{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:44:00Z","timestamp":1765827840632,"version":"3.37.3"},"reference-count":79,"publisher":"Springer Science and Business Media LLC","issue":"21-22","license":[{"start":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T00:00:00Z","timestamp":1568764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T00:00:00Z","timestamp":1568764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005788","name":"Medical University of Vienna","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005788","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Wien Klin Wochenschr"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hemophilia is a\u00a0congenital bleeding disorder with an estimated frequency of 1:10,000 births. Repeated joint bleeding is a\u00a0hallmark of the disorder and leads to painful hemophilic arthropathy. Regular exercise can help improve joint stability and function, reduce the risk of injury and bleeding and improve physical fitness and quality of life. This method paper describes an online training concept aiming to offer access to appropriate exercise instructions for people with hemophilia who are not able to attend regular training at a\u00a0hemophilia center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The online exercise program is accessible through the homepage of the Department of Physical Medicine, Rehabilitation and Occupational Medicine of the Medical University Vienna as well as through scanning a\u00a0QR code printed on information material using a\u00a0smart phone or tablet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The program contains exercises to improve mobility, coordination, muscular strength and flexibility. A\u00a0brief introduction is given by a\u00a0hematologist, a pediatrician and a physiatrist. An introductory video informs about contraindications and essential precautions, such as medical attendance and sufficient factor therapy to consider before starting the training. Another video gives advice on the exercise composition. The demonstrated exercises are explained by a\u00a0physician and are available for adults and children. To individualize training recommendations and offer further diagnostic tools and physical treatment options as necessary, the Department of Physical Medicine, Rehabilitation and Occupational Medicine of the Medical University of Vienna will establish consultation hours for people with hemophilia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>As hemophilia is an orphan disease, patients are mainly treated in specialized centers. For patients who live far from these centers or have limited access to a\u00a0training there for other reasons, the physical medicine consultation hour and the implementation of online exercise instructions offer individually adapted exercise information for a\u00a0regular home-based training to benefit from increased physical fitness and joint stability.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00508-019-01548-1","type":"journal-article","created":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T13:04:51Z","timestamp":1568811891000},"page":"558-566","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Establishing an online physical exercise program for people with hemophilia"],"prefix":"10.1007","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1239-6538","authenticated-orcid":false,"given":"Barbara","family":"Wagner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Seuser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Kr\u00fcger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie Luca","family":"Herzig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Hilberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cihan","family":"Ay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Hasen\u00f6hrl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Crevenna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,9,18]]},"reference":[{"key":"1548_CR1","unstructured":"Guidelines for the management of haemophilia, World Federation of Haemophilia. 2012. https:\/\/www1.wfh.org\/publication\/files\/pdf-1472.pdf . Accessed 5th Sept 2019."},{"key":"1548_CR2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011180.pub2","author":"K Strike","year":"2016","unstructured":"Strike\u00a0K, Mulder\u00a0K, Michael\u00a0R. Exercise for haemophilia. Cochrane Database Syst Rev. 2016; https:\/\/doi.org\/10.1002\/14651858.CD011180.pub2 .","journal-title":"Cochrane Database Syst. Rev."