{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:45:10Z","timestamp":1792107910299,"version":"4.4.0"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Infections are a leading cause of hospitalization and death in children receiving maintenance peritoneal dialysis (PD). Touch contamination is an established risk factor for development of peritonitis, but data regarding optimal management of touch contamination are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study using data submitted to the Standardizing Care to Improve Outcomes in Pediatric End Stage Kidney Disease (SCOPE) collaborative between 10\/1\/2011 and 7\/31\/2025 to evaluate touch contamination in children. Reported touch contamination events and their management, including administration of prophylactic antibiotics and transfer set changes, were evaluated. Univariate and multivariable generalized linear mixed modeling were used to assess relationships between demographic factors and episodes of touch contamination and between management of touch contamination events and temporally associated peritonitis. We also evaluated the microbiology of touch contamination-associated peritonitis and compared it to peritonitis not associated with touch contamination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 2685 children included, 846 (32%) reported at least one touch contamination. In a multivariable model, younger age and non-Hispanic Black race were associated with increased rates of touch contamination. Administration of prophylactic antibiotics following touch contamination was associated with a lower prevalence of peritonitis (23% vs. 38%). Most episodes of touch contamination-associated peritonitis were Gram-positive (46%) or culture negative (24%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Touch contaminations are common in children undergoing maintenance PD. Administration of prophylactic antibiotics following touch contamination is associated with decreased risk of peritonitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                    <jats:p>A higher resolution version of the Graphical abstract is available as Supplementary information.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00467-026-07455-8","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T09:33:42Z","timestamp":1783676022000},"page":"4589-4596","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Touch contamination and associated peritonitis in children undergoing maintenance peritoneal dialysis"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0337-1168","authenticated-orcid":false,"given":"Rebecca G.","family":"Same","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie K.","family":"Grills","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreejata","family":"Dutta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia M.","family":"Neu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley A.","family":"Warady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandy","family":"Begin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"7455_CR1","unstructured":"United States Renal Data System (2024) USRDS annual data report: epidemiology of kidney disease in the United States. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases,\u00a0Bethesda, MD"},{"key":"7455_CR2","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.2215\/CJN.02540316","volume":"11","author":"CB Sethna","year":"2016","unstructured":"Sethna CB, Bryant K, Munshi R et al (2016) Risk factors for and outcomes of catheter-associated peritonitis in children: the SCOPE collaborative. Clin J Am Soc Nephrol 11:1590\u20131596. https:\/\/doi.org\/10.2215\/CJN.02540316","journal-title":"Clin J Am Soc Nephrol"},{"key":"7455_CR3","doi-asserted-by":"publisher","first-page":"612","DOI":"10.3747\/pdi.2011.00268","volume":"32","author":"DYH Yap","year":"2012","unstructured":"Yap DYH, Chu WL, Ng F, Yip TPS, Lui SL, Lo WK (2012) Risk factors and outcome of contamination in patients on peritoneal dialysis- -a single-center experience of 15 years. Perit Dial Int J Int Soc Perit Dial 32:612\u2013616. https:\/\/doi.org\/10.3747\/pdi.2011.00268","journal-title":"Perit Dial Int J Int Soc Perit Dial"},{"key":"7455_CR4","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1177\/08968608241274096","volume":"44","author":"BA Warady","year":"2024","unstructured":"Warady BA, Same R, Borzych-Duzalka D et al (2024) Clinical practice guideline for the prevention and management of peritoneal dialysis associated infections in children: 2024 update. Perit Dial Int J Int Soc Perit Dial 44:303\u2013364. https:\/\/doi.org\/10.1177\/08968608241274096","journal-title":"Perit Dial Int J Int Soc Perit Dial"},{"key":"7455_CR5","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1177\/08968608221080586","volume":"42","author":"PKT Li","year":"2022","unstructured":"Li PKT, Chow KM, Cho Y et al (2022) ISPD peritonitis guideline recommendations: 2022 update on prevention and treatment. Perit Dial Int J Int Soc Perit Dial 42:110\u2013153. https:\/\/doi.org\/10.1177\/08968608221080586","journal-title":"Perit Dial Int J Int Soc Perit Dial"},{"key":"7455_CR6","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1007\/s00467-016-3530-2","volume":"32","author":"M Laster","year":"2017","unstructured":"Laster M, Soohoo M, Hall C et al (2017) Racial-ethnic disparities in mortality and kidney transplant outcomes among pediatric dialysis patients. Pediatr Nephrol 32:685\u2013695. https:\/\/doi.org\/10.1007\/s00467-016-3530-2","journal-title":"Pediatr Nephrol"},{"key":"7455_CR7","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1007\/s00467-017-3872-4","volume":"33","author":"R Munshi","year":"2018","unstructured":"Munshi R, Sethna CB, Richardson T et al (2018) Fungal peritonitis in the standardizing care to improve outcomes in pediatric end stage renal disease (SCOPE) collaborative. Pediatr Nephrol 33:873\u2013880. https:\/\/doi.org\/10.1007\/s00467-017-3872-4","journal-title":"Pediatr Nephrol"},{"key":"7455_CR8","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1093\/jpids\/piaa173","volume":"10","author":"RG Same","year":"2021","unstructured":"Same RG, Hsu AJ, Cosgrove SE et al (2021) Antibiotic-associated adverse events in hospitalized children. J Pediatr Infect Dis Soc 10:622\u2013628. https:\/\/doi.org\/10.1093\/jpids\/piaa173","journal-title":"J Pediatr Infect Dis Soc"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-026-07455-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00467-026-07455-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-026-07455-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:54:12Z","timestamp":1792104852000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00467-026-07455-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,10]]},"references-count":8,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["7455"],"URL":"https:\/\/doi.org\/10.1007\/s00467-026-07455-8","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,10]]},"assertion":[{"value":"7 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}