{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:13:09Z","timestamp":1792782789632,"version":"4.5.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Programme Hospitalier de Recherche Clinique","award":["10 138 01\u2014N\u00b0 RCB 2010-AO1151-38"],"award-info":[{"award-number":["10 138 01\u2014N\u00b0 RCB 2010-AO1151-38"]}]},{"name":"Fondation pour la recherche medicale","award":["DEQ20170336759"],"award-info":[{"award-number":["DEQ20170336759"]}],"id":[{"id":"https:\/\/ror.org\/04w6kn183","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Agence de la biomedecine","award":["METAPhOR project"],"award-info":[{"award-number":["METAPhOR project"]}],"id":[{"id":"https:\/\/ror.org\/03tajza86","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Association pour l'information et de la recherche sur les maladies r\u00e9nales g\u00e9n\u00e9tiques","id":[{"id":"https:\/\/ror.org\/05q35d534","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Orphan Kidney Disease"},{"name":"Universit\u00e9 de Toulouse","id":[{"id":"https:\/\/ror.org\/01ahyrz84","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s00467-026-07375-7","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T12:29:21Z","timestamp":1780662561000},"page":"4311-4323","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prenatal body fluid analysis in the evaluation of CAKUT"],"prefix":"10.1007","volume":"41","author":[{"given":"Thomas","family":"Simon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9n\u00e9dicte","family":"Buffin-Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Decramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost P.","family":"Schanstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,5]]},"reference":[{"key":"7375_CR1","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1038\/nrneph.2015.140","volume":"11","author":"N Nicolaou","year":"2015","unstructured":"Nicolaou N, Renkema KY, Bongers EM et al (2015) Genetic, environmental, and epigenetic factors involved in CAKUT. Nat Rev Nephrol 11:720\u2013731. https:\/\/doi.org\/10.1038\/nrneph.2015.140","journal-title":"Nat Rev Nephrol"},{"key":"7375_CR2","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1056\/NEJMoa1700993","volume":"378","author":"R Calderon-Margalit","year":"2018","unstructured":"Calderon-Margalit R, Golan E, Twig G et al (2018) History of childhood kidney disease and risk of adult end-stage renal disease. N Engl J Med 378:428\u2013438. https:\/\/doi.org\/10.1056\/NEJMoa1700993","journal-title":"N Engl J Med"},{"key":"7375_CR3","doi-asserted-by":"publisher","first-page":"67","DOI":"10.2215\/CJN.03310412","volume":"8","author":"E W\u00fchl","year":"2013","unstructured":"W\u00fchl E, van Stralen KJ, Verrina E et al (2013) Timing and outcome of renal replacement therapy in patients with congenital malformations of the kidney and urinary tract. Clin J Am Soc Nephrol 8:67\u201374. https:\/\/doi.org\/10.2215\/CJN.03310412","journal-title":"Clin J Am Soc Nephrol"},{"key":"7375_CR4","doi-asserted-by":"publisher","first-page":"723","DOI":"10.2215\/CJN.12581019","volume":"15","author":"V Murugapoopathy","year":"2020","unstructured":"Murugapoopathy V, Gupta IR (2020) A primer on congenital anomalies of the kidneys and urinary tracts (CAKUT). Clin J Am Soc Nephrol 15:723\u2013731. https:\/\/doi.org\/10.2215\/CJN.12581019","journal-title":"Clin J Am Soc Nephrol"},{"key":"7375_CR5","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/s41585-022-00563-8","volume":"19","author":"V Capone","year":"2022","unstructured":"Capone V, Persico N, Berrettini A et al (2022) Definition, diagnosis and management of fetal lower urinary tract obstruction: consensus of the ERKNet CAKUT-Obstructive Uropathy Work Group. Nat Rev Urol 