{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T10:03:07Z","timestamp":1772445787731,"version":"3.50.1"},"reference-count":5,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["TL1DK143326"],"award-info":[{"award-number":["TL1DK143326"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K23DK134847"],"award-info":[{"award-number":["K23DK134847"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["T32HD043021"],"award-info":[{"award-number":["T32HD043021"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Kidney biopsy is the standard of diagnosis for many kidney diseases and conditions. Severe bleeding following a kidney biopsy is a complication for which limited therapeutic interventions exist. The use of recombinant activated factor VII (rFVIIa) is described in pediatric patients to control severe intra-operative hemorrhage and has been used in at least one adult patient to manage post-kidney biopsy hemorrhage. We present a 10-year-old female who presented with acute kidney injury, thrombocytopenia, and hypertension, ultimately diagnosed with ANCA-vasculitis. Following a kidney biopsy, the patient experienced a large, expanding hematoma with active bleeding that did not improve despite pre-biopsy desmopressin, 90\u00a0min of pressure to the biopsy site, and platelet transfusions. Recombinant activated FVIIa was administered, and the bleeding immediately stopped. This case supports the use of recombinant FVIIa in post-kidney biopsy hemorrhage when bleeding is not controlled using conventional strategies.<\/jats:p>","DOI":"10.1007\/s00467-025-07063-y","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T07:56:25Z","timestamp":1764662185000},"page":"1007-1011","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Use of recombinant activated factor VII to stop post-kidney biopsy bleeding in a child"],"prefix":"10.1007","volume":"41","author":[{"given":"Elena","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0036-5427","authenticated-orcid":false,"given":"Stephanie P.","family":"Kerkvliet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1251-2404","authenticated-orcid":false,"given":"Andrew D.","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6932-9803","authenticated-orcid":false,"given":"Amy J.","family":"Kogon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,2]]},"reference":[{"key":"7063_CR1","doi-asserted-by":"publisher","first-page":"354","DOI":"10.2215\/CJN.05750515","volume":"11","author":"JJ Hogan","year":"2016","unstructured":"Hogan JJ, Mocanu M, Berns JS (2016) The native kidney biopsy: update and evidence for best practice. Clin J Am Soc Nephrol 11:354\u2013362. https:\/\/doi.org\/10.2215\/CJN.05750515","journal-title":"Clin J Am Soc Nephrol"},{"key":"7063_CR2","first-page":"S7","volume":"49","author":"GA Allen","year":"2002","unstructured":"Allen GA, Hoffman M, Roberts HR, Monroe DM 3rd (2002) Recombinant activated factor VII: its mechanism of action and role in the control of hemorrhage. Can J Anaesth 49:S7\u2013S14","journal-title":"Can J Anaesth"},{"key":"7063_CR3","unstructured":"U.S. Food and Drug Administration (2014) Highlights of prescribing information: NovoSeven.  https:\/\/www.fda.gov\/media\/70442\/download.  Accessed 18 Nov 2025"},{"key":"7063_CR4","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1001\/archsurg.2007.66","volume":"143","author":"M Ranucci","year":"2008","unstructured":"Ranucci M, Isgr\u00f2 G, Soro G, Conti D, De Toffol B (2008) Efficacy and safety of recombinant activated factor VII in major surgical procedures: systematic review and meta-analysis of randomized clinical trials. Arch Surg 143:296\u2013304. https:\/\/doi.org\/10.1001\/archsurg.2007.66","journal-title":"Arch Surg"},{"key":"7063_CR5","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1097\/MBC.0b013e32835029a5","volume":"23","author":"B Maksimovic","year":"2012","unstructured":"Maksimovic B, Neretljak I, Vidas Z, Vojtusek IK, Tomulic K, Knotek M (2012) Treatment of bleeding after kidney biopsy with recombinant activated factor VII. Blood Coagul Fibrinolysis 23:241\u2013243. https:\/\/doi.org\/10.1097\/MBC.0b013e32835029a5","journal-title":"Blood Coagul Fibrinolysis"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-025-07063-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00467-025-07063-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-025-07063-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T09:12:27Z","timestamp":1772442747000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00467-025-07063-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,2]]},"references-count":5,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["7063"],"URL":"https:\/\/doi.org\/10.1007\/s00467-025-07063-y","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,2]]},"assertion":[{"value":"21 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 October 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}