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Data regarding demographics, office BP,\u00a0 24-h ambulatory BP monitoring if\u2009&gt;\u20095-years, biochemistry and echocardiography were collated. Cyst burden was assessed by kidney ultrasound and classified as \u2018low burden\u2019 or \u2018high burden\u2019. Participants with hypertension (BP\u2009\u2265\u200995th percentile) or \u2018high-normal\u2019 BP (BP\u2009\u2265\u200990th and\u2009&lt;\u200995th percentile) were grouped as \u2018High BP\u2019 (BP\u2009\u2265\u200990th percentile), and the remaining as normotensive (BP\u2009&lt;\u200990th percentile).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Amongst 116 children (mean age 9.99\u2009\u00b1\u20095.2 years; 57.8% female), hypertension prevalence was 12% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200914), 8 with masked hypertension. Those with High BP (26% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930)) had a higher cyst burden (56% vs. 34%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.036), LV hypertrophy (LVH) (16.6% vs. 4.6%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.034) and relative LV wall thickness (0.34\u2009\u00b1\u20090.08 vs. 0.29\u2009\u00b1\u20090.05,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) but similar indexed LV mass (LVMI) and LV function when compared with normotensives. In multivariable analysis, cyst burden independently predicted LVMI (standardised\u00a0\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.23,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02), whereas systolic BP did not (standardised\u00a0\u03b2 = 0.19,\u00a0\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.14).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Hypertension affected 12% of untreated children with ADPKD and preserved kidney function. High BP was associated with increased prevalence of LVH and relative wall thickness when compared to those who were normotensive. Cyst burden correlated with adverse cardiac remodelling, suggesting a BP-independent mechanism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00467-026-07312-8","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T19:04:38Z","timestamp":1779131078000},"page":"3477-3487","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cystic burden meets blood pressure: cardiac remodelling in paediatric autosomal dominant polycystic kidney disease"],"prefix":"10.1007","volume":"41","author":[{"given":"Camille","family":"Heming","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Haseler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Savis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Samuel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7593-1203","authenticated-orcid":false,"given":"Manish D.","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"7312_CR1","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1007\/s00431-019-03384-x","volume":"178","author":"F Schaefer","year":"2019","unstructured":"Schaefer F, Mekahli D, Emma F, Gilbert RD, Bockenhauer D, Cadnapaphornchai MA, Shi L, Dandurand A, Sikes K, Shoaf SE (2019) Tolvaptan use in children and adolescents with autosomal dominant polycystic kidney disease: rationale and design of a two-part, randomized, double-blind, placebo-controlled trial. 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