{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:02:42Z","timestamp":1780459362478,"version":"3.54.1"},"reference-count":84,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T00:00:00Z","timestamp":1672617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T00:00:00Z","timestamp":1672617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Schmerz"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec>\n                <jats:title>Hintergrund<\/jats:title>\n                <jats:p>Aktuelle Leitlinien empfehlen f\u00fcr die Behandlung chronischer Schmerzen einen personalisierten, multimodalen und interdisziplin\u00e4ren Ansatz. Bereits in der akuten Behandlung postoperativer Schmerzen kann es sinnvoll sein, Risikofaktoren f\u00fcr die Chronifizierung zu minimieren. Die aurikul\u00e4re Vagusnervstimulation (aVNS) k\u00f6nnte eine effektive nichtmedikament\u00f6se Therapie zur Behandlung von Schmerzen darstellen.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ziel der Arbeit<\/jats:title>\n                <jats:p>Ziel dieser Arbeit ist die Evaluierung der klinischen Wirksamkeit der aVNS bei chronischen und akuten Schmerzen sowie deren Einfluss auf die begleitende Medikamenteneinnahme.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Material und Methoden<\/jats:title>\n                <jats:p>Es wurde eine systematische Literaturrecherche zur Anwendung aurikul\u00e4rer elektrischer Stimulation bei chronischen und akuten Schmerzen durchgef\u00fchrt. Die Studien wurden entsprechend ihrem Evidenzgrad klassifiziert, gem\u00e4\u00df Jadad-Skala und wissenschaftlicher Validit\u00e4t bewertet, und anschlie\u00dfend in Bezug auf Indikation, Methode, Stimulationsparameter, Behandlungsdauer, Wirksamkeit und Sicherheit analysiert.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ergebnisse<\/jats:title>\n                <jats:p>Es konnten 20\u00a0Studien zu chronischen Schmerzindikationen, 10\u00a0Studien zu akuten postoperativen Schmerzen sowie 7\u00a0Studien zu experimentellen akuten Schmerzen identifiziert und analysiert werden. Die Recherche ergab eine Gesamtanzahl von <jats:italic>n<\/jats:italic>\u202f=\u20091105 mit aVNS behandelten Patient*innen. Die beste Evidenz zur Wirksamkeit der aVNS liegt f\u00fcr die Indikationen chronischer Kreuzschmerz, chronisches Zervikalsyndrom, chronischer Unterleibsschmerz und chronischer Migr\u00e4ne sowie zu akutem postoperativen Schmerz bei Oozytenaspiration, laparoskopischer Nephrektomie und offenen kolorektalen Eingriffen vor. In der Mehrzahl der Studien konnte au\u00dferdem eine signifikante Reduktion der Schmerzmittel- bzw. Opiateinnahme gezeigt werden. In 3 randomisierten kontrollierten Studien bei chronischen Schmerzpatient*innen konnte eine nachhaltige Schmerzreduktion \u00fcber einen Zeitraum von bis zu 12\u00a0Monaten gezeigt werden. Insgesamt wurde die aVNS sehr gut vertragen.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Schlussfolgerung<\/jats:title>\n                <jats:p>Die Studienlage zeigt, dass die aVNS eine erg\u00e4nzende, effektive nichtmedikament\u00f6se Behandlung f\u00fcr Patient*innen mit chronischen und akuten postoperativen Schmerzen sein kann. Zuk\u00fcnftige Studien in den genannten Indikationen sollten auf eine Standardisierung und Optimierung von Behandlungsparametern, die st\u00e4rkere Einbeziehung von Quality-of-Life-Outcome-Parametern sowie l\u00e4ngere Follow-up-Perioden zum besseren Verst\u00e4ndnis der nachhaltigen therapeutischen Wirkung der aVNS fokussieren.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00482-022-00686-2","type":"journal-article","created":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T15:03:02Z","timestamp":1672671782000},"page":"267-278","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Klinische Wirksamkeit der aurikul\u00e4ren Vagusnervstimulation in der Behandlung chronischer und akuter Schmerzen","Clinical efficacy of auricular vagus nerve stimulation in the treatment of chronic and acute pain"],"prefix":"10.1007","volume":"38","author":[{"given":"Rudolf","family":"Likar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Perruchoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Kampusch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"K\u00f6stenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Sator","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Stremnitzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Neuwersch-Sommeregger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,2]]},"reference":[{"key":"686_CR1","doi-asserted-by":"publisher","first-page":"2040","DOI":"10.1016\/j.soard.2021.08.003","volume":"17","author":"BH Ahmed","year":"2021","unstructured":"Ahmed\u00a0BH, Courcoulas\u00a0AP, Monroe\u00a0AL et al (2021) Auricular nerve stimulation using the NSS\u20112 BRIDGE device to reduce opioid requirement following laparoscopic Roux-en\u2011Y gastric bypass. 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