{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T16:08:15Z","timestamp":1773936495489,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Biometeorol"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1007\/s00484-026-03153-0","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T17:26:07Z","timestamp":1771953967000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Psychological correlates of acute mountain sickness: a prospective study"],"prefix":"10.1007","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5684-5625","authenticated-orcid":false,"given":"Zhengyang","family":"Zeng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9984-5948","authenticated-orcid":false,"given":"Lun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6369-4105","authenticated-orcid":false,"given":"Xing","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0152-5219","authenticated-orcid":false,"given":"Hao","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"issue":"3","key":"3153_CR1","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1113\/jphysiol.2006.113936","volume":"575","author":"M Amann","year":"2006","unstructured":"Amann M, Eldridge MW, Lovering AT, Stickland MK, Pegelow DF, Dempsey JA (2006) Arterial oxygenation influences central motor output and exercise performance via effects on peripheral locomotor muscle fatigue in humans. J Physiol 575(3):937\u2013952. https:\/\/doi.org\/10.1113\/jphysiol.2006.113936","journal-title":"J Physiol"},{"issue":"2","key":"3153_CR2","doi-asserted-by":"publisher","first-page":"222","DOI":"10.35235\/uicd.465913","volume":"1","author":"D Aras","year":"2018","unstructured":"Aras D, Ak\u00e7a F, G\u00fcler \u00d6, Bi\u0307Rol A, Erteti\u0307K G, \u00c7eti\u0307Nkaya G, Akalan C (2018) Extreme altitude mountain climbing decreases sensation seeking score and increases the anxiety level. Uluslararas\u0131 \u0130nsan \u00c7al\u0131\u015fmalar\u0131 Dergisi 1(2):222\u2013234. https:\/\/doi.org\/10.35235\/uicd.465913","journal-title":"Uluslararas\u0131 \u0130nsan \u00c7al\u0131\u015fmalar\u0131 Dergisi"},{"issue":"2","key":"3153_CR3","doi-asserted-by":"publisher","first-page":"97","DOI":"10.2165\/00007256-199316020-00003","volume":"16","author":"MS Bahrke","year":"1993","unstructured":"Bahrke MS, Shukitt-Hale B (1993) Effects of altitude on mood, behaviour and cognitive functioning: A review. Sports Med 16(2):97\u2013125. https:\/\/doi.org\/10.2165\/00007256-199316020-00003","journal-title":"Sports Med"},{"key":"3153_CR4","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.physbeh.2016.09.008","volume":"167","author":"S-Z Bian","year":"2016","unstructured":"Bian S-Z, Jin J, Dong J-Q, Li Q-N, Yu J, Tang C-F, Yu S-Y, Zhao X-H, Qin J, Huang L (2016) A higher baseline somatization score at sea level as an independent predictor of acute mountain sickness. Physiol Behav 167:202\u2013208. https:\/\/doi.org\/10.1016\/j.physbeh.2016.09.008","journal-title":"Physiol Behav"},{"issue":"1","key":"3153_CR5","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/s41398-019-0510-x","volume":"9","author":"S-Z Bian","year":"2019","unstructured":"Bian S-Z, Zhang L, Jin J, Zhang J-H, Li Q-N, Yu J, Chen J-F, Yu S-Y, Zhao X-H, Qin J (2019) The onset of sleep disturbances and their associations with anxiety after acute high-altitude exposure at 3700 m. Translational Psychiatry 9(1):175. https:\/\/doi.org\/10.1038\/s41398-019-0510-x","journal-title":"Translational Psychiatry"},{"issue":"6","key":"3153_CR6","doi-asserted-by":"publisher","first-page":"e0197147","DOI":"10.1371\/journal.pone.0197147","volume":"13","author":"CJ Boos","year":"2018","unstructured":"Boos CJ, Bass M, O\u2019Hara