},{"key":"1548_CR3","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1675354","author":"J Rejt\u0151","year":"2018","unstructured":"Rejt\u0151\u00a0J, Reitter-Pfoertner\u00a0S, Kepa\u00a0S, Feistritzer\u00a0C, Grundbichler\u00a0M, H\u00f6rbst\u00a0A, et al. Epidemiology and treatment of patients with haemophilia in Austria-update from the Austrian haemophilia registry. Hamostaseologie. 2018; https:\/\/doi.org\/10.1055\/s-0038-1675354 .","journal-title":"Hamostaseologie"},{"issue":"3","key":"1548_CR4","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1097\/MBC.0b013e32835084dd","volume":"23","author":"EC Rodriguez-Merchan","year":"2012","unstructured":"Rodriguez-Merchan\u00a0EC. Cartilage damage in the haemophilic joints: Pathophysiology, diagnosis and management. Blood Coagul Fibrinolysis. 2012;23(3):179\u201383.","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"4","key":"1548_CR5","first-page":"164","volume":"22","author":"I Khriesat","year":"2000","unstructured":"Khriesat\u00a0I, Thonaibat\u00a0W, Hammaury\u00a0M. Haemophiliac knee: role of physiotherapy. Bahrain Med Bull. 2000;22(4):164\u20136.","journal-title":"Bahrain Med Bull"},{"issue":"6","key":"1548_CR6","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1365-2516.2008.01882.x","volume":"14","author":"G Roosendaal","year":"2008","unstructured":"Roosendaal\u00a0G, Jansen\u00a0NWD, Schutgens\u00a0R, Lafeber\u00a0FPJG. Haemophilic arthropathy: the importance of the earliest haemarthroses and consequences for treatment. Haemophilia. 2008;14(6):4\u201310.","journal-title":"Haemophilia"},{"issue":"2","key":"1548_CR7","doi-asserted-by":"crossref","first-page":"518","DOI":"10.3390\/s18020518","volume":"18","author":"A Seuser","year":"2018","unstructured":"Seuser\u00a0A, Kurnik\u00a0K, Mahlein\u00a0A\u2011K. Infrared thermography as a\u00a0non-invasive tool to explore differences in the musculoskeletal system of children with hemophilia compared to an age-matched healthy group. Sensors. 2018;18(2):518.","journal-title":"Sensors"},{"issue":"1","key":"1548_CR8","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s11420-009-9140-9","volume":"6","author":"EC Rodriguez-Merchan","year":"2010","unstructured":"Rodriguez-Merchan\u00a0EC. Musculoskeletal complications of hemophilia. HSS\u00a0J. 2010;6(1):37\u201342.","journal-title":"HSS J"},{"issue":"1","key":"1548_CR9","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1365-2516.2006.01354.x","volume":"13","author":"L-M Gonz\u00e1lez","year":"2007","unstructured":"Gonz\u00e1lez\u00a0L\u2011M, Querol\u00a0F, Gallach\u00a0JE, Gomis\u00a0M, Aznar\u00a0VA. Force fluctuations during the Maximum Isometric Voluntary Contraction of the quadriceps femoris in haemophilic patients. Haemophilia. 2007;13(1):65\u201370.","journal-title":"Haemophilia"},{"issue":"3","key":"1548_CR10","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.pain.2010.10.020","volume":"152","author":"PW Hodges","year":"2011","unstructured":"Hodges\u00a0PW, Tucker\u00a0K. Moving differently in pain: a\u00a0new theory to explain the adaptation to pain. Pain. 2011;152(3):90\u20138.","journal-title":"Pain"},{"issue":"4","key":"1548_CR11","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/hae.13472","volume":"24","author":"S Kr\u00fcger","year":"2018","unstructured":"Kr\u00fcger\u00a0S, Hoffmeister\u00a0M, Hilberg\u00a0T. Pain and structural alterations in knee joints in patients with haemophilia. Haemophilia. 2018;24(4):657\u201366.","journal-title":"Haemophilia"},{"issue":"1","key":"1548_CR12","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/hae.13370","volume":"24","author":"S Kr\u00fcger","year":"2018","unstructured":"Kr\u00fcger\u00a0S, Boettger\u00a0MK, Hilberg\u00a0T. Somatosensory profile of patients with haemophilia. Haemophilia. 2018;24(1):97\u2013103.","journal-title":"Haemophilia"},{"issue":"4","key":"1548_CR13","first-page":"267","volume":"5","author":"AJ Goldfuss","year":"1973","unstructured":"Goldfuss\u00a0AJ, Morehouse\u00a0CA, LeVeau\u00a0BF. Effect of muscular tension on knee stability. Med Sci Sports. 1973;5(4):267\u201371.","journal-title":"Med Sci Sports"},{"issue":"3","key":"1548_CR14","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3109\/17453677208991256","volume":"43","author":"AA White","year":"1972","unstructured":"White\u00a0AA, Raphael\u00a0IG. The effect of quadriceps loads and knee position on strain measurements of the tibial collateral ligament. An experimental study on human amputation specimens. Acta Orthop Scand. 