{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T21:07:38Z","timestamp":1766524058200,"version":"3.48.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:00:00Z","timestamp":1760140800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:00:00Z","timestamp":1760140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s00467-025-06970-4","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:57:14Z","timestamp":1760165834000},"page":"519-527","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The relationship between serum copeptin levels, peritoneal transport parameters, and bioimpedance markers in pediatric patients undergoing peritoneal dialysis"],"prefix":"10.1007","volume":"41","author":[{"given":"Burak","family":"\u00dct\u00fck","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130brahim","family":"Gokce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5859-4177","authenticated-orcid":false,"given":"Neslihan","family":"Cicek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harika","family":"Alpay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,11]]},"reference":[{"key":"6970_CR1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/kisup.2012.73","volume":"3","author":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group","year":"2013","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group (2013) KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl 3:1\u2013150","journal-title":"Kidney Int Suppl"},{"key":"6970_CR2","doi-asserted-by":"publisher","first-page":"237","DOI":"10.2165\/00003495-200363030-00001","volume":"63","author":"MW Dunser","year":"2003","unstructured":"Dunser MW, Wenzel V, Mayr AJ, Hasibeder WR (2003) Management of vasodilatory shock. Drugs 63:237\u2013256. https:\/\/doi.org\/10.2165\/00003495-200363030-00001","journal-title":"Drugs"},{"key":"6970_CR3","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/0167-0115(93)90188-E","volume":"45","author":"K Yamada","year":"1993","unstructured":"Yamada K, Nakayama M, Miura Y, Nakano H, Mimura N, Yoshida S (1993) Role of AVP in the regulation of vascular tonus and blood pressure in patients with chronic renal failure. Regul Pept 45:91\u201395. https:\/\/doi.org\/10.1016\/0167-0115(93)90188-E","journal-title":"Regul Pept"},{"key":"6970_CR4","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/295299a0","volume":"295","author":"H Land","year":"1982","unstructured":"Land H, Sch\u00fctz G, Schmale H, Richter D (1982) Nucleotide sequence of cloned cDNA encoding bovine arginine vasopressin\u2013neurophysin II precursor. Nature 295:299\u2013303. https:\/\/doi.org\/10.1038\/295299a0","journal-title":"Nature"},{"key":"6970_CR5","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1111\/j.1399-3011.1986.tb01827.x","volume":"27","author":"B Levy","year":"1986","unstructured":"Levy B, Chauvet MT, Chauvet J, Acher R (1986) Ontogeny of bovine neurohypophysial hormone precursors. II. Foetal copeptin, the third domain of the vasopressin precursor. Int J Pept Protein Res 27:320\u2013324","journal-title":"Int J Pept Protein Res"},{"key":"6970_CR6","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1111\/j.1432-1033.1972.tb01918.x","volume":"28","author":"D Holwerda","year":"1972","unstructured":"Holwerda D (1972) A glycopeptide from the posterior lobe of pig pituitaries. Eur J Biochem 28:334\u2013339. https:\/\/doi.org\/10.1111\/j.1432-1033.1972.tb01918.x","journal-title":"Eur J Biochem"},{"key":"6970_CR7","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1210\/jc.2010-2499","volume":"96","author":"S Balanescu","year":"2011","unstructured":"Balanescu S, Kopp P, Gaskill MB, Morgenthaler NG, Schindler C, Rutishauser J (2011) Correlation of plasma copeptin and vasopressin concentrations in hypo-, iso-, and hyperosmolar states. J Clin Endocrinol Metab 96:1046\u20131052. https:\/\/doi.org\/10.1210\/jc.2010-2499","journal-title":"J Clin Endocrinol Metab"},{"key":"6970_CR8","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s11154-019-09509-9","volume":"20","author":"M Christ-Crain","year":"2019","unstructured":"Christ-Crain M (2019) Vasopressin and copeptin in health and disease. Rev Endocr Metab Disord 20:283\u2013294. https:\/\/doi.org\/10.1007\/s11154-019-09509-9","journal-title":"Rev