{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:12:39Z","timestamp":1767139959759,"version":"build-2238731810"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"7-8","license":[{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005788","name":"Medical University of Vienna","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005788","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Wien Klin Wochenschr"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The role of the family history in the development and prognosis of gastroesophageal cancer is a\u00a0controversially discussed topic as appropriate data from western cohorts are lacking. This study aims to explore its associations with disease and outcome parameters in a\u00a0large European cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed self-reported family history in patients with gastroesophageal cancer treated between 1\u00a0January 1990 and 31 December 2021 at the Medical University of Vienna. Association analyses with patient characteristics, tumor characteristics, symptoms and overall survival (OS) were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In our cohort of 1762 gastroesophageal cancer patients, 592 (34%) reported a\u00a0positive family history of cancer (159, 9%, gastroesophageal cancer). No associations were found with histopathological parameters or initial symptoms; however, a\u00a0positive family history correlated with female gender (cancer in general:\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u20090.011; gastroesophageal cancer:\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u20090.015). Family history of cancer in general was associated with earlier cancer stages (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u20090.04), higher BMI (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u20090.005), and alcohol consumption (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u20090.010), while a\u00a0positive history for gastroesophageal cancer was associated with higher age at diagnosis (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u20090.002) and stomach cancer (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u20090.002). There was no statistically significant association of positive family history with OS (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u20090.1,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u20090.45), also not in subgroups for histology (adeno and squamous cell), number of family members and degree of relative.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results emphasize that a\u00a0positive family history is neither statistically significantly associated with prognosis nor with specific histopathological features in patients with gastroesophageal cancer. Yet, associations with distinct patient characteristics and positive family history indicate that specific subgroups might profit from endoscopic surveillance. Prospective studies are warranted to investigate these findings further.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00508-024-02432-3","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T11:19:50Z","timestamp":1725535190000},"page":"214-223","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of family history with patient characteristics and prognosis in a\u00a0large European gastroesophageal cancer cohort"],"prefix":"10.1007","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7203-8732","authenticated-orcid":false,"given":"Hannah C.","family":"Puhr","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luzia","family":"Berchtold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Zingerle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Felfernig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Weissenbacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerd","family":"Jomrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Asari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian F.","family":"Schoppmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7854-7781","authenticated-orcid":false,"given":"Gerald W.","family":"Prager","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0374-1408","authenticated-orcid":false,"given":"Elisabeth S.","family":"Bergen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9379-6797","authenticated-orcid":false,"given":"Anna S.","family":"Berghoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3541-2315","authenticated-orcid":false,"given":"Matthias","family":"Preusser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayseg\u00fcl","family":"Ilhan-Mutlu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,5]]},"reference":[{"issue":"3","key":"2432_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung\u00a0H, Ferlay\u00a0J, Siegel\u00a0RL, Laversanne\u00a0M, Soerjomataram\u00a0I, Jemal\u00a0A, et\u00a0al. 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Ann Geriatr Med Res. 2022;26(1):33\u201341. https:\/\/doi.org\/10.4235\/agmr.21.0144.","journal-title":"Ann Geriatr Med Res"}],"updated-by":[{"DOI":"10.1007\/s00508-024-02456-9","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:00:00Z","timestamp":1729209600000}}],"container-title":["Wiener klinische Wochenschrift"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00508-024-02432-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00508-024-02432-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00508-024-02432-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T06:50:43Z","timestamp":1744872643000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00508-024-02432-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,5]]},"references-count":28,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["2432"],"URL":"https:\/\/doi.org\/10.1007\/s00508-024-02432-3","relation":{},"ISSN":["0043-5325","1613-7671"],"issn-type":[{"value":"0043-5325","type":"print"},{"value":"1613-7671","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,5]]},"assertion":[{"value":"4 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2024","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original online version of this article was revised: In this article the author sequence is incorrectly given as:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Ayseg\u00fcl Ilhan-Mutlu, Hannah C. Puhr, Luzia Berchtold, Linda Zingerle, Melanie Felfernig, Lisa Weissenbacher, Gerd Jomrich, Reza Asari, Sebastian F. Schoppmann, Gerald W. Prager, Elisabeth S. Bergen, Anna S. Berghoff, Matthias Preusser.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"It should have been:","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Puhr Hannah, Berchtold Luzia, Zingerle Linda, Felfernig Melanie, Weissenbacher Lisa, Jomrich Gerd, Asari Reza, Schoppmann Sebastian, Prager Gerald, Bergen Elisabeth, Berghoff Anna, Preusser Matthias, Ilhan-Mutlu Ayseg\u00fcl.","order":9,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2024","order":10,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":11,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":12,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00508-024-02456-9","URL":"https:\/\/doi.org\/10.1007\/s00508-024-02456-9","order":13,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"A.\u00a0Ilhan-Mutlu: participation in advisory boards organized by MSD, Servier, Daiichi Sankyo and BMS, lecture honoraria from Eli Lilly, Servier, BMS, MSD, Astellas and Daiichi Sankyo, local principal investigator for clinical trials sponsored by BMS and Roche, consulting for Astellas and MSD, travel support from BMS, Roche, Eli Lilly and Daiichi Sankyo. H.C.\u00a0Puhr has received travel support from Eli Lilly, MSD, Novartis, Pfizer, Pierre Fabre and Roche and received lecture honoraria from Eli Lilly. G.W.\u00a0Prager has the following to declare: advisory role\/speaker fees: Merck Serono, Roche, Amgen, Sanofi, Lilly, Servier, Taiho, Bayer, Halozyme, BMS, MSD, Celgene, Pierre Fabre, Shire, CECOG, Astra Zeneca. A.S.\u00a0Berghoff has received research support from Daiichi Sankyo and Roche, honoraria for lectures, consultation or advisory board participation from Roche, Bristol-Meyers Squibb, Merck, Daiichi Sankyo as well as travel support from Roche, Amgen, Daiichi Sankyo, and AbbVie. M.\u00a0Preusser has received honoraria for lectures, consultation or advisory board participation from the following for-profit companies: Bayer, Bristol-Myers Squibb, Novartis, Gerson Lehrman Group (GLG), CMC Contrast, GlaxoSmithKline, Mundipharma, Roche, BMJ Journals, MedMedia, Astra Zeneca, AbbVie, Lilly, Medahead, Daiichi Sankyo, Sanofi, Merck Sharp & Dome, Tocagen, Adastra, Gan & Lee Pharmaceuticals, Servier. E.S.\u00a0Bergen, L.\u00a0Berchtold, L.\u00a0Zingerle, M.\u00a0Felfernig, L.\u00a0Weissenbacher, G.\u00a0Jomrich, R.\u00a0Asari and S.F.\u00a0Schoppmann declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants or on human tissue were in accordance with the ethical standards of the institutional and with the 1975 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the ethics committee of the Medical University of Vienna (reference number: 1600\/2021). The risk of publication of sensitive patient data was minimized by restrictions of data accession and pseudonymized statistical analysis. Due to the retrospective design no separate informed consent was necessary in the scope of this study. This is in line with local ethical standards and was approved by the ethics committee of the Medical University of Vienna (reference number: 1600\/2021).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}