19:295\u2013303. https:\/\/doi.org\/10.1038\/s41585-022-00563-8","journal-title":"Nat Rev Urol"},{"key":"7375_CR6","doi-asserted-by":"publisher","first-page":"2864","DOI":"10.1681\/ASN.2006030277","volume":"17","author":"S Weber","year":"2006","unstructured":"Weber S, Moriniere V, Knuppel T et al (2006) Prevalence of mutations in renal developmental genes in children with renal hypodysplasia: results of the ESCAPE study. J Am Soc Nephrol 17:2864\u20132870","journal-title":"J Am Soc Nephrol"},{"key":"7375_CR7","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1111\/j.1471-0528.2009.02194.x","volume":"116","author":"RK Morris","year":"2009","unstructured":"Morris RK, Malin GL, Khan KS, Kilby MD (2009) Antenatal ultrasound to predict postnatal renal function in congenital lower urinary tract obstruction: systematic review of test accuracy. BJOG 116:1290\u20131299. https:\/\/doi.org\/10.1111\/j.1471-0528.2009.02194.x","journal-title":"BJOG"},{"key":"7375_CR8","doi-asserted-by":"publisher","first-page":"2351","DOI":"10.1093\/ndt\/gfac207","volume":"37","author":"S Kohl","year":"2022","unstructured":"Kohl S, Avni FE, Boor P et al (2022) Definition, diagnosis, and clinical management of non-obstructive kidney dysplasia: a consensus statement by the ERKNet working group on kidney malformations. Nephrol Dial Transplant 37:2351\u20132362. https:\/\/doi.org\/10.1093\/ndt\/gfac207","journal-title":"Nephrol Dial Transplant"},{"key":"7375_CR9","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1007\/s00467-015-3140-4","volume":"31","author":"W Aulbert","year":"2016","unstructured":"Aulbert W, Kemper MJ (2016) Severe antenatally diagnosed renal disorders: background, prognosis and practical approach. Pediatr Nephrol 31:563\u2013574. https:\/\/doi.org\/10.1007\/s00467-015-3140-4","journal-title":"Pediatr Nephrol"},{"key":"7375_CR10","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/s00467-011-2068-6","volume":"27","author":"J Hogan","year":"2012","unstructured":"Hogan J, Dourthe ME, Blondiaux E et al (2012) Renal outcome in children with antenatal diagnosis of severe CAKUT. Pediatr Nephrol 27:497\u2013502","journal-title":"Pediatr Nephrol"},{"key":"7375_CR11","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/j.kint.2020.06.043","volume":"99","author":"J Klein","year":"2021","unstructured":"Klein J, Buffin-Meyer B, Boizard F et al (2021) Amniotic fluid peptides predict postnatal kidney survival in developmental kidney disease. Kidney Int 99:737\u2013749. https:\/\/doi.org\/10.1016\/j.kint.2020.06.043","journal-title":"Kidney Int"},{"key":"7375_CR12","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1093\/ndt\/gfae145","volume":"40","author":"B Buffin-Meyer","year":"2024","unstructured":"Buffin-Meyer B, Klein J, Aziza J et al (2024) Improved prenatal assessment of kidney disease using multiple ultrasound features. Nephrol Dial Transplant 40:341\u2013351. https:\/\/doi.org\/10.1093\/ndt\/gfae145","journal-title":"Nephrol Dial Transplant"},{"key":"7375_CR13","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-59248-4","volume":"14","author":"OX Miguel","year":"2024","unstructured":"Miguel OX, Kaczmarek E, Lee I et al (2024) Deep learning prediction of renal anomalies for prenatal ultrasound diagnosis. Sci Rep 14:9013. https:\/\/doi.org\/10.1038\/s41598-024-59248-4","journal-title":"Sci Rep"},{"key":"7375_CR14","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1007\/s00467-025-06911-1","volume":"41","author":"A Nada","year":"2026","unstructured":"Nada A, Ahmed Y, Hu J et al (2026) AI-powered insights in pediatric nephrology: current applications and future opportunities. Pediatr Nephrol 41:1275\u20131286. https:\/\/doi.org\/10.1007\/s00467-025-06911-1","journal-title":"Pediatr