{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T08:49:40Z","timestamp":1773391780613,"version":"3.50.1"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"15-16","license":[{"start":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T00:00:00Z","timestamp":1579046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T00:00:00Z","timestamp":1579046400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100010109","name":"Medical University of Graz","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010109","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Wien Klin Wochenschr"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>The outcome of patients with cancer of the head and neck is significantly improved by increased interdisciplinary cooperation. The main focus of this study was a\u00a0comparison of epidemiologic factors (age, sex, origin, staging) of patients with head and neck cancer in Styria, with those for patients throughout Austria.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>A\u00a0retrospective data analysis of collected archived tumor board protocols of the Comprehensive Cancer Center (CCC) Graz included the patient\u2019s age, sex, area of residence, TNM stage, reasons for inoperability, comorbidities and performance status by ECOG (Eastern Cooperative Oncology Group), was performed. This study focuses on 340 patients who presented with a\u00a0head and neck malignancy for the first time.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>In the period from January 2014 to December 2015 a total of 252 men (74.1%) and 88\u00a0women (25.9%) with malignant head and neck tumors, were presented in the tumor board for the first time. The mean age at diagnosis was 63.4\u00a0years. In 45.5% the patients already demonstrated advanced tumor stages (T4\u202f=\u200927.9%, T3\u202f=\u200917.6%). Most newly diagnosed neoplasms were cancers of the oropharynx (24.1%), larynx (19.4%) and oral cavity (18.8%) and 36.5% were considered to be inoperable. Curative and palliative treatments were initiated in 83.2% and 16.9%, respectively.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The region of south Styria showed a\u00a0higher incidence of T3 and T4 tumors of the oropharynx than the average Austrian population. Measures to increase awareness of this problem should be initiated to support general otorhinolaryngologists and general practitioners in detecting oropharyngeal cancers at an earlier stage.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s00508-019-01591-y","type":"journal-article","created":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T14:02:46Z","timestamp":1579096966000},"page":"444-451","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Head and neck cancer in Styria"],"prefix":"10.1007","volume":"132","author":[{"given":"Sarah M.","family":"Vasicek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prisca","family":"Pondorfer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clemens","family":"Holzmeister","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Graupp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Weiland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Moser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominik","family":"Wild","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dietmar","family":"Thurnher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,1,15]]},"reference":[{"issue":"5","key":"1591_CR1","doi-asserted-by":"publisher","first-page":"E359","DOI":"10.1002\/ijc.29210","volume":"136","author":"J Ferlay","year":"2015","unstructured":"Ferlay\u00a0J, Soerjomataram\u00a0I, Dikshit\u00a0R, et\u00a0al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):E359\u201386.","journal-title":"Int J Cancer"},{"issue":"1","key":"1591_CR2","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1159\/000446117","volume":"91","author":"B Gupta","year":"2016","unstructured":"Gupta\u00a0B, Johnson\u00a0NW, Kumar\u00a0N. Global epidemiology of head and neck cancers: a continuing challenge. Oncology. 2016;91(1):13\u201323.","journal-title":"Oncology"},{"issue":"2","key":"1591_CR3","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1007\/s10900-011-9447-6","volume":"37","author":"R Byakodi","year":"2012","unstructured":"Byakodi\u00a0R, Byakodi\u00a0S, Hiremath\u00a0S, et\u00a0al. Oral cancer in India: an epidemiologic and clinical review. J\u00a0Community Health. 2012;37(2):316\u20139.","journal-title":"J Community Health"},{"key":"1591_CR4","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006386.pub2","author":"S Furness","year":"2011","unstructured":"Furness\u00a0S, Glenny\u00a0AM, Worthington\u00a0HV, et\u00a0al. Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy. Cochrane Database Syst Rev. 2011; https:\/\/doi.org\/10.1002\/14651858.CD006386.pub2.","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"1591_CR5","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3322\/caac.21384","volume":"67","author":"KD Shield","year":"2017","unstructured":"Shield\u00a0KD, Ferlay\u00a0J, Jemal\u00a0A, et\u00a0al. The global incidence of lip, oral cavity, and pharyngeal cancers by subsite in 2012. CA Cancer J Clin. 2017;67(1):51\u201364.","journal-title":"CA Cancer J Clin"},{"key":"1591_CR6","isbn-type":"print","volume-title":"Jahrbuch der Gesundheitsstatistik","author":"Statistics Austria","year":"2015","unstructured":"Statistics Austria. Jahrbuch der Gesundheitsstatistik. Verlag \u00d6sterreich GmbH: Statistik Austria; 2015. ISBN 978-3-903106-31\u20114.","ISBN":"https:\/\/id.crossref.org\/isbn\/9783903106314"},{"issue":"5","key":"1591_CR7","doi-asserted-by":"publisher","first-page":"479","DOI":"10.6004\/jnccn.2018.0026","volume":"16","author":"AD Colevas","year":"2018","unstructured":"Colevas AD, Yom SS, Pfister DG, et\u00a0al. NCCN Guidelines Insights: Head and Neck Cancers, Version 1.2018. Journal of the National Comprehensive Cancer Network 2018;16(5):479\u201390.","journal-title":"Journal of the National Comprehensive Cancer Network"},{"issue":"5","key":"1591_CR8","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1093\/aje\/kwt029","volume":"178","author":"A Wyss","year":"2013","unstructured":"Choi\u00a0SH, Terrell\u00a0JE, Fowler\u00a0KE, et\u00a0al. Socioeconomic and other demographic disparities predicting survival among head and neck cancer patients. PLoS ONE. 2016;11(3):e149886.","journal-title":"Am J Epidemiol"},{"key":"1591_CR9","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1972-8","author":"GM McCutchan","year":"2015","unstructured":"McCutchan\u00a0GM, Wood\u00a0F, Edwards\u00a0A, Richards\u00a0R, Brain\u00a0KE. Influences of cancer symptom knowledge, beliefs and barriers on cancer symptom presentation in relation to socioeconomic deprivation: a systematic review. BMC Cancer. 