1972;43(3):176\u201387.","journal-title":"Acta Orthop Scand"},{"issue":"3","key":"1548_CR15","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/BF00337349","volume":"29","author":"DA Winter","year":"1978","unstructured":"Winter\u00a0DA, Robertson\u00a0DG. Joint torque and energy patterns in normal gait. Biol Cybern. 1978;29(3):137\u201342.","journal-title":"Biol Cybern"},{"issue":"4","key":"1548_CR16","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/hae.12636","volume":"21","author":"A Seuser","year":"2015","unstructured":"Seuser\u00a0A, Boehm\u00a0P, Ochs\u00a0S, Trunz-Carlisi\u00a0E, Halimeh\u00a0S, Klamroth\u00a0R. How fit are children and adolescents with haemophilia in Germany? Results of a\u00a0prospective study assessing the sport-specific motor performance by means of modern test procedures of sports science. Haemophilia. 2015;21(4):523\u20139.","journal-title":"Haemophilia"},{"issue":"5","key":"1548_CR17","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/hae.12957","volume":"22","author":"B Runkel","year":"2016","unstructured":"Runkel\u00a0B, Czepa\u00a0D, Hilberg\u00a0T. RCT of a\u00a06-month programmed sports therapy (PST) in patients with haemophilia\u2014Improvement of physical fitness. Haemophilia. 2016;22(5):765\u201371.","journal-title":"Haemophilia"},{"issue":"1","key":"1548_CR18","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1046\/j.1365-2516.2003.00679.x","volume":"9","author":"T Hilberg","year":"2003","unstructured":"Hilberg\u00a0T, Herbsleb\u00a0M, Puta\u00a0C, Gabriel\u00a0HHW, Schramm\u00a0W. Physical training increases isometric muscular strength and proprioceptive performance in haemophilic subjects. Haemophilia. 2003;9(1):86\u201393.","journal-title":"Haemophilia"},{"issue":"2","key":"1548_CR19","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/hae.12034","volume":"19","author":"A Brunner","year":"2013","unstructured":"Brunner\u00a0A, St\u00e4uber\u00a0F, G\u00f6hler\u00a0S, Czepa\u00a0D, Kr\u00fcger\u00a0S, Wendel\u00a0M, et al. Quadriceps strength, inter-extremity difference (IED) and joint status in adult persons with severe haemophilia in different age stages. Haemophilia. 2013;19(2):267\u201374.","journal-title":"Haemophilia"},{"issue":"1","key":"1548_CR20","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1365-2516.2011.02607.x","volume":"18","author":"D Czepa","year":"2012","unstructured":"Czepa\u00a0D, Von Mackensen\u00a0S, Hilberg\u00a0T. Haemophilia & Exercise Project (HEP): subjective and objective physical performance in adult haemophilia patients\u2014results of a\u00a0cross-sectional study. Haemophilia. 2012;18(1):80\u20135.","journal-title":"Haemophilia"},{"issue":"1","key":"1548_CR21","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1365-2516.2008.01860.x","volume":"15","author":"M Herbsleb","year":"2009","unstructured":"Herbsleb\u00a0M, Hilberg\u00a0T. Maximal and submaximal endurance performance in adults with severe haemophilia. Haemophilia. 2009;15(1):114\u201321.","journal-title":"Haemophilia"},{"issue":"1","key":"1548_CR22","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/hae.13037","volume":"23","author":"E Kurz","year":"2017","unstructured":"Kurz\u00a0E, Herbsleb\u00a0M, Grassme\u00a0R, Anders\u00a0C, Hilberg\u00a0T. Trunk muscle activation characteristics in patients with severe haemophilia. Haemophilia. 2017;23(1):122\u20138.","journal-title":"Haemophilia"},{"issue":"6","key":"1548_CR23","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1046\/j.1365-2516.2001.00563.x","volume":"7","author":"T Hilberg","year":"2001","unstructured":"Hilberg\u00a0T, Herbsleb\u00a0M, Gabriel\u00a0HHW, Jeschke\u00a0D, Schramm\u00a0W. Proprioception and isometric muscular strength in haemophilic subjects. Haemophilia. 2001;7(6):582\u20138.","journal-title":"Haemophilia"},{"issue":"4","key":"1548_CR24","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/j.1365-2516.2010.02200.x","volume":"16","author":"M Fearn","year":"2010","unstructured":"Fearn\u00a0M, Hill\u00a0K, Williams\u00a0S, Mudge\u00a0L, Walsh\u00a0C, McCarthy\u00a0P, et\u00a0al. Balance dysfunction in adults with haemophilia. Haemophilia. 2010;16(4):606\u201314.","journal-title":"Haemophilia"},{"issue":"1","key":"1548_CR25","first-page":"12","volume":"35","author":"B Runkel","year":"2015","unstructured":"Runkel\u00a0B, Kappelhoff\u00a0M, Hilberg\u00a0T. Complex strength performance in patients with haemophilia A. Method development and testing. Hamostaseologie. 