{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T02:41:35Z","timestamp":1769654495431,"version":"3.49.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1007\/s00467-025-06981-1","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T06:49:08Z","timestamp":1763362148000},"page":"831-836","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation of serum beta-2 microglobulin with hemodialysis prescription and comorbid factors in children undergoing chronic hemodialysis"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5540-8714","authenticated-orcid":false,"given":"Budyarini Prima","family":"Sari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudung O.","family":"Pardede","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pustika Amalia","family":"Wahidiyat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aman","family":"Pulungan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eka Laksmi","family":"Hidayati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piprim Basarah","family":"Yanuarso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"6981_CR1","doi-asserted-by":"publisher","unstructured":"Jha VK, Shashibhushan (2018) Clinical profile of chronic kidney disease patients in a tertiary care hospital - an observational study. SM Arch Nephrol Kidney Dis 2:1016. https:\/\/doi.org\/10.36876\/smjnkd.1016","DOI":"10.36876\/smjnkd.1016"},{"key":"6981_CR2","doi-asserted-by":"publisher","first-page":"8","DOI":"10.18311\/mvpjms\/2017\/v4i1\/8555","volume":"4","author":"ST Chaudhari","year":"2017","unstructured":"Chaudhari ST, Sadavarte AV, Chafekar D (2017) Clinical profile of end stage renal disease in patients undergoing hemodialysis. MVP J Med Sci 4:8\u201313. https:\/\/doi.org\/10.18311\/mvpjms\/2017\/v4i1\/8555","journal-title":"MVP J Med Sci"},{"key":"6981_CR3","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1007\/s00467-018-3920-8","volume":"33","author":"E Snauwaert","year":"2018","unstructured":"Snauwaert E, Van Biesen W, Raes A, Glorieux G, Vanholder R, Vande Walle J, Eloot S (2018) A plea for more uremic toxin research in children with chronic kidney disease. Pediatr Nephrol 33:921\u2013924. https:\/\/doi.org\/10.1007\/s00467-018-3920-8","journal-title":"Pediatr Nephrol"},{"key":"6981_CR4","doi-asserted-by":"publisher","unstructured":"Vanholder R, De Smet R, Glorieux G, Argil\u00e9s A, Baurmeister U, Brunet P et al; European Uremic Toxin Work Group (EUTox) (2003) Review on uremic toxins: classification, concentration, and interindividual variability. Kidney Int 63:1934\u20131943. https:\/\/doi.org\/10.1046\/j.1523-1755.2003.00924.x","DOI":"10.1046\/j.1523-1755.2003.00924.x"},{"key":"6981_CR5","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1159\/000085693","volume":"149","author":"R Vanholder","year":"2005","unstructured":"Vanholder R, Glorieux G, Lameire GN (2005) New insights in uremic toxicity. Contrib Nephrol 149:315\u2013324. https:\/\/doi.org\/10.1159\/000085693","journal-title":"Contrib Nephrol"},{"key":"6981_CR6","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.4103\/1319-2442.344740","volume":"32","author":"AG Assounga","year":"2021","unstructured":"Assounga AG (2021) Beta 2 microglobulin in kidney failure: a review and an algorithm for renal replacement therapy. Saudi J Kidney Dis Transpl 32:1214\u20131220. https:\/\/doi.org\/10.4103\/1319-2442.344740","journal-title":"Saudi J Kidney Dis Transpl"},{"issue":"Suppl 4","key":"6981_CR7","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1093\/ndt\/16.suppl_4.31","volume":"16","author":"JJ Kazama","year":"2001","unstructured":"Kazama JJ, Maruyama H, Gejyo F (2001) Reduction of circulating beta2-microglobulin level for the treatment of dialysis-related amyloidosis. Nephrol Dial Transplant 16(Suppl 4):31\u201335. https:\/\/doi.org\/10.1093\/ndt\/16.suppl_4.31","journal-title":"Nephrol Dial Transplant"},{"key":"6981_CR8","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1177\/089686088800800110","volume":"8","author":"CR DiRaimondo","year":"1988","unstructured":"DiRaimondo CR, McCarley P, Stone WJ (1988) Beta-2 microglobulin in peritoneal dialysis patients: serum levels and peritoneal clearances. Perit Dial Int 8:43\u201347. https:\/\/doi.org\/10.1177\/089686088800800110","journal-title":"Perit Dial Int"},{"key":"6981_CR9","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1177\/089686088900900107","volume":"9","author":"A Scalamogna","year":"1989","unstructured":"Scalamogna A, Imbasciati E, De Vecchi A, Castelnovo C, Pagliari B, De Cristofaro V, Ponticelli C (1989) Beta-2 microglobulin