{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T17:01:50Z","timestamp":1765040510551},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"15-16","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Wien Klin Wochenschr"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1007\/s00508-014-0536-2","type":"journal-article","created":{"date-parts":[[2014,6,30]],"date-time":"2014-06-30T15:32:42Z","timestamp":1404142362000},"page":"480-484","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The effect of growth hormone replacement therapy on the morphological and functional changes in the left ventricle in patients with adult-onset growth hormone deficiency"],"prefix":"10.1007","volume":"126","author":[{"given":"Anton","family":"Dlesk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Kamensk\u00fd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivica","family":"Laz\u00farov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Ku\u017ema","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juraj","family":"Payer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,7,1]]},"reference":[{"key":"536_CR1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1161\/01.RES.83.1.50","volume":"83","author":"A Cittadini","year":"1998","unstructured":"Cittadini A, Ishiguro Y, Str\u00f6mer H, et al. Insulin-like growth factor-1 but not growth hormone augments mammalian myocardial contractility by sensitizing the myofilament to Ca2+ through a wortmannin-sensitive pathway studies in rat and ferret isolated muscles. Circ Res.1998;83:50\u20139.","journal-title":"Circ Res"},{"key":"536_CR2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/BF00408662","volume":"163","author":"NS Freestone","year":"1996","unstructured":"Freestone NS, Ribaric S, Mason WT. The effect of insulin-like growth factor-1 on adult rat cardiac contractility. Mol Cell Biochem. 1996;163:223\u20139.","journal-title":"Mol Cell Biochem"},{"key":"536_CR3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/joe.0.1520001","volume":"152","author":"BA Bengtsson","year":"1997","unstructured":"Bengtsson BA, Christiansen JS, Cuneo RC, Sacca L. Cardiovascular effects of GH. J Endocrinol. 1997;152:1\u20133.","journal-title":"J Endocrinol"},{"key":"536_CR4","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1210\/edrv-15-5-555","volume":"15","author":"L Sacca","year":"1994","unstructured":"Sacca L, Atteolini A, Fazio S. Growth hormone and the heart. Endocr Rev. 1994;15:555\u201373.","journal-title":"Endocr Rev"},{"key":"536_CR5","first-page":"S33","volume":"155","author":"G Lombardini","year":"1997","unstructured":"Lombardini G, Colao A, Marzullo P, et al. Is growth hormone bad for your heart: cardiovascular impact of GH deficiency and excess. J Endocrinol. 1997;155:S33\u20137.","journal-title":"J Endocrinol"},{"key":"536_CR6","doi-asserted-by":"crossref","unstructured":"Rosen T, Eden S, Larson G, Wilhelmsen L, Bengtsson BA. Cardiovascular risk factors in adult patients with growth hormone deficiency. Acta Endocrinol (Copenh). 1993;129:195\u2013200.","DOI":"10.1530\/acta.0.1290195"},{"key":"536_CR7","first-page":"1658","volume":"77","author":"B Merola","year":"1993","unstructured":"Merola B, Cittadini A, Colao A, et al. Cardiac structural and functional abnormalities in adult patients with growth hormone deficiency. J Clin Endocrinol Metab. 1993;77:1658\u201361.","journal-title":"J Clin Endocrinol Metab"},{"key":"536_CR8","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1046\/j.1365-2265.1998.00281.x","volume":"48","author":"S Longobardi","year":"1998","unstructured":"Longobardi S, Cuocolo A, Merola B, et al. Left ventricular function in young adults with childhood and adulthood onset growth hormone deficiency. Clin Endocrinol. 1998;48:137\u201343.","journal-title":"Clin Endocrinol"},{"key":"536_CR9","doi-asserted-by":"crossref","first-page":"3950","DOI":"10.1210\/jcem.84.11.6112","volume":"84","author":"A Colao","year":"1999","unstructured":"Colao A, Cuocolo A, Di Somma C, et al. Impaired cardiac performance in elderly patients with growth hormone deficiency. J Clin Endocrinol Metab. 1999;84:3950\u20135.","journal-title":"J Clin Endocrinol Metab"},{"key":"536_CR10","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1210\/jcem.82.5.3951","volume":"82","author":"B Capaldo","year":"1997","unstructured":"Capaldo B, Patti L, Oliviero U, et al. Increased arterial intima-media thickness in childhood onset growth hormone deficiency. J Clin Endocrinol Metab. 1997;82:1378\u201381.","journal-title":"J Clin Endocrinol Metab"},{"key":"536_CR11","first-page":"453","volume":"84","author":"M Pfeifer","year":"1999","unstructured":"Pfeifer M, Verhovec R, Zizek B. Growth hormone (GH) treatment reverses early atherosclerotic changes in GH-deficient adults. J Clin Endocrinol Metab. 