Endocr Metab Disord"},{"key":"6970_CR9","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1210\/jc.2017-01891","volume":"103","author":"WK Fenske","year":"2018","unstructured":"Fenske WK, Schnyder I, Koch G et al (2018) Release and decay kinetics of copeptin vs AVP in response to osmotic alterations in healthy volunteers. J Clin Endocrinol Metab 103:505\u2013513. https:\/\/doi.org\/10.1210\/jc.2017-01891","journal-title":"J Clin Endocrinol Metab"},{"key":"6970_CR10","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.ijcard.2016.07.058","volume":"221","author":"C Engelbertz","year":"2016","unstructured":"Engelbertz C, Brand E, Fobker M, Fischer D, Pavenst\u00e4dt H, Reinecke H (2016) Elevated copeptin is a prognostic factor for mortality even in patients with renal dysfunction. Int J Cardiol 221:327\u2013332. https:\/\/doi.org\/10.1016\/j.ijcard.2016.07.058","journal-title":"Int J Cardiol"},{"key":"6970_CR11","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1042\/CS20080140","volume":"116","author":"SS Bhandari","year":"2009","unstructured":"Bhandari SS, Loke I, Davies JE, Squire IB, Struck J, Ng LL (2009) Gender and renal function influence plasma levels of copeptin in healthy individuals. Clin Sci 116:257\u2013263. https:\/\/doi.org\/10.1042\/CS20080140","journal-title":"Clin Sci"},{"key":"6970_CR12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086148","volume":"9","author":"F Artunc","year":"2014","unstructured":"Artunc F, Nowak A, Mueller C et al (2014) Plasma concentrations of the vasoactive peptide fragments mid-regional pro-adrenomedullin, C-terminal pro-endothelin 1 and copeptin in hemodialysis patients: associated factors and prediction of mortality. PLoS One 9:e86148. https:\/\/doi.org\/10.1371\/journal.pone.0086148","journal-title":"PLoS One"},{"key":"6970_CR13","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1681\/ASN.2010070691","volume":"22","author":"W Fenske","year":"2011","unstructured":"Fenske W, Wanner C, Allolio B et al (2011) Copeptin levels associate with cardiovascular events in patients with ESRD and type 2 diabetes mellitus. J Am Soc Nephrol 22:782\u2013790. https:\/\/doi.org\/10.1681\/ASN.2010070691","journal-title":"J Am Soc Nephrol"},{"key":"6970_CR14","doi-asserted-by":"publisher","first-page":"976","DOI":"10.3349\/ymj.2015.56.4.976","volume":"56","author":"JS Kim","year":"2015","unstructured":"Kim JS, Yang JW, Chai MH et al (2015) Copeptin in hemodialysis patients with left ventricular dysfunction. Yonsei Med J 56:976. https:\/\/doi.org\/10.3349\/ymj.2015.56.4.976","journal-title":"Yonsei Med J"},{"key":"6970_CR15","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1097\/TP.0b013e3181b11ae4","volume":"88","author":"E Meijer","year":"2009","unstructured":"Meijer E, Bakker SJL, de Jong PE et al (2009) Copeptin, a surrogate marker of vasopressin, is associated with accelerated renal function decline in renal transplant recipients. Transplantation 88:561\u2013567. https:\/\/doi.org\/10.1097\/TP.0b013e3181b11ae4","journal-title":"Transplantation"},{"key":"6970_CR16","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1007\/s11255-019-02191-5","volume":"51","author":"M Fija\u0142kowski","year":"2019","unstructured":"Fija\u0142kowski M, Safranow K, Lindholm B et al (2019) Dialysate copeptin and peritoneal transport in incident peritoneal dialysis patients. Int Urol Nephrol 51:1667\u20131673. https:\/\/doi.org\/10.1007\/s11255-019-02191-5","journal-title":"Int Urol Nephrol"},{"key":"6970_CR17","doi-asserted-by":"publisher","first-page":"2835","DOI":"10.1681\/ASN.V7112385","volume":"7","author":"BA Warady","year":"1996","unstructured":"Warady BA, Alexander SR, Hossli S et al (1996) Peritoneal membrane transport function in children receiving long-term dialysis. J Am Soc Nephrol 7:2835\u20132891. https:\/\/doi.org\/10.1681\/ASN.V7112385","journal-title":"J Am Soc Nephrol"},{"key":"6970_CR18","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000021460","volume":"99","author":"WY Park","year":"2020","unstructured":"Park WY, Park S, Kim Y-W, Jin K (2020) Clinical efficacy of biomarkers for evaluation of volume status in dialysis patients. Medicine (Baltimore) 99:e21460. https:\/\/doi.org\/10.1097\/MD.0000000000021460","journal-title":"Medicine (Baltimore)"},{"key":"6970_CR19","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1373\/clinchem.2005.060038","volume":"52","author":"NG Morgenthaler","year":"2006","unstructured":"Morgenthaler NG, Struck J, Alonso C, Bergmann A (2006) Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin. Clin Chem 52:112\u2013119. https:\/\/doi.org\/10.1373\/clinchem.2005.060038","journal-title":"Clin Chem"},{"key":"6970_CR20","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1186\/s12882-017-0589-3","volume":"18","author":"FM Rasche","year":"2017","unstructured":"Rasche FM, Stoebe S, Ebert T et al (2017) Modern peptide biomarkers and echocardiography in cardiac healthy haemodialysis patients. BMC Nephrol 18:175. https:\/\/doi.org\/10.1186\/s12882-017-0589-3","journal-title":"BMC Nephrol"},{"key":"6970_CR21","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/5584_2018_189","volume":"1096","author":"S Niemczyk","year":"2018","unstructured":"Niemczyk S, Niemczyk L, \u017bmudzki W et al (2018) Copeptin blood content as a diagnostic marker of chronic kidney disease. Adv Exp Med Biol 1096:83\u201391. https:\/\/doi.org\/10.1007\/5584_2018_189","journal-title":"Adv Exp Med Biol"},{"key":"6970_CR22","doi-asserted-by":"publisher","first-page":"99","DOI":"10.5455\/msm.2020.32.99-104","volume":"32","author":"S Uncanin","year":"2020","unstructured":"Uncanin S, Serdarevic N, Klapuh N, Haskovic E (2020) Peritoneal transport characteristics at the beginning and in long term peritoneal dialysis: a single center experience. Mater Sociomed 32:99\u2013104. https:\/\/doi.org\/10.5455\/msm.2020.32.99-104","journal-title":"Mater Sociomed"},{"key":"6970_CR23","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1093\/ndt\/gfl529","volume":"22","author":"MJ Reyes","year":"2007","unstructured":"Reyes MJ, Bajo MA, Hev\u00eda C et al (2007) Inherent high peritoneal transport and ultrafiltration deficiency: their mid-term clinical relevance. Nephrol Dial Transplant 22:218\u2013223. https:\/\/doi.org\/10.1093\/ndt\/gfl529","journal-title":"Nephrol Dial Transplant"},{"key":"6970_CR24","doi-asserted-by":"publisher","first-page":"346","DOI":"10.4103\/0971-4065.116301","volume":"23","author":"R Balasubramaniyam","year":"2013","unstructured":"Balasubramaniyam R, Nirmala VR, Yogesh V et al (2013) Comparison of peritoneal transport characteristics at the second week and at six months of peritoneal dialysis commencement. Indian J Nephrol 23:346\u2013350. https:\/\/doi.org\/10.4103\/0971-4065.116301","journal-title":"Indian J Nephrol"},{"key":"6970_CR25","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1038\/sj.ijo.0803230","volume":"30","author":"EC Rush","year":"2006","unstructured":"Rush EC, Chandu V, Plank LD (2006) Prediction of fat-free mass by bioimpedance analysis in migrant Asian Indian men and women: a cross validation study. Int J Obes 30:1125\u20131131. https:\/\/doi.org\/10.1038\/sj.ijo.0803230","journal-title":"Int J Obes"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-025-06970-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00467-025-06970-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-025-06970-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T21:02:41Z","timestamp":1766523761000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00467-025-06970-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,11]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["6970"],"URL":"https:\/\/doi.org\/10.1007\/s00467-025-06970-4","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"type":"print","value":"0931-041X"},{"type":"electronic","value":"1432-198X"}],"subject":[],"published":{"date-parts":[[2025,10,11]]},"assertion":[{"value":"16 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 September 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval was obtained from Marmara University Medical School Ethical Committee (reference number: 09.2020.878). The study was conducted in accordance with the Declaration of Helsinki. Informed consent was obtained from all participants\u2019 parents.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}