JP, Vincent E, Mellor A, Sevier L, Abdul-Razakq H, Cooke M, Barlow M, Woods DR (2018) The relationship between anxiety and acute mountain sickness. PLoS ONE 13(6):e0197147. https:\/\/doi.org\/10.1371\/journal.pone.0197147","journal-title":"PLoS ONE"},{"issue":"19","key":"3153_CR7","doi-asserted-by":"publisher","first-page":"e70601","DOI":"10.14814\/phy2.70601","volume":"13","author":"RM Bottura","year":"2025","unstructured":"Bottura RM, Bisio A, Hipolide DC (2025) Early adaptation to high-altitude: mood and cognitive responses at simulated 4500 m. Physiological Rep 13(19):e70601. https:\/\/doi.org\/10.14814\/phy2.70601","journal-title":"Physiological Rep"},{"key":"3153_CR8","doi-asserted-by":"publisher","first-page":"104718","DOI":"10.1016\/j.neubiorev.2022.104718","volume":"138","author":"J Burtscher","year":"2022","unstructured":"Burtscher J, Niedermeier M, H\u00fcfner K, van den Burg E, Kopp M, Stoop R, Burtscher M, Gatterer H, Millet GP (2022) The interplay of hypoxic and mental stress: implications for anxiety and depressive disorders. Neurosci Biobehavioral Reviews 138:104718. https:\/\/doi.org\/10.1016\/j.neubiorev.2022.104718","journal-title":"Neurosci Biobehavioral Reviews"},{"issue":"2","key":"3153_CR9","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/0022-3999(93)90081-P","volume":"37","author":"T Chalder","year":"1993","unstructured":"Chalder T, Berelowitz G, Pawlikowska T, Watts L, Wessely S, Wright D, Wallace EP (1993) Development of a fatigue scale. J Psychosom Res 37(2):147\u2013153. https:\/\/doi.org\/10.1016\/0022-3999(93)90081-P","journal-title":"J Psychosom Res"},{"issue":"1","key":"3153_CR10","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s11682-019-00241-1","volume":"15","author":"X Chen","year":"2021","unstructured":"Chen X, Liu, Jian, Wang J, Xin Z, Zhang Q, Zhang W, Xi Y, Zhu Y, Li C, Li J, Han Y, Liu, Jie, Li B, Luo W, Chen J (2021) Altered resting-state networks May explain the executive impairment in young health immigrants into high-altitude area. Brain Imaging Behav 15(1):147\u2013156. https:\/\/doi.org\/10.1007\/s11682-019-00241-1","journal-title":"Brain Imaging Behav"},{"issue":"9","key":"3153_CR11","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1111\/j.1469-8986.2012.01411.x","volume":"49","author":"V De Aquino Lemos","year":"2012","unstructured":"De Aquino Lemos V, Antunes HKM, Santos D, Lira RVT, Tufik FS, S., De Mello MT (2012) High altitude exposure impairs sleep patterns, mood, and cognitive functions. Psychophysiology 49(9):1298\u20131306. https:\/\/doi.org\/10.1111\/j.1469-8986.2012.01411.x","journal-title":"Psychophysiology"},{"issue":"1","key":"3153_CR12","first-page":"13","volume":"9","author":"LR Derogatis","year":"1973","unstructured":"Derogatis LR, Lipman RS, Covi L (1973) SCL-90: An outpatient psychiatric rating scale\u2013preliminary report. Psychopharmacol Bull 9(1):13\u201328","journal-title":"Psychopharmacol Bull"},{"key":"3153_CR13","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.physbeh.2013.02.001","volume":"112","author":"J Dong","year":"2013","unstructured":"Dong J, Zhang J, Qin J, Li Q, Huang W, Gao X, Yu J, Chen G, Tang X, Huang L (2013) Anxiety correlates with somatic symptoms and sleep status at high altitudes. Physiol Behav 112:23\u201331. https:\/\/doi.org\/10.1016\/j.physbeh.2013.02.001","journal-title":"Physiol Behav"},{"issue":"5","key":"3153_CR14","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1249\/01.MSS.0000162688.54089.CE","volume":"37","author":"M Facco","year":"2005","unstructured":"Facco M, Zilli C, Siviero M, Ermolao A, Travain G, Baesso I, Bonamico S, Cabrelle A, Zaccaria M, Agostini C (2005) Modulation