Nephrol"},{"key":"7375_CR15","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1002\/pd.5610","volume":"40","author":"GE Chalouhi","year":"2020","unstructured":"Chalouhi GE, Millischer A-\u00c9, Mahallati H et al (2020) The use of fetal MRI for renal and urogenital tract anomalies. Prenat Diagn 40:100\u2013109. https:\/\/doi.org\/10.1002\/pd.5610","journal-title":"Prenat Diagn"},{"key":"7375_CR16","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1007\/s00467-024-06479-2","volume":"40","author":"LM Vendrig","year":"2025","unstructured":"Vendrig LM, Ten Hoor MAC, K\u00f6nig BH et al (2025) Translational strategies to uncover the etiology of congenital anomalies of the kidney and urinary tract. Pediatr Nephrol 40:685\u2013699. https:\/\/doi.org\/10.1007\/s00467-024-06479-2","journal-title":"Pediatr Nephrol"},{"key":"7375_CR17","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1038\/s41581-023-00742-9","volume":"19","author":"CM Kolvenbach","year":"2023","unstructured":"Kolvenbach CM, Shril S, Hildebrandt F (2023) The genetics and pathogenesis of CAKUT. Nat Rev Nephrol 19:709\u2013720. https:\/\/doi.org\/10.1038\/s41581-023-00742-9","journal-title":"Nat Rev Nephrol"},{"key":"7375_CR18","doi-asserted-by":"publisher","first-page":"2514","DOI":"10.1016\/j.ekir.2024.05.007","volume":"9","author":"B Buffin-Meyer","year":"2024","unstructured":"Buffin-Meyer B, Richard J, Guigonis V et al (2024) Renal and extrarenal phenotypes in patients with HNF1B variants and chromosome 17q12 microdeletions. Kidney Int Rep 9:2514\u20132526. https:\/\/doi.org\/10.1016\/j.ekir.2024.05.007","journal-title":"Kidney Int Rep"},{"key":"7375_CR19","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/j.ajhg.2012.10.007","volume":"91","author":"S Sanna-Cherchi","year":"2012","unstructured":"Sanna-Cherchi S, Kiryluk K, Burgess KE et al (2012) Copy-number disorders are a common cause of congenital kidney malformations. Am J Hum Genet 91:987\u2013997. https:\/\/doi.org\/10.1016\/j.ajhg.2012.10.007","journal-title":"Am J Hum Genet"},{"key":"7375_CR20","doi-asserted-by":"publisher","first-page":"227.e1","DOI":"10.1016\/j.jpurol.2016.02.020","volume":"12","author":"A Faure","year":"2016","unstructured":"Faure A, Bouty A, Caruana G et al (2016) DNA copy number variants: a potentially useful predictor of early onset renal failure in boys with posterior urethral valves. J Pediatr Urol 12:227.e1-227.e7. https:\/\/doi.org\/10.1016\/j.jpurol.2016.02.020","journal-title":"J Pediatr Urol"},{"key":"7375_CR21","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1038\/ki.2015.319","volume":"89","author":"N Nicolaou","year":"2016","unstructured":"Nicolaou N, Pulit SL, Nijman IJ et al (2016) Prioritization and burden analysis of rare variants in 208 candidate genes suggest they do not play a major role in CAKUT. Kidney Int 89:476\u2013486. https:\/\/doi.org\/10.1038\/ki.2015.319","journal-title":"Kidney Int"},{"key":"7375_CR22","doi-asserted-by":"publisher","first-page":"379","DOI":"10.3233\/NPM-17131","volume":"11","author":"S Watanabe","year":"2018","unstructured":"Watanabe S, Kondo Y, Naoe A et al (2018) Effects of assisted reproductive technologies in neonates with indications for surgery (2007\u20132016). J Neonatal Perinatal Med 11:379\u2013385. https:\/\/doi.org\/10.3233\/NPM-17131","journal-title":"J Neonatal Perinatal Med"},{"key":"7375_CR23","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1681\/ASN.2018070736","volume":"30","author":"N Wanner","year":"2019","unstructured":"Wanner N, Vornweg J, Combes A et al (2019) DNA methyltransferase 1 controls nephron progenitor cell renewal and differentiation. J Am Soc Nephrol 30:63\u201378. https:\/\/doi.org\/10.1681\/ASN.2018070736","journal-title":"J Am Soc