2015;35(1):12\u20137.","journal-title":"Hamostaseologie"},{"issue":"1","key":"1548_CR26","first-page":"62","volume":"32","author":"M Herbsleb","year":"2012","unstructured":"Herbsleb\u00a0M, Abou-Hamdan\u00a0R, Puta\u00a0C, Donath\u00a0L, Kobelt\u00a0R, Stanek\u00a0F\u2011D, et al. Schwere und mittelschwere H\u00e4mophilie unter prophylaktischer Substitutionstherapie. Maximale Drehmomente der Knieextensoren und Knieflexoren bei Kindern und Jugendlichen [Severe and moderate haemophilia under prophylactic replacement treatment\u2014maximal kn. Hamostaseologie. 2012;32(1):62\u20139.","journal-title":"Hamostaseologie"},{"issue":"2","key":"1548_CR27","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1365-2516.2008.01928.x","volume":"15","author":"DCM Douma-van Riet","year":"2009","unstructured":"Douma-van Riet\u00a0DCM, Engelbert\u00a0RHH, van Genderen\u00a0FR, Ter Horst-De Ronde\u00a0MTM, de Goede-Bolder\u00a0A, Hartman\u00a0A. Physical fitness in children with haemophilia and the effect of overweight. Haemophilia. 2009;15(2):519\u201327.","journal-title":"Haemophilia"},{"issue":"6","key":"1548_CR28","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.jpeds.2007.12.016","volume":"152","author":"RHH Engelbert","year":"2008","unstructured":"Engelbert\u00a0RHH, Plantinga\u00a0M, Van der Net\u00a0J, Van Genderen\u00a0FR, Van den Berg\u00a0MH, Helders\u00a0PJM, et\u00a0al. Aerobic capacity in children with hemophilia. J\u00a0Pediatr. 2008;152(6):833\u20138838.","journal-title":"J Pediatr"},{"issue":"4","key":"1548_CR29","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/j.1365-2516.2005.01116.x","volume":"11","author":"B Falk","year":"2005","unstructured":"Falk\u00a0B, Portal\u00a0S, Tiktinsky\u00a0R, Zigel\u00a0L, Weinstein\u00a0Y, Constantini\u00a0N, et\u00a0al. Bone properties and muscle strength of young haemophilia patients. Haemophilia. 2005;11(4):380\u20136.","journal-title":"Haemophilia"},{"issue":"1","key":"1548_CR30","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1097\/00005768-200001000-00009","volume":"32","author":"B Falk","year":"2000","unstructured":"Falk\u00a0B, Portal\u00a0S, Tiktinsky\u00a0R, Weinstein\u00a0Y, Constantini\u00a0N, Martinowitz\u00a0U. Anaerobic power and muscle strength in young hemophilia patients. Med Sci Sports Exerc. 2000;32(1):52\u20137.","journal-title":"Med Sci Sports Exerc"},{"issue":"1","key":"1548_CR31","first-page":"22","volume":"73","author":"MM Pietri","year":"1992","unstructured":"Pietri\u00a0MM, Frontera\u00a0WR, Pratts\u00a0IS, S\u00faarez\u00a0EL. Skeletal muscle function in patients with hemophilia A and unilateral hemarthrosis of the knee. Arch Phys Med Rehabil. 1992;73(1):22\u20138.","journal-title":"Arch Phys Med Rehabil"},{"issue":"4","key":"1548_CR32","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/hae.13455","volume":"24","author":"A Seuser","year":"2018","unstructured":"Seuser\u00a0A, Navarrete-Duran\u00a0M, Auerswald\u00a0G, Mancuso\u00a0ME. Muscle function deterioration in patients with haemophilia: Prospective experience from Costa Rica. Haemophilia. 2018;24(4):230\u201341.","journal-title":"Haemophilia"},{"issue":"1","key":"1548_CR33","first-page":"38","volume":"31","author":"A Seuser","year":"2011","unstructured":"Seuser\u00a0A, Wendel\u00a0M, Navarrete-Duran\u00a0M, Fink\u00a0D, Auerswald\u00a0G, B\u00f6hm\u00a0P. Analysis of muscle function with kinetic superficial EMG in children with haemophilia\u2014recognizing subclinical changes, establishing individual therapy, quality control]. Muskelfunktionsmessung mit kinetischem Oberfl\u00e4chen-EMG bei Kindern mit H\u00e4mophilie E. Hamostaseologie. 2011;31(1):38\u201345.","journal-title":"Hamostaseologie"},{"issue":"7","key":"1548_CR34","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1249\/MSS.0b013e318213fefb","volume":"43","author":"CE Garber","year":"2011","unstructured":"Garber\u00a0CE, Blissmer\u00a0B, Deschenes\u00a0MR, Franklin\u00a0BA, Lamonte\u00a0MJ, Lee\u00a0I\u2011M, et al. American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc. 2011;43(7):1334\u201359.","journal-title":"Med Sci Sports Exerc"},{"issue":"3","key":"1548_CR35","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1055\/s-0031-1275337","volume":"223","author":"K Pierstorff","year":"2011","unstructured":"Pierstorff\u00a0K, Seuser\u00a0A, Weinspach\u00a0S, Laws\u00a0H\u2011J. Physiotherapy home exercise program for haemophiliacs. Klin Padiatr. 