{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:11:37Z","timestamp":1792782697253,"version":"4.5.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Verein zur Forschung in der pneumologischen Intensivmedizin"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Wien Klin Wochenschr"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1007\/s00508-022-02073-4","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T06:03:14Z","timestamp":1661925794000},"page":"35-44","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of intravenous ferric carboxymaltose on exercise capacity and quality of life in patients with COPD"],"prefix":"10.1007","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5209-7201","authenticated-orcid":false,"given":"Erwin","family":"Grasmuk-Siegl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias Helmuth","family":"Urban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Scherrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg-Christian","family":"Funk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,31]]},"reference":[{"issue":"4","key":"2073_CR1","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1164\/ajrccm\/146.4.935","volume":"146","author":"Killian","year":"1992","unstructured":"Killian, et\u00a0al. Exercise capacity and ventilatory, circulatory and symptom limitation in patients in chronic airflow limitation. Am Rev Respir Dis. 1992;146(4):935\u201340.","journal-title":"Am Rev Respir Dis"},{"issue":"3","key":"2073_CR2","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1093\/ajcn\/71.3.733","volume":"71","author":"Engelen","year":"2000","unstructured":"Engelen, et al. Skeletal muscle weakness is associated with wasting of extremity fat-free mass but not with airflow obstruction in patients with chronic obstructive pulmonary disease. Am J Clin Nutr. 2000;71(3):733\u20138.","journal-title":"Am J Clin Nutr"},{"issue":"5","key":"2073_CR3","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1378\/chest.123.5.1416","volume":"123","author":"HR Gosker","year":"2003","unstructured":"Gosker\u00a0HR, et\u00a0al. Striking similarities in systemic factors contributing to decreased exercise capacity in patients with severe chronic heart failure or COPD. Chest. 2003;123(5):1416\u201324.","journal-title":"Chest"},{"key":"2073_CR4","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1093\/ajcn\/71.5.1033","volume":"71","author":"HR Gosker","year":"1999","unstructured":"Gosker\u00a0HR, et\u00a0al. Skeletal muscle dysfunction in chronic obstructive pulmonary disease and chronic heart failure: underlying mechanisms and therapy perspectives. Am J Clin Nutr. 1999;71:1033\u201347.","journal-title":"Am J Clin Nutr"},{"issue":"7 Suppl","key":"2073_CR5","first-page":"S662","volume":"33","author":"R Casburi","year":"2011","unstructured":"Casburi\u00a0R. Skeletal muscle dysfunction and chronic obstructive pulmonry disease. Med Sci Sports Exerc. 2011;33(7 Suppl):S662\u2013S70.","journal-title":"Med Sci Sports Exerc"},{"issue":"25","key":"2073_CR6","doi-asserted-by":"publisher","first-page":"2436","DOI":"10.1056\/NEJMoa0908355","volume":"361","author":"SD Anker","year":"2009","unstructured":"Anker\u00a0SD, Colet\u00a0JC, Filippatos\u00a0G, Willenheimer\u00a0R, Dickstein\u00a0K, Drexler\u00a0H, et\u00a0al. Ferric carboxymaltose in patients with heart failure and iron deficiency. N\u00a0Engl J Med. 2009;361(25):2436\u201348.","journal-title":"N Engl J Med"},{"key":"2073_CR7","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1007\/s004240050215","volume":"432","author":"SD Harridge","year":"1996","unstructured":"Harridge\u00a0SD, Bottinelli\u00a0R, Canepari\u00a0M, Pellegrino\u00a0MA, Reggiani\u00a0C, Esbj\u00f6rnsson\u00a0M, Saltinet\u00a0B. Whole-muscle and single-fibre contractile properties and myosin heavy chain isoforms in humans. Pfflugers Arch. 1996;432:913\u201320.","journal-title":"Pfflugers Arch"},{"issue":"5","key":"2073_CR8","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1113\/expphysiol.2006.036525","volume":"92","author":"SDR Harridge","year":"2007","unstructured":"Harridge\u00a0SDR. Plasticity of human skeletal muscle:gene expression to in vivo function. Exp Physiol. 