All of them had multiple tiny kidney cysts on US after birth. This specific finding on fetal MRI may point at this specific genetic condition.<\/jats:p>","DOI":"10.1007\/s00467-025-06938-4","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T03:27:15Z","timestamp":1755746835000},"page":"77-79","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Reversed cortico-medullary differentiation in kidneys on fetal magnetic resonance imaging \u2014 a case series"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1787-3425","authenticated-orcid":false,"given":"Monika","family":"Bekiesinska-Figatowska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaroslaw","family":"Madzik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Ring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Skorka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Smyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Obersztyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"6938_CR1","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/s00247-023-05833-0","volume":"54","author":"M Cassart","year":"2024","unstructured":"Cassart M, Garel C, Ulinski T, Avni FE (2024) Reversed cortico-medullary differentiation in the fetal and neonatal kidneys: an indicator of poor prognosis? Pediatr Radiol 54:285\u2013292. https:\/\/doi.org\/10.1007\/s00247-023-05833-0","journal-title":"Pediatr Radiol"},{"key":"6938_CR2","first-page":"165","volume":"3","author":"A Hindryckx","year":"2011","unstructured":"Hindryckx A, De Catte L (2011) Prenatal diagnosis of congenital renal and urinary tract malformations. Facts Views Vis Obgyn 3:165\u2013174","journal-title":"Facts Views Vis Obgyn"},{"key":"6938_CR3","first-page":"40","volume":"70","author":"T Seeman","year":"2015","unstructured":"Seeman T, Malina M, Dusatkova P, Kotalov\u00e1 R, Lebl J, Pr\u016fhov\u00e1 \u0160 (2015) Renal cysts and diabetes syndrome. Cesko-Slovenska Pediatrie 70:40\u201345","journal-title":"Cesko-Slovenska Pediatrie"},{"key":"6938_CR4","doi-asserted-by":"publisher","first-page":"3130","DOI":"10.21037\/tp-21-386","volume":"10","author":"R Cleper","year":"2021","unstructured":"Cleper R, Reches A, Shapira D, Simchoni S, Reisman L, Ben-Sira L, Yaron Y, Wolman I, Malinger G, Brabbing-Goldstein D, Ben-Shachar S (2021) Improving renal phenotype and evolving extra-renal features of 17q12 deletion encompassing the HNF1B gene. Transl Pediatr 10:3130\u20133139. https:\/\/doi.org\/10.21037\/tp-21-386","journal-title":"Transl Pediatr"},{"key":"6938_CR5","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.2215\/CJN.10221012","volume":"8","author":"L Madariaga","year":"2013","unstructured":"Madariaga L, Morini\u00e8re V, Jeanpierre C, Bouvier R, Loget P, Martinovic J, Dechelotte P, Leporrier N, Thauvin-Robinet C, Jensen UB, Gaillard D, Mathieu M, Turlin B, Attie-Bitach T, Salomon R, G\u00fcbler MC, Antignac C, Heidet L (2013) Severe prenatal renal anomalies associated with mutations in HNF1B or PAX2 genes. Clin J Am Soc Nephrol 8:1179\u20131187. https:\/\/doi.org\/10.2215\/CJN.10221012","journal-title":"Clin J Am Soc Nephrol"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-025-06938-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00467-025-06938-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-025-06938-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T08:39:50Z","timestamp":1765528790000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00467-025-06938-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,21]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["6938"],"URL":"https:\/\/doi.org\/10.1007\/s00467-025-06938-4","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,21]]},"assertion":[{"value":"4 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval was waived by the Bioethics Committee of the Institute of  Mother and Child in view of the retrospective nature of the study, and all the  procedures performed were part of routine care.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent"}},{"value":"Written informed consent for the clinical studies was obtained from the parents.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}