{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:45:16Z","timestamp":1792107916508,"version":"4.4.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Joint Fund Project of Science and Technology Research and Development Plan of Henan Province","award":["232301420090"],"award-info":[{"award-number":["232301420090"]}]},{"name":"National Center for Inheritance and Innovation of Traditional Chinese Medicine jointly established a scientific research project","award":["2024ZXZX1126"],"award-info":[{"award-number":["2024ZXZX1126"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s00467-026-07444-x","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T16:48:39Z","timestamp":1783010919000},"page":"4461-4469","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation between urinary soluble CD163 and endocapillary proliferation and fibrinoid necrosis in IgA vasculitis with nephritis"],"prefix":"10.1007","volume":"41","author":[{"given":"Xiaoqing","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueli","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangliang","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianqing","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5035-4411","authenticated-orcid":false,"given":"Yanjie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"7444_CR1","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1097\/MNH.0000000000000972","volume":"33","author":"M Haas","year":"2024","unstructured":"Haas M (2024) IgA vasculitis nephritis: insights from kidney biopsies. Curr Opin Nephrol Hypertens 33:298\u2013303","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"7444_CR2","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s12882-024-03465-6","volume":"25","author":"Y Wang","year":"2024","unstructured":"Wang Y, Wang H, Ma X, Zhu Z, Tian X, Fu R, Jia L (2024) Characteristics of renal pathology and coagulation function in IgA nephropathy and IgA vasculitis associated nephritis. BMC Nephrol 25:35\u201341","journal-title":"BMC Nephrol"},{"key":"7444_CR3","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1186\/s12887-023-04243-3","volume":"23","author":"Y Lv","year":"2023","unstructured":"Lv Y, Fu R, Peng X-J, Wang Y, Yin T-T, Deng Y-Q (2023) Comparative study on clinicopathological features and prognosis of IgA vasculitis nephritis and IgA nephropathy in children. BMC Pediatr 23:423\u2013433","journal-title":"BMC Pediatr"},{"key":"7444_CR4","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/s00467-024-06502-6","volume":"40","author":"M Vivarelli","year":"2024","unstructured":"Vivarelli M, Samuel S, Coppo R, Barratt J, Bonilla-Felix M, Haffner D, Gibson K, Haas M, Abdel-Hafez MA, Adragna M, Brogan P, Kim S, Liu I, Liu Z-H, Mantan M, Shima Y, Shimuzu M, Shen Q, Trimarchi H, Hahn D, Hodson E, Pfister K, Alladin A, Boyer O, Nakanishi K (2024) IPNA clinical practice recommendations for the diagnosis and management of children with IgA nephropathy and IgA vasculitis nephritis. Pediatr Nephrol 40:533\u2013569","journal-title":"Pediatr Nephrol"},{"key":"7444_CR5","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1038\/nri2448","volume":"8","author":"DM Mosser","year":"2008","unstructured":"Mosser DM, Edwards JP (2008) Exploring the full spectrum of macrophage activation. Nat Rev Immunol 8:958\u2013969","journal-title":"Nat Rev Immunol"},{"key":"7444_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/cells13201679","volume":"13","author":"A Plevriti","year":"2024","unstructured":"Plevriti A, Lamprou M, Mourkogianni E, Skoulas N, Giannakopoulou M, Sajib MS, Wang Z, Mattheolabakis G, Chatzigeorgiou A, Marazioti A, Mikelis CM (2024) The role of soluble CD163 (sCD163) in human physiology and pathophysiology. Cells 13:1679","journal-title":"Cells"},{"key":"7444_CR7","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.2215\/CJN.07210520","volume":"15","author":"JP Aendekerk","year":"2020","unstructured":"Aendekerk JP, Timmermans SAMEG, Busch MH, Potjewijd J, Heeringa P, Damoiseaux JGMC, Reutelingsperger CP, van Paassen P (2020) Urinary soluble CD163 and disease activity in biopsy-proven ANCA-associated glomerulonephritis. Clin J Am Soc Nephrol 15:1740\u20131748","journal-title":"Clin J Am Soc Nephrol"},{"key":"7444_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtauto.2024.100244","volume":"9","author":"Y Renaudineau","year":"2024","unstructured":"Renaudineau Y, Chauveau D, Faguer S, Huart A, Ribes D, Pugnet G, Sailler L, Jamme T, Treiner E, Fortenfant F, Bost C, Carl\u00e9 C, Belliere J (2024) Urinary soluble CD163 is useful as \u201cliquid biopsy\u201d marker in lupus nephritis at both diagnosis and follow-up to predict impending flares. J Transl Autoimmun 9:100244","journal-title":"J Transl Autoimmun"},{"key":"7444_CR9","doi-asserted-by":"publisher","first-page":"3016","DOI":"10.1016\/j.ekir.2024.07.031","volume":"9","author":"J