2011;223(3):189\u201392.","journal-title":"Klin Padiatr"},{"issue":"2","key":"1548_CR36","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1365-2516.2007.01504.x","volume":"13","author":"K Wittmeier","year":"2007","unstructured":"Wittmeier\u00a0K, Mulder\u00a0K. Enhancing lifestyle for individuals with haemophilia through physical activity and exercise: the role of physiotherapy. Haemophilia. 2007;13(2):31\u20137.","journal-title":"Haemophilia"},{"issue":"2","key":"1548_CR37","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1469-8749.1983.tb13743.x","volume":"25","author":"WB Greene","year":"1983","unstructured":"Greene\u00a0WB, Strickler\u00a0EM. A modified isokinetic strengthening program for patients with severe hemophilia. Dev Med Child Neurol. 1983;25(2):189\u201396.","journal-title":"Dev Med Child Neurol"},{"issue":"5","key":"1548_CR38","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1365-2516.2010.02312.x","volume":"16","author":"G Blamey","year":"2010","unstructured":"Blamey\u00a0G, Forsyth\u00a0A, Zourikian\u00a0N, Short\u00a0L, Jankovic\u00a0N, De Kleijn\u00a0P, et\u00a0al. Comprehensive elements of a\u00a0physiotherapy exercise programme in haemophilia\u2014a global perspective. Haemophilia. 2010;16(5):136\u201345.","journal-title":"Haemophilia"},{"key":"1548_CR39","volume-title":"Designing resistance training programs","author":"SJKW Fleck","year":"2004","unstructured":"Fleck\u00a0SJKW. Designing resistance training programs. 3rd\u00a0ed. Campaign: Hum Kinet; 2004.","edition":"3"},{"issue":"3","key":"1548_CR40","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1365-2516.2007.01537.x","volume":"13","author":"A Seuser","year":"2007","unstructured":"Seuser\u00a0A, Berdel\u00a0P. Rehabilitation of synovitis in patients with haemophilia. Haemophilia. 2007;13(3):26\u201331.","journal-title":"Haemophilia"},{"issue":"2","key":"1548_CR41","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1055\/s-0031-1286292","volume":"33","author":"JC Souza","year":"2012","unstructured":"Souza\u00a0JC, Simoes\u00a0HG, Campbell\u00a0CSG, Pontes\u00a0FL, Boullosa\u00a0DA, Prestes\u00a0J. Haemophilia and exercise. Int J Sports Med. 2012;33(2):83\u20138.","journal-title":"Int J Sports Med"},{"issue":"1","key":"1548_CR42","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1046\/j.1365-2516.2002.00575.x","volume":"8","author":"R Tiktinsky","year":"2002","unstructured":"Tiktinsky\u00a0R, Falk\u00a0B, Heim\u00a0M, Martinovitz\u00a0U. The effect of resistance training on the frequency of bleeding in haemophilia patients: a\u00a0pilot study. Haemophilia. 2002;8(1):22\u20137.","journal-title":"Haemophilia"},{"issue":"1","key":"1548_CR43","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1365-2516.2008.01867.x","volume":"15","author":"M Gomis","year":"2009","unstructured":"Gomis\u00a0M, Querol\u00a0F, Gallach\u00a0JE, Gonz\u00e1lez\u00a0LM, Aznar\u00a0JA. Exercise and sport in the treatment of haemophilic patients: a\u00a0systematic review. Haemophilia. 2009;15(1):43\u201354.","journal-title":"Haemophilia"},{"issue":"8","key":"1548_CR44","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1097\/MBC.0000000000000571","volume":"27","author":"G Auerswald","year":"2016","unstructured":"Auerswald\u00a0G, Dolan\u00a0G, Duffy\u00a0A, Hermans\u00a0C, Jim\u00e9nez-Yuste\u00a0V, Ljung\u00a0R, et al. Pain and pain management in haemophilia. Blood Coagul Fibrinolysis. 2016;27(8):845\u201354.","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"1","key":"1548_CR45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MBC.0b013e32835a72f3","volume":"24","author":"H De la Corte-Rodriguez","year":"2013","unstructured":"De la Corte-Rodriguez\u00a0H, Rodriguez-Merchan\u00a0CE, Rodriguez-Merchan\u00a0EC. The role of physical medicine and rehabilitation in haemophiliac patients. Blood Coagul Fibrinolysis. 2013;24(1):1\u20139.","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"3","key":"1548_CR46","first-page":"525","volume":"12","author":"P Giangrande","year":"2014","unstructured":"Giangrande\u00a0P, Calizzani\u00a0G, Menichini\u00a0I, Candura\u00a0F, Mannucci\u00a0PM, Makris\u00a0M. The European standards of Haemophilia Centres. Blood Transfus. 2014;12(3):525\u201330.","journal-title":"Blood Transfus"},{"issue":"2","key":"1548_CR47","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1365-2516.2007.01507.x","volume":"13","author":"A Seuser","year":"2007","unstructured":"Seuser\u00a0A, Boehm\u00a0P, Kurme\u00a0A, Schumpe\u00a0G, Kurnik\u00a0K. Orthopaedic issues in sports for persons with haemophilia. Haemophilia. 