{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T13:14:19Z","timestamp":1792761259930,"version":"4.5.0"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"9-10","license":[{"start":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:00:00Z","timestamp":1687910400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:00:00Z","timestamp":1687910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005788","name":"Medical University of Vienna","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005788","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Wien Klin Wochenschr"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec>\n                <jats:title>Background and aims<\/jats:title>\n                <jats:p>Heart failure (HF) might lead to increased hepatic venous pressure, thereby impairing hepatic blood outflow and subsequently inducing congestive hepatopathy. We aimed to evaluate prevalence of congestive hepatopathy in patients undergoing heart transplantation (HTX) as well as their post-transplant course.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Patients undergoing HTX from 2015\u20132020 at the Vienna General Hospital were included (<jats:italic>n<\/jats:italic>\u202f=\u2009205). Congestive hepatopathy was defined by hepatic congestion on abdominal imaging and hepatic injury. Laboratory parameters, ascites severity, and clinical events were assessed and post-HTX outcomes evaluated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>At listing, 104 (54%) patients showed hepatic congestion, 97 (47%) hepatic injury, and 50 (26%) had ascites. Congestive hepatopathy was diagnosed in 60 (29%) patients, who showed more often ascites, lower serum sodium and cholinesterase activity, and higher hepatic injury markers. Mean albumin-bilirubin (ALBI)-score as well as (modified)-model for end-stage liver disease (MELD)-scores were higher in patients with congestive hepatopathy. Median levels of laboratory parameters\/scores normalised after HTX, and ascites resolved in most patients with congestive hepatopathy (<jats:italic>n<\/jats:italic>\u202f=\u200948\/56, 86%). The post-HTX (median follow-up 55.1\u00a0months) survival was 87% and liver-related events were rare (3%). Severe ascites, low cholinesterase, and MELD\/MELD-XI were associated with ascites persistence\/death 1\u2011year after HTX. Age, male sex, and severe ascites were the only independent predictors of post-HTX mortality. Both ALBI and MELD-scores were robust indicators of post-HTX survival when measured 4\u00a0weeks after HTX (ALBI log-rank test <jats:italic>p<\/jats:italic>\u202f&lt;\u20090.001; MELD log-rank test <jats:italic>p<\/jats:italic>\u202f=\u20090.012).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Congestive hepatopathy and ascites were mostly reversible after HTX. Liver-related scores and ascites improve prognostication in patients after HTX.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00508-023-02231-2","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T15:03:08Z","timestamp":1687964588000},"page":"267-277","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical course of congestive hepatopathy pre\/post heart transplantation"],"prefix":"10.1007","volume":"136","author":[{"given":"Lorenz","family":"Balcar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Semmler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Scheiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert Friedrich","family":"St\u00e4ttermayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"\u0106osi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Schwabl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niema","family":"Kazem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattias","family":"Mandorfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"H\u00fclsmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Zuckermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4590-3583","authenticated-orcid":false,"given":"Thomas","family":"Reiberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,6,28]]},"reference":[{"issue":"24","key":"2231_CR1","doi-asserted-by":"publisher","first-page":"9420","DOI":"10.3390\/ijms21249420","volume":"21","author":"JI Fortea","year":"2020","unstructured":"Fortea\u00a0JI, Puente \u00c1, Cuadrado\u00a0A, Huelin\u00a0P, Pell\u00f3n\u00a0R, Gonz\u00e1lez S\u00e1nchez\u00a0FJ, et\u00a0al. Congestive hepatopathy. Int J Mol Sci. 2020;21(24):9420. https:\/\/doi.org\/10.3390\/ijms21249420.","journal-title":"Int J Mol Sci"},{"issue":"2","key":"2231_CR2","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.gtc.2017.01.012","volume":"46","author":"AK Koehne de Gonzalez","year":"2017","unstructured":"Koehne de Gonzalez\u00a0AK, Lefkowitch\u00a0JH. Heart disease and the liver: pathologic evaluation. Gastroenterol Clin North Am. 2017;46(2):421\u201335.","journal-title":"Gastroenterol Clin North Am"},{"issue":"8","key":"2231_CR3","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1007\/s00261-017-1387-x","volume":"43","author":"ML Wells","year":"2018","unstructured":"Wells\u00a0ML, Venkatesh\u00a0SK. Congestive hepatopathy. 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Eur Heart\u00a0J. 2013;34(36):2804\u201311.","journal-title":"Eur Heart J"}],"container-title":["Wiener klinische Wochenschrift"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00508-023-02231-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00508-023-02231-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00508-023-02231-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T11:11:18Z","timestamp":1715166678000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00508-023-02231-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,28]]},"references-count":12,"journal-issue":{"issue":"9-10","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["2231"],"URL":"https:\/\/doi.org\/10.1007\/s00508-023-02231-2","relation":{},"ISSN":["0043-5325","1613-7671"],"issn-type":[{"value":"0043-5325","type":"print"},{"value":"1613-7671","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,28]]},"assertion":[{"value":"29 March 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 May 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"L.\u00a0Balcar, G.\u00a0Semmler, A.F.\u00a0St\u00e4ttermayer, S.\u00a0\u0106osi\u0107, P.\u00a0Schwabl and N.\u00a0Kazem declare that they have no competing interests. B.\u00a0Scheiner received travel support from AbbVie, Ipsen, and Gilead. M.\u00a0Mandorfer served as a\u00a0speaker and\/or consultant and\/or advisory board member for AbbVie, Collective Acumen, Gilead, and W. L. Gore & Associates and received travel support from AbbVie and Gilead. M.\u00a0H\u00fclsmann received grant support, speaker fee and consultant honoraria from Roche Diagnostics, Bayer, Boehringer Ingelheim, Astra Zeneca, Novartis, Biopeutics, Thermo Fisher. A.\u00a0Zuckermann serves on the speakers\u2019 bureau of Paragonix, Mallincrodt, and Franz K\u00f6hler Chemie. He served on the speakers\u2019 bureau of Sanofi-Genzyme and on the advisory board for Chiesi. T.\u00a0Reiberger received grant support from AbbVie, Boehringer-Ingelheim, Gilead, Intercept, MSD, Myr Pharmaceuticals, Philips Healthcare, Pliant, Siemens, and W. L. Gore & Associates; speaking honoraria from AbbVie, Gilead, Gore, Intercept, Roche, and MSD; consulting\/advisory board fees from AbbVie, Bayer, Boehringer-Ingelheim, Gilead, Intercept, MSD, and Siemens; and travel support from AbbVie, Boehringer-Ingelheim, Gilead, and Roche.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants or on human tissue were in accordance with the ethical standards of the institutional and\/or national research committee (EK1512\/2021) and with the 1975 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}