{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:09:40Z","timestamp":1790266180715,"version":"4.1.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:00:00Z","timestamp":1780704000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:00:00Z","timestamp":1780704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UM1TR004405"],"award-info":[{"award-number":["UM1TR004405"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>COVID-19 infection has been associated with significant morbidity and mortality across all age groups, yet data on pediatric kidney transplant outcomes associated with COVID-19 positive (COVID +) donors remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using the Scientific Registry of Transplant Recipients, we identified 143 pediatric kidney recipients (&lt; 18\u00a0years) of COVID + donors transplanted between September 2020 and February 2025 and compared them with 1808 recipients of COVID-19 negative (COVID \u2212) donors using propensity score weighting to account for transplant year, age at transplant, sex, race, human leukocyte antigen mismatch, prior transplant, and immunosuppression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 1940 pediatric recipients, 7.3% received kidneys from COVID +\u2009donors, with utilization increasing from 2.5% in 2020 to 10.5% in 2025. No statistically significant differences were observed in patient survival (HR 0.83, 95% CI 0.10\u20136.73,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.86) and overall graft failure (HR 1.35, 95% CI 0.67\u20132.73,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.41) between COVID +\u2009and COVID \u2212 groups over a median follow-up of 1.2\u00a0years. Delayed graft function (7.7% vs. 7.2%) and median initial hospital stay (8.0 vs. 8.0\u00a0days) were also comparable.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The use of COVID + donors for pediatric kidney transplantation has increased over time. The posttransplant outcomes are similar between COVID + and COVID \u2212 pediatric recipients, supporting the use of COVID + donors in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                    <jats:p>A higher resolution version of the Graphical abstract is available as Supplementary information<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00467-026-07362-y","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T06:59:13Z","timestamp":1780729153000},"page":"4017-4026","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Utilization and outcomes of COVID-19 positive donors in pediatric kidney transplantation\u2014a population-based study"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6696-6743","authenticated-orcid":false,"given":"Saritha","family":"Ranabothu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7449-3993","authenticated-orcid":false,"given":"Michael D.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5824-7856","authenticated-orcid":false,"given":"Sarah J.","family":"Kizilbash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,6]]},"reference":[{"key":"7362_CR1","doi-asserted-by":"publisher","unstructured":"Rees L (2009) Long-term outcome after renal transplantation in childhood. Pediatr Nephrol 24:475\u2013484. https:\/\/doi.org\/10.1007\/s00467-007-0559-2","DOI":"10.1007\/s00467-007-0559-2"},{"key":"7362_CR2","doi-asserted-by":"publisher","unstructured":"Lentine KL, Smith JM,  Lyden GR, Miller JM ,  Booker SE, Dolan TG, Temple KR, Weiss S,  Handarova D,  Israni AK,  Snyder JJ (2025) OPTN\/SRTR 2023 annual data report: kidney. Am J Transplant 25:S22\u2013S137.\u00a0https:\/\/doi.org\/10.1016\/j.ajt.2025.01.020","DOI":"10.1016\/j.ajt.2025.01.020"},{"key":"7362_CR3","doi-asserted-by":"publisher","unstructured":"Nimmo A,  Gardiner D,  Ushiro-Lumb I,  Ravanan R,  Forsythe JLR (2022) The global impact of COVID-19 on solid organ transplantation: two years into a pandemic. 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The interpretation and reporting of these data are the responsibility of the authors and in no way should be seen as an official policy of or interpretation by the OPTN or the U.S. Government. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health\u2019s National Center for Advancing Translational Sciences.","order":2,"name":"Ethics","label":"Disclaimer","group":{"name":"EthicsHeading","label":"Declarations"}}]}}