1999;84:453\u20137.","journal-title":"J Clin Endocrinol Metab"},{"key":"536_CR12","doi-asserted-by":"crossref","unstructured":"Ter Maaten JC, De Boer H, Kamp O, et al. Long-term effects of growth hormone (GH) replacement in men with childhood-onset GH deficiency. J Clin Endocrinol Metab. 1999;84:2373\u201380.","DOI":"10.1210\/jc.84.7.2373"},{"key":"536_CR13","first-page":"659","volume":"80","author":"R Vacaldi","year":"1995","unstructured":"Vacaldi R, Gaddi O, Zini M, et al. Cardiac performance and mass in adults with hypopituitarism: effects of one year of growth hormone treatment. J Clin Endocrinol Metab. 1995;80:659\u201366.","journal-title":"J Clin Endocrinol Metab"},{"key":"536_CR14","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1210\/jc.2005-2227","volume":"91","author":"ME Molitch","year":"2006","unstructured":"Molitch ME, Clemmons DR, Malozowski S, et al. Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2006;91:1621\u201334.","journal-title":"J Clin Endocrinol Metab"},{"key":"536_CR15","first-page":"1007","volume":"11","author":"JG Dumesnil","year":"1995","unstructured":"Dumesnil JG, Dion D, Yvorchuk K, et al. A new, simple and accurate method for determining ejection fraction by Doppler echocardiography. Can J Cardiol. 1995;11:1007\u201314.","journal-title":"Can J Cardiol"},{"key":"536_CR16","doi-asserted-by":"crossref","first-page":"5146","DOI":"10.1210\/jc.2005-0597","volume":"90","author":"A Colao","year":"2005","unstructured":"Colao A, Di Somma C, Cuocolo A, et al. Does a gender-related effect of growth hormone (GH) replacement exist on cardiovascular risk factors, cardiac morphology, and performance and atherosclerosis? Results of a two-year open, prospective study in young adult men and women with severe GH deficiency. J Clin Endocrinol Metab. 2005;90:5146\u201355.","journal-title":"J Clin Endocrinol Metab"},{"key":"536_CR17","first-page":"82","volume":"82","author":"AF Attanasio","year":"1997","unstructured":"Attanasio AF, Lamberts SW, Matranga AM, et al. Adult growth hormone (GH)-deficient patients demonstrate heterogeneity between childhood onset and adult onset before and during human GH treatment. Adult Growth Hormone Deficiency Study Group. J Clin Endocrinol Metab. 1997;82:82\u20138.","journal-title":"J Clin Endocrinol Metab"},{"key":"536_CR18","doi-asserted-by":"crossref","first-page":"682","DOI":"10.4158\/EP.12.6.682","volume":"12","author":"AG Burger","year":"2006","unstructured":"Burger AG, Monson JP, Colao AM, et al. Cardiovascular risk in patients with growth hormone deficiency: effects of growth hormone substitution. Endocr Pract. 2006;12:682\u20139.","journal-title":"Endocr Pract"},{"key":"536_CR19","first-page":"1874","volume":"86","author":"A Colao","year":"2001","unstructured":"Colao A, di Somma C, Cuocolo A, et al. Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients with GH deficiency. J Clin Endocrinol Metab. 2001;86:1874\u201381.","journal-title":"J Clin Endocrinol Metab"},{"key":"536_CR20","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.ijcard.2004.03.036","volume":"101","author":"A Minczykowski","year":"2005","unstructured":"Minczykowski A, Gryczynska M, Ziemnicka K, et al. The influence of growth hormonetherapy on ultrasound myocardial tissue characterization in patients with childhood onset GH deficiency. Int J Cardiol. 2005;101:257\u201363.","journal-title":"Int J Cardiol"},{"key":"536_CR21","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1210\/jcem.85.10.6881","volume":"85","author":"G Amato","year":"2000","unstructured":"Amato G, Mazziotti G, di Somma C, et al. Recombinant growth hormone (GH) therapy in GH-deficient adults: a long-term controlled study on daily versus thrice weekly injections. J Clin Endocrinol Metab. 2000;85:3720\u20135.","journal-title":"J Clin Endocrinol Metab"},{"key":"536_CR22","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.amjcard.2007.04.051","volume":"100","author":"GY Cho","year":"2007","unstructured":"Cho GY, Jeong IK, Kim SH, et al. Effect of growth hormone on cardiac contractility in patients with adult onset growth hormone deficiency. Am J Cardiol. 2007;100:1035\u20139.","journal-title":"Am J Cardiol"}],"container-title":["Wiener klinische Wochenschrift"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00508-014-0536-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00508-014-0536-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00508-014-0536-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T00:47:05Z","timestamp":1565570825000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00508-014-0536-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,1]]},"references-count":22,"journal-issue":{"issue":"15-16","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["536"],"URL":"https:\/\/doi.org\/10.1007\/s00508-014-0536-2","relation":{},"ISSN":["0043-5325","1613-7671"],"issn-type":[{"value":"0043-5325","type":"print"},{"value":"1613-7671","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,1]]}}}