{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T05:03:34Z","timestamp":1764997414570,"version":"3.37.3"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"23-24","license":[{"start":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T00:00:00Z","timestamp":1635206400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T00:00:00Z","timestamp":1635206400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"tirol kliniken gmbh"},{"name":"University of Innsbruck and Medical University of Innsbruck"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Wien Klin Wochenschr"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Seroepidemiological studies provide important insight into the spread of severe acute respiratory syndrome coronavirus\u00a02 (SARS-CoV\u20112) in our society. We aimed to determine seropositivity of SARS-CoV\u20112 antibodies and its cross-sectional correlates in a\u00a0large cohort of blood donors.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In this observational cohort study, we tested healthy blood donors residing in Tyrol, Austria, for SARS-CoV\u20112 antibodies using the Abbott SARS-CoV\u20112 IgG chemiluminescent microparticle immunoassay. We estimated 95% confidence intervals (95% CI) of seroprevalences using bootstrapping and tested for differences by participant characteristics using logistic regression.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Findings<\/jats:title>\n                <jats:p>Between 8\u00a0June and 4\u00a0September 2020, we screened 5345\u00a0healthy individuals at local blood donor sessions (mean age 42.7\u00a0years, SD 13.5 years, 46.7% female). Overall seroprevalence was 3.1% (95% CI 2.7\u20133.6%, 165\u00a0cases), which is 5.1-fold higher (95% CI 4.5\u20136.0%) than the case number identified by the health authorities in the state-wide testing program (0.6%; 4536 out of 757,634). Seroprevalence was higher in the district Landeck (16.6%, <jats:italic>P<\/jats:italic>\u202f&lt;\u20090.001) and in individuals aged &lt;\u202f25\u00a0years (4.7%, <jats:italic>P<\/jats:italic>\u202f=\u20090.043), but did not differ by gender, blood types, or medication intake. The odds ratio for seropositivity was 2.51 for participants who had\u00a0travelled to Ischgl (1.49\u20134.21, <jats:italic>P<\/jats:italic>\u202f=\u20090.001), 1.39 who had\u00a0travelled to other federal states (1.00\u20131.93, <jats:italic>P<\/jats:italic>\u202f=\u20090.052), and 2.41 who had travelled abroad (1.61\u20133.63, <jats:italic>P<\/jats:italic>\u202f&lt;\u20090.001). Compared to participants who had a\u00a0suspected\/confirmed SARS-CoV\u20112 infection but were seronegative, seropositive participants more frequently reported loss of smell (odds ratio\u202f=\u20092.49, 1.32\u20134.68, <jats:italic>P<\/jats:italic>\u202f=\u20090.005) and taste (odds ratio\u202f=\u20092.76, 1.54\u20134.92, <jats:italic>P<\/jats:italic>\u202f=\u20090.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>In summer 2020, SARS-CoV\u20112 seroprevalence in Tyrolean blood donors was 3.1%. Our study revealed regional variation and associations with young age, travel history and specific symptoms.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00508-021-01963-3","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T11:48:01Z","timestamp":1635248881000},"page":"1272-1280","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Prevalence of SARS-CoV-2 antibodies in healthy blood donors from the state of Tyrol, Austria, in summer 2020"],"prefix":"10.1007","volume":"133","author":[{"given":"Anita","family":"Siller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregor A.","family":"Wachter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Neururer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Pfeifer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Astl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wegene","family":"Borena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janine","family":"Kimpel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Elmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franziska","family":"Sp\u00f6ck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Vales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annelies","family":"M\u00fchlbacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Gaber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1866-7159","authenticated-orcid":false,"given":"Peter","family":"Willeit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Schennach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,10,26]]},"reference":[{"issue":"18","key":"1963_CR1","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1056\/NEJMoa2002032","volume":"382","author":"WJ Guan","year":"2020","unstructured":"Guan\u00a0WJ, Ni\u00a0ZY, Hu\u00a0Y, Liang\u00a0WH, Ou\u00a0CQ, He\u00a0JX, et\u00a0al. 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