2007;13(2):47\u201352.","journal-title":"Haemophilia"},{"key":"1548_CR48","volume-title":"Fit durch Bewegung \u2013 fit for life \u2013 ein Ratgeber f\u00fcr H\u00e4mophilie zu Spiel, Sport und Tanz","author":"A Kurme","year":"2007","unstructured":"Kurme\u00a0A, Seuser\u00a0A, Hofert\u00a0F, Trunz-Carlisi\u00a0E, B\u00f6hm\u00a0P, Joeres\u00a0J. Fit durch Bewegung \u2013 fit for life \u2013 ein Ratgeber f\u00fcr H\u00e4mophilie zu Spiel, Sport und Tanz. Hamburg: OmniMed Verlagsgesellschaft mbH; 2007."},{"key":"1548_CR49","volume-title":"All about hemophilia: a guide for families; chapter 12: physical activity, exercise and sports","author":"N Zourikian","year":"2010","unstructured":"Zourikian\u00a0N, Jarock\u00a0C, Mulder\u00a0K. All about hemophilia: a guide for families; chapter 12: physical activity, exercise and sports. 2010. http:\/\/www.hemophilia.ca\/files\/Chapter12.pdf . Accessed 25th Aug 2018"},{"issue":"4","key":"1548_CR50","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/hae.12118","volume":"19","author":"C Negrier","year":"2013","unstructured":"Negrier\u00a0C, Seuser\u00a0A, Forsyth\u00a0A, Lobet\u00a0S, Llinas\u00a0A, Rosas\u00a0M, et\u00a0al. The benefits of exercise for patients with haemophilia and recommendations for safe and effective physical activity. Haemophilia. 2013;19(4):487\u201398.","journal-title":"Haemophilia"},{"key":"1548_CR51","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00508-015-0872-x","volume":"127","author":"I Pabinger","year":"2015","unstructured":"Pabinger\u00a0I, Heistinger\u00a0M, Muntean\u00a0W, Reitter-Pfoertner\u00a0S\u2011E, Rosenlechner\u00a0S, Schindl\u00a0T, et al. Treatment of haemophilia in Austria. Wien Klin Wochenschr. 2015;127:115\u201330.","journal-title":"Wien Klin Wochenschr"},{"issue":"3","key":"1548_CR52","doi-asserted-by":"crossref","first-page":"174","DOI":"10.21037\/tp.2017.04.07","volume":"6","author":"C Howell","year":"2017","unstructured":"Howell\u00a0C, Scott\u00a0K, Patel\u00a0DR. Sports participation recommendations for patients with bleeding disorders. Transl Pediatr. 2017;6(3):174\u201380.","journal-title":"Transl Pediatr"},{"key":"1548_CR53","volume-title":"Playing It Safe\u2014Bleeding Disorders, Sports and Exercise. National Haemophilia foundation","author":"A Anderson","year":"2017","unstructured":"Anderson\u00a0A, Forsynth\u00a0A. Playing It Safe\u2014Bleeding Disorders, Sports and Exercise. National Haemophilia foundation. 2017. https:\/\/www.hemophilia.org\/sites\/default\/files\/document\/files\/Playing-It-Safe_0.pdf . Accessed 5th Sept 2019."},{"issue":"5","key":"1548_CR54","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1542\/peds.2009-0072","volume":"124","author":"C Ross","year":"2009","unstructured":"Ross\u00a0C, Goldenberg\u00a0NA, Hund\u00a0D, Manco-Johnson\u00a0MJ. Athletic participation in severe hemophilia: bleeding and joint outcomes in children on prophylaxis. Pediatrics. 2009;124(5):1267\u201372.","journal-title":"Pediatrics"},{"issue":"3","key":"1548_CR55","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1365-2516.2009.01990.x","volume":"15","author":"R Tiktinsky","year":"2009","unstructured":"Tiktinsky\u00a0R, Kenet\u00a0G, Dvir\u00a0Z, Falk\u00a0B, Heim\u00a0M, Martinowitz\u00a0U, et\u00a0al. Physical activity participation and bleeding characteristics in young patients with severe haemophilia. Haemophilia. 2009;15(3):695\u2013700.","journal-title":"Haemophilia"},{"key":"1548_CR56","volume-title":"Canadian Hemophilia Society. Destination fitness. 2nd edition","author":"C Cecchini","year":"2012","unstructured":"Cecchini\u00a0C, Creighton\u00a0K, Hann\u00a0A, Hilliard\u00a0P, Mulder\u00a0K, O\u2019Shaughnessy\u00a0R, et\u00a0al. Canadian Hemophilia Society. Destination fitness. 2nd edition. 2012. https:\/\/www.hemophilia.ca\/wp-content\/uploads\/2018\/05\/Destination-fitness-FINAL.pdf . Accessed 5th Sept 2019."},{"key":"1548_CR57","volume-title":"Schulsport und H\u00e4mophilie \u2013 Ratgeber f\u00fcr Lehrer, Sch\u00fcler und Eltern","author":"A Seuser","year":"2013","unstructured":"Seuser\u00a0A, Joeres\u00a0J, Kurme\u00a0A, Ochs\u00a0S, B\u00f6hm\u00a0P, Trunz-Carlisi\u00a0E. Schulsport und H\u00e4mophilie \u2013 Ratgeber f\u00fcr Lehrer, Sch\u00fcler und Eltern. Unterschlei\u00dfheim: Baxter Deutschland; 2013."},{"key":"1548_CR58","unstructured":"Fit for Life, Institut f\u00fcr Pr\u00e4vention und Nachsorge (IPN).. www.fitforlife.eu . Accessed 5th Sept 2019."