{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T09:14:00Z","timestamp":1783329240855,"version":"3.54.6"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002352","name":"Ain Shams University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002352","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Wilson's disease (WD) is a rare copper (Cu) metabolism disorder with toxic organ accumulation. Diagnosis challenges persist in children with atypical multisystem presentations, including uncommon kidney involvement, that may mimic autoimmune and systemic diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Presentation<\/jats:title>\n                    <jats:p>A 10-year-old girl presented with recurrent jaundice, abdominal pain, weight loss, poor school performance, and polyuria. She had cachexia, hepatosplenomegaly, kinetic hand tremors, non-immune hemolytic anemia, and mild glomerular and tubular dysfunction. Urosepsis triggered decompensation with worsening hepatic function, acute kidney injury (AKI) with Fanconi-like tubulopathy, coagulopathy, low complements,\u2009+\u2009ve autoantibodies, and elevated IgG. Despite autoimmune and malignancy mimics, Cu studies confirmed WD; D-penicillamine and zinc achieved rapid hepatorenal and hemolysis recovery. Fibrosis regressed at 1\u00a0year despite late ocular affection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case underscores diagnostic challenges of pediatric WD with multisystem involvement mimicking autoimmune and malignant disorders, emphasizing early Cu studies in multisystem jaundice. Timely chelation therapy achieved rapid improvement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00467-026-07186-w","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T14:13:24Z","timestamp":1772115204000},"page":"2461-2465","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A diagnostic dilemma in a child with Wilson's disease"],"prefix":"10.1007","volume":"41","author":[{"given":"Dina E.","family":"Sallam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria Thomas","family":"Guergues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noha Mohsen","family":"Samak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Eladawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally Gouda","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6900-6269","authenticated-orcid":false,"given":"Armia Mounir","family":"Agour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"7186_CR1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0018-3","volume":"4","author":"A Cz\u0142onkowska","year":"2018","unstructured":"Cz\u0142onkowska A, Litwin T, Dusek P, Ferenci P, Lutsenko S, Medici V, Rybakowski JK, Weiss KH, Schilsky ML (2018) Wilson disease. 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