of immune response by the acute and chronic exposure to high altitude. Med Sci Sports Exerc 37(5):768\u2013774. https:\/\/doi.org\/10.1249\/01.MSS.0000162688.54089.CE","journal-title":"Med Sci Sports Exerc"},{"issue":"10","key":"3153_CR15","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1111\/ene.12507","volume":"22","author":"Y-X Gao","year":"2015","unstructured":"Gao Y-X, Li P, Jiang C, \u2010H., Liu C, Chen Y, Chen L, Ruan H, \u2010Z., Gao Y\u2010Q (2015) Psychological and cognitive impairment of long\u2010term migrators to high altitudes and the relationship to physiological and biochemical changes. Eur J Neurol 22(10):1363\u20131369. https:\/\/doi.org\/10.1111\/ene.12507","journal-title":"Eur J Neurol"},{"issue":"2","key":"3153_CR16","doi-asserted-by":"publisher","first-page":"E297","DOI":"10.1152\/ajpendo.00243.2019","volume":"318","author":"DM Keenan","year":"2020","unstructured":"Keenan DM, Hefti P, Veldhuis J, J. D., Von Wolff M (2020) Regulation and adaptation of endocrine axes at high altitude. Am J Physiology-Endocrinology Metabolism 318(2):E297\u2013E309. https:\/\/doi.org\/10.1152\/ajpendo.00243.2019","journal-title":"Am J Physiology-Endocrinology Metabolism"},{"issue":"2","key":"3153_CR17","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/BF00626758","volume":"62","author":"EA Koller","year":"1991","unstructured":"Koller EA, Bischoff M, B\u00fchrer A, Felder L, Schopen M (1991) Respiratory, circulatory and neuropsychological responses to acute hypoxia in acclimatized and non-acclimatized subjects. Eur J Appl Physiol Occup Physiol 62(2):67\u201372. https:\/\/doi.org\/10.1007\/BF00626758","journal-title":"Eur J Appl Physiol Occup Physiol"},{"key":"3153_CR18","doi-asserted-by":"publisher","first-page":"122319","DOI":"10.1016\/j.lfs.2023.122319","volume":"336","author":"X Li","year":"2024","unstructured":"Li X, Zhang, Juanhong, Liu G, Wu G, Wang R, Zhang J (2024) High altitude hypoxia and oxidative stress: the new hope brought by free radical scavengers. Life Sci 336:122319. https:\/\/doi.org\/10.1016\/j.lfs.2023.122319","journal-title":"Life Sci"},{"issue":"1suppl","key":"3153_CR19","doi-asserted-by":"publisher","first-page":"2S","DOI":"10.1016\/j.wem.2023.05.013","volume":"35","author":"AM Luks","year":"2024","unstructured":"Luks AM, Beidleman BA, Freer L, Grissom CK, Keyes LE, McIntosh SE, Rodway GW, Schoene RB, Zafren K, Hackett PH (2024) Wilderness medical society clinical practice guidelines for the prevention, diagnosis, and treatment of acute altitude illness: 2024 update. Wilderness Environ Med 35(1suppl):2S\u201319S. https:\/\/doi.org\/10.1016\/j.wem.2023.05.013","journal-title":"Wilderness Environ Med"},{"issue":"12","key":"3153_CR20","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.3357\/ASEM.4083.2014","volume":"85","author":"AJ Mellor","year":"2014","unstructured":"Mellor AJ, Woods DR, O\u2019Hara J, Howley M, Watchorn J, Boos C (2014) Rating of perceived exertion and acute mountain sickness during a high-altitude trek. Aviat Space Environ Med 85(12):1214\u20131216. https:\/\/doi.org\/10.3357\/ASEM.4083.2014","journal-title":"Aviat Space Environ Med"},{"key":"3153_CR21","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1159\/000435938","volume":"30","author":"ML Peters","year":"2015","unstructured":"Peters ML (2015) Emotional and cognitive influences on pain experience. Mod Trends Pharmacopsychiatry 30:138\u2013152. https:\/\/doi.org\/10.1159\/000435938","journal-title":"Mod Trends Pharmacopsychiatry"},{"key":"3153_CR22","unstructured":"Qiu L, Xue Z, Yanfei W (2008) Revision of the positive affect negative affect scale (PANAS). Chin J Appl Psychol 