{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:06:29Z","timestamp":1790186789957,"version":"4.1.0"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004497","name":"Onderzoeksraad, KU Leuven","doi-asserted-by":"publisher","award":["CELSA 24\/022"],"award-info":[{"award-number":["CELSA 24\/022"]}],"id":[{"id":"10.13039\/501100004497","id-type":"DOI","asserted-by":"publisher"}]},{"name":"FWO Vlaanderen","award":["18E2H24N"],"award-info":[{"award-number":["18E2H24N"]}]},{"name":"FWO Vlaanderen","award":["G0D0520N"],"award-info":[{"award-number":["G0D0520N"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Serum creatinine (Scr) centile values were recently described in a cohort of 1136 (near)-term neonates that underwent therapeutic hypothermia (TH) because of moderate to severe hypoxic-ischemic encephalopathy. Recent methodological progress enables conversion of these Scr centiles to estimated glomerular filtration rate (eGFR) values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Scr centiles in the TH dataset during the first 10\u00a0days of life were converted to eGFR values, using the Schwartz formula, with the Smeets k-value (0.31) and fixed body length (50\u00a0cm) to generate postnatal reference eGFR values, centiles, and an equation for median eGFRs. These findings were compared to published eGFR data in term controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A polynomial function was estimated:\n                      <jats:inline-formula>\n                        <jats:alternatives>\n                          <jats:tex-math>$$\\mathrm{eGFR} \\left(\\frac{\\mathrm{mL}}{\\mathrm{min}}\\bullet 1.73{ \\mathrm{m}}^{2}\\right)=9.1667+7.1173 x -0.3439{x}^{2},(x=\\mathrm{days})$$<\/jats:tex-math>\n                          <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                            <mml:mrow>\n                              <mml:mi>eGFR<\/mml:mi>\n                              <mml:mfenced>\n                                <mml:mfrac>\n                                  <mml:mi>mL<\/mml:mi>\n                                  <mml:mi>min<\/mml:mi>\n                                <\/mml:mfrac>\n                                <mml:mo>\u2219<\/mml:mo>\n                                <mml:mn>1.73<\/mml:mn>\n                                <mml:msup>\n                                  <mml:mrow>\n                                    <mml:mi>m<\/mml:mi>\n                                  <\/mml:mrow>\n                                  <mml:mn>2<\/mml:mn>\n                                <\/mml:msup>\n                              <\/mml:mfenced>\n                              <mml:mo>=<\/mml:mo>\n                              <mml:mn>9.1667<\/mml:mn>\n                              <mml:mo>+<\/mml:mo>\n                              <mml:mn>7.1173<\/mml:mn>\n                              <mml:mi>x<\/mml:mi>\n                              <mml:mo>-<\/mml:mo>\n                              <mml:mn>0.3439<\/mml:mn>\n                              <mml:msup>\n                                <mml:mrow>\n                                  <mml:mi>x<\/mml:mi>\n                                <\/mml:mrow>\n                                <mml:mn>2<\/mml:mn>\n                              <\/mml:msup>\n                              <mml:mo>,<\/mml:mo>\n                              <mml:mrow>\n                                <mml:mo>(<\/mml:mo>\n                                <mml:mi>x<\/mml:mi>\n                                <mml:mo>=<\/mml:mo>\n                                <mml:mi>days<\/mml:mi>\n                                <mml:mo>)<\/mml:mo>\n                              <\/mml:mrow>\n                            <\/mml:mrow>\n                          <\/mml:math>\n                        <\/jats:alternatives>\n                      <\/jats:inline-formula>\n                      for eGFR in TH neonates. The median eGFR increases 2- to threefold over the first week (day 1: 16.1; day 2: 19.4; day 7: 41.2\u00a0mL\/min\u22191.73 m\n                      <jats:sup>2<\/jats:sup>\n                      ), while the polynomial function does not fully reflect the interindividual variability in eGFR values (intra-day variability is also 2- to threefold). Patterns in acute kidney injury (AKI) TH cases differ significantly from non-AKI TH cases. Based on pooling of published eGFR data, this was compared to a function in healthy term neonates:\n                      <jats:inline-formula>\n                        <jats:alternatives>\n                          <jats:tex-math>$$\\mathrm{eGFR} \\left(\\frac{\\mathrm{mL}}{\\mathrm{min}}\\bullet 1.73 {\\mathrm{m}}^{2}\\right)=14.2167+6.7644 x-0.3901{x}^{2}(x=\\mathrm{days})$$<\/jats:tex-math>\n                          <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                            <mml:mrow>\n                              <mml:mi>eGFR<\/mml:mi>\n                              <mml:mfenced>\n                                <mml:mfrac>\n                                  <mml:mi>mL<\/mml:mi>\n                                  <mml:mi>min<\/mml:mi>\n                                <\/mml:mfrac>\n                                <mml:mo>\u2219<\/mml:mo>\n                                <mml:mn>1.73<\/mml:mn>\n                                <mml:msup>\n                                  <mml:mrow>\n                                    <mml:mi>m<\/mml:mi>\n                                  <\/mml:mrow>\n                                  <mml:mn>2<\/mml:mn>\n                                <\/mml:msup>\n                              <\/mml:mfenced>\n                              <mml:mo>=<\/mml:mo>\n                              <mml:mn>14.2167<\/mml:mn>\n                              <mml:mo>+<\/mml:mo>\n                              <mml:mn>6.7644<\/mml:mn>\n                              <mml:mi>x<\/mml:mi>\n                              <mml:mo>-<\/mml:mo>\n                              <mml:mn>0.3901<\/mml:mn>\n                              <mml:msup>\n                                <mml:mrow>\n                                  <mml:mi>x<\/mml:mi>\n                                <\/mml:mrow>\n                                <mml:mn>2<\/mml:mn>\n                              <\/mml:msup>\n                              <mml:mrow>\n                                <mml:mo>(<\/mml:mo>\n                                <mml:mi>x<\/mml:mi>\n                                <mml:mo>=<\/mml:mo>\n                                <mml:mi>days<\/mml:mi>\n                                <mml:mo>)<\/mml:mo>\n                              <\/mml:mrow>\n                            <\/mml:mrow>\n                          <\/mml:math>\n                        <\/jats:alternatives>\n                      <\/jats:inline-formula>\n                      (day 1: 20; day 2: 26; day 7: 42\u00a0mL\/min\/1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Based on a pooled dataset in TH cases, we converted Scr centiles to eGFR centiles. Based on median values, this resulted in a polynomial function in TH cases, compared to healthy term neonates. This eGFR function enables precision pharmacotherapy for GFR-cleared drugs in this vulnerable population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00467-025-06957-1","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T21:22:03Z","timestamp":1758230523000},"page":"233-238","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Progression of the estimated glomerular filtration rate in asphyxiated neonates undergoing therapeutic hypothermia during the first 10\u00a0days of life"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9921-5105","authenticated-orcid":false,"given":"Karel","family":"Allegaert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4452-5867","authenticated-orcid":false,"given":"Julia","family":"Macente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0954-6088","authenticated-orcid":false,"given":"Djalila","family":"Mekahli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0571-7492","authenticated-orcid":false,"given":"John","family":"van den Anker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3525-7351","authenticated-orcid":false,"given":"Pieter","family":"Annaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0710-6698","authenticated-orcid":false,"given":"Anne","family":"Smits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"key":"6957_CR1","doi-asserted-by":"publisher","first-page":"184","DOI":"10.2215\/CJN.03670318","volume":"14","author":"JR Charlton","year":"2019","unstructured":"Charlton JR, Boohaker L, Askenazi D et al (2019) Incidence and risk factors of early onset neonatal AKI. 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Specifically, the terms 7.1173x and 6.7644x were mistakenly published as 7.1173 and 6.7644, respectively. The article and graphical abstract have been updated accordingly.","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2026","order":9,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":10,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":11,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00467-026-07474-5","URL":"https:\/\/doi.org\/10.1007\/s00467-026-07474-5","order":12,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Previously provided ethical approval covered the analysis, and no additional data search in patients was needed (internal study number S63365, Ethics Committee Research UZ\/KU Leuven) [\n                      \n                      ].","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Due to the nature of this study, no additional consent was needed.","order":2,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Due to the nature of this study, no additional consent was needed.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}