2015; https:\/\/doi.org\/10.1186\/s12885-015-1972-8.","journal-title":"BMC Cancer"},{"issue":"4","key":"1591_CR10","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.healthplace.2012.03.005","volume":"18","author":"LR Reitzel","year":"2012","unstructured":"Reitzel\u00a0LR, Nguyen\u00a0N, Zafereo\u00a0ME, Li\u00a0G, Wei\u00a0Q, Sturgis\u00a0EM. Neighborhood deprivation and clinical outcomes among head and neck cancer patients. Health Place. 2012;18(4):861\u20138.","journal-title":"Health Place"},{"key":"1591_CR11","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1186\/1471-2407-14-316","volume":"14","author":"A Auluck","year":"2014","unstructured":"Auluck\u00a0A, Walker\u00a0BB, Hislop\u00a0G, Lear\u00a0SA, Schuurman\u00a0N, Rosin\u00a0M. Population-based incidence trends of oropharyngeal and oral cavity cancers by sex among the poorest and underprivileged populations. BMC Cancer. 2014;14:316. https:\/\/doi.org\/10.1186\/1471-2407-14-316.","journal-title":"BMC Cancer"},{"key":"1591_CR12","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-015-2111-9","author":"BB Walker","year":"2015","unstructured":"Walker\u00a0BB, Schuurman\u00a0N, Auluck\u00a0A, Lear\u00a0SA, Rosin\u00a0M. Suburbanisation of oral cavity cancers: evidence from a\u00a0geographically-explicit observational study of incidence trends in British columbia, Canada, 1981\u20132010. Bmc Public Health. 2015; https:\/\/doi.org\/10.1186\/s12889-015-2111-9.","journal-title":"Bmc Public Health"},{"issue":"1","key":"1591_CR13","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S1470-2045(13)70546-1","volume":"15","author":"R De Angelis","year":"2014","unstructured":"Wyss\u00a0A, Hashibe\u00a0M, Chuang\u00a0SC, et\u00a0al. Cigarette, cigar, and pipe smoking and the risk of head and neck cancers: pooled analysis in the international head and neck cancer epidemiology consortium. Am J Epidemiol. 2013;178(5):679\u201390.","journal-title":"lancet Oncol"},{"issue":"4","key":"1591_CR14","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1002\/ijc.2910410403","volume":"41","author":"AJ Tuyns","year":"1988","unstructured":"Tuyns\u00a0AJ, Esteve\u00a0J, Raymond\u00a0L, et al. Cancer of the larynx\/hypopharynx, tobacco and alcohol: IARC international case-control study in Turin and Varese (Italy), Zaragoza and Navarra (Spain), Geneva (Switzerland) and Calvados (France). Int J Cancer. 1988;41(4):483\u201391.","journal-title":"Int J Cancer"},{"issue":"4","key":"1591_CR15","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1093\/jnci\/djn011","volume":"100","author":"C Fakhry","year":"2008","unstructured":"Fakhry\u00a0C, Westra\u00a0WH, Li\u00a0S, et al. Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a\u00a0prospective clinical trial. J\u00a0Natl Cancer Inst. 2008;100(4):261\u20139.","journal-title":"J Natl Cancer Inst"},{"key":"1591_CR16","unstructured":"Bundesministerium f\u00fcr Arbeit, Soziales, Gesundheit und Konsumentenschutz. HPV Impfung gegen Krebs. 2016. https:\/\/www.bmgf.gv.at\/. Accessed 2016.."},{"issue":"3","key":"1591_CR17","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1093\/jnci\/djs491","volume":"105","author":"A Jemal","year":"2013","unstructured":"Jemal\u00a0A, Simard\u00a0EP, Dorell\u00a0C, et\u00a0al. Annual report to the nation on the status of cancer, 1975\u20132009, featuring the burden and trends in human papillomavirus (HPV)\u2014associated cancers and HPV vaccination coverage levels. J\u00a0Natl Cancer Inst. 2013;105(3):175\u2013201.","journal-title":"J Natl Cancer Inst"},{"issue":"1","key":"1591_CR18","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S1470-2045(13)70546-1","volume":"15","author":"R De Angelis","year":"2014","unstructured":"De Angelis\u00a0R, Sant\u00a0M, Coleman\u00a0MP, et al. Cancer survival in Europe 1999\u20132007 by country and age: results of EUROCARE\u20145\u2011a population-based study. Lancet Oncol. 2014;15(1):23\u201334.","journal-title":"Lancet Oncol."}],"container-title":["Wiener klinische Wochenschrift"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00508-019-01591-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00508-019-01591-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00508-019-01591-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T07:29:32Z","timestamp":1610609372000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00508-019-01591-y"}},"subtitle":["An epidemiologic and clinical audit"],"short-title":[],"issued":{"date-parts":[[2020,1,15]]},"references-count":18,"journal-issue":{"issue":"15-16","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["1591"],"URL":"https:\/\/doi.org\/10.1007\/s00508-019-01591-y","relation":{},"ISSN":["0043-5325","1613-7671"],"issn-type":[{"value":"0043-5325","type":"print"},{"value":"1613-7671","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,15]]},"assertion":[{"value":"29 August 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 December 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical guidelines"}},{"value":"S.M.\u00a0Vasicek, P.\u00a0Pondorfer, C.\u00a0Holzmeister, M.\u00a0Graupp, T.\u00a0Weiland, A.\u00a0Wolf, U.\u00a0Moser, D.\u00a0Wild, and D.\u00a0Thurnher declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1975 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}