in patients on peritoneal dialysis and hemodialysis. Perit Dial Int 9:37\u201340. https:\/\/doi.org\/10.1177\/089686088900900107","journal-title":"Perit Dial Int"},{"key":"6981_CR10","first-page":"879","volume":"4","author":"AM Abd El-Hamid","year":"2016","unstructured":"Abd El-Hamid AM, El Gendy SA, Abd El-Gowad ER, El-Rebigi AM, Hady SA (2016) Beta-2 microglobulin level in patients with chronic kidney disease. Int J Adv Res 4:879\u2013888","journal-title":"Int J Adv Res"},{"key":"6981_CR11","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-1904","volume":"140","author":"JT Flynn","year":"2017","unstructured":"Flynn JT, Kaelber DC, Baker-Smith CM et al (2017) Clinical practice guideline for screening and management of high blood pressure in children and adolescents. Pediatrics 140:e20171904. https:\/\/doi.org\/10.1542\/peds.2017-1904","journal-title":"Pediatrics"},{"key":"6981_CR12","unstructured":"Rees L, Feather S, Shroff R (2008) Haemodialysis clinical practice guidelines for children and adolescents. Br Assoc Paediatr Nephrol. https:\/\/www.erknet.org\/fileadmin\/files\/user_upload\/British_Association_for_Paediatric_Nephrology._Haemodialysis_clinical_practice_guidelines_for_children_and_adolescents.pdf. Accessed 7 October 2024"},{"key":"6981_CR13","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1681\/ASN.2005020132","volume":"17","author":"AK Cheung","year":"2006","unstructured":"Cheung AK, Rocco MV, Yan G, Leypoldt JK, Levin NW, Greene T et al (2006) Serum beta-2 microglobulin levels predict mortality in dialysis patients: results of the HEMO study. J Am Soc Nephrol 17:546\u2013555. https:\/\/doi.org\/10.1681\/ASN.2005020132","journal-title":"J Am Soc Nephrol"},{"key":"6981_CR14","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1093\/ndt\/gfx311","volume":"33","author":"M-E Roumelioti","year":"2018","unstructured":"Roumelioti M-E, Trietley G, Nolin TD, Ng Y-H, Xu Z, Alaini A et al (2018) Beta-2 microglobulin clearance in high-flux dialysis and convective dialysis modalities: a meta-analysis of published studies. Nephrol Dial Transplant 33:1025\u20131039. https:\/\/doi.org\/10.1093\/ndt\/gfx311","journal-title":"Nephrol Dial Transplant"},{"key":"6981_CR15","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3390\/toxins10010033","volume":"10","author":"R Vanholder","year":"2018","unstructured":"Vanholder R, Pletinck A, Schepers E, Glorieux G (2018) Biochemical and clinical impact of organic uremic retention solutes: a comprehensive update. Toxins (Basel) 10:33. https:\/\/doi.org\/10.3390\/toxins10010033","journal-title":"Toxins (Basel)"},{"key":"6981_CR16","doi-asserted-by":"publisher","first-page":"152","DOI":"10.3390\/membranes12020152","volume":"12","author":"Y-A Chen","year":"2022","unstructured":"Chen Y-A, Ou S-M, Lin C-C (2022) Influence of dialysis membranes on clinical outcomes: from history to innovation. Membranes (Basel) 12:152. https:\/\/doi.org\/10.3390\/membranes12020152","journal-title":"Membranes (Basel)"},{"key":"6981_CR17","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1046\/j.1523-1755.1999.00669.x","volume":"56","author":"JK Leypoldt","year":"1999","unstructured":"Leypoldt JK, Cheung AK, Deeter RB (1999) Rebound kinetics of beta2-microglobulin after hemodialysis. Kidney Int 56:1571\u20131577. https:\/\/doi.org\/10.1046\/j.1523-1755.1999.00669.x","journal-title":"Kidney Int"},{"key":"6981_CR18","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1080\/00365510802047693","volume":"68","author":"V Lindstrom","year":"2008","unstructured":"Lindstrom V, Grubb A, Hegbrant MA, Christenson A (2008) Different elimination patterns of \u03b2-trace protein, \u03b2 2-microglobulin and cystatin c in haemodialysis, haemodiafiltration and haemofiltration. Scand J Clin Lab Invest 68:685\u2013691. https:\/\/doi.org\/10.1080\/00365510802047693","journal-title":"Scand J Clin Lab Invest"},{"key":"6981_CR19","doi-asserted-by":"publisher","first-page":"684","DOI":"10.3390\/membranes12070684","volume":"12","author":"T Kiguchi","year":"2022","unstructured":"Kiguchi T, Ito H, Yamashita AC (2022) Effect of membrane surface area on solute removal performance of dialyzers with fouling. Membranes 12:684. https:\/\/doi.org\/10.3390\/membranes12070684","journal-title":"Membranes"},{"key":"6981_CR20","doi-asserted-by":"publisher","DOI":"10.3390\/toxins11040235","volume":"11","author":"E Snauwaert","year":"2019","unstructured":"Snauwaert E, Holvoet E, Van Biesen W, Raes A, Glorieux G, Vande Walle J et al (2019) Uremic toxin concentrations are related to residual kidney