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A total of 1275 patients with an average age of 61.2 years participated in the study. The vertigo symptoms, measured by a validated mean vertigo score (primary efficacy endpoint) improved by 61\u2009% in the course of the observational period (median: 6 weeks). Concomitant symptoms frequently associated with vertigo such as nausea, vomiting and tinnitus were also markedly reduced by 84, 85 and 51\u2009%, respectively. Overall efficacy has been rated by the physicians as \u2018very much improved\u2019 or \u2018much improved\u2019 in 95\u2009% of the patients. A total of 47 patients (3.7\u2009%) reported 51 adverse drug reactions (all nonserious). The results indicate a good tolerability and efficacy of the fixed combination of cinnarizine and dimenhydrinate in the treatment of vertigo in daily medical practice, which is in line with previous findings of numerous interventional, randomised, double-blind, controlled clinical trials.<\/jats:p>","DOI":"10.1007\/s00508-015-0905-5","type":"journal-article","created":{"date-parts":[[2015,12,11]],"date-time":"2015-12-11T09:32:09Z","timestamp":1449826329000},"page":"341-347","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Cinnarizine and dimenhydrinate in the treatment of vertigo in medical practice"],"prefix":"10.1007","volume":"128","author":[{"given":"Arne-Wulf","family":"Scholtz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justus","family":"Ilgner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Loader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd W.","family":"Pritschow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Weisshaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,12,11]]},"reference":[{"key":"905_CR1","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1097\/WCO.0b013e328013f432","volume":"20","author":"HK Neuhauser","year":"2007","unstructured":"Neuhauser HK. 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