{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T02:02:52Z","timestamp":1769652172370,"version":"3.49.0"},"reference-count":5,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100008899","name":"University of South Carolina","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008899","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Autosomal dominant tubulointerstitial kidney disease (ADTKD-\n                    <jats:italic>UMOD<\/jats:italic>\n                    ) is a chronic and progressive kidney disease that typically presents with elevated serum creatinine and gout between the second and fourth decades of life. Our patient presented at age 6\u00a0years with persistent headaches and nosebleeds that began the year prior to presentation with nephrology. Stage 2 hypertension prompted her nephrology referral from the pediatrician. Laboratory evaluation was not initially remarkable for significant elevation in creatinine as would be expected; however, her creatinine level did eventually rise to a concerning level after months of antihypertensive therapy. Kidney biopsy was remarkable for findings consistent with\n                    <jats:italic>UMOD<\/jats:italic>\n                    -associated ADTKD. This case demonstrates an unusual presentation of ADTKD\n                    <jats:italic>-UMOD<\/jats:italic>\n                    with Stage 2 hypertension at an early age in the absence of significant kidney injury and highlights a further emerging role for genetic testing in suspected secondary hypertension.\n                  <\/jats:p>","DOI":"10.1007\/s00467-025-07024-5","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T08:53:49Z","timestamp":1762764829000},"page":"687-689","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An unusual presentation of UMOD-associated autosomal dominant tubulointerstitial kidney disease in a pediatric patient"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8618-6905","authenticated-orcid":false,"given":"Andrew","family":"Murray","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Cramer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"7024_CR1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-1904","volume":"140","author":"JT Flynn","year":"2017","unstructured":"Flynn JT, Kaelber DC, Baker-Smith CM et al (2017) Subcommittee on Screening and Management of High Blood Pressure in Children; Clinical practice guideline for screening and management of high blood pressure in children and adolescents. Pediatrics 140:e20171904","journal-title":"Pediatrics"},{"key":"7024_CR2","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1053\/j.ackd.2016.11.012","volume":"24","author":"AJ Bleyer","year":"2017","unstructured":"Bleyer AJ, Kidd K, \u017divn\u00e1 M, Kmoch S (2017) Autosomal dominant tubulointerstitial kidney disease \u2013 UMOD. Adv Chronic Kidney Dis 24:86\u201393","journal-title":"Adv Chronic Kidney Dis"},{"key":"7024_CR3","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1007\/s00467-021-05118-4","volume":"37","author":"AJ Bleyer","year":"2022","unstructured":"Bleyer AJ, Wolf MT, Kidd KO et al (2022) Autosomal dominant tubulointerstitial kidney disease: more than just HNF1\u03b2. Pediatr Nephrol 37:933\u2013946. https:\/\/doi.org\/10.1007\/s00467-021-05118-4","journal-title":"Pediatr Nephrol"},{"key":"7024_CR4","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1146\/annurev-physiol-031620-092817","volume":"83","author":"C Schaeffer","year":"2021","unstructured":"Schaeffer C, Devuyst O, Rampoldi L (2021) Uromodulin: roles in health and disease. Annu Rev Physiol 83:477\u2013501","journal-title":"Annu Rev Physiol"},{"key":"7024_CR5","doi-asserted-by":"publisher","first-page":"2332","DOI":"10.1016\/j.ekir.2022.08.012","volume":"7","author":"L Econimo","year":"2022","unstructured":"Econimo L, Schaeffer C, Zeni L (2022) Autosomal dominant tubulointerstitial kidney disease: an emerging cause of genetic CKD. Kidney Int Rep 7:2332\u20132344","journal-title":"Kidney Int Rep"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-025-07024-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00467-025-07024-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-025-07024-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T14:02:05Z","timestamp":1769608925000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00467-025-07024-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,10]]},"references-count":5,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["7024"],"URL":"https:\/\/doi.org\/10.1007\/s00467-025-07024-5","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,10]]},"assertion":[{"value":"9 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no financial, non-financial, or competing interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}