249\u2009\u2013\u200954\u2009+\u200968 (in Chinese)"},{"issue":"4","key":"3153_CR23","first-page":"291","volume":"62","author":"M Regard","year":"1991","unstructured":"Regard M, Landis T, Casey J, Maggiorini M, B\u00e4rtsch P, Oelz O (1991) Cognitive changes at high altitude in healthy climbers and in climbers developing acute mountain sickness. Aviat Space Environ Med 62(4):291\u2013295","journal-title":"Aviat Space Environ Med"},{"issue":"1","key":"3153_CR24","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1089\/ham.2017.0164","volume":"19","author":"RC Roach","year":"2018","unstructured":"Roach RC, Hackett PH, Oelz O, B\u00e4rtsch P, Luks AM, MacInnis MJ, Baillie JK, The Lake Louise AMS Score Consensus Committee, Achatz E, Albert E, Andrews JS, Anholm JD, Ashraf MZ, Auerbach P, Basnyat B, Beidleman BA, Berendsen RR, Berger MM, Bloch KE, Zafren K (2018) The 2018 lake Louise acute mountain sickness score. High Alt Med Biol 19(1):4\u20136. https:\/\/doi.org\/10.1089\/ham.2017.0164","journal-title":"High Alt Med Biol"},{"issue":"4667","key":"3153_CR25","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1136\/bmj.1.4667.1383","volume":"1","author":"H Selye","year":"1950","unstructured":"Selye H (1950) Stress and the general adaptation syndrome. BMJ 1(4667):1383. https:\/\/doi.org\/10.1136\/bmj.1.4667.1383","journal-title":"BMJ"},{"issue":"9 Pt 1","key":"3153_CR26","first-page":"865","volume":"62","author":"B Shukitt-Hale","year":"1991","unstructured":"Shukitt-Hale B, Banderet LE, Lieberman HR (1991) Relationships between symptoms, moods, performance, and acute mountain sickness at 4, 700 meters. Aviat Space Environ Med 62(9 Pt 1):865\u2013869. https:\/\/asma.kglmeridian.com\/downloadpdf\/view\/journals\/asem\/62\/9\/article-p865.pdf","journal-title":"Aviat Space Environ Med"},{"issue":"1","key":"3153_CR27","doi-asserted-by":"publisher","first-page":"e13906","DOI":"10.1111\/hex.13906","volume":"27","author":"LJ Smith","year":"2023","unstructured":"Smith LJ, Pyke W, Fowler R, Matthes B, de Goederen E, Surenthiran S (2023) Impact and experiences of vestibular disorders and psychological distress: qualitative findings from patients, family members and healthcare professionals. Health Expectations: Int J Public Participation Health Care Health Policy 27(1):e13906. https:\/\/doi.org\/10.1111\/hex.13906","journal-title":"Health Expectations: Int J Public Participation Health Care Health Policy"},{"issue":"4","key":"3153_CR28","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1177\/026988110201600408","volume":"16","author":"J Van Der Post","year":"2002","unstructured":"Van Der Post J, Noordzij LAW, De Kam ML, Blauw GJ, Cohen AF, Van Gerven JMA (2002) Evaluation of tests of central nervous system performance after hypoxemia for a model for cognitive impairment. J Psychopharmacol 16(4):337\u2013343. https:\/\/doi.org\/10.1177\/026988110201600408","journal-title":"J Psychopharmacol"},{"issue":"4","key":"3153_CR29","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s11065-004-8159-4","volume":"14","author":"J Viru\u00e9s-Ortega","year":"2004","unstructured":"Viru\u00e9s-Ortega J, Buela-Casal G, Garrido E, Alc\u00e1zar B (2004) Neuropsychological functioning associated with high-altitude exposure. Neuropsychol Rev 14(4):197\u2013224. https:\/\/doi.org\/10.1007\/s11065-004-8159-4","journal-title":"Neuropsychol Rev"},{"key":"3153_CR32","unstructured":"Wang Z (1984) Self-rating symptom scale (SCL-90). Shanghai Psychiatry, 68\u201370 (in Chinese)"},{"key":"3153_CR31","unstructured":"Wang T, Zhang C, Liu Y, Jiao Y (2000) A study on the characteristic of fatigue, depression, anxiety, life event and their correlation