Nephrol"},{"key":"7375_CR24","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.kint.2015.10.010","volume":"89","author":"J Klein","year":"2016","unstructured":"Klein J, Bascands J-L, Mischak H, Schanstra JP (2016) The role of urinary peptidomics in kidney disease research. Kidney Int 89:539\u2013545. https:\/\/doi.org\/10.1016\/j.kint.2015.10.010","journal-title":"Kidney Int"},{"key":"7375_CR25","doi-asserted-by":"publisher","first-page":"3966","DOI":"10.1016\/j.febslet.2009.10.036","volume":"583","author":"T Maier","year":"2009","unstructured":"Maier T, Guell M, Serrano L (2009) Correlation of mRNA and protein in complex biological samples. FEBS Lett 583:3966\u20133973. https:\/\/doi.org\/10.1016\/j.febslet.2009.10.036","journal-title":"FEBS Lett"},{"key":"7375_CR26","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s12920-020-0690-5","volume":"13","author":"AL Tarca","year":"2020","unstructured":"Tarca AL, Romero R, Pique-Regi R et al (2020) Amniotic fluid cell-free transcriptome: a glimpse into fetal development and placental cellular dynamics during normal pregnancy. BMC Med Genomics 13:25. https:\/\/doi.org\/10.1186\/s12920-020-0690-5","journal-title":"BMC Med Genomics"},{"key":"7375_CR27","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1080\/10408444.2021.1907530","volume":"51","author":"BN Chorley","year":"2021","unstructured":"Chorley BN, Atabakhsh E, Doran G et al (2021) Methodological considerations for measuring biofluid-based microRNA biomarkers. Crit Rev Toxicol 51:264\u2013282. https:\/\/doi.org\/10.1080\/10408444.2021.1907530","journal-title":"Crit Rev Toxicol"},{"key":"7375_CR28","doi-asserted-by":"publisher","first-page":"34453","DOI":"10.1038\/srep34453","volume":"6","author":"F Boizard","year":"2016","unstructured":"Boizard F, Brunchault V, Moulos P et al (2016) A capillary electrophoresis coupled to mass spectrometry pipeline for long term comparable assessment of the urinary metabolome. Sci Rep 6:34453. https:\/\/doi.org\/10.1038\/srep34453","journal-title":"Sci Rep"},{"key":"7375_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jprot.2018.06.012","volume":"184","author":"B Buffin-Meyer","year":"2018","unstructured":"Buffin-Meyer B, Klein J, Breuil B et al (2018) Combination of the fetal urinary metabolome and peptidome for the prediction of postnatal renal outcome in fetuses with PUV. J Proteomics 184:1\u20139. https:\/\/doi.org\/10.1016\/j.jprot.2018.06.012","journal-title":"J Proteomics"},{"key":"7375_CR30","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1373\/clinchem.2018.287045","volume":"64","author":"JA Kirwan","year":"2018","unstructured":"Kirwan JA, Brennan L, Broadhurst D et al (2018) Preanalytical processing and biobanking procedures of biological samples for metabolomics research: a white paper, community perspective (for \u201cPrecision Medicine and Pharmacometabolomics Task Group\u201d-The Metabolomics Society Initiative). Clin Chem 64:1158\u20131182. https:\/\/doi.org\/10.1373\/clinchem.2018.287045","journal-title":"Clin Chem"},{"key":"7375_CR31","doi-asserted-by":"publisher","first-page":"2607","DOI":"10.1096\/fj.11-198093","volume":"26","author":"S Krug","year":"2012","unstructured":"Krug S, Kastenmuller G, Stuckler F et al (2012) The dynamic range of the human metabolome revealed by challenges. FASEB J 26:2607\u20132619. https:\/\/doi.org\/10.1096\/fj.11-198093","journal-title":"FASEB J"},{"key":"7375_CR32","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.1074\/mcp.R800001-MCP200","volume":"7","author":"S Decramer","year":"2008","unstructured":"Decramer S, Gonzalez de Peredo A, Breuil B et al (2008) Urine in clinical proteomics. Mol Cell Proteomics 7:1850\u20131862. https:\/\/doi.org\/10.1074\/mcp.R800001-MCP200","journal-title":"Mol Cell