Li","year":"2024","unstructured":"Li J, Lv J, Wong MG, Shi S, Zan J, Monaghan H, Perkovic V, Zhang H, Zhang H, Perkovic V, Agarwal R, Barbour S, Cattran D, Cass A, Chan TM, Feehally J, Glassock R, Hladunewich MA, Hooi LS, Jardine MJ, Jha V, Johnson DW, Levin A, Liu Z-H, Lv J, Monaghan H, Reich H, Remuzzi G, Wheeler DC, Wong MG, Woodward M, Wu Y, Zhao M (2024) Correlation of urinary soluble CD163 levels with disease activity and treatment response in IgA nephropathy. Kidney Int Rep 9:3016\u20133026","journal-title":"Kidney Int Rep"},{"key":"7444_CR10","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1016\/j.kint.2017.02.003","volume":"91","author":"Trimarchi H, Barratt J, Cattran DC, Cook HT, Coppo R, Haas M, Liu ZH, Roberts IS, Yuzawa Y, Zhang H, Feehally J; IgAN Classification Working Group of the International IgA Nephropathy Network and the Renal Pathology Society; Conference Participants","year":"2017","unstructured":"Trimarchi H, Barratt J, Cattran DC, Cook HT, Coppo R, Haas M, Liu ZH, Roberts IS, Yuzawa Y, Zhang H, Feehally J; IgAN Classification Working Group of the International IgA Nephropathy Network and the Renal Pathology Society; Conference Participants (2017) Oxford Classification of IgA nephropathy 2016: an update from the IgA Nephropathy Classification Working Group. Kidney Int 91:1014\u20131021","journal-title":"Kidney Int"},{"key":"7444_CR11","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s12865-022-00529-w","volume":"23","author":"X-N An","year":"2022","unstructured":"An X-N, Wei Z-N, Xie Y-Y, Xu J, Shen Y, Ni L-Y, Shi H, Shen P-Y, Zhang W, Chen Y-X (2022) CD206+CD68+ mono-macrophages and serum soluble CD206 level are increased in antineutrophil cytoplasmic antibodies associated glomerulonephritis. BMC Immunol 23:55\u201367","journal-title":"BMC Immunol"},{"key":"7444_CR12","doi-asserted-by":"publisher","first-page":"2906","DOI":"10.1681\/ASN.2015050511","volume":"27","author":"VP O\u2019Reilly","year":"2016","unstructured":"O\u2019Reilly VP, Wong L, Kennedy C, Elliot LA, O\u2019Meachair S, Coughlan AM, O\u2019Brien EC, Ryan MM, Sandoval D, Connolly E, Dekkema GJ, Lau J, Abdulahad WH, Sanders J-S, Heeringa P, Buckley C, O\u2019Brien C, Finn S, Cohen CD, Lindemeyer MT, Hickey FB, O\u2019Hara PV, Feighery C, Moran SM, Mellotte G, Clarkson MR, Dorman AJ, Murray PT, Little MA (2016) Urinary soluble CD163 in active renal vasculitis. J Am Soc Nephrol 27:2906\u20132916","journal-title":"J Am Soc Nephrol"},{"key":"7444_CR13","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-92655-5","volume":"11","author":"M Arai","year":"2021","unstructured":"Arai M, Mii A, Kashiwagi T, Shimizu A, Sakai Y (2021) The severity of glomerular endothelial cell injury is associated with infiltrating macrophage heterogeneity in endocapillary proliferative glomerulonephritis. Sci Rep 11:13339","journal-title":"Sci Rep"},{"key":"7444_CR14","doi-asserted-by":"publisher","first-page":"54","DOI":"10.2215\/CJN.03230314","volume":"10","author":"L Zhao","year":"2015","unstructured":"Zhao L, David MZ, Hyjek E, Chang A, Meehan SM (2015) M2 macrophage infiltrates in the early stages of ANCA-associated pauci-immune necrotizing GN. Clin J Am Soc Nephrol 10:54\u201362","journal-title":"Clin J Am Soc Nephrol"},{"key":"7444_CR15","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1172\/JCI112112","volume":"76","author":"SR Holdsworth","year":"1985","unstructured":"Holdsworth SR, Tipping PG (1985) Macrophage-induced glomerular fibrin deposition in experimental glomerulonephritis in the rabbit. J Clin Invest 76:1367\u20131374","journal-title":"J Clin Invest"},{"key":"7444_CR16","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1172\/JCI108670","volume":"59","author":"H Rothberger","year":"1977","unstructured":"Rothberger H, Zimmerman TS, Spiegelberg HL, Vaughan JH (1977) Leukocyte procoagulant activity: enhancement of production in vitro by IgG and antigen-antibody complexes. J Clin Invest 59:549\u2013557","journal-title":"J Clin Invest"},{"key":"7444_CR17","first-page":"38","volume":"37","author":"SR Holdsworth","year":"1979","unstructured":"Holdsworth SR, Thomson NM, Glasgow EF, Atkins RC (1979) The effect of defibrination on macrophage participation in rabbit nephrotoxic nephritis: studies using glomerular culture and electronmicroscopy. Clin Exp Immunol 37:38\u201343","journal-title":"Clin Exp Immunol"},{"key":"7444_CR18","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/0049-3848(82)90300-0","volume":"27","author":"H Rothberger","year":"1982","unstructured":"Rothberger H, Lee TK, Dunne J, Zimmerman TS (1982) Increases of leukocyte tissue factor activity stimulated by red cells sensitized with human blood group alloantibodies. Thromb Res 