function in the pediatric hemodialysis population. Toxins (Basel) 11:235. https:\/\/doi.org\/10.3390\/toxins11040235","journal-title":"Toxins (Basel)"},{"key":"6981_CR21","doi-asserted-by":"publisher","unstructured":"Penne EL, van der Weerd NC, Blankestijn PJ, van den Dorpel MA, Grooteman MPC, Nub\u00e9 MJ, ter Wee PM, L\u00e9vesque R, Bots ML; CONTRAST investigators (2010) Role of residual kidney function and convective volume on change in \u03b22-microglobulin levels in hemodiafiltration patients. Clin J Am Soc Nephrol 5:80\u201386. https:\/\/doi.org\/10.2215\/CJN.03340509a","DOI":"10.2215\/CJN.03340509a"},{"key":"6981_CR22","doi-asserted-by":"publisher","unstructured":"Portales-Castillo I, Yee J, Tanaka H, Fenves AZ (2020) Beta-2 microglobulin amyloidosis: past, present, and future. Kidney360 1:1447\u20131455. https:\/\/doi.org\/10.34067\/KID.0004922020","DOI":"10.34067\/KID.0004922020"},{"key":"6981_CR23","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1038\/ki.2012.301","volume":"82","author":"S Liabeuf","year":"2012","unstructured":"Liabeuf S, Lenglet A, Desjardins L, Neirynck N, Glorieux G, Lemke H-D, Vanholder R, Diouf M, Choukroun G, Massy ZA (2012) Plasma beta-2 microglobulin is associated with cardiovascular disease in uremic patients. Kidney Int 82:1297\u20131303. https:\/\/doi.org\/10.1038\/ki.2012.301","journal-title":"Kidney Int"},{"key":"6981_CR24","doi-asserted-by":"publisher","first-page":"4914","DOI":"10.21037\/jtd-22-1581","volume":"15","author":"Y Shen","year":"2023","unstructured":"Shen Y, Chen JJ, Yao WB, Feng SJ, Yang HL, Chen DM et al (2023) Predictive value of serum \u03b22-microglobulin in cardiac valve calcification in maintenance hemodialysis patients. J Thorac Dis 15:4914\u20134924. https:\/\/doi.org\/10.21037\/jtd-22-1581","journal-title":"J Thorac Dis"},{"key":"6981_CR25","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1007\/s00467-019-04288-6","volume":"35","author":"AC Wilson","year":"2020","unstructured":"Wilson AC, Flynn JT (2020) Blood pressure in children with chronic kidney disease: lessons learned from the chronic kidney disease in children cohort study. Pediatr Nephrol 35:1203\u20131209. https:\/\/doi.org\/10.1007\/s00467-019-04288-6","journal-title":"Pediatr Nephrol"},{"key":"6981_CR26","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1161\/atvbaha.114.303465","volume":"34","author":"K Matsushita","year":"2014","unstructured":"Matsushita K, Sang Y, Ballew SH, Astor BC, Hoogeveen RC, Solomon SD et al (2014) Cardiac and kidney markers for cardiovascular prediction in individuals with chronic kidney disease: the Atherosclerosis Risk in Communities study. Arterioscler Thromb Vasc Biol 34:1770\u20131777. https:\/\/doi.org\/10.1161\/atvbaha.114.303465","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"6981_CR27","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.1137853","volume":"11","author":"S Quennelle","year":"2023","unstructured":"Quennelle S, Bonnet D (2023) Pediatric heart failure with preserved ejection fraction, a review. Front Pediatr 11:1137853. https:\/\/doi.org\/10.3389\/fped.2023.1137853","journal-title":"Front Pediatr"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-025-06981-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00467-025-06981-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-025-06981-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T14:02:26Z","timestamp":1769608946000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00467-025-06981-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,17]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["6981"],"URL":"https:\/\/doi.org\/10.1007\/s00467-025-06981-1","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,17]]},"assertion":[{"value":"6 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethics Committee of RSUP Nasional Dr. Cipto Mangunkusumo Fakultas Kedokteran Universitas Indonesia (approval number KET-182\/UN2.F1\/ETIK\/PPM.00.02\/2024) and was performed in line with the principles of the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from legal guardians.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Additional informed consent was obtained from all individual participants for whom identifying information is included in this article.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing\u00a0interest"}},{"value":"This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article\u2019s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article\u2019s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Open access"}}]}}