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Bodyweight changes were obtained from the medical records of 84 oncological patients (59 men and 25 women, age range 37\u201391 yrs). Mean monthly AT was used to examine the association of weight changes across cold and warm bimesters -BIMs (December and January, vs. July and August), Trimesters -TRIMs (July to September vs. December to February), and Semesters -SEMs (May to October vs. November to April). Weight changes between two consecutive weight measures were categorized as weight gain, weight loss, or no weight change. Differences across cold and warm seasons were analysed using parametric (ANOVA), and nonparametric statistics (Chi-square and binomial z tests). An alpha-rate of 0.05 was used for all analyses. <\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A weight loss trend was observed during BIMs cold periods in comparison to warm ones (<jats:italic>p<\/jats:italic> 0.04). However, differences in average bodyweight were not significant. The negative impact of cold periods was more marked in men than in women, (<jats:italic>p<\/jats:italic>\u2009=\u20090.05; <jats:italic>p<\/jats:italic>\u2009=\u20090.03, for cold vs. warm BIMs and TRIMs, respectively). In contrast, significantly higher weight gain percentages were found in women during warm TRIMs and SEMs (<jats:italic>p<\/jats:italic>\u2009=\u20090.03, and <jats:italic>p<\/jats:italic>\u2009=\u20090.01, respectively). As for the number of patients dying during the study (<jats:italic>N<\/jats:italic>\u2009=\u200956; 39 men, 17 women), there were a significant interaction between temperature (cold\/warm), and mean weight <jats:italic>F (<\/jats:italic>1, 499)\u2009=\u20096.06, <jats:italic>p<\/jats:italic>\u2009=\u20090.01, which revealed a pattern of weight loss in the cold semester as opposed to weight gain during the warm SEM months. <\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>AT temperature modulated body weight changes in patients with advanced oncological disease and ACS. Two main limitations of the study were the absence of information on diets as a moderating factor of weight loss\/gain, and the lack of the patients\u2019 weight measurements closest to the date of diagnosis prior to admittance to the study. As for the practical implications, it remains to be seen whether an adjunctive heat supply will serve a buffering effect on weight loss during colder seasons for patients with advanced cancer and ACS. <\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00484-023-02513-4","type":"journal-article","created":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T02:01:31Z","timestamp":1688436091000},"page":"1451-1459","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ambient temperature modulates body weight changes in patients with advanced oncological diseases and anorexia cachexia syndrome"],"prefix":"10.1007","volume":"67","author":[{"given":"Paloma","family":"Encinas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Luis","family":"Rodriguez-Arias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Miguel Luengo","family":"P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Cortizo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5808-353X","authenticated-orcid":false,"given":"Emilio","family":"Gutierrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,7,4]]},"reference":[{"issue":"7","key":"2513_CR1","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1038\/sj.bjp.0706929","volume":"149","author":"RA Adan","year":"2006","unstructured":"Adan RA, Tiesjema B, Hillebrand JJ, la Fleur SE, Kas MJ, de Krom M (2006) The MC4 receptor and control of appetite. 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