{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T09:14:04Z","timestamp":1783329244340,"version":"3.54.6"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:00:00Z","timestamp":1773446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:00:00Z","timestamp":1773446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s00467-026-07252-3","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T16:34:13Z","timestamp":1773506053000},"page":"2489-2497","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hydroxychloroquine use in pediatric IgA nephropathy"],"prefix":"10.1007","volume":"41","author":[{"given":"Karma","family":"Abukasm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lison","family":"Lachize Neanne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Lafitte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe","family":"Reverand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Phan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Boyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevi\u00e8ve","family":"Benoit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Rabant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Laure","family":"Lapeyraque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Dossier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2593-1456","authenticated-orcid":false,"given":"Alexandra","family":"Cambier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,14]]},"reference":[{"key":"7252_CR1","doi-asserted-by":"publisher","first-page":"199","DOI":"10.4103\/0971-4065.159304","volume":"26","author":"S Imtiaz","year":"2016","unstructured":"Imtiaz S, Nasir K, Drohlia MF, Salman B, Ahmad A (2016) Frequency of kidney diseases and clinical indications of pediatric renal biopsy: a single center experience. Indian J Nephrol 26:199\u2013205","journal-title":"Indian J Nephrol"},{"key":"7252_CR2","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1007\/s00467-006-0163-x","volume":"21","author":"J Ronkainen","year":"2006","unstructured":"Ronkainen J, Ala-Houhala M, Autio-Harmainen H, Jahnukainen T, Koskimies O, Merenmies J et al (2006) Long-term outcome 19 years after childhood IgA nephritis: a retrospective cohort study. Pediatr Nephrol 21:1266\u20131273","journal-title":"Pediatr Nephrol"},{"key":"7252_CR3","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/S0022-3476(95)70027-7","volume":"127","author":"RJ Wyatt","year":"1995","unstructured":"Wyatt RJ, Kritchevsky SB, Woodford SY, Miller PM, Roy S 3rd, Holland NH et al (1995) IgA nephropathy: long-term prognosis for pediatric patients. J Pediatr 127:913\u2013919","journal-title":"J Pediatr"},{"key":"7252_CR4","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/s00467-020-04475-w","volume":"36","author":"A Cambier","year":"2021","unstructured":"Cambier A, Gleeson PJ, Flament H, Le Stang MB, Monteiro RC (2021) New therapeutic perspectives for IgA nephropathy in children. Pediatr Nephrol 36:497\u2013506","journal-title":"Pediatr Nephrol"},{"key":"7252_CR5","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1007\/s00281-021-00888-3","volume":"43","author":"J Floege","year":"2021","unstructured":"Floege J, Rauen T, Tang SCW (2021) Current treatment of IgA nephropathy. Semin Immunopathol 43:717\u2013728","journal-title":"Semin Immunopathol"},{"key":"7252_CR6","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1016\/j.ekir.2018.03.013","volume":"3","author":"A Cambier","year":"2018","unstructured":"Cambier A, Rabant M, Peuchmaur M, Hertig A, Deschenes G, Couchoud C et al (2018) Immunosuppressive treatment in children with IgA nephropathy and the clinical value of podocytopathic features. Kidney Int Rep 3:916\u2013925","journal-title":"Kidney Int Rep"},{"key":"7252_CR7","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1093\/ndt\/gfac025","volume":"37","author":"Cambier A, Troyanov S, Tesar V, Coppo R, Validation Study of Oxford Classification (VALIGA) Group","year":"2022","unstructured":"Cambier A, Troyanov S, Tesar V, Coppo R, Validation Study of Oxford Classification (VALIGA) Group (2022) Indication for corticosteroids in IgA nephropathy: validation in the European VALIGA cohort of a treatment score based on the Oxford classification. Nephrol Dial Transplant 