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Although pharmacological treatments, including painkillers, are commonly used, they frequently provide only symptomatic relief and may cause side effects. Therefore, interest in non-pharmacological and dietary interventions is increasing. While inner ear sensitivity to barometric pressure fluctuations\u2014activating the sympathetic nervous system\u2014has traditionally been considered the main mechanism, we propose that reduced oxygen utilization due to peripheral hypoxia under low barometric pressure is also a key factor. Kaempferol, a dietary flavonoid, has been shown in prior studies to enhance oxygen utilization and promote parasympathetic nervous system dominance. We hypothesized that daily kaempferol intake would alleviate weather-related discomfort by improving oxygen use and autonomic balance. In this pilot study, 458 individuals with moderate weather-related symptoms took 10\u00a0mg of kaempferol daily for 4 weeks. Participants completed questionnaires before and after the intervention. Data from 387 individuals with over 80% adherence were analyzed. Results showed significant reductions in symptom frequency (e.g., headache: Cohen\u2019s\n                    <jats:italic>d<\/jats:italic>\n                    \u2009=\u20090.61,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), duration (rank-biserial correlation\u2009=\u20090.64,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and severity (Cohen\u2019s\n                    <jats:italic>d<\/jats:italic>\n                    \u2009=\u20090.57,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). By the end of the intervention, over 80% of participants reported symptom improvement. These findings suggest that kaempferol is a promising non-pharmacological strategy for managing weather-related physical and mental symptoms by targeting oxygen utilization and autonomic regulation. This trial is registered with the UMIN Clinical Trials Registry (UMIN000045066).\n                  <\/jats:p>","DOI":"10.1007\/s00484-025-02985-6","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T13:56:45Z","timestamp":1753365405000},"page":"2697-2709","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of kaempferol on weather-related pain: an open-label pilot study of subjective headache and other discomforts in pre-intervention and intervention periods in Japan"],"prefix":"10.1007","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9128-279X","authenticated-orcid":false,"given":"Yasutaka","family":"Ikeda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0105-3707","authenticated-orcid":false,"given":"Moe","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0979-2265","authenticated-orcid":false,"given":"Aina","family":"Gotoh-Katoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8926-8027","authenticated-orcid":false,"given":"Shoichiro","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8840-5149","authenticated-orcid":false,"given":"Jun","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"key":"2985_CR1","doi-asserted-by":"publisher","first-page":"108949","DOI":"10.1016\/j.jnutbio.2022.108949","volume":"103","author":"M Akiyama","year":"2022","unstructured":"Akiyama M, Mizokami T, Miyamoto S, Ikeda Y (2022) Kaempferol increases intracellular ATP content in C2C12 myotubes under hypoxic conditions by suppressing the HIF-1\u03b1 stabilization and\/or by enhancing the mitochondrial complex IV activity. 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(approval number 2102, dated July 28, 2021). The procedures used in this study adhere to the tenets of the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The participant has consented to the submission of the report to the journal.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"This study complies with the current laws of Japan.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}