Proteomics"},{"key":"7375_CR33","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3005807","volume":"5","author":"J Klein","year":"2013","unstructured":"Klein J, Lacroix C, Caubet C et al (2013) Fetal urinary peptides to predict postnatal outcome of renal disease in fetuses with posterior urethral valves (PUV). Sci Transl Med 5:198ra106. https:\/\/doi.org\/10.1126\/scitranslmed.3005807","journal-title":"Sci Transl Med"},{"key":"7375_CR34","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/s00467-019-04390-9","volume":"35","author":"B Buffin-Meyer","year":"2020","unstructured":"Buffin-Meyer B, Tkaczyk M, Sta\u0144czyk M et al (2020) A single-center study to evaluate the efficacy of a fetal urine peptide signature predicting postnatal renal outcome in fetuses with posterior urethral valves. Pediatr Nephrol 35:469\u2013475. https:\/\/doi.org\/10.1007\/s00467-019-04390-9","journal-title":"Pediatr Nephrol"},{"key":"7375_CR35","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1007\/s00467-017-3614-7","volume":"32","author":"\u00c9LM Vieira","year":"2017","unstructured":"Vieira \u00c9LM, Pessoa Rocha N, Macedo Bastos F et al (2017) Posterior urethral valve in fetuses: evidence for the role of inflammatory molecules. Pediatr Nephrol 32:1391\u20131400. https:\/\/doi.org\/10.1007\/s00467-017-3614-7","journal-title":"Pediatr Nephrol"},{"key":"7375_CR36","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1007\/s00467-024-06608-x","volume":"40","author":"N Geraud","year":"2025","unstructured":"Geraud N, Casemayou A, Alves M et al (2025) Evaluation of predictive performance of fetal urinary inflammatory markers of postnatal kidney function in fetuses with posterior urethral valves. Pediatr Nephrol 40:1023\u20131032. https:\/\/doi.org\/10.1007\/s00467-024-06608-x","journal-title":"Pediatr Nephrol"},{"key":"7375_CR37","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1038\/jp.2016.107","volume":"36","author":"P Danziger","year":"2016","unstructured":"Danziger P, Berman DR, Luckritz K et al (2016) Severe congenital anomalies of the kidney and urinary tract: epidemiology can inform ethical decision-making. J Perinatol 36:954\u2013959. https:\/\/doi.org\/10.1038\/jp.2016.107","journal-title":"J Perinatol"},{"key":"7375_CR38","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-025-06994-w","author":"J Mulder","year":"2025","unstructured":"Mulder J, Kohl S, Fontanella F et al (2025) Early diagnosis and intervention in congenital lower urinary tract obstruction: time to revise our approach? Pediatr Nephrol. https:\/\/doi.org\/10.1007\/s00467-025-06994-w","journal-title":"Pediatr Nephrol"},{"key":"7375_CR39","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/S2352-4642(26)00011-8","volume":"10","author":"EC Weber","year":"2026","unstructured":"Weber EC, Kohl S, Gottschalk I et al (2026) Survival, kidney function, and complications in the first year of life following intrauterine shunting for first-trimester fetal megacystis (IUS1st): analysis of a prospective observational cohort. Lancet Child Adolesc Health 10:330\u2013339. https:\/\/doi.org\/10.1016\/S2352-4642(26)00011-8","journal-title":"Lancet Child Adolesc Health"},{"key":"7375_CR40","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1016\/S0140-6736(13)60992-7","volume":"382","author":"RK Morris","year":"2013","unstructured":"Morris RK, Malin GL, Quinlan-Jones E et al (2013) Percutaneous vesicoamniotic shunting versus conservative management for fetal lower urinary tract obstruction (PLUTO): a randomised trial. Lancet 382:1496\u20131506. https:\/\/doi.org\/10.1016\/S0140-6736(13)60992-7","journal-title":"Lancet"},{"key":"7375_CR41","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/s41585-024-00976-7","volume":"22","author":"AR