27:537\u2013547","journal-title":"Thromb Res"},{"key":"7444_CR19","doi-asserted-by":"publisher","first-page":"3231","DOI":"10.1172\/JCI122045","volume":"128","author":"AR Kitching","year":"2018","unstructured":"Kitching AR, Alikhan MA (2018) CD8+ cells and glomerular crescent formation: outside-in as well as inside-out. J Clin Invest 128:3231\u20133233","journal-title":"J Clin Invest"},{"key":"7444_CR20","doi-asserted-by":"publisher","first-page":"3413","DOI":"10.1172\/JCI97879","volume":"128","author":"A Chen","year":"2018","unstructured":"Chen A, Lee K, D\u2019Agati VD, Wei C, Fu J, Guan T-J, He JC, Schlondorff D, Agudo J (2018) Bowman\u2019s capsule provides a protective niche for podocytes from cytotoxic CD8+ T cells. J Clin Invest 128:3413\u20133424","journal-title":"J Clin Invest"},{"key":"7444_CR21","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1093\/ndt\/gfz043","volume":"35","author":"D Schlondorff","year":"2020","unstructured":"Schlondorff D, He JC, Guan T, Lee K, Chen A (2020) Role of CD8+ T cells in crescentic glomerulonephritis. Nephrol Dial Transplant 35:564\u2013572","journal-title":"Nephrol Dial Transplant"},{"key":"7444_CR22","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.831253","volume":"13","author":"L Ye","year":"2022","unstructured":"Ye L, Liu Y, Zhu X, Duan T, Wang C, Fu X, Song P, Yuan S, Liu H, Sun L, Liu F, Lee K, He JC, Chen A (2022) Digital spatial profiling of individual glomeruli from patients with anti-neutrophil cytoplasmic autoantibody-associated glomerulonephritis. Front Immunol 13:831253","journal-title":"Front Immunol"},{"key":"7444_CR23","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1007\/s00467-021-04950-y","volume":"37","author":"MC Hastings","year":"2021","unstructured":"Hastings MC, Rizk DV, Kiryluk K, Nelson R, Zahr RS, Novak J, Wyatt RJ (2021) IgA vasculitis with nephritis: update of pathogenesis with clinical implications. Pediatr Nephrol 37:719\u2013733","journal-title":"Pediatr Nephrol"},{"key":"7444_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2025.151571","volume":"44","author":"E Pillebout","year":"2025","unstructured":"Pillebout E (2025) IgA vasculitis and IgA nephropathy: two sides of the same coin? Semin Nephrol 44:151571","journal-title":"Semin Nephrol"},{"key":"7444_CR25","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1093\/ndt\/gfae143","volume":"40","author":"J Friedrich","year":"2024","unstructured":"Friedrich J, Bellmann M, Klank D, Porubsky S, Bergner R (2024) Clinical and histological comparison of IgA nephritis and renal IgA vasculitis. Nephrol Dial Transplant 40:182\u2013192","journal-title":"Nephrol Dial Transplant"},{"key":"7444_CR26","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.2215\/CJN.07210520","volume":"15","author":"JP Aendekerk","year":"2020","unstructured":"Aendekerk JP, Timmermans SAMEG, Busch MH, Potjewijd J, Heeringa P, Damoiseaux JGMC, Reutelingsperger CP, van Paassen P, Registry LR (2020) Urinary soluble CD163 and disease activity in biopsy-proven ANCA-associated glomerulonephritis. Clin J Am Soc Nephrol 15:1740\u20131748","journal-title":"Clin J Am Soc Nephrol"},{"key":"7444_CR27","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.clim.2019.06.005","volume":"205","author":"P-p Sun","year":"2019","unstructured":"Sun P-p, Zhou X-j, Su J-q, Wang C, Yu X-j, Su T, Liu G, Wang S-x, Nie J, Yang L (2019) Urine macrophages reflect kidney macrophage content during acute tubular interstitial and glomerular injury. Clin Immunol 205:65\u201374","journal-title":"Clin Immunol"},{"key":"7444_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2022.102914","volume":"133","author":"JP Aendekerk","year":"2022","unstructured":"Aendekerk JP, Jiemy WF, Raveling-Eelsing E, Bijnens N, Abdul-Hamid MA, Strating IM, Dekkema GJ, Sanders JF, Stegeman CA, Damoiseaux JGMC, Little MA, Heeringa P, van Paassen P (2022) CD163 and CD206 expression define distinct macrophage subsets involved in active ANCA-associated glomerulonephritis. J Autoimmun 133:102914","journal-title":"J Autoimmun"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-026-07444-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00467-026-07444-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-026-07444-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:54:25Z","timestamp":1792104865000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00467-026-07444-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,2]]},"references-count":28,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["7444"],"URL":"https:\/\/doi.org\/10.1007\/s00467-026-07444-x","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,2]]},"assertion":[{"value":"25 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The author declares no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}