2007;92(5):783\u201397.","journal-title":"Exp Physiol"},{"key":"2073_CR9","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.biochi.2014.01.009","volume":"100","author":"LK Beilschmidt","year":"2014","unstructured":"Beilschmidt\u00a0LK, Puccio\u00a0HM. Mammilian Fe\u2011S cluster biogenesis and its implication in disease. Biochimie. 2014;100:48\u201360.","journal-title":"Biochimie"},{"issue":"5","key":"2073_CR10","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1097\/MCO.0b013e32833cc93d","volume":"13","author":"IR Lanza","year":"2010","unstructured":"Lanza\u00a0IR, Sreekumaran\u00a0N. Mitochondrial metabolic function assessed in vivo and in vitro. Curr Opin Clin Nutr Metab Care. 2010;13(5):511\u20137.","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"2073_CR11","doi-asserted-by":"publisher","first-page":"2933","DOI":"10.2337\/db08-0349","volume":"57","author":"IR Lanza","year":"2008","unstructured":"Lanza\u00a0IR, et\u00a0al. Endurance exercise as a\u00a0countermeasure for aging. Diabetes. 2008;57:2933\u201342.","journal-title":"Diabetes"},{"issue":"3","key":"2073_CR12","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.cmet.2006.02.003","volume":"3","author":"WH Tong","year":"2006","unstructured":"Tong\u00a0WH, Rouault\u00a0TA. Function of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis. Cell Metab. 2006;3(3):199\u2013210.","journal-title":"Cell Metab"},{"issue":"22","key":"2073_CR13","doi-asserted-by":"publisher","first-page":"4460","DOI":"10.1093\/hmg\/ddt295","volume":"22","author":"LSC al et","year":"2013","unstructured":"al et\u00a0LSC. Mutations in LYRM4, encoding iron-sulfur cluster biogenesis factor ISD 11, cause deficiency of multiple respiatory chain complexes. Hum Mol Genet. 2013;22(22):4460\u201373.","journal-title":"Hum Mol Genet"},{"issue":"1","key":"2073_CR14","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1074\/jbc.M114.610402","volume":"290","author":"A Panday","year":"2015","unstructured":"Panday\u00a0A, Pain\u00a0J, Ghosh\u00a0AK, Dancis\u00a0A, Pain\u00a0D. Fe\u2011S cluster biogenesis in isolated mammalian mitochondria: coordinated use of persulfide sulfur and iron and requirements for GTP, NADH and ATP. J\u00a0Biol Chem. 2015;290(1):640\u201357.","journal-title":"J Biol Chem"},{"issue":"9","key":"2073_CR15","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1164\/rccm.201702-0311PP","volume":"196","author":"SM Cloonan","year":"2017","unstructured":"Cloonan\u00a0SM, Mumby\u00a0S, Adcock\u00a0IM, Choi\u00a0AMK, Chung\u00a0KF, Quinlan\u00a0GJ. The \u201ciron\u201d-y of iron overload and iron deficiency in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2017;196(9):1103\u201312.","journal-title":"Am J Respir Crit Care Med"},{"key":"2073_CR16","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-14-24","author":"DS Silverberg","year":"2014","unstructured":"Silverberg\u00a0DS, et al. Anemia and iron deficiency in COPD patients:prevalence and the effects of correction of the anemia with erythropoiesis stimulating agents and intravenous iron. BMC Pulm. 2014. https:\/\/doi.org\/10.1186\/1471-2466-14-24.","journal-title":"BMC Pulm"},{"issue":"1","key":"2073_CR17","doi-asserted-by":"publisher","first-page":"e000577","DOI":"10.1136\/bmjresp-2020-000577","volume":"7","author":"P Santer","year":"2020","unstructured":"Santer\u00a0P, McGahey\u00a0A, Frise\u00a0MC, Petousi\u00a0N, Talbot\u00a0NP, Baskerville\u00a0R, et