Jackson","year":"2025","unstructured":"Jackson AR, Amado NG, Mann N et al (2025) Advancing the state of the art in congenital obstructive uropathy. Nat Rev Urol 22:249\u2013250. https:\/\/doi.org\/10.1038\/s41585-024-00976-7","journal-title":"Nat Rev Urol"},{"key":"7375_CR42","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1007\/s00467-017-3593-8","volume":"32","author":"R Ruano","year":"2017","unstructured":"Ruano R, Dunn T, Braun MC et al (2017) Lower urinary tract obstruction: fetal intervention based on prenatal staging. Pediatr Nephrol 32:1871\u20131878. https:\/\/doi.org\/10.1007\/s00467-017-3593-8","journal-title":"Pediatr Nephrol"},{"key":"7375_CR43","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.jpurol.2021.01.034","volume":"17","author":"M-K Farrugia","year":"2021","unstructured":"Farrugia M-K, Kilby MD (2021) Therapeutic intervention for fetal lower urinary tract obstruction: current evidence and future strategies. J Pediatr Urol 17:193\u2013199. https:\/\/doi.org\/10.1016\/j.jpurol.2021.01.034","journal-title":"J Pediatr Urol"},{"key":"7375_CR44","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/ncpneph0098","volume":"2","author":"RL Chevalier","year":"2006","unstructured":"Chevalier RL (2006) Obstructive nephropathy: towards biomarker discovery and gene therapy. Nat Clin Pract Nephrol 2:157\u2013168","journal-title":"Nat Clin Pract Nephrol"},{"key":"7375_CR45","doi-asserted-by":"publisher","first-page":"4802","DOI":"10.1016\/j.jprot.2012.05.018","volume":"75","author":"A Khan","year":"2012","unstructured":"Khan A (2012) Detection and quantitation of forty eight cytokines, chemokines, growth factors and nine acute phase proteins in healthy human plasma, saliva and urine. J Proteomics 75:4802\u20134819. https:\/\/doi.org\/10.1016\/j.jprot.2012.05.018","journal-title":"J Proteomics"},{"key":"7375_CR46","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1111\/eci.12428","volume":"45","author":"C Nobles","year":"2015","unstructured":"Nobles C, Bertone-Johnson ER, Ronnenberg AG et al (2015) Correlation of urine and plasma cytokine levels among reproductive-aged women. Eur J Clin Invest 45:460\u2013465. https:\/\/doi.org\/10.1111\/eci.12428","journal-title":"Eur J Clin Invest"},{"key":"7375_CR47","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1056\/NEJMra1300575","volume":"372","author":"DC Rockey","year":"2015","unstructured":"Rockey DC, Bell PD, Hill JA (2015) Fibrosis \u2014 a common pathway to organ injury and failure. N Engl J Med 372:1138\u20131149. https:\/\/doi.org\/10.1056\/NEJMra1300575","journal-title":"N Engl J Med"},{"key":"7375_CR48","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-78730-3","volume":"10","author":"C F\u00e9dou","year":"2020","unstructured":"F\u00e9dou C, Breuil B, Golovko I et al (2020) Comparison of the amniotic fluid and fetal urine peptidome for biomarker discovery in renal developmental disease. Sci Rep 10:21706. https:\/\/doi.org\/10.1038\/s41598-020-78730-3","journal-title":"Sci Rep"},{"key":"7375_CR49","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1038\/ki.2013.209","volume":"84","author":"Y Zuo","year":"2013","unstructured":"Zuo Y, Chun B, Potthoff SA et al (2013) Thymosin beta4 and its degradation product, Ac-SDKP, are novel reparative factors in renal fibrosis. Kidney Int 84:1166\u20131175. https:\/\/doi.org\/10.1038\/ki.2013.209","journal-title":"Kidney Int"},{"key":"7375_CR50","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.jpurol.2015.07.012","volume":"11","author":"LI Smith-Harrison","year":"2015","unstructured":"Smith-Harrison LI, Hougen HY, Timberlake MD, Corbett ST (2015) Current applications of in utero intervention for lower urinary tract obstruction. J Pediatr Urol 