in the patients with chronic fatigue syndrome. Chin J Behav Med Sci (2):8\u201310. https:\/\/oversea.cnki.net\/kcms2\/article\/abstract?v=9r23aJBcv3ZyiUsYYxKENP2JIbWu-_Lw9ZRu8wzWUxcNrBsNjxksc2rcECdIcaipBYmGSJMcHpsGp2CKtZKVHx94hI1P-5jEaefl8sUf4nVD3jdJQwuJVZh7QLywlS_5JKcEkdEOC4VRmQ3TMb7VAND6rXjEGWKQ&uniplatform=OVERSEA (in Chinese)"},{"key":"3153_CR30","doi-asserted-by":"publisher","first-page":"goae019","DOI":"10.1093\/gastro\/goae019","volume":"12","author":"S Wang","year":"2024","unstructured":"Wang S, Tan C, Liu C, Liu Z, Jiang C, Shi J, Wu K, Dong W (2024) Common Gastrointestinal symptoms and their impact on psychological state and quality of life in patients with inflammatory bowel disease: A cross-sectional multicenter study in China. Gastroenterol Rep 12:goae019. https:\/\/doi.org\/10.1093\/gastro\/goae019","journal-title":"Gastroenterol Rep"},{"issue":"6","key":"3153_CR33","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1037\/0022-3514.54.6.1063","volume":"54","author":"D Watson","year":"1988","unstructured":"Watson D, Clark LA, Tellegen A (1988) Development and validation of brief measures of positive and negative affect: the PANAS scales. J Personal Soc Psychol 54(6):1063. https:\/\/doi.org\/10.1037\/0022-3514.54.6.1063","journal-title":"J Personal Soc Psychol"},{"issue":"2","key":"3153_CR34","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/S1474-4422(09)70014-6","volume":"8","author":"MH Wilson","year":"2009","unstructured":"Wilson MH, Newman S, Imray CH (2009) The cerebral effects of ascent to high altitudes. Lancet Neurol 8(2):175\u2013191. https:\/\/doi.org\/10.1016\/S1474-4422(09)70014-6","journal-title":"Lancet Neurol"},{"key":"3153_CR35","unstructured":"Xie H (2005) Evaluation of SCL-90 scale quality and application in psychology health measurement in our country [Master]. Jiangxi Normal University"},{"issue":"1","key":"3153_CR36","doi-asserted-by":"publisher","first-page":"4799","DOI":"10.1038\/s41598-024-55291-3","volume":"14","author":"Z Zeng","year":"2024","unstructured":"Zeng Z, Zhou Y, Li L (2024) Acute mountain sickness predicts the emotional state of amateur mountaineers. Sci Rep 14(1):4799. https:\/\/www.nature.com\/articles\/s41598-024-55291-3","journal-title":"Sci Rep"}],"container-title":["International Journal of Biometeorology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00484-026-03153-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00484-026-03153-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00484-026-03153-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T14:14:30Z","timestamp":1773929670000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00484-026-03153-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,24]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["3153"],"URL":"https:\/\/doi.org\/10.1007\/s00484-026-03153-0","relation":{},"ISSN":["0020-7128","1432-1254"],"issn-type":[{"value":"0020-7128","type":"print"},{"value":"1432-1254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,24]]},"assertion":[{"value":"17 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was reviewed and approved by the Academic Integrity and Research Ethics Committee of China University of Geosciences (Wuhan, China).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained from all participants prior to data collection.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient consent"}},{"value":"The authors declare no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was registered with the Chinese Clinical Trial Registry (ChiCTR2400088099).","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial registration"}}],"article-number":"72"}}