{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:43:17Z","timestamp":1791726197034,"version":"4.3.4"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Growth failure is a common and serious complication of chronic kidney disease (CKD) in children, resulting from numerous factors, including growth hormone (GH) resistance. Suppressor of cytokine signaling 2 (SOCS2), a negative regulator of GH signaling, has been implicated in growth regulation but has not been previously studied in pediatric CKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this cross-sectional study, we assessed serum SOCS2 concentrations in 55 children with CKD (stages 2\u20135) and 27 age- and sex-matched healthy controls using a high-sensitivity ELISA. We evaluated anthropometric parameters, kidney function, and biochemical markers. Associations between SOCS2 levels and growth (height standard deviation scores, HtSDS) were analyzed using correlation and multivariate regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      SOCS2 levels were significantly higher in children with CKD compared to controls (median 1526.5 vs. 1294.6\u00a0pg\/ml,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In patients\u00a0with CKD, SOCS2 negatively correlated with HtSDS (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u2009\u22120.30,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.029). In multivariate analysis, SOCS2 was an independent predictor of lower HtSDS alongside eGFR. SOCS2 concentrations were higher in short-statured children, and ROC analysis showed acceptable diagnostic performance for predicting short stature (AUC 0.78, 95% CI 0.64\u20130.91; 79.5% sensitivity, 68.8% specificity).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Circulating SOCS2 levels are elevated in pediatric CKD and independently associated with growth impairment, suggesting its potential link to GH resistance, which is typical of CKD. SOCS2 might be a potential new marker of growth retardation. Further longitudinal studies are needed to explore its predictive value for longitudinal growth and GH treatment response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s00467-025-07029-0","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T21:35:34Z","timestamp":1764365734000},"page":"1151-1159","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Suppressor of cytokine signaling 2 is associated with growth impairment in pediatric chronic kidney disease"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9901-4140","authenticated-orcid":false,"given":"Anna","family":"Deja","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Leszczy\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola","family":"Materny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Wujec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Stelmaszczyk-Emmel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Pa\u0144czyk-Tomaszewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"key":"7029_CR1","volume":"11","author":"T Todisco","year":"2024","unstructured":"Todisco T, Ubertini GM, Bizzarri C, Loche S, Cappa M (2024) Chronic kidney disease and growth failure in children. 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