37:1195\u20131197","journal-title":"Nephrol Dial Transplant"},{"key":"7252_CR8","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1007\/s40620-020-00725-0","volume":"33","author":"R Coppo","year":"2020","unstructured":"Coppo R, Robert T (2020) IgA nephropathy in children and in adults: two separate entities or the same disease? J Nephrol 33:1219\u20131229","journal-title":"J Nephrol"},{"key":"7252_CR9","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.kint.2019.08.022","volume":"97","author":"Y Makita","year":"2020","unstructured":"Makita Y, Suzuki H, Kano T, Takahata A, Julian BA, Novak J et al (2020) TLR9 activation induces aberrant IgA glycosylation via APRIL- and IL-6-mediated pathways in IgA nephropathy. Kidney Int 97:340\u2013349","journal-title":"Kidney Int"},{"key":"7252_CR10","doi-asserted-by":"publisher","first-page":"2384","DOI":"10.1681\/ASN.2007121311","volume":"19","author":"H Suzuki","year":"2008","unstructured":"Suzuki H, Suzuki Y, Narita I, Aizawa M, Kihara M, Yamanaka T et al (2008) Toll-like receptor 9 affects severity of IgA nephropathy. J Am Soc Nephrol 19:2384\u20132395","journal-title":"J Am Soc Nephrol"},{"key":"7252_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.clim.2018.07.003","volume":"195","author":"M Torigoe","year":"2018","unstructured":"Torigoe M, Sakata K, Ishii A, Iwata S, Nakayamada S, Tanaka Y (2018) Hydroxychloroquine efficiently suppresses inflammatory responses of human class-switched memory B cells via Toll-like receptor 9 inhibition. Clin Immunol 195:1\u20137","journal-title":"Clin Immunol"},{"key":"7252_CR12","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-025-07004-9","author":"A Cambier","year":"2025","unstructured":"Cambier A, Neanne LL, Sahu S, Arbez L, Maillard N (2025) IgA nephropathy new therapies: from data in adults to application in children. Pediatr Nephrol. https:\/\/doi.org\/10.1007\/s00467-025-07004-9","journal-title":"Pediatr Nephrol"},{"key":"7252_CR13","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1007\/s11255-017-1574-2","volume":"49","author":"R Gao","year":"2017","unstructured":"Gao R, Wu W, Wen Y, Li X (2017) Hydroxychloroquine alleviates persistent proteinuria in IgA nephropathy. Int Urol Nephrol 49:1233\u20131241","journal-title":"Int Urol Nephrol"},{"key":"7252_CR14","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-019-1488-6","volume":"20","author":"YZ Yang","year":"2019","unstructured":"Yang YZ, Chen P, Liu LJ, Cai QQ, Shi SF, Chen YQ et al (2019) Comparison of the effects of hydroxychloroquine and corticosteroid treatment on proteinuria in IgA nephropathy: a case-control study. BMC Nephrol 20:297","journal-title":"BMC Nephrol"},{"key":"7252_CR15","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-020-02141-9","volume":"21","author":"C Tang","year":"2020","unstructured":"Tang C, Lv JC, Shi SF, Chen YQ, Liu LJ, Zhang H (2020) Effect of hydroxychloroquine in patients with IgA nephropathy with insufficient responses to immunosuppressive therapy: a retrospective case-control study. BMC Nephrol 21:469","journal-title":"BMC Nephrol"},{"key":"7252_CR16","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1053\/j.ajkd.2019.01.026","volume":"74","author":"LJ Liu","year":"2019","unstructured":"Liu LJ, Yang YZ, Shi SF, Bao YF, Yang C, Zhu SN et al (2019) Effects of hydroxychloroquine on proteinuria in IgA nephropathy: a randomized controlled trial. Am J Kidney Dis 74:15\u201322","journal-title":"Am J Kidney Dis"},{"key":"7252_CR17","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1681\/ASN.2008030287","volume":"20","author":"GJ Schwartz","year":"2009","unstructured":"Schwartz GJ, Munoz A, Schneider MF, Mak RH, Kaskel F, Warady BA et al (2009) New equations to estimate GFR in children with CKD. J Am Soc Nephrol 20:629\u2013637","journal-title":"J Am Soc Nephrol"},{"key":"7252_CR18","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1016\/j.kint.2017.02.003","volume":"91","author":"H Trimarchi","year":"2017","unstructured":"Trimarchi H, Barratt J, Cattran DC, Cook HT, Coppo R, Haas M et al (2017) Oxford classification of IgA nephropathy 2016: an update from the IgA Nephropathy Classification Working Group. Kidney Int 91:1014\u20131021","journal-title":"Kidney