{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T14:19:27Z","timestamp":1789395567515,"version":"build-2803163510"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"13-14","license":[{"start":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T00:00:00Z","timestamp":1623283200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T00:00:00Z","timestamp":1623283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100010109","name":"Medical University of Graz","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010109","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Wien Klin Wochenschr"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>To evaluate gastrointestinal tract (GIT) perforations in very low birth weight infants and the effects on neurodevelopmental outcome.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Between 2000 and 2017 all cases with GIT perforation were analyzed regarding causes, associated morbidities and neurodevelopmental outcome and compared with matched (gestational age, birth weight, gender, year of birth) by 1:2 controls.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The incidence of GIT perforation was 2.0% (<jats:italic>n<\/jats:italic>\u202f=\u200938\/1878). Diagnoses associated with GIT were meconium obstruction of prematurity (MOP,<jats:italic>n<\/jats:italic>\u202f=\u200919\/50%), spontaneous intestinal perforation (SIP, <jats:italic>n<\/jats:italic>\u202f=\u20097\/18%), necrotizing enterocolitis (NEC, <jats:italic>n<\/jats:italic>\u202f=\u20096\/16%), iatrogenic perforation (<jats:italic>n<\/jats:italic>\u202f=\u20093\/8%), volvulus (<jats:italic>n<\/jats:italic>\u202f=\u20092\/5%) and meconium ileus (<jats:italic>n<\/jats:italic>\u202f=\u20091\/3%). The NEC-associated perforations occurred later compared to those associated with MOP and SIP (median 8\u00a0days and 6\u00a0days vs. 17\u00a0days, <jats:italic>p<\/jats:italic>\u202f=\u20090.001 and 0.023, respectively) and main localization was the terminal ileum (84%). Cases had higher rates of late onset sepsis (55% vs. 24%, <jats:italic>p<\/jats:italic>\u202f=\u20090.003), longer duration of mechanical ventilation (median\u00a030 days vs 18\u00a0days, <jats:italic>p<\/jats:italic>\u202f=\u20090.013) and longer stays at the hospital (median 122 days vs 83\u00a0days, <jats:italic>p<\/jats:italic>\u202f&lt;\u20090.001); mortality rates did not differ. The 2\u2011year neurodevelopment follow-up revealed no differences between groups (normal development 49% vs. 40%).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Despite increased morbidities preterm infants with GIT perforation did not have a\u00a0higher mortality rate and groups did not differ regarding neurodevelopmental outcome at the corrected for prematurity age of 2\u00a0years.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00508-021-01886-z","type":"journal-article","created":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T16:13:00Z","timestamp":1623341580000},"page":"680-686","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Neurodevelopmental outcome of very preterm infants with gastrointestinal tract perforations does not differ compared to controls"],"prefix":"10.1007","volume":"133","author":[{"given":"Michael F.","family":"Moser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina J.","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Schalamon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4348-8299","authenticated-orcid":false,"given":"Bernhard","family":"Resch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,10]]},"reference":[{"key":"1886_CR1","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1097\/PEC.0b013e31826beb0c","volume":"28","author":"G Sakellaris","year":"2012","unstructured":"Sakellaris\u00a0G, Partalis\u00a0N, Dede\u00a0O, et\u00a0al. 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B.\u00a0Resch has received speaker fees from Germania, Abbvie, Milupa and Nestle.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the local ethic committee of the Medical University of Graz (30-152\u00a0ex\u00a017\/18). This article does not contain any studies with animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}