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A\u00a0conservative treatment should be considered in mild to moderate cases. The aim of this study was to assess the effect of a\u00a0focused extracorporeal shock wave therapy in the treatment of mild to moderate carpal tunnel syndrome.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Material and Methods<\/jats:title>\n                <jats:p>In this study 30 patients were randomly assigned into 2 groups. Subjects in the study group received three sessions of focused extracorporeal shock wave therapy, whereas the control group underwent a\u00a0sham therapy. Patients were evaluated 3 and 12\u00a0weeks after treatment. The primary outcome was the visual analogue scale score. Secondary outcome measurements included hand grip strength, Boston Carpal Tunnel Syndrome Questionnaire, SF-36 Health Survey and electrodiagnostic measurements.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A\u00a0significant improvement of visual analogue scale at week\u00a03 (<jats:italic>p<\/jats:italic>\u202f=\u20090.018) and week\u00a012 (<jats:italic>p<\/jats:italic>\u202f=\u20090.007) as well as hand grip strength at week\u00a012 (<jats:italic>p<\/jats:italic>\u202f=\u20090.019) could be observed in the study group. The study group showed a\u00a0significantly better sensory nerve conduction velocity at week\u00a012 than the control group, before correcting for multiple testing, and also a\u00a0significant improvement in distal motor latency of the median nerve at week\u00a012 (<jats:italic>p<\/jats:italic>\u202f=\u20090.009) as well as in both questionnaires (SF-36 subscale bodily pain, <jats:italic>p<\/jats:italic>\u202f=\u20090.020 and severity symptom scale, <jats:italic>p<\/jats:italic>\u202f=\u20090.003). No such improvement was observed in the control group.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Focused extracorporeal shock wave therapy is an effective and noninvasive treatment method for mild to moderate carpal tunnel syndrome.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00508-020-01785-9","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T15:03:17Z","timestamp":1608649397000},"page":"568-577","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Effectiveness of focused extracorporeal shock wave therapy in the treatment of carpal tunnel syndrome"],"prefix":"10.1007","volume":"133","author":[{"given":"Christina","family":"Gesslbauer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mickel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Othmar","family":"Schuhfried","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominikus","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Keilani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9177-0101","authenticated-orcid":false,"given":"Richard","family":"Crevenna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,12,22]]},"reference":[{"issue":"12","key":"1785_CR1","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1016\/S1474-4422(16)30231-9","volume":"15","author":"L Padua","year":"2016","unstructured":"Padua\u00a0L, Coraci\u00a0D, Erra\u00a0C, Pazzaglia\u00a0C, Paolasso\u00a0I, Loreti\u00a0C, et\u00a0al. 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