Int"},{"key":"7252_CR19","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1016\/j.kint.2021.05.021","volume":"100","author":"KDIGO","year":"2021","unstructured":"KDIGO (2021) Clinical practice guideline for the management of glomerular diseases. Kidney Int 100:S1-s276","journal-title":"Kidney Int"},{"key":"7252_CR20","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1136\/annrheumdis-2019-215089","volume":"78","author":"A Fanouriakis","year":"2019","unstructured":"Fanouriakis A, Kostopoulou M, Alunno A, Aringer M, Bajema I, Boletis JN et al (2019) 2019 update of the EULAR recommendations for the management of systemic lupus erythematosus. Ann Rheum Dis 78:736\u2013745","journal-title":"Ann Rheum Dis"},{"key":"7252_CR21","doi-asserted-by":"publisher","first-page":"S117","DOI":"10.1016\/j.kint.2023.10.018","volume":"105","author":"KDIGO","year":"2024","unstructured":"KDIGO (2024) Clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int 105:S117-s314","journal-title":"Kidney Int"},{"key":"7252_CR22","doi-asserted-by":"publisher","first-page":"2403","DOI":"10.1007\/s00467-024-06361-1","volume":"39","author":"B Su","year":"2024","unstructured":"Su B, Jiang Y, Li Z, Zhou J, Rong L, Feng S et al (2024) Are children with IgA nephropathy different from adult patients? Pediatr Nephrol 39:2403\u20132412","journal-title":"Pediatr Nephrol"},{"key":"7252_CR23","first-page":"160","volume":"33","author":"N Yoshikawa","year":"1990","unstructured":"Yoshikawa N, Iijima K, Matsuyama S, Suzuki J, Kameda A, Okada S et al (1990) Repeat renal biopsy in children with IgA nephropathy. Clin Nephrol 33:160\u2013167","journal-title":"Clin Nephrol"},{"key":"7252_CR24","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1111\/ped.13074","volume":"59","author":"Y Kawasaki","year":"2017","unstructured":"Kawasaki Y, Maeda R, Kanno S, Suzuki Y, Ohara S, Suyama K et al (2017) Long-term follow up of pediatric immunoglobulin A nephropathy treated with tonsillectomy plus methylprednisolone pulse therapy. Pediatr Int 59:41\u201347","journal-title":"Pediatr Int"},{"key":"7252_CR25","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/s00467-024-06502-6","volume":"40","author":"M Vivarelli","year":"2025","unstructured":"Vivarelli M, Samuel S, Coppo R, Barratt J, Bonilla-Felix M, Haffner D et al (2025) IPNA clinical practice recommendations for the diagnosis and management of children with IgA nephropathy and IgA vasculitis nephritis. Pediatr Nephrol 40:533\u2013569","journal-title":"Pediatr Nephrol"},{"key":"7252_CR26","doi-asserted-by":"publisher","first-page":"2107","DOI":"10.1007\/s00467-024-06648-3","volume":"40","author":"A Cambier","year":"2025","unstructured":"Cambier A, Dossier C, Lapeyraque A-L, Phan V, Laroche C, Abukasm K et al (2025) Bridging pediatric and adult IgAN: challenges in applying proteinuria-driven recommendations in the new IPNA guidelines. Pediatr Nephrol 40:2107\u20132111","journal-title":"Pediatr Nephrol"},{"key":"7252_CR27","doi-asserted-by":"publisher","first-page":"2411","DOI":"10.1007\/s00467-025-06744-y","volume":"40","author":"M Haas","year":"2025","unstructured":"Haas M, Cambier A (2025) IPNA recommendations for treatment of IgA nephropathy: why there should be a greater emphasis on pathology moving forward. Pediatr Nephrol 40:2411","journal-title":"Pediatr Nephrol"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-026-07252-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00467-026-07252-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-026-07252-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T08:14:28Z","timestamp":1783325668000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00467-026-07252-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,14]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["7252"],"URL":"https:\/\/doi.org\/10.1007\/s00467-026-07252-3","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,14]]},"assertion":[{"value":"19 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2026","order":6,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":7,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original online version of this article was revised: The author name tagging for Lison Lachize Neanne has been corrected.","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}