al. Intravenous iron and chronic obstructive pulmonary disease: a randomised controlled trial. BMJ Open Respir Res. 2020;7(1):e000577. https:\/\/doi.org\/10.1136\/bmjresp-2020-000577.","journal-title":"BMJ Open Respir Res"},{"issue":"5","key":"2073_CR18","first-page":"700","volume":"131","author":"NL Jones","year":"1985","unstructured":"Jones\u00a0NL, Makrides\u00a0L, Hitchcock\u00a0C, Chypchar\u00a0T, McCartney\u00a0N. Normal standards for an incremental progressive cycle ergometer test. Am Rev Respir Dis. 1985;131(5):700\u20138.","journal-title":"Am Rev Respir Dis"},{"issue":"6","key":"2073_CR19","doi-asserted-by":"publisher","first-page":"863","DOI":"10.33549\/physiolres.933867","volume":"67","author":"AJ Lopes","year":"2018","unstructured":"Lopes\u00a0AJ, Vig\u00e1rio\u00a0PS, Hora\u00a0AL, Deus\u00a0CA, Soares\u00a0MS, Guimaraes\u00a0FS, et\u00a0al. Ventilation distribution, pulmonary diffusion and peripheral muscle endurance as determinants of exercise intolerance in elderly patients with chronic obstructive pulmonary disease. Physiol Res. 2018;67(6):863\u201374.","journal-title":"Physiol Res"},{"issue":"5","key":"2073_CR20","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1183\/09031936.00116808","volume":"33","author":"M Weatherall","year":"2009","unstructured":"Weatherall\u00a0M, Marsh\u00a0S, Shirtcliffe\u00a0P, Williams\u00a0M, Travers\u00a0J, Beasley\u00a0R. Quality of life measured by the St george\u2019s respiratory questionnaire and spirometry. Eur Respir\u00a0J. 2009;33(5):1025\u201330.","journal-title":"Eur Respir J"},{"key":"2073_CR21","doi-asserted-by":"publisher","first-page":"e007911","DOI":"10.1136\/bmjopen-2015-007911","volume":"5","author":"A Nickol","year":"2015","unstructured":"Nickol\u00a0A, et al. A cross-sectional study of the prevalence and associations of iron deficiency in a\u00a0cohort of patients with chronic obstructive pulmonary disease. BMJ Open. 2015;5:e7911.","journal-title":"BMJ Open"},{"issue":"12","key":"2073_CR22","doi-asserted-by":"publisher","first-page":"2485","DOI":"10.1016\/j.jacc.2006.08.034","volume":"48","author":"J Nanas","year":"2006","unstructured":"Nanas\u00a0J, Matsouka\u00a0C, Karageorgopoulos\u00a0D, Leonti\u00a0A, Tsolakis\u00a0E, Drakos\u00a0S, et\u00a0al. Etiology of anemia in patients with advanced heart failure. J\u00a0Am Coll Cardiol. 2006;48(12):2485\u20139.","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"2073_CR23","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1152\/jappl.1998.84.5.1768","volume":"84","author":"Y Zhu","year":"1998","unstructured":"Zhu\u00a0Y, Haas\u00a0J. Altered metabolic response of iron-depleted nonanemic women during a\u00a015-km time trial. J\u00a0Appl Physiol. 1998;84(5):1768\u201375.","journal-title":"J Appl Physiol"},{"issue":"3","key":"2073_CR24","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1136\/thoraxjnl-2014-206440","volume":"70","author":"SE Jones","year":"2015","unstructured":"Jones\u00a0SE, et\u00a0al. Sarcopenia in COPD: prevalence, clinical correlates and response to pulmonary rehabilitation. Thorax. 2015;70(3):213\u20138.","journal-title":"Thorax"},{"key":"2073_CR25","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003793.pub3","author":"B McCarthy","year":"2015","unstructured":"McCarthy\u00a0B, Casey\u00a0D, Devane\u00a0D, Murphy\u00a0K, Murphy\u00a0E, Lacasse\u00a0Y. Pulmonary rehabilitation for chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2015; https:\/\/doi.org\/10.1002\/14651858.CD003793.pub3.","journal-title":"Cochrane Database Syst Rev"},{"issue":"5","key":"2073_CR26","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1136\/thoraxjnl-2018-211855","volume":"74","author":"JM Fermont","year":"2019","unstructured":"Fermont\u00a0JM, Masconi\u00a0KL, Jensen\u00a0MT, Ferrari\u00a0R, Di Lorenzo\u00a0VAP, Marott\u00a0JM, et al. Biomarkers and clinical outcomes in COPD: a\u00a0systematic review and meta-analysis. Thorax. 