},{"issue":"1","key":"1548_CR59","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13023-018-0777-7","volume":"13","author":"T Hilberg","year":"2018","unstructured":"Hilberg\u00a0T. Programmed sports therapy (PST) in people with Haemophilia (PwH) \u201csports therapy model for rare diseases\u201d. Orphanet J Rare Dis. 2018;13(1):38.","journal-title":"Orphanet J Rare Dis"},{"issue":"6","key":"1548_CR60","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.mehy.2013.02.006","volume":"80","author":"J Hoffman","year":"2013","unstructured":"Hoffman\u00a0J, Gabel\u00a0P. Expanding Panjabi\u2019s stability model to express movement: a\u00a0theoretical model. Med Hypotheses. 2013;80(6):692\u20137.","journal-title":"Med Hypotheses"},{"issue":"4","key":"1548_CR61","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/00002517-199212000-00001","volume":"5","author":"MM Panjabi","year":"1992","unstructured":"Panjabi\u00a0MM. The stabilizing system of the spine. Part I. Function, dysfunction, adaptation, and enhancement. J\u00a0Spinal Disord. 1992;5(4):383\u20139. discussion 397.","journal-title":"J Spinal Disord"},{"key":"1548_CR62","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/978-3-540-73535-9_7","volume-title":"37th Hemophilia Symposium","author":"M Herbsleb","year":"2008","unstructured":"Herbsleb\u00a0M, Puta\u00a0C, Hilberg\u00a0T. Hemophilia and exercise project (HEP) conception and contents of a\u00a0\u201cprogrammed sports therapy\u201d for hemophilic patients. In: 37th Hemophilia Symposium. Berlin, Heidelberg: Springer; 2008. pp.\u00a045\u201359."},{"key":"1548_CR63","first-page":"137","volume-title":"The integrated model of joint function and its clinical application","author":"D Lee","year":"2001","unstructured":"Lee\u00a0D. The integrated model of joint function and its clinical application. Proceedings of the 4th Interdisciplinary World Congress on Low Back and Pelvic Pain; 8.11.\u201310.11.; Montreal. 2001. pp.\u00a0137\u201352."},{"key":"1548_CR64","unstructured":"\u00d6sterreichische H\u00e4mophilie Gesellschaft. from.. http:\/\/bluter.at\/joomla\/new_site\/ . Accessed 5th Sept 2019."},{"key":"1548_CR65","unstructured":"Haemophilia & Exercise, Interdisziplin\u00e4res Zentrum f\u00fcr Bewegungs- und Sportmedizin Wuppertal e.\u202fV... www.haemophilia-exercise.de . Accessed 5th Sept 2019."},{"issue":"3","key":"1548_CR66","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1365-2516.2006.01214.x","volume":"12","author":"S Harris","year":"2006","unstructured":"Harris\u00a0S, Boggio\u00a0LN. Exercise may decrease further destruction in the adult haemophilic joint. Haemophilia. 2006;12(3):237\u201340.","journal-title":"Haemophilia"},{"issue":"1","key":"1548_CR67","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1249\/00005768-198902000-00015","volume":"21","author":"JE Graves","year":"1989","unstructured":"Graves\u00a0JE, Pollock\u00a0ML, Jones\u00a0AE, Colvin\u00a0AB, Leggett\u00a0SH. Specificity of limited range of motion variable resistance training. Med Sci Sports Exerc. 1989;21(1):84\u20139.","journal-title":"Med Sci Sports Exerc"},{"issue":"12","key":"1548_CR68","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/0026-0495(92)90107-L","volume":"41","author":"ET Poehlman","year":"1992","unstructured":"Poehlman\u00a0ET, Gardner\u00a0AW, Ades\u00a0PA, Katzman-Rooks\u00a0SM, Montgomery\u00a0SM, Atlas\u00a0OK, et al. Resting energy metabolism and cardiovascular disease risk in resistance-trained and aerobically trained males. Metabolism. 1992;41(12):1351\u201360.","journal-title":"Metabolism"},{"issue":"3","key":"1548_CR69","first-page":"134","volume":"8","author":"MH Stone","year":"1983","unstructured":"Stone\u00a0MH, Wilson\u00a0GD, Blessing\u00a0D, Rozenek\u00a0R. Cardiovascular responses to short-term olympic style weight-training in young men. Can J Appl Sport Sci. 1983;8(3):134\u20139.","journal-title":"Can J Appl Sport Sci"},{"issue":"2","key":"1548_CR70","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/BOR.0b013e328324f8a8","volume":"21","author":"LF Callahan","year":"2009","unstructured":"Callahan\u00a0LF. Physical activity programs for chronic arthritis. Curr Opin Rheumatol. 2009;21(2):177\u201382.","journal-title":"Curr Opin Rheumatol"},{"issue":"14","key":"1548_CR71","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1001\/jama.2012.13303","volume":"308","author":"MJ Manco-Johnson","year":"2012","unstructured":"Manco-Johnson\u00a0MJ. Collision sports and risk of bleeding in children with hemophilia. JAMA. 2012;308(14):1480\u20131.","journal-title":"JAMA"},{"issue":"1","key":"1548_CR72","first-page":"39","volume":"23","author":"CC Johnson","year":"1983","unstructured":"Johnson\u00a0CC, Stone\u00a0MH, Byrd\u00a0RJ, Lopez\u2011S A. The response of serum lipids and plasma androgens to weight training exercise in sedentary males. J\u00a0Sports Med Phys Fitness. 