{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T07:14:58Z","timestamp":1788506098366,"version":"build-2803163510"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>While successful kidney transplantation has been reported in pediatric patients with primary mitochondrial diseases, immunosuppression regimen and its effect on systemic disease were not described. We present four pediatric patients with genetically confirmed RMND1 disease in a quaternary nephrology center. They presented at a very young age and progressed rapidly to stage 5 chronic kidney disease. All underwent successful kidney transplantation. Their allograft function remained stable throughout the follow-up period, and they did not manifest any major systemic deterioration.<\/jats:p>","DOI":"10.1007\/s00467-026-07527-9","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T07:06:29Z","timestamp":1788505589000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immunosuppression in children with primary mitochondrial diseases after kidney transplantation: insight from case series of RMND1-related disease"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7265-9798","authenticated-orcid":false,"given":"Sze Wa","family":"Wong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Tomlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9887-9081","authenticated-orcid":false,"given":"Jelena","family":"Stojanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"7527_CR1","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/j.ajhg.2012.08.020","volume":"91","author":"A Janer","year":"2012","unstructured":"Janer A, Antonicka H, Lalonde E, Nishimura T, Sasarman F, Brown GK, Brown RM, Majewski J, Shoubridge EA (2012) An RMND1 mutation causes encephalopathy associated with multiple oxidative phosphorylation complex deficiencies and a mitochondrial translation defect. Am J Hum Genet 91:737\u2013743. https:\/\/doi.org\/10.1016\/j.ajhg.2012.08.020","journal-title":"Am J Hum Genet"},{"key":"7527_CR2","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1136\/jmedgenet-2016-103910","volume":"53","author":"YS Ng","year":"2016","unstructured":"Ng YS, Alston CL, Diodato D et al (2016) The clinical, biochemical and genetic features associated with RMND1-related mitochondrial disease. J Med Genet 53:768\u2013775. https:\/\/doi.org\/10.1136\/jmedgenet-2016-103910","journal-title":"J Med Genet"},{"key":"7527_CR3","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s00467-023-06079-6","volume":"39","author":"M K\u00f6mhoff","year":"2024","unstructured":"K\u00f6mhoff M, Gracchi V, Dijkman H, Beck BB, Monnens L (2024) Hyporeninemic hypoaldosteronism in RMND1-related mitochondrial disease. Pediatr Nephrol 39:125\u2013129. https:\/\/doi.org\/10.1007\/s00467-023-06079-6","journal-title":"Pediatr Nephrol"},{"key":"7527_CR4","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.1007\/s00467-025-06787-1","volume":"40","author":"L Marsili","year":"2025","unstructured":"Marsili L, Mantecon M, Arrondel C, Barcia G, Assouline Z, Gribouval O, Wellesley D, Harrison V, Marijon P, Colson C, Stichelbout M, Gubler MC, Antignac C, Rotig A, Heidet L (2025) Genome sequencing identifies RMND1 as a strong candidate gene for severe prenatal kidney failure mimicking renal tubular dysgenesis associated with hyporeninism. Pediatr Nephrol 40:2823\u20132828. https:\/\/doi.org\/10.1007\/s00467-025-06787-1","journal-title":"Pediatr Nephrol"},{"key":"7527_CR5","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-021-02460-5","volume":"22","author":"J Dudley","year":"2021","unstructured":"Dudley J, Christian M, Andrews A et al (2021) Clinical practice guidelines standardisation of immunosuppressive and anti-infective drug regimens in UK paediatric renal transplantation: the harmonisation programme. BMC Nephrol 22. https:\/\/doi.org\/10.1186\/s12882-021-02460-5","journal-title":"BMC Nephrol"},{"key":"7527_CR6","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-025-07034-3","author":"SW Wong","year":"2025","unstructured":"Wong SW, Fung CW, Tomlin F, Stojanovic J (2025) Kidney transplantation in mitochondrial diseases: a systematic review. Pediatr Nephrol. https:\/\/doi.org\/10.1007\/s00467-025-07034-3","journal-title":"Pediatr Nephrol"},{"key":"7527_CR7","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.kint.2018.08.0386","volume":"95","author":"SC Johnson","year":"2019","unstructured":"Johnson SC, Martinez F, Bitto A, Gonzalez B, Tazaerslan C, Cohen C, Delaval L, Timsit J, Knebelmann B, Terzi F, Mahal T, Zhu Y, Morgan PG, Sedensky MM, Kaeberlein M, Legendre C, Suh Y, Canaud G (2019) MTOR inhibitors may benefit kidney transplant recipients with mitochondrial diseases. Kidney Int 95:455\u2013466. https:\/\/doi.org\/10.1016\/j.kint.2018.08.0386","journal-title":"Kidney Int"},{"issue":"1","key":"7527_CR8","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s12964-017-0203-0","volume":"15","author":"A Lombardi","year":"2017","unstructured":"Lombardi A, Trimarco B, Iaccarino G, Santulli G (2017) Impaired mitochondrial calcium uptake caused by tacrolimus underlies beta-cell failure. Cell Commun Signal 15(1):47. https:\/\/doi.org\/10.1186\/s12964-017-0203-0","journal-title":"Cell Commun Signal"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-026-07527-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00467-026-07527-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-026-07527-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T07:06:29Z","timestamp":1788505589000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00467-026-07527-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,4]]},"references-count":8,"alternative-id":["7527"],"URL":"https:\/\/doi.org\/10.1007\/s00467-026-07527-9","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,4]]},"assertion":[{"value":"26 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written consents for inclusion into Rare Diseases Research Registry in the Department of Paediatric Nephology of GOSH were obtained from patient\u2019s legal guardian.","order":2,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}