2019;74(5):439\u201346.","journal-title":"Thorax"},{"key":"2073_CR27","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1183\/09031936.00150414","volume":"44","author":"SJ Singh","year":"2014","unstructured":"Singh\u00a0SJ, Puhan\u00a0MA, Andrianopoulos\u00a0V, Hernandes\u00a0NA, Mitchell\u00a0KE, Hill\u00a0CJ, et\u00a0al. An official systematic review of the European Respiratory Society\/American Thoracic Society: measurement properties of field walking tests in chronic respiratory disease. Eur Respir\u00a0J. 2014;44:1447\u201378.","journal-title":"Eur Respir J"},{"issue":"4","key":"2073_CR28","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1164\/rccm.201209-1596OC","volume":"187","author":"MI Polkey","year":"2013","unstructured":"Polkey\u00a0MI, Spruit\u00a0MA, Edwards\u00a0LD, Watkins\u00a0ML, Pinto-Plata\u00a0V, Vestbo\u00a0J, et al. Six-minute-walk test in chronic obstructive pulmonary disease: minimal clinically important difference for death or hospitalization. Am J Respir Crit Care Med. 2013;187(4):382\u20136.","journal-title":"Am J Respir Crit Care Med"},{"key":"2073_CR29","volume-title":"Use of exercise testing in the evaluation of interventional efficacy: an official ERS statement Task Force Report in Press","author":"L Puente-Maestu","year":"2016","unstructured":"Puente-Maestu\u00a0L, Palange\u00a0P, Casaburi\u00a0R, Laveneziana\u00a0P, Maltais\u00a0F, Neder\u00a0JA, et al. Use of exercise testing in the evaluation of interventional efficacy: an official ERS statement Task Force Report in Press. 2016. Corrected Proof."},{"key":"2073_CR30","doi-asserted-by":"publisher","DOI":"10.1081\/copd-200050513","author":"PW Jones","year":"2005","unstructured":"Jones\u00a0PW. St. George\u2019s respiratory questionnaire: MCID. J Chronic Obstr Pulm Dis. 2005. https:\/\/doi.org\/10.1081\/copd-200050513.","journal-title":"J Chronic Obstr Pulm Dis"},{"issue":"2","key":"2073_CR31","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/0197-2456(90)90005-M","volume":"11","author":"WD Dupont","year":"1990","unstructured":"Dupont\u00a0WD, Plummer\u00a0WDJ. Power and sample size calculations. A review and computer program. Control Clin Trials. 1990;11(2):116\u201328.","journal-title":"Control Clin Trials"},{"key":"2073_CR32","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i5239","author":"SM Eldridge","year":"2016","unstructured":"Eldridge\u00a0SM, Chan\u00a0CL, Campbell\u00a0MJ, Bond\u00a0CM, Hopewell\u00a0S, Thabane\u00a0L, et al. CONSORT 2010 statement: extension to randomised pilot and feasibility trials. BMJ. 2016. https:\/\/doi.org\/10.1136\/bmj.i5239.","journal-title":"BMJ"}],"container-title":["Wiener klinische Wochenschrift"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00508-022-02073-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00508-022-02073-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00508-022-02073-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T02:19:13Z","timestamp":1674008353000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00508-022-02073-4"}},"subtitle":["A\u00a0pilot study"],"short-title":[],"issued":{"date-parts":[[2022,8,31]]},"references-count":32,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["2073"],"URL":"https:\/\/doi.org\/10.1007\/s00508-022-02073-4","relation":{},"ISSN":["0043-5325","1613-7671"],"issn-type":[{"value":"0043-5325","type":"print"},{"value":"1613-7671","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,31]]},"assertion":[{"value":"11 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"E.\u00a0Grasmuk-Siegl, M.H.\u00a0Urban, S.\u00a0Scherrer and G.-C.\u00a0Funk declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}