1983;23(1):39\u201344.","journal-title":"J Sports Med Phys Fitness"},{"issue":"4","key":"1548_CR73","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.ejmhg.2013.02.002","volume":"14","author":"LA Zaky","year":"2013","unstructured":"Zaky\u00a0LA, Hassan\u00a0WF. Effect of partial weight bearing program on functional ability and quadriceps muscle performance in hemophilic knee arthritis. Egypt J Med Hum Genet. 2013;14(4):413\u20138.","journal-title":"Egypt J Med Hum Genet"},{"issue":"2","key":"1548_CR74","doi-asserted-by":"crossref","first-page":"e121","DOI":"10.1111\/hae.12355","volume":"20","author":"M Goto","year":"2014","unstructured":"Goto\u00a0M, Takedani\u00a0H, Haga\u00a0N, Kubota\u00a0M, Ishiyama\u00a0M, Ito\u00a0S, et al. Self-monitoring has potential for home exercise programmes in patients with haemophilia. Haemophilia. 2014;20(2):e121\u2013e7.","journal-title":"Haemophilia"},{"issue":"1","key":"1548_CR75","first-page":"50","volume":"4","author":"M Kargarfard","year":"2013","unstructured":"Kargarfard\u00a0M, Dehghadani\u00a0M, Ghias\u00a0R. The effect of aquatic exercise therapy on muscle strength and joint\u2019s range of motion in hemophilia patients. Int J Prev Med. 2013;4(1):50\u20136.","journal-title":"Int J Prev Med"},{"issue":"5","key":"1548_CR76","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1177\/0269215513505299","volume":"28","author":"B Parhampour","year":"2014","unstructured":"Parhampour\u00a0B, Torkaman\u00a0G, Hoorfar\u00a0H, Hedayati\u00a0M, Ravanbod\u00a0R. Effects of short-term resistance training and pulsed electromagnetic fields on bone metabolism and joint function in severe haemophilia A patients with osteoporosis: a\u00a0randomized controlled trial. Clin Rehabil. 2014;28(5):440\u201350.","journal-title":"Clin Rehabil"},{"issue":"4","key":"1548_CR77","doi-asserted-by":"crossref","first-page":"509","DOI":"10.2522\/ptj.20080202","volume":"90","author":"R Mulvany","year":"2010","unstructured":"Mulvany\u00a0R, Zucker-Levin\u00a0AR, Jeng\u00a0M, Joyce\u00a0C, Tuller\u00a0J, Rose\u00a0JM, et al. Effects of a\u00a06-week, individualized, supervised exercise program for people with bleeding disorders and hemophilic arthritis. Phys Ther. 2010;90(4):509\u201326.","journal-title":"Phys Ther"},{"issue":"2","key":"1548_CR78","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ejmhg.2013.12.002","volume":"15","author":"MA Eid","year":"2014","unstructured":"Eid\u00a0MA, Ibrahim\u00a0MM, Aly\u00a0SM. Effect of resistance and aerobic exercises on bone mineral density, muscle strength and functional ability in children with hemophilia. Egypt J Med Hum Genet. 2014;15(2):139\u201347.","journal-title":"Egypt J Med Hum Genet"},{"key":"1548_CR79","doi-asserted-by":"crossref","unstructured":"Wagner B, Kr\u00fcger S, Hilberg T, Ay C, Hasenoehrl T, Huber D, Crevenna R.\u00a0The effect of resistance exercise on strength and safety outcome for people with haemophilia: a systematic review (unpublished: resubmitted to Disability and Rehabilitation in September 2019, under consideration for publication)","DOI":"10.1111\/hae.13938"}],"container-title":["Wiener klinische Wochenschrift"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00508-019-01548-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00508-019-01548-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00508-019-01548-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T18:20:40Z","timestamp":1721758840000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00508-019-01548-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,18]]},"references-count":79,"journal-issue":{"issue":"21-22","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["1548"],"URL":"https:\/\/doi.org\/10.1007\/s00508-019-01548-1","relation":{},"ISSN":["0043-5325","1613-7671"],"issn-type":[{"type":"print","value":"0043-5325"},{"type":"electronic","value":"1613-7671"}],"subject":[],"published":{"date-parts":[[2019,9,18]]},"assertion":[{"value":"20 January 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"B.\u00a0Wagner, A.\u00a0Seuser, S.\u00a0Kr\u00fcger, M.L.\u00a0Herzig, T.\u00a0Hilberg, C.\u00a0Ay, T.\u00a0Hasenoe\u00f6hrl, and R.\u00a0Crevenna declare that they have no competing interests. The sponsor had no role in the development of the exercise concept and the content of the videos.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}