11:341\u2013347. https:\/\/doi.org\/10.1016\/j.jpurol.2015.07.012","journal-title":"J Pediatr Urol"},{"key":"7375_CR51","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001249","volume":"2","author":"H Mischak","year":"2010","unstructured":"Mischak H, Allmaier G, Apweiler R et al (2010) Recommendations for biomarker identification and qualification in clinical proteomics. Sci Transl Med 2:46ps42. https:\/\/doi.org\/10.1126\/scitranslmed.3001249","journal-title":"Sci Transl Med"},{"key":"7375_CR52","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1093\/ckj\/sfz107","volume":"13","author":"B Buffin-Meyer","year":"2020","unstructured":"Buffin-Meyer B, Klein J, van der Zanden LFM et al (2020) The ANTENATAL multicentre study to predict postnatal renal outcome in fetuses with posterior urethral valves: objectives and design. Clin Kidney J 13:371\u2013379. https:\/\/doi.org\/10.1093\/ckj\/sfz107","journal-title":"Clin Kidney J"},{"key":"7375_CR53","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1373\/clinchem.2015.248146","volume":"62","author":"PJ Jannetto","year":"2016","unstructured":"Jannetto PJ, Fitzgerald RL (2016) Effective use of mass spectrometry in the clinical laboratory. Clin Chem 62:92\u201398. https:\/\/doi.org\/10.1373\/clinchem.2015.248146","journal-title":"Clin Chem"},{"key":"7375_CR54","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/S2213-8587(20)30026-7","volume":"8","author":"N Tofte","year":"2020","unstructured":"Tofte N, Lindhardt M, Adamova K et al (2020) Early detection of diabetic kidney disease by urinary proteomics and subsequent intervention with spironolactone to delay progression (PRIORITY): a prospective observational study and embedded randomised placebo-controlled trial. Lancet Diabetes Endocrinol 8:301\u2013312. https:\/\/doi.org\/10.1016\/S2213-8587(20)30026-7","journal-title":"Lancet Diabetes Endocrinol"},{"key":"7375_CR55","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1038\/s41416-019-0472-z","volume":"120","author":"M Frantzi","year":"2019","unstructured":"Frantzi M, Gomez Gomez E, Blanca Pedregosa A et al (2019) CE\u2013MS-based urinary biomarkers to distinguish non-significant from significant prostate cancer. Br J Cancer 120:1120\u20131128. https:\/\/doi.org\/10.1038\/s41416-019-0472-z","journal-title":"Br J Cancer"},{"key":"7375_CR56","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.clinbiochem.2012.09.025","volume":"46","author":"H Mischak","year":"2013","unstructured":"Mischak H, Vlahou A, Ioannidis JP (2013) Technical aspects and inter-laboratory variability in native peptide profiling: the CE\u2013MS experience. Clin Biochem 46:432\u2013443. https:\/\/doi.org\/10.1016\/j.clinbiochem.2012.09.025","journal-title":"Clin Biochem"},{"key":"7375_CR57","doi-asserted-by":"publisher","unstructured":"Nkuipou-Kenfack E, Z\u00fcrbig P, Mischak H (2017) The long path towards implementation of clinical proteomics: exemplified based on CKD273. Proteomics Clin Appl 11:(5\u20136). https:\/\/doi.org\/10.1002\/prca.201600104","DOI":"10.1002\/prca.201600104"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-026-07375-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00467-026-07375-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-026-07375-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:54:14Z","timestamp":1792104854000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00467-026-07375-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,5]]},"references-count":57,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["7375"],"URL":"https:\/\/doi.org\/10.1007\/s00467-026-07375-7","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,5]]},"assertion":[{"value":"16 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}